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Harold Wolferstan Thomas
Harold Wolferstan Thomas (1875–1931) was a Canadian doctor, noted for his research in the field of tropical medicine. Early life Harold Wolferstan Thomas was born in 1875 in Montreal, Quebec, the son of the banker Francis Wolferstan Thomas (1834-1900) and his wife Harriet Amelia Thomas (née Goodhue). He studied medicine at McGill University in Montreal until 1897. Career Thomas worked in Germany (including at Göttingen and Munich) and at the Montreal General Hospital. From 1903, he worked at the Liverpool School of Tropical Medicine (LSTM) and from 1904 was head of a laboratory in Runcorn. In 1904 he took part in an expedition to study tropical diseases in the Amazon region. Along with Anton Breinl (1880-1944), he discovered in 1905 that the arsenic preparation Atoxyl killed Trypanosomatida, trypanosomes, the causative agent of sleeping sickness. The studies were performed by infecting laboratory animals such as mice, dogs and monkeys with Trypanosoma brucei, Trypanosoma bruc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anton Breinl
Anton Breinl (2 July 1880 – 28 June 1944) was a medical practitioner and medical researcher, who established the Australian Institute of Tropical Medicine in Townsville, Queensland, Australia. Early life Anton Breinl was born on 2 July 1880 in Vienna. He was the son of Anton Breinl, lace manufacturer in Graslitz, Bohemia (now Kraslice in the Czech Republic) and his wife Leopoldine (née Stammhammer). He was educated in Vienna and then took his medical degree at Prague University. Liverpool School of Tropical Medicine Breinl worked at the Liverpool School of Tropical Medicine. He was an exceptional medical scientist who had received awards for his contribution to tropical medicine, particularly for his work with Harold Wolferstan Thomas, on a cure for sleeping sickness. The treatment he helped develop, using an organic arsenical " atoxyl", later became a corner stone in the early development of chemotherapy. Australian Institute for Tropical Medicine In 1908, respond ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Canadian Tropical Physicians
Canadians (french: Canadiens) are people identified with the country of Canada. This connection may be residential, legal, historical or cultural. For most Canadians, many (or all) of these connections exist and are collectively the source of their being ''Canadian''. Canada is a multilingual and multicultural society home to people of groups of many different ethnic, religious, and national origins, with the majority of the population made up of Old World immigrants and their descendants. Following the initial period of French and then the much larger British colonization, different waves (or peaks) of immigration and settlement of non-indigenous peoples took place over the course of nearly two centuries and continue today. Elements of Indigenous, French, British, and more recent immigrant customs, languages, and religions have combined to form the culture of Canada, and thus a Canadian identity. Canada has also been strongly influenced by its linguistic, geographic, and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1931 Deaths
Events January * January 2 – South Dakota native Ernest Lawrence invents the cyclotron, used to accelerate particles to study nuclear physics. * January 4 – German pilot Elly Beinhorn begins her flight to Africa. * January 22 – Sir Isaac Isaacs is sworn in as the first Australian-born Governor-General of Australia. * January 25 – Mohandas Gandhi is again released from imprisonment in India. * January 27 – Pierre Laval forms a government in France. February * February 4 – Soviet leader Joseph Stalin gives a speech calling for rapid industrialization, arguing that only strong industrialized countries will win wars, while "weak" nations are "beaten". Stalin states: "We are fifty or a hundred years behind the advanced countries. We must make good this distance in ten years. Either we do it, or they will crush us." The first five-year plan in the Soviet Union is intensified, for the industrialization and collectivization of agriculture. * February 10 – O ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1875 Births
Events January–March * January 1 – The Midland Railway of England abolishes the Second Class passenger category, leaving First Class and Third Class. Other British railway companies follow Midland's lead during the rest of the year (Third Class is renamed Second Class in 1956). * January 5 – The Palais Garnier, one of the most famous opera houses in the world, is inaugurated in Paris. * January 12 – Guangxu Emperor, Guangxu becomes the 11th Qing Dynasty Emperor of China at the age of 3, in succession to his cousin. * January 14 – The newly proclaimed King Alfonso XII of Spain (Queen Isabella II's son) arrives in Spain to restore the monarchy during the Third Carlist War. * February 3 – Third Carlist War – Battle of Lácar: Carlist commander Torcuato Mendiri, Torcuato Mendíri secures a brilliant victory, when he surprises and routs a Government force under General Enrique Bargés at Lácar, east of Estella, nearly capturing newly cr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trypanosoma Brucei
''Trypanosoma brucei'' is a species of parasitic Kinetoplastida, kinetoplastid belonging to the genus ''Trypanosoma'' that is present in sub-Saharan Africa. Unlike other protozoan parasites that normally infect blood and tissue cells, it is exclusively extracellular and inhabits the blood plasma and body fluids. It causes deadly vector-borne diseases: African trypanosomiasis or sleeping sickness in humans, and animal trypanosomiasis or ''nagana'' in cattle and horses. It is a species complex grouped into three subspecies: ''T. b. brucei'', ''T. b. gambiense'' and ''T. b. rhodesiense''. The first is a parasite of non-human mammals and causes ''nagana'', while the latter two are zoonotic infecting both humans and animals and cause African trpanosomiasis. ''T. brucei'' is transmitted between mammal hosts by an insect Vector (epidemiology), vector belonging to different species of tsetse fly (''Glossina''). Transmission occurs by biting during the insect's blood meal. The parasites un ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trypanosomatida
Trypanosomatida is a group of kinetoplastid excavates distinguished by having only a single flagellum. The name is derived from the Greek ''trypano'' (borer) and ''soma'' (body) because of the corkscrew-like motion of some trypanosomatid species. All members are exclusively parasitic, found primarily in insects. A few genera have life-cycles involving a secondary host, which may be a vertebrate, invertebrate or plant. These include several species that cause major diseases in humans. Some trypanosomatida are intracellular parasites, with the important exception of Trypanosoma brucei. Medical importance The three major human diseases caused by trypanosomatids are; African trypanosomiasis (sleeping sickness, caused by ''Trypanosoma brucei'' and transmitted by tsetse flies), South American trypanosomiasis (Chagas disease, caused by '' T. cruzi'' and transmitted by triatomine bugs), and leishmaniasis (a set of trypanosomal diseases caused by various species of ''Leishmania'' trans ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Atoxyl
Arsanilic acid, also known as aminophenyl arsenic acid or aminophenyl arsonic acid, is an organoarsenic compound, an amino derivative of phenylarsonic acid whose amine group is in the 4-position. A crystalline powder introduced medically in the late 19th century as Atoxyl, its sodium salt was used by injection in the early 20th century as the first organic arsenical drug, but it was soon found prohibitively toxic for human use. Arsanilic acid saw long use as a veterinary feed additive promoting growth and to prevent or treat dysentery in poultry and swine. In 2013, its approval by US government as an animal drug was voluntarily withdrawn by its sponsors. Still sometimes used in laboratories, arsanilic acid's legacy is principally through its influence on Paul Ehrlich in launching the antimicrobial chemotherapy approach to treating infectious diseases of humans. Chemistry Synthesis was first reported in 1863 by Antoine Béchamp and became the basis of the Bechamp reaction. The p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arsenic
Arsenic is a chemical element with the symbol As and atomic number 33. Arsenic occurs in many minerals, usually in combination with sulfur and metals, but also as a pure elemental crystal. Arsenic is a metalloid. It has various allotropes, but only the gray form, which has a metallic appearance, is important to industry. The primary use of arsenic is in alloys of lead (for example, in car batteries and ammunition). Arsenic is a common n-type dopant in semiconductor electronic devices. It is also a component of the III-V compound semiconductor gallium arsenide. Arsenic and its compounds, especially the trioxide, are used in the production of pesticides, treated wood products, herbicides, and insecticides. These applications are declining with the increasing recognition of the toxicity of arsenic and its compounds. A few species of bacteria are able to use arsenic compounds as respiratory metabolites. Trace quantities of arsenic are an essential dietary element in rats, ham ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amazon Region
The Amazon basin is the part of South America drained by the Amazon River and its tributaries. The Amazon drainage basin covers an area of about , or about 35.5 percent of the South American continent. It is located in the countries of Bolivia, Brazil, Colombia, Ecuador, Guyana, Peru, Suriname, and Venezuela. Most of the basin is covered by the Amazon rainforest, also known as Amazonia. With a area of dense tropical forest, this is the largest rainforest in the world. Geography The Amazon River begins in the Andes, Andes Mountains at the west of the basin with its main tributary the Marañón River and Apurímac River, Apurimac River in Peru. The highest point in the Drainage divide, watershed of the Amazon is the second biggest peak of Yerupajá at . With a length of about before it drains into the Atlantic Ocean, it is List of rivers by length, one of the two longest rivers in the world. A team of scientists has claimed that the Amazon is longer than the Nile, but ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Montreal
Montreal ( ; officially Montréal, ) is the List of the largest municipalities in Canada by population, second-most populous city in Canada and List of towns in Quebec, most populous city in the Provinces and territories of Canada, Canadian province of Quebec. Founded in 1642 as ''Fort Ville-Marie, Ville-Marie'', or "City of Mary", it is named after Mount Royal, the triple-peaked hill around which the early city of Ville-Marie is built. The city is centred on the Island of Montreal, which obtained its name from the same origin as the city, and a few much smaller peripheral islands, the largest of which is Île Bizard. The city is east of the national capital Ottawa, and southwest of the provincial capital, Quebec City. As of 2021, the city had a population of 1,762,949, and a Census Metropolitan Area#Census metropolitan areas, metropolitan population of 4,291,732, making it the List of the largest municipalities in Canada by population, second-largest city, and List of cen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Runcorn
Runcorn is an industrial town and cargo port in the Borough of Halton in Cheshire, England. Its population in 2011 was 61,789. The town is in the southeast of the Liverpool City Region, with Liverpool to the northwest across the River Mersey. Runcorn is on the southern bank of the River Mersey, where the estuary narrows to form the Runcorn Gap. Runcorn was founded by Ethelfleda in 915 AD as a fortification to guard against Viking invasion at a narrowing of the River Mersey. Under Norman rule, Runcorn fell under the Barony of Halton and an Augustinian abbey was established here in 1115. It remained a small, isolated settlement until the Industrial Revolution when the extension of the Bridgewater Canal to Runcorn in 1776 established it as a port which would link Liverpool with inland Manchester and Staffordshire. and The docks enabled the growth of industry, initially shipwrights and sandstone quarries. In the late 18th and early 19th centuries, it was a spa and health resort b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
_Trypanosoma_equiperdum.jpg "Click for more on -> Trypanosomatida")
