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Harry Schachter
Harry Schachter FRSC (born 25 February 1933 in Vienna, Austria) is a Canadian biochemist and glycobiologist, and professor emeritus at the University of Toronto and the Hospital For Sick Children in Toronto, Canada. Biography Harry Schachter was born in Vienna, Austria in 1933, to Miriam Freund, a businesswoman, and to Ulrich (Usher) Schachter, a dentist and medical doctor. Harry's father was the cousin of Austro-Hungarian and Romanian tenor and actor, Joseph Schmidt. The Schachter family fled the Nazis in 1938, escaping to Port of Spain, Trinidad. He attended secondary school at Saint Mary's College, placing first in Trinidad in the Cambridge Advanced Level Examinations, and winning the Jerningham Gold Medal and the Island Scholarship in Mathematics. He also worked part-time as a reporter for the local Guardian newspaper. His family immigrated to Toronto, Canada in 1951. Education and career At the University of Toronto, Schachter completed his BA in Physiology and Biochemis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Canadians
Canadians (french: Canadiens) are people identified with the country of Canada. This connection may be residential, legal, historical or cultural. For most Canadians, many (or all) of these connections exist and are collectively the source of their being ''Canadian''. Canada is a multilingual and Multiculturalism, multicultural society home to people of groups of many different ethnic, religious, and national origins, with the majority of the population made up of Old World Immigration to Canada, immigrants and their descendants. Following the initial period of New France, French and then the much larger British colonization of the Americas, British colonization, different waves (or peaks) of immigration and settlement of non-indigenous peoples took place over the course of nearly two centuries and continue today. Elements of Indigenous, French, British, and more recent immigrant customs, languages, and religions have combined to form the culture of Canada, and thus a Canadian ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical Doctor
A physician (American English), medical practitioner (Commonwealth English), medical doctor, or simply doctor, is a health professional who practices medicine, which is concerned with promoting, maintaining or restoring health through the study, diagnosis, prognosis and treatment of disease, injury, and other physical and mental impairments. Physicians may focus their practice on certain disease categories, types of patients, and methods of treatment—known as specialities—or they may assume responsibility for the provision of continuing and comprehensive medical care to individuals, families, and communities—known as general practice. Medical practice properly requires both a detailed knowledge of the academic disciplines, such as anatomy and physiology, underlying diseases and their treatment—the ''science'' of medicine—and also a decent competence in its applied practice—the art or ''craft'' of medicine. Both the role of the physician and the meaning o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Congenital Disorder Of Glycosylation
A congenital disorder of glycosylation (previously called carbohydrate-deficient glycoprotein syndrome) is one of several rare inborn errors of metabolism in which glycosylation of a variety of tissue proteins and/or lipids is deficient or defective. Congenital disorders of glycosylation are sometimes known as CDG syndromes. They often cause serious, sometimes fatal, malfunction of several different organ systems (especially the nervous system, muscles, and intestines) in affected infants. The most common sub-type is PMM2-CDG (formally known as CDG-Ia) where the genetic defect leads to the loss of phosphomannomutase 2 (PMM2), the enzyme responsible for the conversion of mannose-6-phosphate into mannose-1-phosphate. Presentation The specific problems produced differ according to the particular abnormal synthesis involved. Common manifestations include ataxia; seizures; retinopathy; liver disease; coagulopathies; failure to thrive (FTT); dysmorphic features (''e.g.,'' inverted nip ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carbohydrate-deficient Glycoprotein Syndrome
A congenital disorder of glycosylation (previously called carbohydrate-deficient glycoprotein syndrome) is one of several rare inborn errors of metabolism in which glycosylation of a variety of tissue proteins and/or lipids is deficient or defective. Congenital disorders of glycosylation are sometimes known as CDG syndromes. They often cause serious, sometimes fatal, malfunction of several different organ systems (especially the nervous system, muscles, and intestines) in affected infants. The most common sub-type is PMM2-CDG (formally known as CDG-Ia) where the genetic defect leads to the loss of phosphomannomutase 2 (PMM2), the enzyme responsible for the conversion of mannose-6-phosphate into mannose-1-phosphate. Presentation The specific problems produced differ according to the particular abnormal synthesis involved. Common manifestations include ataxia; seizures; retinopathy; liver disease; coagulopathies; failure to thrive (FTT); dysmorphic features (''e.g.,'' inverte ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell Surface Receptors
Cell surface receptors (membrane receptors, transmembrane receptors) are receptors that are embedded in the plasma membrane of cells. They act in cell signaling by receiving (binding to) extracellular molecules. They are specialized integral membrane proteins that allow communication between the cell and the extracellular space. The extracellular molecules may be hormones, neurotransmitters, cytokines, growth factors, cell adhesion molecules, or nutrients; they react with the receptor to induce changes in the metabolism and activity of a cell. In the process of signal transduction, ligand binding affects a cascading chemical change through the cell membrane. Structure and mechanism Many membrane receptors are transmembrane proteins. There are various kinds, including glycoproteins and lipoproteins. Hundreds of different receptors are known and many more have yet to be studied. Transmembrane receptors are typically classified based on their tertiary (three-dimensional) struct ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glycoproteins
Glycoproteins are proteins which contain oligosaccharide chains covalently attached to amino acid side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification. This process is known as glycosylation. Secreted extracellular proteins are often glycosylated. In proteins that have segments extending extracellularly, the extracellular segments are also often glycosylated. Glycoproteins are also often important integral membrane proteins, where they play a role in cell–cell interactions. It is important to distinguish endoplasmic reticulum-based glycosylation of the secretory system from reversible cytosolic-nuclear glycosylation. Glycoproteins of the cytosol and nucleus can be modified through the reversible addition of a single GlcNAc residue that is considered reciprocal to phosphorylation and the functions of these are likely to be an additional regulatory mechanism that controls phosphorylation-based signalling. In contrast, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Johns Hopkins University
Johns Hopkins University (Johns Hopkins, Hopkins, or JHU) is a private university, private research university in Baltimore, Maryland. Founded in 1876, Johns Hopkins is the oldest research university in the United States and in the western hemisphere. It consistently ranks among the most prestigious universities in the United States and the world. The university was named for its first benefactor, the American entrepreneur and Quaker philanthropist Johns Hopkins. Hopkins' $7 million bequest to establish the university was the largest Philanthropy, philanthropic gift in U.S. history up to that time. Daniel Coit Gilman, who was inaugurated as :Presidents of Johns Hopkins University, Johns Hopkins's first president on February 22, 1876, led the university to revolutionize higher education in the U.S. by integrating teaching and research. In 1900, Johns Hopkins became a founding member of the American Association of Universities. The university has led all Higher education in the U ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Saul Roseman
Saul Roseman (March 9, 1921 - July 2, 2011) was an American biochemist at Johns Hopkins University in Baltimore, Maryland. Among many discoveries related to carbohydrate biochemistry, he discovered the phosphotransferase system in bacteria. Awards * 1971 Member of the American Academy of Arts and Sciences * 1972 Member of the National Academy of Sciences * 1974 Rosenstiel Award (together with H. Ronald Kaback) * 1981 Gairdner Foundation International Award of the (gairdner.org) * 1984 of the |
Glycobiology
Defined in the narrowest sense, glycobiology is the study of the structure, biosynthesis, and biology of saccharides (sugar chains or glycans) that are widely distributed in nature. Sugars or saccharides are essential components of all living things and aspects of the various roles they play in biology are researched in various medical, biochemical and biotechnological fields. History According to ''Oxford English Dictionary'' the specific term ''glycobiology'' was coined in 1988 by Prof. Raymond Dwek to recognize the coming together of the traditional disciplines of carbohydrate chemistry and biochemistry. This coming together was as a result of a much greater understanding of the cellular and molecular biology of glycans. However, as early as the late nineteenth century pioneering efforts were being made by Emil Fisher to establish the structure of some basic sugar molecules. Each year the Society of Glycobiology awards the Rosalind Kornfeld award for lifetime achievement in the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trinidad And Tobago Guardian
The ''Trinidad and Tobago Guardian'' (together with the ''Sunday Guardian'') is the oldest daily newspaper in Trinidad and Tobago. The paper is considered the newspaper of record for Trinidad and Tobago. History Its first edition was published on Sunday 2 September 1917. The newspaper, now owned and published by Guardian Media Limited, began as a broadsheet but in November 2002 changed to tabloid format, known as the "G-sized Guardian". In June 2008, the paper changed to a smaller-size tabloid. The main office of the ''Guardian'' is located at St. Vincent Street, Port of Spain, with a branch office on Chancery Lane, San Fernando, and the Head office which is located on 4-10 Rodney Road in Chaguanas. On 2 September 2017, the ''Trinidad and Tobago Guardian'' celebrated its 100th anniversary. Shortly after on 11 September 2017, the company launched a new layout. The slogan of the paper is ''The Guardian of Democracy''. Since 1955, according to an advertisement in '' Editor & Pub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trinidad
Trinidad is the larger and more populous of the two major islands of Trinidad and Tobago. The island lies off the northeastern coast of Venezuela and sits on the continental shelf of South America. It is often referred to as the southernmost island in the West Indies. With an area of , it is also the List of Caribbean islands by area, fifth largest in the West Indies. Name The original name for the island in the Arawak language, Arawaks' language was which meant "Land of the Hummingbird". Christopher Columbus renamed it ('The Island of the Holy Trinity, Trinity'), fulfilling a vow he had made before setting out on his third voyage. This has since been shortened to ''Trinidad''. History Island Caribs, Caribs and Arawaks lived in Trinidad long before Christopher Columbus encountered the islands on his third voyage on 31 July 1498. The island remained Spanish until 1797, but it was largely settled by French colonists from the French Caribbean, especially Martinique.Besson, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Saint Mary's College, Trinidad And Tobago
St. Mary's College (popularly known as CIC, which stands for College of the Immaculate Conception) is a government-assisted selective Catholic secondary school situated on Frederick Street in the heart of Port of Spain, Trinidad and Tobago. The school was established in 1863 with only a handful of students, presently, enrollment averages 1200 students inclusive of Forms 1 to Upper 6. The school's motto is "''Virtus et Scientia''" (Manliness and Knowledge). St. Mary's College is a seven-year school that prepares students for the Caribbean Examinations Council (CXC) Caribbean Secondary Education Certificate known as "CSEC" at 5th Form and the Caribbean Advanced Proficiency Examinations (CAPE) level examinations. The school offers education in a number of fields including the sciences, mathematics, humanities and social sciences. The College also provides opportunities for computer science students, such as artificial intelligence. Past principals *Fr. Victor Guilloux 1863–67 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
