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Giuseppe Brotzu
Giuseppe Brotzu (Cagliari, 24 January 1895 – Cagliari, 8 April 1976) was an Italian pharmacologist and politician. Biography Giuseppe Brotzu was born in Ghilarza, a town of the Province of Oristano, Sardinia. He graduated from the University of Cagliari, Sardinia in (1919) and later completed the specialization in Hygiene at University of Siena in 1922. He graduated in Medicine and Surgery at the University of Bologna in 1925. He became a professor at the University of Modena and Reggio Emilia in 1932, and between 1939 and 1943 he was the director of University of Cagliari. Scientific research Brotzu is recognized as the discoverer of the cephalosporin-based antibiotics, that were first isolated from cultures of ''Cephalosporium'' (now known as ''Acremonium'') in 1948. He noticed that these cultures produced substances that were effective against ''Salmonella typhi'', the cause of typhoid fever, which had beta-lactamase. He was awarded the ''Laurea ad honorem'' at the Uni ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cagliari
Cagliari (, also , , ; sc, Casteddu ; lat, Caralis) is an Italian municipality and the capital of the island of Sardinia, an autonomous region of Italy. Cagliari's Sardinian name ''Casteddu'' means ''castle''. It has about 155,000 inhabitants, while its metropolitan city (including Cagliari and 16 other nearby municipalities) has more than 431,000 inhabitants. According to Eurostat, the population of the Functional urban area, the commuting zone of Cagliari, rises to 476,975. Cagliari is the 26th largest city in Italy and the largest city on the island of Sardinia. An ancient city with a long history, Cagliari has seen the rule of several civilisations. Under the buildings of the modern city there is a continuous stratification attesting to human settlement over the course of some five thousand years, from the Neolithic to today. Historical sites include the prehistoric Domus de Janas, very damaged by cave activity, a large Carthaginian era necropolis, a Roman era amphi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Typhoid Fever
Typhoid fever, also known as typhoid, is a disease caused by '' Salmonella'' serotype Typhi bacteria. Symptoms vary from mild to severe, and usually begin six to 30 days after exposure. Often there is a gradual onset of a high fever over several days. This is commonly accompanied by weakness, abdominal pain, constipation, headaches, and mild vomiting. Some people develop a skin rash with rose colored spots. In severe cases, people may experience confusion. Without treatment, symptoms may last weeks or months. Diarrhea may be severe, but is uncommon. Other people may carry the bacterium without being affected, but they are still able to spread the disease. Typhoid fever is a type of enteric fever, along with paratyphoid fever. ''S. enterica'' Typhi is believed to infect and replicate only within humans. Typhoid is caused by the bacterium ''Salmonella enterica'' subsp. ''enterica'' serovar Typhi growing in the intestines, peyers patches, mesenteric lymph nodes, spleen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Members Of The Regional Council Of Sardinia
Member may refer to: * Military jury, referred to as "Members" in military jargon * Element (mathematics), an object that belongs to a mathematical set * In object-oriented programming, a member of a class ** Field (computer science), entries in a database ** Member variable, a variable that is associated with a specific object * Limb (anatomy), an appendage of the human or animal body ** Euphemism for penis * Structural component of a truss, connected by nodes * User (computing), a person making use of a computing service, especially on the Internet * Member (geology), a component of a geological formation * Member of parliament * The Members, a British punk rock band * Meronymy, a semantic relationship in linguistics * Church membership, belonging to a local Christian congregation, a Christian denomination and the universal Church * Member, a participant in a club or learned society A learned society (; also learned academy, scholarly society, or academic association) is a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Italian Pharmacologists
Italian(s) may refer to: * Anything of, from, or related to the people of Italy over the centuries ** Italians, an ethnic group or simply a citizen of the Italian Republic or Italian Kingdom ** Italian language, a Romance language *** Regional Italian, regional variants of the Italian language ** Languages of Italy, languages and dialects spoken in Italy ** Italian culture, cultural features of Italy ** Italian cuisine, traditional foods ** Folklore of Italy, the folklore and urban legends of Italy ** Mythology of Italy, traditional religion and beliefs Other uses * Italian dressing, a vinaigrette-type salad dressing or marinade * Italian or Italian-A, alternative names for the Ping-Pong virus, an extinct computer virus See also * * * Italia (other) * Italic (other) * Italo (other) * The Italian (other) * Italian people (other) Italian people may refer to: * in terms of ethnicity: all ethnic Italians, in and outside of Italy * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
People From Cagliari
A person ( : people) is a being that has certain capacities or attributes such as reason, morality, consciousness or self-consciousness, and being a part of a culturally established form of social relations such as kinship, ownership of property, or legal responsibility. The defining features of personhood and, consequently, what makes a person count as a person, differ widely among cultures and contexts. In addition to the question of personhood, of what makes a being count as a person to begin with, there are further questions about personal identity and self: both about what makes any particular person that particular person instead of another, and about what makes a person at one time the same person as they were or will be at another time despite any intervening changes. The plural form "people" is often used to refer to an entire nation or ethnic group (as in "a people"), and this was the original meaning of the word; it subsequently acquired its use as a plural form of p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Presidents Of Sardinia
President most commonly refers to: *President (corporate title) *President (education), a leader of a college or university * President (government title) President may also refer to: Automobiles * Nissan President, a 1966–2010 Japanese full-size sedan * Studebaker President, a 1926–1942 American full-size sedan * VinFast President, a 2020–present Vietnamese mid-size SUV Film and television *'' Præsidenten'', a 1919 Danish silent film directed by Carl Theodor Dreyer * ''The President'' (1928 film), a German silent drama * ''President'' (1937 film), an Indian film * ''The President'' (1961 film) * ''The Presidents'' (film), a 2005 documentary * ''The President'' (2014 film) * ''The President'' (South Korean TV series), a 2010 South Korean television series * ''The President'' (Palestinian TV series), a 2013 Palestinian reality television show *''The President Show'', a 2017 Comedy Central political satirical parody sitcom Music *The Presidents (American soul band) *The ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1976 Deaths
Events January * January 3 – The International Covenant on Economic, Social and Cultural Rights enters into force. * January 5 – The Pol Pot regime proclaims a new constitution for Democratic Kampuchea. * January 11 – The 1976 Philadelphia Flyers–Red Army game results in a 4–1 victory for the National Hockey League's Philadelphia Flyers over HC CSKA Moscow of the Soviet Union. * January 16 – The trial against jailed members of the Red Army Faction (the West German extreme-left militant Baader–Meinhof Group) begins in Stuttgart. * January 18 ** Full diplomatic relations are established between Bangladesh and Pakistan 5 years after the Bangladesh Liberation War. ** The Scottish Labour Party is formed as a breakaway from the UK-wide party. ** Super Bowl X in American football: The Pittsburgh Steelers defeat the Dallas Cowboys, 21–17, in Miami. * January 21 – First commercial Concorde flight, from London to Bahrain. * January 27 ** The United States vetoes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1895 Births
Events January–March * January 5 – Dreyfus affair: French officer Alfred Dreyfus is stripped of his army rank, and sentenced to life imprisonment on Devil's Island. * January 12 – The National Trust for Places of Historic Interest or Natural Beauty is founded in England by Octavia Hill, Robert Hunter and Canon Hardwicke Rawnsley. * January 13 – First Italo-Ethiopian War: Battle of Coatit – Italian forces defeat the Ethiopians. * January 17 – Félix Faure is elected President of the French Republic, after the resignation of Jean Casimir-Perier. * February 9 – Mintonette, later known as volleyball, is created by William G. Morgan at Holyoke, Massachusetts. * February 11 – The lowest ever UK temperature of is recorded at Braemar, in Aberdeenshire. This record is equalled in 1982, and again in 1995. * February 14 – Oscar Wilde's last play, the comedy ''The Importance of Being Earnest'', is first shown at St James's The ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Discovery And Development Of Cephalosporins
Cephalosporins are a broad class of bactericidal antibiotics that include the β-lactam ring and share a structural similarity and mechanism of action with other β-lactam antibiotics (e.g. penicillins, carbapenems and monobactams). The cephalosporins (and other β-lactams) have the ability to kill bacteria by inhibiting essential steps in the bacterial cell wall synthesis which in the end results in osmotic lysis and death of the bacterial cell. Cephalosporins are widely used antibiotics because of their clinical efficiency and desirable safety profile. The cephalosporins are diverse in their antibacterial spectrum, water solubility, acid tolerability, oral bioavailability, biological half-life and other properties. Therefore, the cephalosporins can be further classified into generations depending on antibacterial activity, time of invention and structural basis. Basic structure of cephalosporins The core of the basic cephalosporin molecule consists of a two ring system which ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cephalosporin
The cephalosporins (sg. ) are a class of β-lactam antibiotics originally derived from the fungus ''Acremonium'', which was previously known as ''Cephalosporium''. Together with cephamycins, they constitute a subgroup of β-lactam antibiotics called cephems. Cephalosporins were discovered in 1945, and first sold in 1964. Discovery The aerobic mold which yielded cephalosporin C was found in the sea near a sewage outfall in Su Siccu, by Cagliari harbour in Sardinia, by the Italian pharmacologist Giuseppe Brotzu in July 1945. Structure Cephalosporin contains a 6-membered dihydrothiazine ring. Substitutions at position 3 generally affect pharmacology; substitutions at position 7 affect antibacterial activity, but these cases are not always true. Medical uses Cephalosporins can be indicated for the prophylaxis and treatment of infections caused by bacteria susceptible to this particular form of antibiotic. First-generation cephalosporins are active predominantly against ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nobel Prize
The Nobel Prizes ( ; sv, Nobelpriset ; no, Nobelprisen ) are five separate prizes that, according to Alfred Nobel's will of 1895, are awarded to "those who, during the preceding year, have conferred the greatest benefit to humankind." Alfred Nobel was a Swedish chemist, engineer, and industrialist most famously known for the invention of dynamite. He died in 1896. In his will, he bequeathed all of his "remaining realisable assets" to be used to establish five prizes which became known as "Nobel Prizes." Nobel Prizes were first awarded in 1901. Nobel Prizes are awarded in the fields of Physics, Chemistry, Physiology or Medicine, Literature, and Peace (Nobel characterized the Peace Prize as "to the person who has done the most or best to advance fellowship among nations, the abolition or reduction of standing armies, and the establishment and promotion of peace congresses"). In 1968, Sveriges Riksbank (Sweden's central bank) funded the establishment of the Prize in Ec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Laurea Ad Honorem
An honorary degree is an academic degree for which a university (or other degree-awarding institution) has waived all of the usual requirements. It is also known by the Latin phrases ''honoris causa'' ("for the sake of the honour") or ''ad honorem '' ("to the honour"). The degree is typically a doctorate or, less commonly, a master's degree, and may be awarded to someone who has no prior connection with the academic institution or no previous postsecondary education. An example of identifying a recipient of this award is as follows: Doctorate in Business Administration (''Hon. Causa''). The degree is often conferred as a way of honouring a distinguished visitor's contributions to a specific field or to society in general. It is sometimes recommended that such degrees be listed in one's curriculum vitae (CV) as an award, and not in the education section. With regard to the use of this honorific, the policies of institutions of higher education generally ask that recipients ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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