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Hoodia Gordonii
''Hoodia gordonii'', also known as Bushman’s hat, is a leafless spiny succulent plant supposed to have therapeutic properties in folk medicine. It grows naturally in Botswana, South Africa and Namibia. The species became internationally known and threatened by collectors, after a marketing campaign falsely claimed that it was an appetite suppressant for weight loss. The flowers smell like rotten meat and are pollinated mainly by flies. The indigenous San people of the Namib desert call this plant ''ǁhoba'' (pronounced – the initial sound is a lateral click) is used to refer to all species of ''Hoodia''. Potential properties The genus became internationally known and threatened by collectors, after a marketing campaign falsely claimed that it was an appetite suppressant for weight loss. Folk medicine practitioners indigenous to Southern Africa believed the plant to be an appetite suppressant and to have other medicinal properties, such as treating indigestion and small in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biedouw Valley
Biedouw Valley (where Biedouw is a surname) is a valley situated in the Western Cape province of South Africa South Africa, officially the Republic of South Africa (RSA), is the southernmost country in Africa. It is bounded to the south by of coastline that stretch along the South Atlantic and Indian Oceans; to the north by the neighbouring countri ... at an elevation of 376 m. It is located near Pakhuis Pass,Marion Whitehead. ''Passes & Poorts.'' 2010. between Clanwilliam and Uitspankraal. References Landforms of the Western Cape Valleys of South Africa {{WesternCape-geo-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
P57 (glycoside)
P57 is an oxypregnane steroidal glycoside isolated from the African cactiform '' Hoodia gordonii''. P57 is hypothesized to be the chemical constituent from this plant mainly responsible for the putative appetite suppressant activity of ''Hoodia'' extracts. In a rat study at Brown Medical School, intracerebroventricular injections of the purified P57 demonstrated that the compound has a likely central nervous system (CNS) mechanism of action like that of neuroactive steroids. The studies demonstrated that the compound increases the content of ATP by 50-150% in hypothalamic neurons. In addition, third ventricle administration of P57 reduced subsequent 24-hour food intake by 40-60%. See also * Anorectic An anorectic or anorexic is a drug which reduces appetite, resulting in lower food consumption, leading to weight loss. By contrast, an appetite stimulant is referred to as orexigenic. The term is (from the Greek ''ἀν-'' (an-) = "without" a ..., for additional info ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hoodia Gordonii00
''Hoodia'' (; known locally as "ghaap" or "bobbejaanghaap") is a genus of flowering plants in the family Apocynaceae, under the subfamily Asclepiadoideae, native to Southern Africa. One species of ''Hoodia'' in particular, ''Hoodia gordonii'', has achieved a degree of fame and controversy, after being investigated for use as a possible appetite suppressant. Description The group was first described as a genus in 1844. Hoodia are stem succulents, described as "cactiform" because of their remarkable similarity to the unrelated cactus family. They have a branching, shrub-like form, and the largest species (''Hoodia parviflora'') can grow to the size of a tree — over in height. The flowers are extremely variable in size — from less than 1 cm, to almost 20 cm in diameter, depending on the species. Flowers appear in large numbers, always near the tops of the stems. Those of larger-flowered species (such as ''Hoodia gordonii'') are often a papery pink-tan colour, pl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bushmen
The San peoples (also Saan), or Bushmen, are members of various Khoe, Tuu, or Kxʼa-speaking indigenous hunter-gatherer cultures that are the first cultures of Southern Africa, and whose territories span Botswana, Namibia, Angola, Zambia, Zimbabwe, Lesotho and South Africa. In 2017, Botswana was home to approximately 63,500 San people (roughly 2.8% of the population) making it the country with the highest number of San people. Definition The term "San" has a long vowel and is spelled Sān (in Khoekhoegowab orthography). It is a Khoekhoe exonym with the meaning of "foragers" and was often used in a derogatory manner to describe nomadic, foraging people. Based on observation of lifestyle, this term has been applied to speakers of three distinct language families living between the Okavango River in Botswana and Etosha National Park in northwestern Namibia, extending up into southern Angola; central peoples of most of Namibia and Botswana, extending into Zambia and Zimbab ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The New York Times
''The New York Times'' (''the Times'', ''NYT'', or the Gray Lady) is a daily newspaper based in New York City with a worldwide readership reported in 2020 to comprise a declining 840,000 paid print subscribers, and a growing 6 million paid digital subscribers. It also is a producer of popular podcasts such as '' The Daily''. Founded in 1851 by Henry Jarvis Raymond and George Jones, it was initially published by Raymond, Jones & Company. The ''Times'' has won 132 Pulitzer Prizes, the most of any newspaper, and has long been regarded as a national " newspaper of record". For print it is ranked 18th in the world by circulation and 3rd in the U.S. The paper is owned by the New York Times Company, which is publicly traded. It has been governed by the Sulzberger family since 1896, through a dual-class share structure after its shares became publicly traded. A. G. Sulzberger, the paper's publisher and the company's chairman, is the fifth generation of the family to head the pa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Food And Drug Administration
The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is responsible for protecting and promoting public health through the control and supervision of food safety, tobacco products, caffeine products, dietary supplements, Prescription drug, prescription and Over-the-counter drug, over-the-counter pharmaceutical drugs (medications), vaccines, biopharmaceuticals, blood transfusions, medical devices, electromagnetic radiation emitting devices (ERED), cosmetics, Animal feed, animal foods & feed and Veterinary medicine, veterinary products. The FDA's primary focus is enforcement of the Federal Food, Drug, and Cosmetic Act (FD&C), but the agency also enforces other laws, notably Section 361 of the Public Health Service Act, as well as associated regulations. Much of this regulatory-enforcement work is not d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Liver
The liver is a major Organ (anatomy), organ only found in vertebrates which performs many essential biological functions such as detoxification of the organism, and the Protein biosynthesis, synthesis of proteins and biochemicals necessary for digestion and growth. In humans, it is located in the quadrant (anatomy), right upper quadrant of the abdomen, below the thoracic diaphragm, diaphragm. Its other roles in metabolism include the regulation of Glycogen, glycogen storage, decomposition of red blood cells, and the production of hormones. The liver is an accessory digestive organ that produces bile, an alkaline fluid containing cholesterol and bile acids, which helps the fatty acid degradation, breakdown of fat. The gallbladder, a small pouch that sits just under the liver, stores bile produced by the liver which is later moved to the small intestine to complete digestion. The liver's highly specialized biological tissue, tissue, consisting mostly of hepatocytes, regulates a w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Seattle Times
''The Seattle Times'' is a daily newspaper serving Seattle, Washington, United States. It was founded in 1891 and has been owned by the Blethen family since 1896. ''The Seattle Times'' has the largest circulation of any newspaper in Washington state and the Pacific Northwest region. The Seattle Times Company, which is owned by the Blethen family, holds 50.5% of the paper. McClatchy company owns 49.5% of the paper. ''The Seattle Times'' had a longstanding rivalry with the ''Seattle Post-Intelligencer'' newspaper until the latter ceased publication in 2009. Copies are sold at $2 daily in King & adjacent counties (except Island, Thurston & other WA counties, $2.5) or $3 Sundays/Thanksgiving Day (except Island, Thurston & other WA counties, $4). Prices are higher outside Washington state. History ''The Seattle Times'' originated as the ''Seattle Press-Times'', a four-page newspaper founded in 1891 with a daily circulation of 3,500, which Maine teacher and attorney Alden J. Blethen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wisconsin State Journal
The ''Wisconsin State Journal'' is a daily newspaper published in Madison, Wisconsin by Lee Enterprises. The newspaper, the second largest in Wisconsin, is primarily distributed in a 19 county region in south-central Wisconsin. As of September 2018, the ''Wisconsin State Journal'' had an average weekday circulation of 51,303 and an average Sunday circulation of 64,820. The ''State Journal'' is the state's official newspaper of record, and statutes and laws passed are regarded as official seven days after the publication of a state legal notice. The State Journal's editorial board earned the newsroom's first Pulitzer finalist honor in 2008 for its "persistent, high-spirited campaign against abuses in the governor's veto power." The state's constitution was amended after the innovative, multi-media editorial campaign and the governor's veto power was limited. The staff of the ''Wisconsin State Journal'' was also a finalist for the Pulitzer Prize for Breaking News Reporting in 20 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Wisconsin–Madison
A university () is an educational institution, institution of higher education, higher (or Tertiary education, tertiary) education and research which awards academic degrees in several Discipline (academia), academic disciplines. Universities typically offer both undergraduate education, undergraduate and postgraduate education, postgraduate programs. In the United States, the designation is reserved for colleges that have a graduate school. The word ''university'' is derived from the Latin ''universitas magistrorum et scholarium'', which roughly means "community of teachers and scholars". The first universities were created in Europe by Catholic Church monks. The University of Bologna (''Università di Bologna''), founded in 1088, is the first university in the sense of: *Being a high degree-awarding institute. *Having independence from the ecclesiastic schools, although conducted by both clergy and non-clergy. *Using the word ''universitas'' (which was coined at its foundation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anorectic
An anorectic or anorexic is a drug which reduces appetite, resulting in lower food consumption, leading to weight loss. By contrast, an appetite stimulant is referred to as orexigenic. The term is (from the Greek ''ἀν-'' (an-) = "without" and ''ὄρεξις'' (órexis) = "appetite"), and such drugs are also known as anorexigenic, anorexiant, or appetite suppressant. History Used on a short-term basis clinically to treat obesity, some appetite suppressants are also available over-the-counter. Most common natural appetite suppressants are based on ''Hoodia'', a genus of 13 species in the flowering plant family Apocynaceae, under the subfamily Asclepiadoideae. Several appetite suppressants are based on a mix of natural ingredients, mostly using green tea as its basis, in combination with other plant extracts such as fucoxanthin, found naturally in seaweed. Drugs of this class are frequently stimulants of the phenethylamine family, related to amphetamine. The German and Fi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pfizer
Pfizer Inc. ( ) is an American multinational pharmaceutical and biotechnology corporation headquartered on 42nd Street in Manhattan, New York City. The company was established in 1849 in New York by two German entrepreneurs, Charles Pfizer (1824–1906) and his cousin Charles F. Erhart (1821–1891). Pfizer develops and produces medicines and vaccines for immunology, oncology, cardiology, endocrinology, and neurology. The company has several blockbuster drugs or products that each generate more than billion in annual revenues. In 2020, 52% of the company's revenues came from the United States, 6% came from each of China and Japan, and 36% came from other countries. Pfizer was a component of the Dow Jones Industrial Average stock market index from 2004 to August 2020. The company ranks 64th on the Fortune 500 and 49th on the Forbes Global 2000. History 1849–1950: Early history Pfizer was founded in 1849 by Charles Pfizer and Charles F. Erhart, two cousins who had i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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