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Hailan Hu
Hu Hailan (; born 1973) is a Chinese neuroscientist, professor, and executive director of the Center for Neuroscience at Zhejiang University School of Medicine in Hangzhou, China. Hu explores neural mechanisms underlying social behaviors and psychiatric diseases. She specifically explores the neural substrates of social rank and the role of neuron-glia interactions in driving depressive behaviors. Hu discovered the anatomical and molecular targets of ketamine's fast-acting antidepressant effects to be localized to the lateral habenular circuits in rodents. Hu was also the first scientist outside of Europe and America to be awarded the IBRO-Kemali Prize in over 20 years. She is also a member of the Jiusan Society. Early life and education Hu was born in Dongyang, Jinhua, Zhejiang province in 1973. Hu pursued her undergraduate degree at Peking University in Beijing, China. In 1996, she received her Bachelors of Science in biochemistry and molecular biology. Hu then moved to the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hu (surname)
Hu (Wikt:胡, 胡) is a Chinese surname. In 2006, it was the 15th most common surname in China. In 2013, it was the 13th most common in China, with 13.7 million Chinese sharing this surname. In 2019, Hu was the fifteenth most common surname in Mainland China. Some other, less common surnames pronounced Hu include Wikt:瓠, 瓠, Wikt:護, 護, Wikt:戶, 戶, Wikt:扈, 扈, Wikt:虎, 虎, Wikt:呼, 呼, Wikt:忽, 忽, Wikt:斛, 斛 and Wikt:壺, 壶. In Cantonese, “胡” is also pronounced as "Wu" or "Woo" or "Ow". Meaning In Classical Chinese, ''hú'' 胡 meant: "dewlap; wattle (anatomy), wattle" and was a variant Chinese character for "how; why; what" (''he'' Wikt:何, 何), "long-lasting; far-reaching" (''xia'' Wikt:遐, 遐), "part of a dagger-axe", ''hu-'' in "butterfly" (''hudie'' Wikt:蝴蝶, 蝴蝶), or possibly "Northern Barbarians". History According to tradition, the Hu (胡) surname has several historical origins. First, Hu could derive from the family of Duke Hu of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jinhua
, alternately romanized as Kinhwa, is a prefecture-level city in central Zhejiang province in eastern China. It borders the provincial capital of Hangzhou to the northwest, Quzhou to the southwest, Lishui to the south, Taizhou to the east, and Shaoxing to the northeast. Its population was 7,050,683 as of the 2020 census including 1,463,990 in the built-up (or metro) area made of two urban districts (not including yet the satellite city of Lanxi, which has become essentially a suburban offshoot of Jinhua's main urban area). Jinhua is rich in red soil and forest resources. The Jinhua or Wu River flows through the Lan and Fuchun to the Qiantang River beside Hangzhou, which flows into Hangzhou Bay and the East China Sea. In medieval China, it formed part of the water network feeding supplies to the southern end of the Grand Canal. It is best known for its dry-cured Jinhua ham. History and culture The history of Jinhua dates back to the 2nd century BC, when it was a county ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fragile X Syndrome
Fragile X syndrome (FXS) is a genetic disorder characterized by mild-to-moderate intellectual disability. The average IQ in males with FXS is under 55, while about two thirds of affected females are intellectually disabled. Physical features may include a long and narrow face, large ears, flexible fingers, and large testicles. About a third of those affected have features of autism such as problems with social interactions and delayed speech. Hyperactivity is common, and seizures occur in about 10%. Males are usually more affected than females. This disorder and finding of Fragile X syndrome has an X-linked dominant inheritance. It is typically caused by an expansion of the CGG triplet repeat within the ''FMR1'' (fragile X messenger ribonucleoprotein 1) gene on the X chromosome. This results in silencing ( methylation) of this part of the gene and a deficiency of the resultant protein (FMRP), which is required for the normal development of connections between neurons. Diagno ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
AMPA Receptor
The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (also known as AMPA receptor, AMPAR, or quisqualate receptor) is an ionotropic receptor, ionotropic transmembrane receptor for glutamate (iGluR) that mediates fast synapse, synaptic transmission in the central nervous system (CNS). It has been traditionally classified as a non-NMDA_receptor, NMDA-type receptor, along with the kainate receptor. Its name is derived from its ability to be activated by the artificial glutamate analog AMPA. The receptor was first named the "quisqualate receptor" by Watkins and colleagues after a naturally occurring agonist quisqualic acid, quisqualate and was only later given the label "AMPA receptor" after the selective agonist developed by Tage Honore and colleagues at the Royal Danish School of Pharmacy in Copenhagen. The ''GRIA2''-encoded AMPA receptor ligand binding core (GluA2 LBD) was the first glutamate receptor ion channel domain to be protein crystal, crystallized. Structure ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of California, San Diego
The University of California, San Diego (UC San Diego or colloquially, UCSD) is a public university, public Land-grant university, land-grant research university in San Diego, California. Established in 1960 near the pre-existing Scripps Institution of Oceanography, UC San Diego is the southernmost of the ten campuses of the University of California, and offers over 200 undergraduate and graduate degree programs, enrolling 33,096 undergraduate and 9,872 graduate students. The university occupies near the coast of the Pacific Ocean, with the main campus resting on approximately . UC San Diego is ranked among the best universities in the world by major college and university rankings. UC San Diego consists of twelve undergraduate, graduate and professional schools as well as seven undergraduate residential colleges. It received over 140,000 applications for undergraduate admissions in Fall 2021, making it the second most applied-to university in the United States. UC San Diego H ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Virginia
The University of Virginia (UVA) is a Public university#United States, public research university in Charlottesville, Virginia. Founded in 1819 by Thomas Jefferson, the university is ranked among the top academic institutions in the United States, with College admissions in the United States, highly selective admission. Set within the The Lawn, Academical Village, a World Heritage Site, UNESCO World Heritage Site, the university is referred to as a "Public Ivy" for offering an academic experience similar to that of an Ivy League university. It is known in part for certain rare characteristics among public universities such as #1800s, its historic foundations, #Honor system, student-run academic honor code, honor code, and Secret societies at the University of Virginia, secret societies. The original governing Board of Visitors included three List of presidents of the United States, U.S. presidents: Thomas Jefferson, Jefferson, James Madison, and James Monroe. The latter as si ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Roberto Malinow
Roberto Malinow. M.D., Ph.D. is an Argentinian-born American neuroscientist at the University of California, San Diego. He is currently a distinguished professor of neurobiology and neurosciences, and holds the Shiley Chair in Alzheimer's Disease Research at UCSD. In 2012 Dr. Malinow was elected to the National Academy of Sciences (Cellular and molecular neuroscience) and in 2015 was elected to the National Academy of Medicine. Malinow has a prolific scientific publication record, and his works have been cited over 25,000 times. For comparison, a scientist in the field of molecular biology & genetics has to receive approximately 1229 citations to be among the most cited 1% of life scientists in the world (see h-index by discipline). Further, he has contributed many ' high-impact' neuroscience articles, with an h-index The ''h''-index is an author-level metric that measures both the productivity and citation impact of the publications, initially used for an individual scienti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Julius Zhu
The gens Julia (''gēns Iūlia'', ) was one of the most prominent patrician families in ancient Rome. Members of the gens attained the highest dignities of the state in the earliest times of the Republic. The first of the family to obtain the consulship was Gaius Julius Iulus in 489 BC. The gens is perhaps best known, however, for Gaius Julius Caesar, the dictator and grand uncle of the emperor Augustus, through whom the name was passed to the so-called Julio-Claudian dynasty of the first century AD. The Julius became very common in imperial times, as the descendants of persons enrolled as citizens under the early emperors began to make their mark in history.''Dictionary of Greek and Roman Biography and Mythology'', vol. II, pp. 642, 643. Origin The Julii were of Alban origin, mentioned as one of the leading Alban houses, which Tullus Hostilius removed to Rome upon the destruction of Alba Longa. The Julii also existed at an early period at Bovillae, evidenced by a very a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
GTPase-activating Protein
GTPase-activating proteins or GTPase-accelerating proteins (GAPs) are a family of regulatory proteins whose members can bind to activated G proteins and stimulate their GTPase activity, with the result of terminating the signaling event. GAPs are also known as RGS protein, or RGS proteins,Kimple, A.J. "Structural Determinants of G-protein α Subunit Selectivity by Regulator of G-protein Signaling 2 (RGS2)". ''The Journal of Biological Chemistry''. 284 (2009): 19402-19411. and these proteins are crucial in controlling the activity of G proteins. Regulation of G proteins is important because these proteins are involved in a variety of important cellular processes. The large G proteins, for example, are involved in transduction of signaling from the G protein-coupled receptor for a variety of signaling processes like hormonal signaling, and small G proteins are involved in processes like cellular trafficking and cell cycling. GAP's role in this function is to turn the G protein's ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Axon Guidance
Axon guidance (also called axon pathfinding) is a subfield of neural development concerning the process by which neurons send out axons to reach their correct targets. Axons often follow very precise paths in the nervous system, and how they manage to find their way so accurately is an area of ongoing research. Axon growth takes place from a region called the growth cone and reaching the axon target is accomplished with relatively few guidance molecules. Growth cone receptors respond to the guidance cues. Mechanisms Growing axons have a highly motile structure at the growing tip called the growth cone, which responds to signals in the extracellular environment that instruct the axon in which direction to grow. These signals, called guidance cues, can be fixed in place or diffusible; they can attract or repel axons. Growth cones contain receptors that recognize these guidance cues and interpret the signal into a chemotropic response. The general theoretical framework is that whe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drosophila
''Drosophila'' () is a genus of flies, belonging to the family Drosophilidae, whose members are often called "small fruit flies" or (less frequently) pomace flies, vinegar flies, or wine flies, a reference to the characteristic of many species to linger around overripe or rotting fruit. They should not be confused with the Tephritidae, a related family, which are also called fruit flies (sometimes referred to as "true fruit flies"); tephritids feed primarily on unripe or ripe fruit, with many species being regarded as destructive agricultural pests, especially the Mediterranean fruit fly. One species of ''Drosophila'' in particular, ''D. melanogaster'', has been heavily used in research in genetics and is a common model organism in developmental biology. The terms "fruit fly" and "''Drosophila''" are often used synonymously with ''D. melanogaster'' in modern biological literature. The entire genus, however, contains more than 1,500 species and is very diverse in appearance, be ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rho Family Of GTPases
The Rho family of GTPases is a family of small (~21 kDa) signaling G proteins, and is a subfamily of the Ras superfamily. The members of the Rho GTPase family have been shown to regulate many aspects of intracellular actin dynamics, and are found in all eukaryotic kingdoms, including yeasts and some plants. Three members of the family have been studied in detail: Cdc42, Rac1, and RhoA. All G proteins are "molecular switches", and Rho proteins play a role in organelle development, cytoskeletal dynamics, cell movement, and other common cellular functions. History Identification of the Rho family of GTPases began in the mid-1980s. The first identified Rho member was RhoA, isolated serendipitously in 1985 from a low stringency cDNA screening. Rac1 and Rac2 were identified next, in 1989 followed by Cdc42 in 1990. Eight additional mammalian Rho members were identified from biological screenings until the late 1990s, a turning point in biology where availability of complete genome seq ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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