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Hartmuth Kolb
Hartmuth Christian Kolb (born August 10, 1964) is a German chemist. He is considered one of the founders of click chemistry. Early life and career After graduating from high school in Marsberg in 1983, Kolb studied at the University of Hanover. He received his doctorate as an academic student of Steven Ley at Imperial College London with a thesis on preparative organic chemistry (''Synthesis of the decalin fragment of azadirachtin''). As a postdoctoral fellow he worked with Barry Sharpless at the Scripps Research Institute in La Jolla, California. He then worked in the research department of Ciba-Geigy in Basel from 1993 to 1997 before taking up a managerial position at Coelacanth Corporation, founded by Sharpless and A. Bader in Princeton, New Jersey. Coelacanth was eventually acquired by Lexicon Pharmaceuticals. In 2002, Kolb obtained an associate professorship in the Department of Chemistry at the Scripps Research Institute. Kolb later obtained a professorship at the Univ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
German Chemist
This is a list of German chemists. A * Richard Abegg * Friedrich Accum * Franz Karl Achard * Georgius Agricola * Reinhart Ahlrichs * Albertus Magnus * Kurt Alder * Fritz Aldinger * Reinhold Aman * Otto Ambros * Johann Gerhard Reinhard Andreae * Andreas von Antropoff (1878-1956), Andreas von Antropoff * Momme Andresen * Leonid Andrussow * Richard Anschütz * Rolf Appel * Fritz Arndt * Karl Arnold (chemist), Karl Arnold * Friedrich Auerbach * Karl von Auwers B * Lambert Heinrich von Babo * Manfred Baerns * Adolf von Baeyer * Eugen Bamberger * Johann Conrad Barchusen * Eugen Baumann * Otto Bayer * Johann Joachim Becher * Gerd Becker (chemist), Gerd Becker * Johan Heinrich Becker * Karl Heinrich Emil Becker * Ernst Otto Beckmann * Walter-Ulrich Behrens * Gottfried Christoph Beireis * Johann Benckiser * Otto Berg (scientist), Otto Berg * Friedrich Bergius * Alfred Bertheim * Basilius Besler * Heinrich Biltz * Wilhelm Biltz * Otto Saly Binswanger * August Bischler * Gustav B ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of California, Los Angeles
The University of California, Los Angeles (UCLA) is a public land-grant research university in Los Angeles, California. UCLA's academic roots were established in 1881 as a teachers college then known as the southern branch of the California State Normal School (now San José State University). This school was absorbed with the official founding of UCLA as the Southern Branch of the University of California in 1919, making it the second-oldest of the 10-campus University of California system (after UC Berkeley). UCLA offers 337 undergraduate and graduate degree programs in a wide range of disciplines, enrolling about 31,600 undergraduate and 14,300 graduate and professional students. UCLA received 174,914 undergraduate applications for Fall 2022, including transfers, making the school the most applied-to university in the United States. The university is organized into the College of Letters and Science and 12 professional schools. Six of the schools offer undergraduate degre ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
IOS Press
IOS Press is a publishing house headquartered in Amsterdam, specialising in the publication of journals and books related to fields of scientific, technical, and medical research. Established in 1987, IOS Press publishes around 100 international journals and releases about 75 book titles annually, covering fields such as computer science, mathematics, the natural sciences, and topics within medicine. A subsidiary based in the United States (IOS Press, Inc.) was created in 1990, based in the Washington, D.C. area. In 2005, IOS Press expanded to acquire the publications list of Delft University Press. Several co-publishing and joint venture relationships have been formed, to extend IOS Press' academic publishing coverage in Germany, Japan, and China. IOS Press is a member of the International Association of Scientific, Technical, and Medical Publishers. ;Publications * ''Information Services & Use'' * ''Journal of Alzheimer's Disease'' * ''Journal of Neutron Research The ''Jou ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Journal Of Alzheimer's Disease
The ''Journal of Alzheimer's Disease'' is a peer-reviewed medical journal published by IOS Press covering the etiology, pathogenesis, epidemiology, genetics, treatment, and psychology of Alzheimer's disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The editor-in-chief is George Perry of the University of Texas at San Antonio. According to the ''Journal Citation Reports'', the journal has a 2020 impact factor of 4.472."Journal of Alzheimer's Disease". ''2020 Journal Citation Reports''. Web of Science (Science ed.). Clarivate Analytics. 2020. Alzheimer Award Each year, the Associate Editors of the journal select the best article from the previous year's volume. The awardee is presented the Alzheimer Medal, a 3" bronze medal with the likeness of Alois Alzheimer Alois Alzheimer ( , , ; 14 June 1864 – 19 December 1915) was a German psychiatrist and neuropathologist and a c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alzheimer's Disease
Alzheimer's disease (AD) is a neurodegeneration, neurodegenerative disease that usually starts slowly and progressively worsens. It is the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in short-term memory, remembering recent events. As the disease advances, symptoms can include primary progressive aphasia, problems with language, Orientation (mental), disorientation (including easily getting lost), mood swings, loss of motivation, self-neglect, and challenging behaviour, behavioral issues. As a person's condition declines, they often withdraw from family and society. Gradually, bodily functions are lost, ultimately leading to death. Although the speed of progression can vary, the typical life expectancy following diagnosis is three to nine years. The cause of Alzheimer's disease is poorly understood. There are many environmental and genetic risk factors associated with its development. The strongest genetic risk factor is from an alle ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Positron Emission Tomography
Positron emission tomography (PET) is a functional imaging technique that uses radioactive substances known as radiotracers to visualize and measure changes in Metabolism, metabolic processes, and in other physiological activities including blood flow, regional chemical composition, and absorption. Different tracers are used for various imaging purposes, depending on the target process within the body. For example, 18F-FDG, -FDG is commonly used to detect cancer, Sodium fluoride#Medical imaging, NaF is widely used for detecting bone formation, and Isotopes of oxygen#Oxygen-15, oxygen-15 is sometimes used to measure blood flow. PET is a common medical imaging, imaging technique, a Scintigraphy#Process, medical scintillography technique used in nuclear medicine. A radiopharmaceutical, radiopharmaceutical — a radioisotope attached to a drug — is injected into the body as a radioactive tracer, tracer. When the radiopharmaceutical undergoes beta plus decay, a positron is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. Almost all metabolic processes in the cell need enzyme catalysis in order to occur at rates fast enough to sustain life. Metabolic pathways depend upon enzymes to catalyze individual steps. The study of enzymes is called ''enzymology'' and the field of pseudoenzyme analysis recognizes that during evolution, some enzymes have lost the ability to carry out biological catalysis, which is often reflected in their amino acid sequences and unusual 'pseudocatalytic' properties. Enzymes are known to catalyze more than 5,000 biochemical reaction types. Other biocatalysts are catalytic RNA molecules, called ribozymes. Enzymes' specificity comes from their unique three-dimensional structures. Like all catalysts, enzymes increase the reaction ra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Microfluidics
Microfluidics refers to the behavior, precise control, and manipulation of fluids that are geometrically constrained to a small scale (typically sub-millimeter) at which surface forces dominate volumetric forces. It is a multidisciplinary field that involves engineering, physics, chemistry, biochemistry, nanotechnology, and biotechnology. It has practical applications in the design of systems that process low volumes of fluids to achieve multiplexing, automation, and high-throughput screening. Microfluidics emerged in the beginning of the 1980s and is used in the development of inkjet printheads, DNA chips, lab-on-a-chip technology, micro-propulsion, and micro-thermal technologies. Typically, micro means one of the following features: * Small volumes (μL, nL, pL, fL) * Small size * Low energy consumption * Microdomain effects Typically microfluidic systems transport, mix, separate, or otherwise process fluids. Various applications rely on passive fluid control using capillary fo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nature Synthesis
Nature, in the broadest sense, is the physical world or universe. "Nature" can refer to the phenomena of the physical world, and also to life in general. The study of nature is a large, if not the only, part of science. Although humans are part of nature, human activity is often understood as a separate category from other natural phenomena. The word ''nature'' is borrowed from the Old French ''nature'' and is derived from the Latin word ''natura'', or "essential qualities, innate disposition", and in ancient times, literally meant "birth". In ancient philosophy, ''natura'' is mostly used as the Latin translation of the Greek word ''physis'' (φύσις), which originally related to the intrinsic characteristics of plants, animals, and other features of the world to develop of their own accord. The concept of nature as a whole, the physical universe, is one of several expansions of the original notion; it began with certain core applications of the word φύσις by pre-Socr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eli Lilly And Company
Eli Lilly and Company is an American pharmaceutical company headquartered in Indianapolis, Indiana, with offices in 18 countries. Its products are sold in approximately 125 countries. The company was founded in 1876 by, and named after, Colonel Eli Lilly, a pharmaceutical chemist and veteran of the American Civil War. As of 2022, Lilly is known for its clinical depression drugs Prozac ( fluoxetine) (1986) and Cymbalta (duloxetine) (2004) and its antipsychotic medication Zyprexa (olanzapine) (1996), although its primary revenue drivers are the diabetes drugs Humalog (insulin lispro) (1996) and Trulicity (dulaglutide) (2014). Lilly's achievements include being the first company to mass-produce the polio vaccine developed by Jonas Salk, and insulin. It was one of the first pharmaceutical companies to produce human insulin using recombinant DNA including Humulin ( insulin medication), Humalog (insulin lispro), and the first approved biosimilar insulin product in the US, Basaglar ( ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Philadelphia, Pennsylvania
Philadelphia, often called Philly, is the largest city in the Commonwealth of Pennsylvania, the sixth-largest city in the U.S., the second-largest city in both the Northeast megalopolis and Mid-Atlantic regions after New York City. Since 1854, the city has been coextensive with Philadelphia County, the most populous county in Pennsylvania and the urban core of the Delaware Valley, the nation's seventh-largest and one of world's largest metropolitan regions, with 6.245 million residents . The city's population at the 2020 census was 1,603,797, and over 56 million people live within of Philadelphia. Philadelphia was founded in 1682 by William Penn, an English Quaker. The city served as capital of the Pennsylvania Colony during the British colonial era and went on to play a historic and vital role as the central meeting place for the nation's founding fathers whose plans and actions in Philadelphia ultimately inspired the American Revolution and the nation's inde ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Avid Radiopharmaceuticals
Avid Radiopharmaceuticals is an American company, founded by Dr. Daniel Skovronsky, and based at the University City Science Center research campus in Philadelphia, Pennsylvania. The company has developed a radioactive tracer called Florbetapir (18F), florbetapir (18F). Florbetapir can be used to detect beta amyloid plaques in patients with memory problems using positron emission tomography (PET) scans, making the company the first to bring to market an FDA-approved method that can directly detect this hallmark pathology of Alzheimer's disease. Eli Lilly and Company announced on November 8, 2010, that they would acquire Avid for $800 million, with $300 million paid out up front and the balance paid later on. Detection of Alzheimer's disease Since the disease was first described by Alois Alzheimer in 1906, the only certain way to determine if a person indeed had the disease was to perform an autopsy on the patient's brain to find distinctive spots on the brain that show the buildu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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