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HAL Allergy Group
HAL Allergy Group is a pharmaceutical company that develops, produces and sells products for allergy diagnostic and allergen immunotherapy (AIT). The research facilities and headquarters are located at the Leiden Bio Science Park, Netherlands. The focus since 1959 stems from the development, production and distribution of allergen immunotherapies for the treatment and prevention of allergic diseases. These immunotherapies produced are subcutaneous (SCIT) or sublingual (SLIT) administrated and used primarily against common allergies such as hay fever, house dust mite allergy and allergic reactions towards wasp or bee stings. With offices in major European countries, HAL Allergy is one of the European top players, particularly in the field of allergy. In addition, HAL Allergy has a specific expertise in the area of contract manufacturing with focus on the production of biopharmaceutical products for preclinical and clinical studies. This is done by its subsidiary HALIX B.V. HAL ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pharmaceutical
A medication (also called medicament, medicine, pharmaceutical drug, medicinal drug or simply drug) is a drug used to diagnose, cure, treat, or prevent disease. Drug therapy (pharmacotherapy) is an important part of the medical field and relies on the science of pharmacology for continual advancement and on pharmacy for appropriate management. Drugs are classified in multiple ways. One of the key divisions is by level of control, which distinguishes prescription drugs (those that a pharmacist dispenses only on the order of a physician, physician assistant, or qualified nurse) from over-the-counter drugs (those that consumers can order for themselves). Another key distinction is between traditional small molecule drugs, usually derived from chemical synthesis, and biopharmaceuticals, which include recombinant proteins, vaccines, blood products used therapeutically (such as IVIG), gene therapy, monoclonal antibodies and cell therapy (for instance, stem cell therapies) ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pre-clinical Development
In drug development, preclinical development, also termed preclinical studies or nonclinical studies, is a stage of research that begins before clinical trials (testing in humans) and during which important feasibility, iterative testing and drug safety data are collected, typically in laboratory animals. The main goals of preclinical studies are to determine a starting, safe dose for first-in-human study and assess potential toxicity of the product, which typically include new medical devices, prescription drugs, and diagnostics. Companies use stylized statistics to illustrate the risks in preclinical research, such as that on average, only one in every 5,000 compounds that enters drug discovery to the stage of preclinical development becomes an approved drug. Types of preclinical research Each class of product may undergo different types of preclinical research. For instance, drugs may undergo pharmacodynamics (what the drug does to the body) (PD), pharmacokinetics (wh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pharmaceutical Companies Established In 1959
A medication (also called medicament, medicine, pharmaceutical drug, medicinal drug or simply drug) is a drug used to diagnose, cure, treat, or prevent disease. Drug therapy (pharmacotherapy) is an important part of the medical field and relies on the science of pharmacology for continual advancement and on pharmacy for appropriate management. Drugs are classified in multiple ways. One of the key divisions is by level of control, which distinguishes prescription drugs (those that a pharmacist dispenses only on the order of a physician, physician assistant, or qualified nurse) from over-the-counter drugs (those that consumers can order for themselves). Another key distinction is between traditional small molecule drugs, usually derived from chemical synthesis, and biopharmaceuticals, which include recombinant proteins, vaccines, blood products used therapeutically (such as IVIG), gene therapy, monoclonal antibodies and cell therapy (for instance, stem cell therapies). Other ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
European Academy Of Allergy And Clinical Immunology
The European Academy of Allergy and Clinical Immunology (EAACI) is a non-profit organisation for European clinicians, researchers and allied health professionals in the field of allergy and clinical immunology, covering asthma, rhinitis, eczema and occupational allergy, food and drug allergy, severe anaphylactic reactions, autoimmune disorders, and immunodeficiencies. More than 50 national allergy societies are members, representing more than 13,000 people from 121 countries. History EAACI was founded in 1956 in Florence, Italy; the following year, its constitution and by-laws were codified in Utrecht, The Netherlands. Conferences and training courses The EAACI organises a five-day annual congress, usually attended by around 7000–8000 international participants. The 2022 congress was held in Prague, Czech Republic. The association also organises smaller three-day meetings addressing specific areas in the field of allergy, which are usually attended by 250–1500 participants. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Peanut Allergy
Peanut allergy is a type of food allergy to peanuts. It is different from tree nut allergies, because peanuts are legumes and not true nuts. Physical symptoms of allergic reaction can include itchiness, hives, swelling, eczema, sneezing, asthma attack, abdominal pain, drop in blood pressure, diarrhea, and cardiac arrest. Anaphylaxis may occur. Those with a history of asthma are more likely to be severely affected. It is due to a type I hypersensitivity reaction of the immune system in susceptible individuals. The allergy is recognized "as one of the most severe food allergies due to its prevalence, persistency, and potential severity of allergic reaction." Prevention may be partly achieved through early introduction of peanuts to the diets of pregnant women and babies. It is recommended that babies at high risk be given peanut products in areas where medical care is available as early as 4 months of age. The principal treatment for anaphylaxis is the injection of epineph ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Allergoid
An allergoid is a protein that has been modified for use in desensitisation protocols, or for induction of oral/sublingual tolerance. The allergoid sustain the linear epitopes recognized by the MHC- TCR cell-present systems (keeps the immunoreactivity) but has less reaginic epitopes (less allergenicity). The elaboration of allergoids through the polymerization of native allergens is performed since some decades by application of glutaraldehyde or formaldehyde. Allergoids may also be produced by genic recombination. Recently it was introduced the production of allergoids by polymerization through the microbial transglutaminases. See also * Allergen immunotherapy Allergen immunotherapy, also known as desensitization or hypo-sensitization, is a medical treatment for environmental allergies, such as insect bites, and asthma. Immunotherapy involves exposing people to larger and larger amounts of allergen in ... References {{Reflist Proteins ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Contract Manufacturer
A contract manufacturer (CM) is a manufacturer that contracts with a firm for components or products (in which case it is a turnkey supplier). It is a form of outsourcing. A contract manufacturer performing packaging operations is called copacker or a ''contract packager''. Brand name companies focus on product innovation, design and sales, while the manufacturing takes place in independent factories (the turnkey suppliers). Most turnkey suppliers specialize in simply manufacturing physical products, but some are also able to handle a significant part of the design and customization process if needed. Some turnkey suppliers specialize in one base component (ex. memory chips) or a base process (e.g. plastic molding). Business model In a contract manufacturing business model, the hiring firm approaches the contract manufacturer with a design or formula. The contract manufacturer will quote the parts based on processes, labor, tooling, and material costs. Typically a hiring firm ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paul Ehrlich Institute
The Paul Ehrlich Institute (German: ''Paul-Ehrlich-Institut – Bundesinstitut für Impfstoffe und biomedizinische Arzneimittel'', PEI) is a German federal agency, medical regulatory body and research institution for vaccines and biomedicines. It was founded in 1896 and is subordinate to the Federal Ministry of Health. The institute is a WHO Collaborating Centre for quality assurance of blood products and ''in vitro'' diagnostic devices. It is located in Langen, Hesse, near Frankfurt, and was located in Frankfurt for most of the 20th century. It is named for its founding director, the immunologist and Nobel Prize laureate Paul Ehrlich. History The Paul Ehrlich Institute was founded on 1 June 1896 in Steglitz, Berlin as the Institute for Serum Research and Serum Testing (Institut für Serumforschung und Serumprüfung), with immunologist Paul Ehrlich, one of Germany's most prominent medical researchers at the time, as its first director. The institute was founded specifically to p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Haarlem
Haarlem (; predecessor of ''Harlem'' in English) is a city and municipality in the Netherlands. It is the capital of the province of North Holland. Haarlem is situated at the northern edge of the Randstad, one of the most populated metropolitan areas in Europe; it is also part of the Amsterdam metropolitan area, being located about 15 km to the west of the core city of Amsterdam. Haarlem had a population of in . Haarlem was granted city status or '' stadsrechten'' in 1245, although the first city walls were not built until 1270. The modern city encompasses the former municipality of Schoten as well as parts that previously belonged to Bloemendaal and Heemstede. Apart from the city, the municipality of Haarlem also includes the western part of the village of Spaarndam. Newer sections of Spaarndam lie within the neighbouring municipality of Haarlemmermeer. Geography Haarlem is located on the river Spaarne, giving it its nickname 'Spaarnestad' (Spaarne city). It is situated a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
House Dust Mite Allergy
House dust mites (HDM, or simply dust mites) are various species of acariform mites belonging to the family Pyroglyphidae that are found in association with dust in dwellings. They are known for causing allergies. Biology Species The currently known species are: * ''Dermatophagoides farinae'' (American house dust mite) * ''Dermatophagoides pteronyssinus'' (European house dust mite) * '' Dermatophagoides evansi'' * '' Dermatophagoides microceras'' * '' Dermatophagoides halterophilus'' * ''Dermatophagoides siboney'' * ''Dermatophagoides neotropicalis'' * ''Dermatophagoides alexfaini'' * ''Dermatophagoides anisopoda'' * ''Dermatophagoides chirovi'' * ''Dermatophagoides deanei'' * ''Dermatophagoides rwandae'' * ''Dermatophagoides scheremeteroskyi'' * ''Dermatophagoides scheremetewskyi'' * ''Dermatophagoides simplex'' * ''Euroglyphus maynei'' (Mayne's house dust mite) * '' Euroglyphus longior'' * '' Hirstia domicola'' * '' Malayoglyphus carmelitus'' * '' Malayoglyphus intermedius'' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Private Ownership
Private property is a legal designation for the ownership of property by non-governmental Legal personality, legal entities. Private property is distinguishable from public property and Personal property, personal property, which is owned by a state entity, and from Collective ownership, collective or cooperative property, which is owned by a group of Non-governmental organization, non-governmental entities. Private property is foundational to capitalism, an economic system based on the private ownership of the means of production and their operation for Profit (economics), profit. The distinction between private and personal property varies depending on political philosophy, with socialist perspectives making a hard distinction between the two. As a legal concept, private property is defined and enforced by a country's political system. History Ideas about and discussion of private property date back to the Persian Empire, and emerge in the Western tradition at least as far ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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