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Glutathione-S-transferase
Glutathione ''S''-transferases (GSTs), previously known as ligandins, are a family of eukaryotic and prokaryotic phase II metabolic isozymes best known for their ability to catalyze the conjugation of the reduced form of glutathione (GSH) to xenobiotic substrates for the purpose of detoxification. The GST family consists of three superfamilies: the cytosolic, mitochondrial, and microsomal—also known as MAPEG—proteins. Members of the GST superfamily are extremely diverse in amino acid sequence, and a large fraction of the sequences deposited in public databases are of unknown function. The Enzyme Function Initiative (EFI) is using GSTs as a model superfamily to identify new GST functions. GSTs can constitute up to 10% of cytosolic protein in some mammalian organs. GSTs catalyse the conjugation of GSH—via a sulfhydryl group—to electrophilic centers on a wide variety of substrates in order to make the compounds more water-soluble. This activity detoxifies endogenous com ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Taxonomy Of Anopheles
''Anopheles'' is a genus of mosquitoes (Culicidae). Of about 484 recognised species, over 100 can transmit human malaria, but only 30–40 commonly transmit parasites of the genus ''Plasmodium'' that cause malaria, which affects humans in endemic (ecology), endemic areas. ''Anopheles gambiae'' is one of the best known, because of its predominant role in the transmission of the deadly species ''Plasmodium falciparum''. Classification The classification of this genus began in 1901 with Frederick Vincent Theobald. Despite the passage of time, the taxonomy remains incompletely settled. Classification into species is based on morphological characteristics - wing spots, head anatomy, larval and pupal anatomy, and chromosome structure, and more recently on DNA sequences. The genus ''Anopheles'' belongs to a subfamily Anophelinae with three genera: ''Anopheles'' Meigen (nearly worldwide distribution), ''Bironella'' Theobald (Australia only: 11 described species) and ''Chagasia'' Cruz ( ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
