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Gilutensin
Etifelmine (INN; also known as gilutensin) is a stimulant drug. It was used for the treatment of hypotension (low blood pressure). Synthesis The base catalyzed reaction between benzophenone 19-61-9(1) and butyronitrile 09-74-0(2) gives 2- ydroxy(diphenyl)methylutanenitrile 2101-20-8(3). Catalytic hydrogenation Hydrogenation is a chemical reaction between molecular hydrogen (H2) and another compound or element, usually in the presence of a catalyst such as nickel, palladium or platinum. The process is commonly employed to reduce or saturate organic ... reduces the nitrile group to a primary amine giving 1,1-diphenyl-2-ethyl-3-aminopropanol 2101-87-7(4). The tertiary hydroxyl group is dehydrated by treatment with anhydrous hydrogen chloride gas, completing the synthesis of Etifelmine (5). See also * 2-MDP * Pridefine References Stimulants Amines Benzhydryl compounds {{nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Etifelmine Synthesis
Etifelmine (International nonproprietary name, INN; also known as gilutensin) is a stimulant drug. It was used for the treatment of hypotension (low blood pressure). Synthesis The base catalyzed reaction between benzophenone [119-61-9] (1) and butyronitrile [109-74-0] (2) gives 2-[hydroxy(diphenyl)methyl]butanenitrile [22101-20-8] (3). Catalytic hydrogenation reduces the nitrile group to a primary amine giving 1,1-diphenyl-2-ethyl-3-aminopropanol [22101-87-7] (4). The tertiary hydroxyl group is dehydrated by treatment with anhydrous hydrogen chloride gas, completing the synthesis of Etifelmine (5). See also *2-MDP *Pridefine References [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
