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Hans Kosterlitz
Hans Walter Kosterlitz FRS (27 April 1903 – 26 October 1996) was a German-born British biochemist. Biography Hans Walter Kosterlitz was born on 27 April 1903 in Berlin. He was the elder son of Bernhard Kosterlitz, a physician, and Selma Helena Lepman. Kosterlitz’s father had recommended a career in law. He gave it a try for six months at the University of Berlin, but then switched to medicine. He graduated in 1928 and worked in the department of Wilhelm His. From 1930-33 he was an assistant at the Charité hospital, University of Berlin, where he worked in the radiology department. His daytime job in clinical radiology funded his evening researches in the laboratory, where he developed an interest in carbohydrate metabolism. In 1933 Adolf Hitler passed the Law for the Restoration of the Professional Civil Service, which applied to non-Aryans. Later a similar law was passed to cover all lawyers, doctors and other professions. Kosterlitz, who had Jewish ancestry, con ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Berlin
Berlin ( , ) is the capital and largest city of Germany by both area and population. Its 3.7 million inhabitants make it the European Union's most populous city, according to population within city limits. One of Germany's sixteen constituent states, Berlin is surrounded by the State of Brandenburg and contiguous with Potsdam, Brandenburg's capital. Berlin's urban area, which has a population of around 4.5 million, is the second most populous urban area in Germany after the Ruhr. The Berlin-Brandenburg capital region has around 6.2 million inhabitants and is Germany's third-largest metropolitan region after the Rhine-Ruhr and Rhine-Main regions. Berlin straddles the banks of the Spree, which flows into the Havel (a tributary of the Elbe) in the western borough of Spandau. Among the city's main topographical features are the many lakes in the western and southeastern boroughs formed by the Spree, Havel and Dahme, the largest of which is Lake Müggelsee. Due to its l ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Registration Act 1939
The National Registration Act 1939 was an Act of Parliament in the United Kingdom. The initial National Registration Bill was introduced to Parliament as an emergency measure at the start of the Second World War. The Act provided for the establishment of a constantly-maintained National Register of the civilian population of the United Kingdom and the Isle of Man, and for the issuance of identity cards based on data held in the register, and required civilians to present their identity cards on demand to police officers and other authorised persons. Following the passing of the Act by Parliament on 5 September 1939, registrations and the issuing of identity cards commenced on 29 September. Registration and identity cards Every man, woman and child had to carry an identity (ID) card at all times and the cards would include the following information: *Name *Sex *Date of birth (and thus age) *Occupation, profession, trade or employment. The Register had also collected informati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Agonist
An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the agonist, while an inverse agonist causes an action opposite to that of the agonist. Etymology From the Greek αγωνιστής (agōnistēs), contestant; champion; rival < αγων (agōn), contest, combat; exertion, struggle < αγω (agō), I lead, lead towards, conduct; drive Types of agonists can be activated by either endogenous agonists (such as |
Homogenization (biology)
Homogenization, in cell biology or molecular biology, is a process whereby different fractions of a biological sample become equal in composition. It can be a disease sign in histopathology, or an intentional process in research: A homogenized sample is equal in composition throughout, so that removing a fraction does not alter the overall molecular make-up of the sample remaining, and is identical to the fraction removed. Induced homogenization in biology is often followed by molecular extraction and various analytical techniques, including ELISA and western blot. Methods Homogenization of tissue in solution is often performed simultaneously with cell lysis. To prevent lysis however, the tissue (or collection of cells, e.g. from cell culture) can be kept at temperatures slightly above zero to prevent autolysis, and in an isotonic solution to prevent osmotic damage. If freezing the tissue is possible, cryohomogenization can be performed under "dry" conditions, and is often the m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Naloxone
Naloxone, sold under the brand names Narcan (4 mg) and Kloxxado (8 mg) among others, is a medication used to reverse or reduce the effects of opioids. It is commonly used to counter decreased breathing in opioid overdose. Effects begin within two minutes when given intravenously, and within five minutes when injected into a muscle. The medicine can also be administered by spraying it into a person's nose. Naloxone commonly blocks the effects of opioids for 30 to 90 minutes. Multiple doses may be required, as the duration of action of some opioids is greater than that of naloxone. Administration to opioid-dependent individuals may cause symptoms of opioid withdrawal, including restlessness, agitation, nausea, vomiting, a fast heart rate, and sweating. To prevent this, small doses every few minutes can be given until the desired effect is reached. In those with previous heart disease or taking medications that negatively affect the heart, further heart problems have occurred. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antagonist
An antagonist is a character in a story who is presented as the chief foe of the protagonist. Etymology The English word antagonist comes from the Greek ἀνταγωνιστής – ''antagonistēs'', "opponent, competitor, villain, enemy, rival," which is derived from ''anti-'' ("against") and ''agonizesthai'' ("to contend for a prize"). Types Heroes and villains The antagonist is commonly positioned against the protagonist and their world order. While most narratives will often portray the protagonist as a hero and the antagonist as a villain, like Harry Potter and Lord Voldemort in '' Harry Potter'', the antagonist does not always appear as the villain. In some narratives, like Light Yagami and L in '' Death Note'', the protagonist is a villain and the antagonist is an opposing hero. Antagonists are conventionally presented as making moral choices less savory than those of protagonists. This condition is often used by an author to create conflict within a story. This is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Opiate
An opiate, in classical pharmacology, is a substance derived from opium. In more modern usage, the term ''opioid'' is used to designate all substances, both natural and synthetic, that bind to opioid receptors in the brain (including antagonists). Opiates are alkaloid compounds naturally found in the opium poppy plant ''Papaver somniferum''. The psychoactive compounds found in the opium plant include morphine, codeine, and thebaine. Opiates have long been used for a variety of medical conditions with evidence of opiate trade and use for pain relief as early as the eighth century AD. Opiates are considered drugs with moderate to high abuse potential and are listed on various "Substance-Control Schedules" under the Uniform Controlled Substances Act of the United States of America. In 2014, between 13 and 20 million people used opiates recreationally (0.3% to 0.4% of the global population between the ages of 15 and 65). According to the CDC, from this population, there were 47,00 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polygraph
A polygraph, often incorrectly referred to as a lie detector test, is a device or procedure that measures and records several physiological indicators such as blood pressure, pulse, respiration, and skin conductivity while a person is asked and answers a series of questions. The belief underpinning the use of the polygraph is that deceptive answers will produce physiological responses that can be differentiated from those associated with non-deceptive answers; however, there are no specific physiological reactions associated with lying, making it difficult to identify factors that separate those who are lying from those who are telling the truth. In some countries, polygraphs are used as an interrogation tool with criminal suspects or candidates for sensitive public or private sector employment. US law enforcement and federal government agencies such as the FBI, DEA, CIA, NSA, and many police departments such as the LAPD and the Virginia State Police use polygraph examinatio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Muscle Contraction
Muscle contraction is the activation of tension-generating sites within muscle cells. In physiology, muscle contraction does not necessarily mean muscle shortening because muscle tension can be produced without changes in muscle length, such as when holding something heavy in the same position. The termination of muscle contraction is followed by muscle relaxation, which is a return of the muscle fibers to their low tension-generating state. For the contractions to happen, the muscle cells must rely on the interaction of two types of filaments which are the thin and thick filaments. Thin filaments are two strands of actin coiled around each, and thick filaments consist of mostly elongated proteins called myosin. Together, these two filaments form myofibrils which are important organelles in the skeletal muscle system. Muscle contraction can also be described based on two variables: length and tension. A muscle contraction is described as isometric if the muscle tension changes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vas Deferens
The vas deferens or ductus deferens is part of the male reproductive system of many vertebrates. The ducts transport sperm from the epididymis to the ejaculatory ducts in anticipation of ejaculation. The vas deferens is a partially coiled tube which exits the abdominal cavity through the inguinal canal. Etymology ''Vas deferens'' is Latin, meaning "carrying-away vessel"; the plural version is ''vasa deferentia''. ''Ductus deferens'' is also Latin, meaning "carrying-away duct"; the plural version is ''ducti deferentes''. Structure There are two vasa deferentia, connecting the left and right epididymis with the seminal vesicles to form the ejaculatory duct in order to move sperm. The (human) vas deferens measures 30–35 cm in length, and 2–3 mm in diameter. The vas deferens is continuous proximally with the tail of the epididymis. The vas deferens exhibits a tortuous, convoluted initial/proximal section (which measures 2–3 cm in length). Distally, it forms ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Endorphin
Endorphins (contracted from endogenous morphine) are chemical signals in the brain that block the perception of pain and increase feelings of wellbeing. They are produced and stored in an area of the brain known as the pituitary gland. History Opioid peptides in the brain were first discovered in 1973 by investigators at the University of Aberdeen, John Hughes and Hans Kosterlitz. They isolated "enkephalins" (from the Greek , ') from pig brain, identified as Met-enkephalin and Leu-enkephalin. This came after the discovery of a receptor that was proposed to produce the pain-relieving analgesic effects of morphine and other opioids, which led Kosterlitz and Hughes to their discovery of the endogenous opioid ligands. Research during this time was focused on the search for a painkiller that did not have the addictive character or overdose risk of morphine. Rabi Simantov and Solomon H. Snyder isolated morphine-like peptides from calf brain. Eric J. Simon, who independently di ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pharmacology
Pharmacology is a branch of medicine, biology and pharmaceutical sciences concerned with drug or medication action, where a drug may be defined as any artificial, natural, or endogenous (from within the body) molecule which exerts a biochemical or physiological effect on the cell, tissue, organ, or organism (sometimes the word ''pharmacon'' is used as a term to encompass these endogenous and exogenous bioactive species). More specifically, it is the study of the interactions that occur between a living organism and chemicals that affect normal or abnormal biochemical function. If substances have medicinal properties, they are considered pharmaceuticals. The field encompasses drug composition and properties,functions,sources,synthesis and drug design, molecular and cellular mechanisms, organ/systems mechanisms, signal transduction/cellular communication, molecular diagnostics, interactions, chemical biology, therapy, and medical applications and antipathogenic capabilities. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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