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Hexobendine Synthesis
Hexobendine is a vasodilator that acts as an adenosine reuptake inhibitor. Synthesis The reaction between 3,4,5-trimethoxybenzoyl chloride 521-61-3(1) and 3-chloropropanol 27-30-5(2) gives the corresponding ester, i.e. 3-chloropropyl 3,4,5-trimethoxybenzoateCID:12350731 029-24-9(3). The last step involves the reaction between two molar equivalents of 3 with one molar equivalent of N,N’-dimethylethanediamine 10-70-3(4) completing the synthesis of hexobendine (5). See also * Dilazep Dilazep is a vasodilator that acts as an adenosine reuptake inhibitor. It is used for the treatment of cardiopathy and renal disorders. Synthesis The reaction of bis-(3-hydroxypropyl)-ethylene diamine (1) with 1-Bromo-3-chloropropane (2) give ... References Vasodilators Phenol ethers Benzoate esters Amines Adenosine reuptake inhibitors {{cardiovascular-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vasodilator
Vasodilation is the widening of blood vessels. It results from relaxation of smooth muscle cells within the vessel walls, in particular in the large veins, large arteries, and smaller arterioles. The process is the opposite of vasoconstriction, which is the narrowing of blood vessels. When blood vessels dilate, the flow of blood is increased due to a decrease in vascular resistance and increase in cardiac output. Therefore, dilation of arterial blood vessels (mainly the arterioles) decreases blood pressure. The response may be intrinsic (due to local processes in the surrounding tissue) or extrinsic (due to hormones or the nervous system). In addition, the response may be localized to a specific organ (depending on the metabolic needs of a particular tissue, as during strenuous exercise), or it may be systemic (seen throughout the entire systemic circulation). Endogenous substances and drugs that cause vasodilation are termed vasodilators. Such vasoactivity is necessary for ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
