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Human Proteome Folding Project
The Human Proteome Folding Project (HPF) is a collaborative effort between New York University ( Bonneau Lab), the Institute for Systems Biology (ISB) and the University of Washington ( Baker Lab), using the Rosetta software developed by the Rosetta Commons. HPF Phase 1 applied Rosetta v4.2x software on the human genome and 89 others, starting in November 2004. Phase 1 ended in July 2006. HPF Phase 2 (HPF2) applies the Rosetta v4.8x software in higher resolution, "full atom refinement" mode, concentrating on cancer biomarkers (proteins found at dramatically increased levels in cancer tissues), human secreted proteins and malaria. Phase 1 ran on two volunteer computing grids: on United Devices' grid.org, and on the World Community Grid, an IBM philanthropic initiative. Phase 2 of the project ran exclusively on the World Community Grid; it terminated in 2013 after more than 9 years of IBM involvement. The Institute for Systems Biology will use the results of the computations within ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Richard Bonneau
Richard Bonneau is an American computational biologist and data scientist whose primary research is in the following areas: learning networks from functional genomics data, predicting and designing protein and peptiodomimetic structure and applying data science to social networks. A professor at New York University, he holds appointments in the department of biology, the Center for Data Science and the Courant Institute of Mathematical Sciences. Biography Bonneau is Vice-President, Machine Learning for Drug Discovery at Genentech and Group leader for the Systems Biology group in the center for computational biology at the Flatiron Institute. He was previously director of New York University Center for Data Science. Scientific work In the area of structure prediction, Bonneau was one of the early authors on the Rosetta code, one of the first codes to demonstrate the ability to predict protein structure in the absence of sequence homology. Using IBM's World Community Grid to ca ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Screensaver HUMAN PROTEOME FOLDING Phase2
A screensaver (or screen saver) is a computer program that blanks the display screen or fills it with moving images or patterns when the computer has been idle for a designated time. The original purpose of screensavers was to prevent phosphor burn-in on CRT or plasma computer monitors (hence the name). Though most modern monitors are not susceptible to this issue (with the notable exception of OLED technology, which has individual pixels vulnerable to burnout), screensaver programs are still used for other purposes. Screensavers are often set up to offer a basic layer of security by requiring a password to re-access the device. Some screensaver programs also use otherwise-idle computer resources to do useful work, such as processing for volunteer computing projects. As well as computers, modern television operating systems, media players, and other digital entertainment systems may include optional screensavers. Purpose Screen protection Before the advent of LCD screens, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Proteomics
Proteomics is the large-scale study of proteins. Proteins are vital parts of living organisms, with many functions such as the formation of structural fibers of muscle tissue, enzymatic digestion of food, or synthesis and replication of DNA. In addition, other kinds of proteins include antibodies that protect an organism from infection, and hormones that send important signals throughout the body. The proteome is the entire set of proteins produced or modified by an organism or system. Proteomics enables the identification of ever-increasing numbers of proteins. This varies with time and distinct requirements, or stresses, that a cell or organism undergoes. Proteomics is an interdisciplinary domain that has benefited greatly from the genetic information of various genome projects, including the Human Genome Project. It covers the exploration of proteomes from the overall level of protein composition, structure, and activity, and is an important component of functional genomics. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Berkeley Open Infrastructure For Network Computing Projects
Berkeley most often refers to: *Berkeley, California, a city in the United States **University of California, Berkeley, a public university in Berkeley, California *George Berkeley (1685–1753), Anglo-Irish philosopher Berkeley may also refer to: Places Australia * Berkeley, New South Wales, a suburb of Wollongong Canada * Berkeley, Ontario, a community in Grey County United Kingdom * Berkeley (hundred), an administrative division from late Saxon period to the 19th century * Berkeley, Gloucestershire, a town in England United States * Berkeley, California, a city in the San Francisco Bay Area, the largest city named Berkeley * Berkeley, Denver, a neighborhood in Denver, Colorado * Berkeley, Illinois, a suburb of Chicago * Berkeley, Missouri, a northwestern suburb of St. Louis * Berkeley Township, Ocean County, New Jersey * Berkeley, Rhode Island * Berkeley, Virginia (other) * Berkeley, West Virginia * Berkeley County (other) People * Berkeley (given nam ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
List Of Volunteer Computing Projects
This is a comprehensive list of volunteer computing projects; a type of distributed computing where volunteers donate computing time to specific causes. The donated computing power comes from idle CPUs and GPUs in personal computers, video game consoles and Android devices. Each project seeks to utilize the computing power of many internet connected devices to solve problems and perform tedious, repetitive research in a very cost effective manner. Active projects Completed projects See also * List of grid computing projects * List of citizen science projects * List of crowdsourcing projects * List of free and open-source Android applications This is a list of notable applications (''apps'') that run on the Android platform which meet guidelines for free software and open-source software. Advertisement blocking Web browsers Office Suites and synchronisation Co ... * List of Berkeley Open Infrastructure for Network Computing (BOINC) projects ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Foldit
Foldit is an online puzzle video game about protein folding. It is part of an experimental research project developed by the University of Washington, Center for Game Science, in collaboration with the UW Department of Biochemistry. The objective of Foldit is to fold the structures of selected proteins as perfectly as possible, using tools provided in the game. The highest scoring solutions are analyzed by researchers, who determine whether or not there is a native structural configuration (native state) that can be applied to relevant proteins in the real world. Scientists can then use these solutions to target and eradicate diseases and create biological innovations. A 2010 paper in the science journal ''Nature'' credited Foldit's 57,000 players with providing useful results that matched or outperformed algorithmically computed solutions. History Rosetta Prof. David Baker, a protein research scientist at the University of Washington, founded the Foldit project. Seth Cooper ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Folding@home
Folding@home (FAH or F@h) is a volunteer computing project aimed to help scientists develop new therapeutics for a variety of diseases by the means of simulating protein dynamics. This includes the process of protein folding and the movements of proteins, and is reliant on simulations run on volunteers' personal computers. Folding@home is currently based at the University of Pennsylvania and led by Greg Bowman, a former student of Vijay Pande. The project utilizes graphics processing units (GPUs), central processing units (CPUs), and ARM processors like those on the Raspberry Pi for volunteer computing and scientific research. The project uses statistical simulation methodology that is a paradigm shift from traditional computing methods. As part of the client–server model network architecture, the volunteered machines each receive pieces of a simulation (work units), complete them, and return them to the project's database servers, where the units are compiled into an overa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BOINC
The Berkeley Open Infrastructure for Network Computing (BOINC, pronounced – rhymes with "oink") is an open-source middleware system for volunteer computing (a type of distributed computing). Developed originally to support SETI@home, it became the platform for many other applications in areas as diverse as medicine, molecular biology, mathematics, linguistics, climatology, environmental science, and astrophysics, among others. The purpose of BOINC is to enable researchers to utilize processing resources of personal computers and other devices around the world. BOINC development began with a group based at the Space Sciences Laboratory (SSL) at the University of California, Berkeley, and led by David P. Anderson, who also led SETI@home. As a high-performance volunteer computing platform, BOINC brings together 34,236 active participants employing 136,341 active computers (hosts) worldwide, processing daily on average 20.164 PetaFLOPS (it would be the 21st largest processin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
World Community Grid
World Community Grid (WCG) is an effort to create the world's largest volunteer computing platform to tackle scientific research that benefits humanity. Launched on November 16, 2004, with proprietary Grid MP client from United Devices and adding support for Berkeley Open Infrastructure for Network Computing (BOINC) in 2005, World Community Grid eventually discontinued the Grid MP client and consolidated on the BOINC platform in 2008. In September 2021, it was announced that IBM transferred ownership to the Krembil Research Institute of University Health Network in Toronto, Ontario. World Community Grid utilizes unused processing power of consumer devices (PCs, Laptops, Android Smartphones, etc.) to analyse data created by the research groups that participate in the grid. WCG projects have analysed data related to the human genome, the human microbiome, HIV, dengue, muscular dystrophy, cancer, influenza, Ebola, Zika virus, virtual screening, rice crop yields, clean energy, water ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Institute For Systems Biology
Institute for Systems Biology (ISB) is a non-profit research institution located in Seattle, Washington, United States. ISB concentrates on systems biology, the study of relationships and interactions between various parts of biological systems, and advocates an interdisciplinary approach to biological research. Goals Systems biology is the study of biological systems in a holistic manner by integrating data at all levels of the biological information hierarchy, from global down to the individual organism, and below down to the molecular level. The vision of ISB is to integrate these concepts using a cross-disciplinary approach combining the efforts of biologists, chemists, computer scientists, engineers, mathematicians, physicists, and physicians. On its website, ISB has defined four areas of focus: * P4 Medicine - This acronym refers to predictive, preventive, personalized and participatory medicine, which focuses on wellness rather than mere treatment of disease. * Global Hea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Grid
Grid, The Grid, or GRID may refer to: Common usage * Cattle grid or stock grid, a type of obstacle is used to prevent livestock from crossing the road * Grid reference, used to define a location on a map Arts, entertainment, and media * News grid, used in communications/public relations Fictional entities * Grid (comics), a fictional character in the DC Comics Universe * Grid (Jotun), Gríðr, a giantess in Norse mythology * The grid, the virtual environment of the game ''Second Life'' * ''The Grid'', the computerized virtual world in which the Tron franchise exists Games and gaming * Nvidia GRID, a cloud gaming platform for Nvidia Tegra products * ''Power Grid'', the English-language edition of the multiplayer German-style board game ''Funkenschlag'' * Grid (series), a series of racing video games developed by Codemasters * Spooks 3 Games - ''The Grid'', a video game based on the television show ''Spooks'' * ''The Grid'' (video game), a 2001 third-person shooter Music * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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