Gilean McVean
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Gilean McVean
Gilean Alistair Tristram McVean (born February 1973) is a professor of statistical genetics at the University of Oxford, fellow of Linacre College, Oxford and co-founder and director of Genomics plc. He also co-chaired the 1000 Genomes Project analysis group. Education From 1991-94, he completed a Bachelor of Arts degree in Biological Sciences at the University of Oxford.Gil McVean's He completed his PhD in the Department of Genetics at the University of Cambridge supervised by Laurence Hurst in 1998. Career and research McVean completed postdoctoral research at the University of Edinburgh from 1997 to 2000, supervised by Brian and Deborah Charlesworth. From 2000-04, he was a Royal Society University Research Fellow in the Department of Statistics at Oxford, where he has also been a University lecturer in Mathematical Genetics since 2004. He was reappointed in 2009 until retirement age. In October 2006, he was appointed professor of statistical genetics at the Universit ...
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University Of Oxford
, mottoeng = The Lord is my light , established = , endowment = £6.1 billion (including colleges) (2019) , budget = £2.145 billion (2019–20) , chancellor = The Lord Patten of Barnes , vice_chancellor = Louise Richardson , students = 24,515 (2019) , undergrad = 11,955 , postgrad = 12,010 , other = 541 (2017) , city = Oxford , country = England , coordinates = , campus_type = University town , athletics_affiliations = Blue (university sport) , logo_size = 250px , website = , logo = University of Oxford.svg , colours = Oxford Blue , faculty = 6,995 (2020) , academic_affiliations = , The University of Oxford is a collegiate research university in Oxf ...
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Postdoctoral Research
A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). The ultimate goal of a postdoctoral research position is to pursue additional research, training, or teaching in order to have better skills to pursue a career in academia, research, or any other field. Postdocs often, but not always, have a temporary academic appointment, sometimes in preparation for an academic faculty position. They continue their studies or carry out research and further increase expertise in a specialist subject, including integrating a team and acquiring novel skills and research methods. Postdoctoral research is often considered essential while advancing the scholarly mission of the host institution; it is expected to produce relevant publications in peer-reviewed academic journals or conferences. In some countries, postdoctoral research may lead to further formal qualificati ...
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European Molecular Biology Organization
The European Molecular Biology Organization (EMBO) is a professional, non-profit organization of more than 1,800 life scientists. Its goal is to promote research in life science and enable international exchange between scientists. It co-funds courses, workshops and conferences, publishes five scientific journals and supports individual scientists. The organization was founded in 1964 and is a founding member of the Initiative for Science in Europe. the Director of EMBO is Fiona Watt, a stem cell researcher, professor at King's College London and a group leader at the European Molecular Biology Laboratory. Conferences and journals EMBO funds or co-funds over 90 meetings involving more than 11,000 participants every year. EMBO publishes five peer-reviewed scientific journals: ''The EMBO Journal'', ''EMBO Reports'', ''Molecular Systems Biology'', ''EMBO Molecular Medicine'', and ''Life Science Alliance'', History The European Molecular Biology Organization (EMBO) was launched ...
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Philip Leverhulme Prize
The Philip Leverhulme Prize is awarded by the Leverhulme Trust to recognise the achievement of outstanding researchers whose work has already attracted international recognition and whose future career is exceptionally promising. The prize scheme makes up to thirty awards of £100,000 a year, across a range of academic disciplines. History and criteria The award is named after Philip Leverhulme who died in 2000. He was the grandson of William Leverhulme, and was the third Viscount Leverhulme. The prizes are payable, in instalments, over a period of two to three years. Prizes can be used for any purpose which can advance the prize-holder’s research, with the exception of enhancing the prize-holder’s salary. Nominees must hold either a permanent post or a long-term fellowship in a UK institution of higher education or research that would extend beyond the duration of the Philip Leverhulme Prize. Those otherwise without salary are not eligible to be nominated. Nominees shou ...
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Big Data Institute
The Big Data Institute (BDI), part of the Li Ka Shing Centre for Health Information and Discovery, is an interdisciplinary research institute at the University of Oxford. The institute brings together researchers from both the Nuffield Department of Population Health and the Nuffield Department of Medicine. The BDI building is on the Old Road Campus in Headington, east Oxford, England. Academics from the BDI are advising the British government about a mobile phone app to track the COVID-19 pandemic in the United Kingdom The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom (UK) or Britain, is a country in Europe, off the north-western coast of the continental mainland. It comprises England, Scotland, Wales and North .... References External links BDI website* Big data COVID-19 pandemic in England Departments of the University of Oxford Medical research institutes in the United Kingdom Organizations with year of establish ...
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Corporate Spin-off
A corporate spin-off, also known as a spin-out, or starburst or hive-off, is a type of corporate action where a company "splits off" a section as a separate business or creates a second incarnation, even if the first is still active. Characteristics Spin-offs are divisions of companies or organizations that then become independent businesses with assets, employees, intellectual property, technology, or existing products that are taken from the parent company. Shareholders of the parent company receive equivalent shares in the new company in order to compensate for the loss of equity in the original stocks. However, shareholders may then buy and sell stocks from either company independently; this potentially makes investment in the companies more attractive, as potential share purchasers can invest narrowly in the portion of the business they think will have the most growth. In contrast, divestment can also sever one business from another, but the assets are sold off rather t ...
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Peter Donnelly
Sir Peter James Donnelly (born 15 May 1959) is an Australian-British mathematician and Professor of Statistical Science at the University of Oxford, and the CEO of Genomics PLC. He is a specialist in applied probability and has made contributions to coalescent theory. His research group at Oxford has an international reputation for the development of statistical methodology to analyze genetic data. Background, family and education Peter James Donnelly was born and raised in Brisbane, Queensland, the son of financial adviser, economic theorist and author Austin Donnelly and Sheila Donnelly. He is the brother of Sharon Donnelly and of eminent Australian financier, funds manager and company director Melda Donnelly. He was educated at St. Joseph's Christian Brothers College, Gregory Terrace, and later at the University of Queensland and at Balliol College, Oxford. Professional life When elected to a chair at Queen Mary College, London in 1988 Donnelly was only 29. He ...
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PRDM9
PR domainpositive-regulatory domain zinc finger protein 9 is a protein that in humans is encoded by the ''PRDM9'' gene. PRDM9 is responsible for positioning recombination hotspots during meiosis by binding a DNA sequence motif encoded in its zinc finger domain. PRDM9 is the only speciation gene found so far in mammals, and is one of the fastest evolving genes in the genome. Domain Architecture PRDM9 has multiple domains including KRAB domain, SSXRD, PR/SET domain ( H3K4 & H3K36 trimethyltransferase), and an array of C2H2 Zinc Finger domains (DNA binding). History In 1974 Jiri Forejt and P. Ivanyi identified a locus which they named Hst1 which controlled hybrid sterility. In 1982 a haplotype was identified controlling recombination rate ''wm7'', which would later be identified as PRDM9. In 1991 a protein binding to the minisatelite consensus sequence 5′-CCACCTGCCCACCTCT-3′ was detected and partially purified (named Msbp3 - minisatelite binding protein 3). This would la ...
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Human Genome
The human genome is a complete set of nucleic acid sequences for humans, encoded as DNA within the 23 chromosome pairs in cell nuclei and in a small DNA molecule found within individual mitochondria. These are usually treated separately as the nuclear genome and the mitochondrial genome. Human genomes include both protein-coding DNA sequences and various types of DNA that does not encode proteins. The latter is a diverse category that includes DNA coding for non-translated RNA, such as that for ribosomal RNA, transfer RNA, ribozymes, small nuclear RNAs, and several types of regulatory RNAs. It also includes promoters and their associated gene-regulatory elements, DNA playing structural and replicatory roles, such as scaffolding regions, telomeres, centromeres, and origins of replication, plus large numbers of transposable elements, inserted viral DNA, non-functional pseudogenes and simple, highly-repetitive sequences. Introns make up a large percentage of non-coding DNA. ...
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International HapMap Project
The International HapMap Project was an organization that aimed to develop a haplotype map (HapMap) of the human genome, to describe the common patterns of human genetic variation. HapMap is used to find genetic variants affecting health, disease and responses to drugs and environmental factors. The information produced by the project is made freely available for research. The International HapMap Project is a collaboration among researchers at academic centers, non-profit biomedical research groups and private companies in Canada, China (including Hong Kong), Japan, Nigeria, the United Kingdom, and the United States. It officially started with a meeting on October 27 to 29, 2002, and was expected to take about three years. It comprises two phases; the complete data obtained in Phase I were published on 27 October 2005. The analysis of the Phase II dataset was published in October 2007. The Phase III dataset was released in spring 2009 and the publication presenting the final resul ...
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Evolutionary Biology
Evolutionary biology is the subfield of biology that studies the evolutionary processes (natural selection, common descent, speciation) that produced the diversity of life on Earth. It is also defined as the study of the history of life forms on Earth. Evolution is based on the theory that all species are related and they gradually change over time. In a population, the genetic variations affect the physical characteristics i.e. phenotypes of an organism. These changes in the phenotypes will be an advantage to some organisms, which will then be passed onto their offspring. Some examples of evolution in species over many generations are the Peppered Moth and Flightless birds. In the 1930s, the discipline of evolutionary biology emerged through what Julian Huxley called the modern synthesis of understanding, from previously unrelated fields of biological research, such as genetics and ecology, systematics, and paleontology. The importance of studying Evolutionary biology is ...
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