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History Of Neuroscience
From the ancient Egyptian mummifications to 18th-century scientific research on "globules" and neurons, there is evidence of neuroscience practice throughout the early periods of history. The early civilizations lacked adequate means to obtain knowledge about the human brain. Their assumptions about the inner workings of the mind, therefore, were not accurate. Early views on the function of the brain regarded it to be a form of "cranial stuffing" of sorts. In ancient Egypt, from the late Middle Kingdom onwards, in preparation for mummification, the brain was regularly removed, for it was the heart that was assumed to be the seat of intelligence. According to Herodotus, during the first step of mummification: "The most perfect practice is to extract as much of the brain as possible with an iron hook, and what the hook cannot reach is mixed with drugs." Over the next five thousand years, this view came to be reversed; the brain is now known to be the seat of intelligence, although co ...
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Herophilos
Herophilos (; grc-gre, Ἡρόφιλος; 335–280 BC), sometimes Latinised Herophilus, was a Greek physician regarded as one of the earliest anatomists. Born in Chalcedon, he spent the majority of his life in Alexandria. He was the first scientist to systematically perform scientific dissections of human cadavers. He recorded his findings in over nine works, which are now all lost. The early Christian author Tertullian states that Herophilos vivisected at least 600 live prisoners; however, this account has been disputed by many historians.Scarboroug"Celsus on Human Vivisection at Ptolemaic Alexandria" ''Clio Medica. Acta Academiae Internationalis Historiae Medicinae. Vol. 11'', 1976 He is often seen as the father of anatomy. Life Herophilos was born in Chalcedon in Asia Minor (now Kadıköy, Turkey), c. 335 BC. Not much is known about his early life other than he moved to Alexandria at a fairly young age to begin his schooling. As an adult Herophilos was a teacher, and ...
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Spinal Cord
The spinal cord is a long, thin, tubular structure made up of nervous tissue, which extends from the medulla oblongata in the brainstem to the lumbar region of the vertebral column (backbone). The backbone encloses the central canal of the spinal cord, which contains cerebrospinal fluid. The brain and spinal cord together make up the central nervous system (CNS). In humans, the spinal cord begins at the occipital bone, passing through the foramen magnum and then enters the spinal canal at the beginning of the cervical vertebrae. The spinal cord extends down to between the first and second lumbar vertebrae, where it ends. The enclosing bony vertebral column protects the relatively shorter spinal cord. It is around long in adult men and around long in adult women. The diameter of the spinal cord ranges from in the cervical and lumbar regions to in the thoracic area. The spinal cord functions primarily in the transmission of nerve signals from the motor cortex to the body, ...
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Charles Bell
Sir Charles Bell (12 November 177428 April 1842) was a Scotland, Scottish surgeon, anatomist, physiologist, neurologist, artist, and philosophical theologian. He is noted for discovering the difference between sensory nerves and motor nerves in the spinal cord. He is also noted for describing Bell's palsy. His three older brothers included Robert Bell (1757–1816) a Society of Writers to Her Majesty's Signet, Writer to the Signet, John Bell (surgeon), John Bell (1763–1820), also a noted surgeon and writer; and the advocate George Joseph Bell (1770–1843) who became a professor of law at the University of Edinburgh and a principal clerk at the Court of Session. Early life and education Charles Bell was born in Edinburgh on 12 November 1774, as the fourth son of the Reverend William Bell, a clergyman of the Episcopal Church of Scotland. Charles's father died in 1779 when he was five years old, and thus his mother had a profound influence on his early life, teaching him how to ...
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François Magendie
__NOTOC__ François Magendie (6 October 1783 – 7 October 1855) was a French physiologist, considered a pioneer of experimental physiology. He is known for describing the foramen of Magendie. There is also a ''Magendie sign'', a downward and inward rotation of the eye due to a lesion in the cerebellum. Magendie was a faculty at the College of France, holding the Chair of Medicine from 1830 to 1855 (he was succeeded by Claude Bernard, who worked previously as his assistant). In 1816 he published ''Précis élementaire de Physiologie'' which described an experiment first illustrating the concept of empty calories: :I took a dog of three years old, fat, and in good health, and put it to feed upon sugar alone...It expired the 32nd day of the experiment. His most important contribution to science was also his most disputed. Contemporaneous to Sir Charles Bell, Magendie conducted a number of experiments on the nervous system, in particular verifying the differentiation between ...
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Muscle
Skeletal muscles (commonly referred to as muscles) are organs of the vertebrate muscular system and typically are attached by tendons to bones of a skeleton. The muscle cells of skeletal muscles are much longer than in the other types of muscle tissue, and are often known as muscle fibers. The muscle tissue of a skeletal muscle is striated – having a striped appearance due to the arrangement of the sarcomeres. Skeletal muscles are voluntary muscles under the control of the somatic nervous system. The other types of muscle are cardiac muscle which is also striated and smooth muscle which is non-striated; both of these types of muscle tissue are classified as involuntary, or, under the control of the autonomic nervous system. A skeletal muscle contains multiple fascicles – bundles of muscle fibers. Each individual fiber, and each muscle is surrounded by a type of connective tissue layer of fascia. Muscle fibers are formed from the fusion of developmental myoblasts in ...
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Barbary Macaque
The Barbary macaque (''Macaca sylvanus''), also known as Barbary ape, is a macaque species native to the Atlas Mountains of Algeria, Libya, Tunisia and Morocco, along with a small introduced population in Gibraltar. It is the type species of the genus ''Macaca''. The species is of particular interest because males play an atypical role in rearing young. Because of uncertain paternity, males are integral to raising all infants. Generally, Barbary macaques of all ages and sexes contribute in alloparental care of young. The diet of the Barbary macaque consists primarily of plants and insects and they are found in a variety of habitats. Males live to around 25 years old while females may live up to 30 years. Besides humans, they are the only free-living primates in Europe. Although the species is commonly referred to as the "Barbary ape", the Barbary macaque is actually a true monkey. Its name refers to the Barbary Coast of Northwest Africa. The population of the Barbary macaques i ...
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Galen
Aelius Galenus or Claudius Galenus ( el, Κλαύδιος Γαληνός; September 129 – c. AD 216), often Anglicized as Galen () or Galen of Pergamon, was a Greek physician, surgeon and philosopher in the Roman Empire. Considered to be one of the most accomplished of all medical researchers of antiquity, Galen influenced the development of various scientific disciplines, including anatomy, physiology, pathology, pharmacology, and neurology, as well as philosophy and logic. The son of Aelius Nicon, a wealthy Greek architect with scholarly interests, Galen received a comprehensive education that prepared him for a successful career as a physician and philosopher. Born in the ancient city of Pergamon (present-day Bergama, Turkey), Galen traveled extensively, exposing himself to a wide variety of medical theories and discoveries before settling in Rome, where he served prominent members of Roman society and eventually was given the position of personal physician to several emp ...
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Roman Empire
The Roman Empire ( la, Imperium Romanum ; grc-gre, Βασιλεία τῶν Ῥωμαίων, Basileía tôn Rhōmaíōn) was the post-Republican period of ancient Rome. As a polity, it included large territorial holdings around the Mediterranean Sea in Europe, North Africa, and Western Asia, and was ruled by emperors. From the accession of Caesar Augustus as the first Roman emperor to the military anarchy of the 3rd century, it was a Principate with Italia as the metropole of its provinces and the city of Rome as its sole capital. The Empire was later ruled by multiple emperors who shared control over the Western Roman Empire and the Eastern Roman Empire. The city of Rome remained the nominal capital of both parts until AD 476 when the imperial insignia were sent to Constantinople following the capture of the Western capital of Ravenna by the Germanic barbarians. The adoption of Christianity as the state church of the Roman Empire in AD 380 and the fall of the Western ...
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Dura Mater
In neuroanatomy, dura mater is a thick membrane made of dense irregular connective tissue that surrounds the brain and spinal cord. It is the outermost of the three layers of membrane called the meninges that protect the central nervous system. The other two meningeal layers are the arachnoid mater and the pia mater. It envelops the arachnoid mater, which is responsible for keeping in the cerebrospinal fluid. It is derived primarily from the neural crest cell population, with postnatal contributions of the paraxial mesoderm. Structure The dura mater has several functions and layers. The dura mater is a membrane that envelops the arachnoid mater. It surrounds and supports the dural sinuses (also called dural venous sinuses, cerebral sinuses, or cranial sinuses) and carries blood from the brain toward the heart. Cranial dura mater has two layers called ''lamellae'', a superficial layer (also called the periosteal layer), which serves as the skull's inner periosteum, called the ...
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Ventricular System
The ventricular system is a set of four interconnected cavities known as cerebral ventricles in the brain. Within each ventricle is a region of choroid plexus which produces the circulating cerebrospinal fluid (CSF). The ventricular system is continuous with the central canal of the spinal cord from the fourth ventricle, allowing for the flow of CSF to circulate. All of the ventricular system and the central canal of the spinal cord are lined with ependyma, a specialised form of epithelium connected by tight junctions that make up the blood–cerebrospinal fluid barrier. Structure The system comprises four ventricles: * lateral ventricles right and left (one for each hemisphere) * third ventricle * fourth ventricle There are several foramina, openings acting as channels, that connect the ventricles. The interventricular foramina (also called the foramina of Monro) connect the lateral ventricles to the third ventricle through which the cerebrospinal fluid can flow. Ventric ...
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Cerebellum
The cerebellum (Latin for "little brain") is a major feature of the hindbrain of all vertebrates. Although usually smaller than the cerebrum, in some animals such as the mormyrid fishes it may be as large as or even larger. In humans, the cerebellum plays an important role in motor control. It may also be involved in some cognition, cognitive functions such as attention and language as well as emotion, emotional control such as regulating fear and pleasure responses, but its movement-related functions are the most solidly established. The human cerebellum does not initiate movement, but contributes to Motor coordination, coordination, precision, and accurate timing: it receives input from sensory systems of the spinal cord and from other parts of the brain, and integrates these inputs to fine-tune motor activity. Cerebellar damage produces disorders in Fine motor skill, fine movement, Equilibrioception, equilibrium, Human positions, posture, and motor learning in humans. Anatomica ...
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