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Haig H. Kazazian Jr.
Haig H. Kazazian, Jr. (July 30, 1937 – January 19/20, 2022) was a professor in the Department of Genetic Medicine at Johns Hopkins University School of Medicine in Baltimore, Maryland. Kazazian was an elected member of the National Academy of Sciences and the American Academy of Arts and Sciences. Kazazian determined the molecular basis of single-gene genetic disorders such as hemoglobinopathies and hemophilia and introduced prenatal diagnosis for such disorders. His group was the first to identify a disease-causing mutation resulting from jumping genes in humans. After this discovery, he focused on basic research into LINE retrotransposition in humans and its implications for disease. Early life and education Kazazian's Armenian father (also Haig H. Kazazian) was from Kayseri, Turkey. He was sent to the Ras el Ain concentration camp in Syria as part of the Armenian genocide, but escaped in 1918 and arrived in the U.S. in 1923. Kazazian's mother Hermine left Istanbul and arri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Toledo, Ohio
Toledo ( ) is a city in and the county seat of Lucas County, Ohio, United States. A major Midwestern United States port city, Toledo is the fourth-most populous city in the state of Ohio, after Columbus, Cleveland, and Cincinnati, and according to the 2020 census, the 79th-largest city in the United States. With a population of 270,871, it is the principal city of the Toledo metropolitan area. It also serves as a major trade center for the Midwest; its port is the fifth-busiest in the Great Lakes and 54th-biggest in the United States. The city was founded in 1833 on the west bank of the Maumee River, and originally incorporated as part of Monroe County, Michigan Territory. It was refounded in 1837, after the conclusion of the Toledo War, when it was incorporated in Ohio. After the 1845 completion of the Miami and Erie Canal, Toledo grew quickly; it also benefited from its position on the railway line between New York City and Chicago. The first of many glass manufacturers ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Istanbul
Istanbul ( , ; tr, İstanbul ), formerly known as Constantinople ( grc-gre, Κωνσταντινούπολις; la, Constantinopolis), is the List of largest cities and towns in Turkey, largest city in Turkey, serving as the country's economic, cultural and historic hub. The city straddles the Bosporus strait, lying in both Europe and Asia, and has a population of over 15 million residents, comprising 19% of the population of Turkey. Istanbul is the list of European cities by population within city limits, most populous European city, and the world's List of largest cities, 15th-largest city. The city was founded as Byzantium ( grc-gre, Βυζάντιον, ) in the 7th century BCE by Ancient Greece, Greek settlers from Megara. In 330 CE, the Roman emperor Constantine the Great made it his imperial capital, renaming it first as New Rome ( grc-gre, Νέα Ῥώμη, ; la, Nova Roma) and then as Constantinople () after himself. The city grew in size and influence, eventually becom ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Pennsylvania School Of Medicine
The Perelman School of Medicine, commonly known as Penn Med, is the medical school of the University of Pennsylvania, a private research university in Philadelphia, Pennsylvania. Founded in 1765, the Perelman School of Medicine is the oldest medical school in the United States and is one of the seven Ivy League medical schools. Penn Med is consistently one of the top recipients of NIH research awards and is currently ranked sixth for research among American medical schools by '' U.S. News & World Report''. History The school of medicine was founded by Dr. John Morgan, a graduate of the College of Philadelphia (the precursor of the University of Pennsylvania) and the University of Edinburgh Medical School. After training in Edinburgh and other European cities, Dr. Morgan returned to Philadelphia in 1765. With fellow University of Edinburgh Medical School graduate Dr. William Shippen Jr., Morgan persuaded the college's trustees to found the first medical school in the Original ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mobile DNA (journal)
''Mobile DNA'' is a peer-reviewed online-only open access scientific journal covering genomics, with a specific focus on transposable elements in DNA. It was established in 2010 and is published by BioMed Central. The current editors-in-chief are Irina Arkhipova (Marine Biological Laboratory at Woods Hole), Kathleen Burns ( Dana-Farber Cancer Institute) and Pascale Lesage ( INSERM). Prior Editors in Chief have included Marlene Belfort Marlene Belfort (born 1945) is an American biochemist known for her research on the factors that interrupt genes and proteins. She is a fellow of the American Academy of Arts and Sciences and has been admitted to the United States National Academy ... ( University at Albany), Cédric Feschotte ( Cornell University), Henry Levin ( National Institutes of Health), and the late Haig Kazazian ( Johns Hopkins University School of Medicine). According to the '' Journal Citation Reports'', the journal has a 2022 impact factor of 4.9. References Ext ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Mutation
''Human Mutation'' is a peer-reviewed medical journal of human genetics published by Wiley-Liss on behalf of the Human Genome Variation Society. It first appeared in 1992. The founding editors-in-chief were Haig H. Kazazian and Richard G.H. Cotton. Cotton served until his death in 2015, latterly with Garry R. Cutting, who became sole EIC. According to the ''Journal Citation Reports'', the journal has a 2020 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as ... of 4.878, ranking it 44th out of 176 journals in the category "Genetics & Heredity". References External links * Human Genome Variation Society Medical genetics journals Publications established in 1992 Wiley-Liss academic journals Monthly journals English-language journals {{genetics-journa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Richard Cotton (geneticist)
Richard Cotton AM (10 November 1940 – 14 June 2015) was an Australian medical researcher and founder of the Murdoch Institute and the Human Variome Project. Cotton focused on the prevention and treatment of genetic disorders and birth defects. As a genetic researcher, he was instrumental in the development of techniques to produce monoclonal antibodies, and his diagnostic techniques and research into diseases such as Phenylketonuria have been fundamental to the early detection of affected individuals which has often lead to life-saving interventions and the prevention of further disease progression. He was a pioneer in the field of Mutation Detection, developing methods for the chemical and enzymatic detection of human genetic mutations. Cotton was one of the first to recognize the need to document the extent of all human genetic variation in order to investigate, treat and prevent human disease. As the Founder and Scientific Director of the Human Variome Project, he has led th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Maxine Singer
Maxine Frank Singer (born February 15, 1931) is an American molecular biologist and science administrator. She is known for her contributions to solving the genetic code, her role in the ethical and regulatory debates on recombinant DNA techniques (including the organization of the Asilomar Conference on Recombinant DNA), and her leadership of Carnegie Institution of Washington. In 2002, '' Discover'' magazine recognized her as one of the 50 most important women in science. Life Singer was born in New York City. After attending Midwood High School in Brooklyn, she majored in chemistry (and minored in biology) at Swarthmore College. She went on to earn a Ph.D. in 1957 at Yale University, researching protein chemistry under Joseph Fruton. Fruton encouraged her to specialize in nucleic acids, and in 1956 she joined the Laboratory of Biochemistry of Leon Heppel at the National Institutes of Health. She led various biochemical research groups as the Chief of the Laboratory of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hemoglobin
Hemoglobin (haemoglobin BrE) (from the Greek word αἷμα, ''haîma'' 'blood' + Latin ''globus'' 'ball, sphere' + ''-in'') (), abbreviated Hb or Hgb, is the iron-containing oxygen-transport metalloprotein present in red blood cells (erythrocytes) of almost all vertebrates (the exception being the fish family Channichthyidae) as well as the tissues of some invertebrates. Hemoglobin in blood carries oxygen from the respiratory organs (''e.g.'' lungs or gills) to the rest of the body (''i.e.'' tissues). There it releases the oxygen to permit aerobic respiration to provide energy to power functions of an organism in the process called metabolism. A healthy individual human has 12to 20grams of hemoglobin in every 100mL of blood. In mammals, the chromoprotein makes up about 96% of the red blood cells' dry content (by weight), and around 35% of the total content (including water). Hemoglobin has an oxygen-binding capacity of 1.34mL O2 per gram, which increases the total blood oxygen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
US Public Health Service
The United States Public Health Service (USPHS or PHS) is a collection of agencies of the Department of Health and Human Services concerned with public health, containing nine out of the department's twelve operating divisions. The Assistant Secretary for Health oversees the PHS. The Public Health Service Commissioned Corps (PHSCC) is the federal uniformed service of the PHS, and is one of the eight uniformed services of the United States. PHS had its origins in the system of marine hospitals that originated in 1798. In 1871 these were consolidated into the Marine Hospital Service, and shortly afterwards the position of Surgeon General and the PHSCC were established. As the system's scope grew to include quarantine authority and research, it was renamed the Public Health Service in 1912. A series of reorganizations in 1966–1973 began a shift where PHS' divisions were promoted into departmental operating agencies. PHS was established as a thin layer of hierarchy above t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Institutes Of Health
The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late 1880s and is now part of the United States Department of Health and Human Services. The majority of NIH facilities are located in Bethesda, Maryland, and other nearby suburbs of the Washington metropolitan area, with other primary facilities in the Research Triangle Park in North Carolina and smaller satellite facilities located around the United States. The NIH conducts its own scientific research through the NIH Intramural Research Program (IRP) and provides major biomedical research funding to non-NIH research facilities through its Extramural Research Program. , the IRP had 1,200 principal investigators and more than 4,000 postdoctoral fellows in basic, translational, and clinical research, being the largest biomedical research instit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harvey Itano
Harvey Akio Itano (November 3, 1920 – May 8, 2010) was an American biochemist best known for his work on the molecular basis of sickle cell anemia and other diseases. In collaboration with Linus Pauling, Itano used electrophoresis to demonstrate the difference between normal hemoglobin and sickle cell hemoglobin; their 1949 paper " Sickle Cell Anemia, a Molecular Disease" (coauthored also with S. J. Singer and Ibert C. Wells) was a landmark in both molecular medicine and protein electrophoresis. In 1979, Itano became the first Japanese American elected to the United States National Academy of Sciences (in the Genetics section). Itano was an emeritus professor of pathology at the University of California, San Diego.K. W. Lee. "Remarkable Parents Who Raised Remarkable Family." ''Sacramento Union'', June 25, 1979.Reprint from the ''Nichi Bei Times''accessed August 25, 2008. Itano died in La Jolla, California of complications from Parkinson's disease. Early life Itano was bo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Barton Childs
Barton Childs (February 29, 1916 – February 18, 2010) was an American and . He was born in Chicago, Illinois, and graduated from in 1938. In 1942, he received his M.D. from . Following military service in |
