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Gumma (pathology)
A gumma (plural gummata or gummas) is a soft, non-cancerous growth resulting from the tertiary stage of syphilis (and yaws). It is a form of granuloma. Gummas are most commonly found in the liver (''gumma hepatis''), but can also be found in brain, heart, skin, bone, testis, and other tissues, leading to a variety of potential problems including neurological disorders or heart valve disease. Presentation Gummas have a firm, necrotic center surrounded by inflamed tissue, which forms an amorphous proteinaceous mass. The center may become partly hyalinized. These central regions begin to die through coagulative necrosis, though they also retain some of the structural characteristics of previously normal tissues, enabling a distinction from the granulomas of tuberculosis where caseous necrosis obliterates preexisting structures. Other histological features of gummas include an ''intervening zone'' containing epithelioid cells with indistinct borders and multinucleated giant cell ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gummata Hepatis
A gumma (plural gummata or gummas) is a soft, non-cancerous growth resulting from the tertiary stage of syphilis (and yaws). It is a form of granuloma. Gummas are most commonly found in the liver (''gumma hepatis''), but can also be found in brain, heart, skin, bone, testis, and other tissues, leading to a variety of potential problems including neurology, neurological disorders or heart valve disease. Presentation Gummas have a firm, necrotic center surrounded by inflamed tissue, which forms an amorphous proteinaceous mass. The center may become partly hyaline, hyalinized. These central regions begin to die through coagulative necrosis, though they also retain some of the structural characteristics of previously normal tissues, enabling a distinction from the granulomas of tuberculosis where caseous necrosis obliterates preexisting structures. Other histological features of gummas include an ''intervening zone'' containing epithelium, epithelioid cells with indistinct borders ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
