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GATC Biotech
GATC Biotech was a German company specialist in DNA and RNA sequencing for academic and industrial partners worldwide. The company offered sequencing and bioinformatics solutions from single samples up to large-scale projects. 'The Genome and Diagnostic Centre' focusing on next and third-generation sequencing was based in the headquarters in Constance, Germany. The fully automated NGS laboratories were certified under ISO 17025. The Sanger sequencing business was located in 'The European Custom Sequencing Centre' in Cologne, Germany. The proximity to Cologne Bonn Cargo GmbH served as the logistical hub within Europe. GATC Biotech was acquired by Eurofins Genomics (part of Eurofins Scientific) in July 2017. History Founded in 1990 the company concentrated in the early days on commercialising a nonradioactive sequencing technology platform, patented by Prof. Pohl, one of the founders of GATC. The direct blotting electrophoresis system, the GATC 1500 was utilised in the Euro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNA Sequencing
DNA sequencing is the process of determining the nucleic acid sequence – the order of nucleotides in DNA. It includes any method or technology that is used to determine the order of the four bases: adenine, guanine, cytosine, and thymine. The advent of rapid DNA sequencing methods has greatly accelerated biological and medical research and discovery. Knowledge of DNA sequences has become indispensable for basic biological research, DNA Genographic Projects and in numerous applied fields such as medical diagnosis, biotechnology, forensic biology, virology and biological systematics. Comparing healthy and mutated DNA sequences can diagnose different diseases including various cancers, characterize antibody repertoire, and can be used to guide patient treatment. Having a quick way to sequence DNA allows for faster and more individualized medical care to be administered, and for more organisms to be identified and cataloged. The rapid speed of sequencing attained with modern D ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RNA Sequencing
RNA-Seq (named as an abbreviation of RNA sequencing) is a sequencing technique which uses next-generation sequencing (NGS) to reveal the presence and quantity of RNA in a biological sample at a given moment, analyzing the continuously changing cellular transcriptome. Specifically, RNA-Seq facilitates the ability to look at alternative gene spliced transcripts, post-transcriptional modifications, gene fusion, mutations/SNPs and changes in gene expression over time, or differences in gene expression in different groups or treatments. In addition to mRNA transcripts, RNA-Seq can look at different populations of RNA to include total RNA, small RNA, such as miRNA, tRNA, and ribosomal profiling. RNA-Seq can also be used to determine exon/intron boundaries and verify or amend previously annotated 5' and 3' gene boundaries. Recent advances in RNA-Seq include single cell sequencing, in situ sequencing of fixed tissue, and native RNA molecule sequencing with single-molecule real-time s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
