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Hofmann–Löffler Reaction
The Hofmann–Löffler reaction (also referred to as Hofmann–Löffler–Freytag reaction, Löffler–Freytag reaction, Löffler–Hofmann reaction, as well as Löffler's method) is an organic reaction in which a cyclic amine 2 (pyrrolidine or, in some cases, piperidine) is generated by thermal or photochemical decomposition of ''N''-halogenated amine 1 in the presence of a strong acid (concentrated sulfuric acid or concentrated CF3CO2H). The Hofmann–Löffler–Freytag reaction proceeds via an intramolecular hydrogen atom transfer to a nitrogen-centered radical and is an example of a remote intramolecular free radical C–H functionalization. Historical perspective In 1878, the structure of piperidine was still unknown, and A. W. Hofmann made attempts to add hydrogen chloride or bromine to it in the belief that the compound possessed unsaturation (i.e. he performed standard alkene classification test reactions). In the course of his studies, A.W. Hofmann synthesized a number ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
August Wilhelm Von Hofmann
August Wilhelm von Hofmann (8 April 18185 May 1892) was a German chemist who made considerable contributions to organic chemistry. His research on aniline helped lay the basis of the aniline-dye industry, and his research on coal tar laid the groundwork for his student Charles Mansfield's practical methods for extracting benzene and toluene and converting them into nitro compounds and amines. Hofmann's discoveries include formaldehyde, hydrazobenzene, the isonitriles, and allyl alcohol. He prepared three ethylamines and tetraethylammonium compounds and established their structural relationship to ammonia. After studying under Justus von Liebig at the University of Giessen, Hofmann became the first director of the Royal College of Chemistry, now part of Imperial College London, in 1845. In 1865 he returned to Germany to accept a position at the University of Berlin as a teacher and researcher. After his return he co-founded the German Chemical Society (''Deutsche Chemische Gese ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Reaction Mechanism Scheme 5
Reaction may refer to a process or to a response to an action, event, or exposure: Physics and chemistry *Chemical reaction *Nuclear reaction *Reaction (physics), as defined by Newton's third law *Chain reaction (other). Biology and medicine *Adverse drug reaction *Allergic reaction *Reflex, neural reaction *Hypersensitivity, immune reaction *Intolerance (other) *Light reaction (other). Psychology *Emotional, reaction *Reactivity (behaviour) *Proactivity, opposite of reactive behaviour *Reactive attachment disorder. Politics and culture *Reactionary, a political tendency *Reaction video *Commentary (other). Proper names and titles * ''Reaction'' (album), a 1986 album by American R&B singer Rebbie Jackson ** "Reaction" (song), the title song from the Rebbie Jackson album *"Reaction", a single by Dead Letter Circus *ReAction GUI, a GUI toolkit used on AmigaOS *Reaction.life, a political news and commentary website edited by Iain Martin *Rea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Modifications And Improvements Scheme 14
Modification may refer to: * Modifications of school work for students with special educational needs * Modifications (genetics), changes in appearance arising from changes in the environment * Posttranslational modifications, changes to proteins arising from protein biosynthesis * Modding, modifying hardware or software ** Mod (video gaming) ** Modified car * Body modification * Grammatical modifier * Home modifications * Chemical modification, processes involving the alteration of the chemical constitution or structure of molecules See also * * Modified (other) * Modifier (other) * Mod (other) * Edit (other) Edit may refer to: Concepts * an action that is part of an editing process (including of images, video, and film) * a particular version that is the result of editing, especially of film (for example, fan edit), or music (for example, radio ... * Manipulation (other) {{disambig ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Modifications And Improvements Scheme 13
Modification may refer to: * Modifications of school work for students with special educational needs * Modifications (genetics), changes in appearance arising from changes in the environment * Posttranslational modifications, changes to proteins arising from protein biosynthesis * Modding, modifying hardware or software ** Mod (video gaming) ** Modified car * Body modification * Grammatical modifier * Home modifications * Chemical modification, processes involving the alteration of the chemical constitution or structure of molecules See also * * Modified (other) * Modifier (other) * Mod (other) * Edit (other) Edit may refer to: Concepts * an action that is part of an editing process (including of images, video, and film) * a particular version that is the result of editing, especially of film (for example, fan edit), or music (for example, radio ... * Manipulation (other) {{disambig ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Modifications And Improvements Scheme 12
Modification may refer to: * Modifications of school work for students with special educational needs * Modifications (genetics), changes in appearance arising from changes in the environment * Posttranslational modifications, changes to proteins arising from protein biosynthesis * Modding, modifying hardware or software ** Mod (video gaming) ** Modified car * Body modification * Grammatical modifier * Home modifications * Chemical modification, processes involving the alteration of the chemical constitution or structure of molecules See also * * Modified (other) * Modifier (other) * Mod (other) * Edit (other) Edit may refer to: Concepts * an action that is part of an editing process (including of images, video, and film) * a particular version that is the result of editing, especially of film (for example, fan edit), or music (for example, radio ... * Manipulation (other) {{disambig ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Photodissociation
Photodissociation, photolysis, photodecomposition, or photofragmentation is a chemical reaction in which molecules of a chemical compound are broken down by photons. It is defined as the interaction of one or more photons with one target molecule. Photodissociation is not limited to visible light. Any photon with sufficient energy can affect the chemical bonds of a chemical compound. Since a photon's energy is inversely proportional to its wavelength, electromagnetic radiations with the energy of visible light or higher, such as ultraviolet light, x-rays, and gamma rays can induce such reactions. Photolysis in photosynthesis Photolysis is part of the light-dependent reaction or light phase or photochemical phase or Hill reaction of photosynthesis. The general reaction of photosynthetic photolysis can be given in terms of photons as: :\ce + 2 \text \longrightarrow \ce The chemical nature of "A" depends on the type of organism. Purple sulfur bacteria oxidize hydrogen sulfide () ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Modifications And Improvements Scheme 11
Modification may refer to: * Modifications of school work for students with special educational needs * Modifications (genetics), changes in appearance arising from changes in the environment * Posttranslational modifications, changes to proteins arising from protein biosynthesis * Modding, modifying hardware or software ** Mod (video gaming) ** Modified car * Body modification * Grammatical modifier * Home modifications * Chemical modification, processes involving the alteration of the chemical constitution or structure of molecules See also * * Modified (other) * Modifier (other) * Mod (other) * Edit (other) Edit may refer to: Concepts * an action that is part of an editing process (including of images, video, and film) * a particular version that is the result of editing, especially of film (for example, fan edit), or music (for example, radio ... * Manipulation (other) {{disambig ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Synthesis (journal)
''Synthesis'' is a scientific journal published from 1969 to the present day by Thieme Medical Publishers, Thieme. Its stated purpose is the "advancement of the science of synthetic chemistry". From August 2006, selected articles are offered free of charge. The impact factor of this journal is 2.867 (2018).Journal Citation Reports, 2018 References [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tetrahedron Lett
''Tetrahedron Letters'' is a weekly international journal for rapid publication of full original research papers in the field of organic chemistry. According to the ''Journal Citation Reports'', the journal has a 2020 impact factor of 2.415. Indexing ''Tetrahedron Letters'' is indexed in: References See also *''Tetrahedron In geometry, a tetrahedron (plural: tetrahedra or tetrahedrons), also known as a triangular pyramid, is a polyhedron composed of four triangular faces, six straight edges, and four vertex corners. The tetrahedron is the simplest of all the o ...'' *'' Tetrahedron: Asymmetry'' Chemistry journals Weekly journals Publications established in 1959 Elsevier academic journals {{chem-journal-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Barton Reaction
The Barton reaction, also known as the Barton nitrite ester reaction, is a photochemical reaction that involves the photolysis of an alkyl nitrite to form a δ-nitroso alcohol. Discovered in 1960, the reaction is named for its discoverer, Nobel Laureate Sir Derek Barton. Barton's Nobel Prize in Chemistry in 1969 was awarded for his work on understanding conformations of organic molecules, work which was key to realizing the utility of the Barton Reaction. The Barton reaction involves a homolytic RO–NO cleavage, followed by δ- hydrogen abstraction, free radical recombination, and tautomerization to form an oxime. Selectivity for the δ-hydrogen is a result of the conformation of the 6-membered radical intermediate. Often, the site of hydrogen atom abstraction can be easily predicted. This allows the regio- and stereo-selective introduction of functionality into complicated molecules with high yield. Due to its unique property at the time to change otherwise inert substrates, Bart ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Six Membered TS For The Hofmann-Löffler-Freytag Reaction
6 is a number, numeral, and glyph. 6 or six may also refer to: * AD 6, the sixth year of the AD era * 6 BC, the sixth year before the AD era * The month of June Science * Carbon, the element with atomic number 6 * 6 Hebe, an asteroid People * Alphonse Six (1890–1914), Belgian football player * Didier Six (born 1954), former French international footballer * Franz Six (1909–1975), Nazi official * Frederick N. Six (born 1929), Justice of the Kansas Supreme Court * James Six (1731–1793), British scientist * Jan Six (1616-1700), an important cultural figure in the Dutch Golden Age * Robert Six (1907–1986), Chief Executive Officer of Continental Airlines between 1936 and 1981 * Regine Sixt, German businessperson * Valérie Six (born 1963), French politician * Perri 6 (an extremely rare surname), social scientist * Six family, family of regents of Amsterdam, founded by Jan Six Music * Six (band), an Irish pop band created by a TV reality show * ''Six'' (musical), a music ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Reaction Mechanism Scheme 9
Reaction may refer to a process or to a response to an action, event, or exposure: Physics and chemistry *Chemical reaction *Nuclear reaction *Reaction (physics), as defined by Newton's third law *Chain reaction (other). Biology and medicine *Adverse drug reaction *Allergic reaction *Reflex, neural reaction *Hypersensitivity, immune reaction *Intolerance (other) *Light reaction (other). Psychology *Emotional, reaction *Reactivity (behaviour) *Proactivity, opposite of reactive behaviour *Reactive attachment disorder. Politics and culture *Reactionary, a political tendency *Reaction video *Commentary (other). Proper names and titles * ''Reaction'' (album), a 1986 album by American R&B singer Rebbie Jackson ** "Reaction" (song), the title song from the Rebbie Jackson album *"Reaction", a single by Dead Letter Circus *ReAction GUI, a GUI toolkit used on AmigaOS *Reaction.life, a political news and commentary website edited by Iain Martin *Rea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
