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GATC Biotech
GATC Biotech was a German company specialist in DNA and RNA sequencing for academic and industrial partners worldwide. The company offered sequencing and bioinformatics solutions from single samples up to large-scale projects. 'The Genome and Diagnostic Centre' focusing on next and third-generation sequencing was based in the headquarters in Constance, Germany. The fully automated NGS laboratories were certified under ISO 17025. The Sanger sequencing business was located in 'The European Custom Sequencing Centre' in Cologne, Germany. The proximity to Cologne Bonn Cargo GmbH served as the logistical hub within Europe. GATC Biotech was acquired by Eurofins Genomics (part of Eurofins Scientific) in July 2017. History Founded in 1990 the company concentrated in the early days on commercialising a nonradioactive sequencing technology platform, patented by Prof. Pohl, one of the founders of GATC. The direct blotting electrophoresis system, the GATC 1500 was utilised in the Euro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNA Sequencing
DNA sequencing is the process of determining the nucleic acid sequence – the order of nucleotides in DNA. It includes any method or technology that is used to determine the order of the four bases: adenine, guanine, cytosine, and thymine. The advent of rapid DNA sequencing methods has greatly accelerated biological and medical research and discovery. Knowledge of DNA sequences has become indispensable for basic biological research, DNA Genographic Projects and in numerous applied fields such as medical diagnosis, biotechnology, forensic biology, virology and biological systematics. Comparing healthy and mutated DNA sequences can diagnose different diseases including various cancers, characterize antibody repertoire, and can be used to guide patient treatment. Having a quick way to sequence DNA allows for faster and more individualized medical care to be administered, and for more organisms to be identified and cataloged. The rapid speed of sequencing attained with modern D ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RNA Sequencing
RNA-Seq (named as an abbreviation of RNA sequencing) is a sequencing technique which uses next-generation sequencing (NGS) to reveal the presence and quantity of RNA in a biological sample at a given moment, analyzing the continuously changing cellular transcriptome. Specifically, RNA-Seq facilitates the ability to look at alternative gene spliced transcripts, post-transcriptional modifications, gene fusion, mutations/SNPs and changes in gene expression over time, or differences in gene expression in different groups or treatments. In addition to mRNA transcripts, RNA-Seq can look at different populations of RNA to include total RNA, small RNA, such as miRNA, tRNA, and ribosomal profiling. RNA-Seq can also be used to determine exon/intron boundaries and verify or amend previously annotated 5' and 3' gene boundaries. Recent advances in RNA-Seq include single cell sequencing, in situ sequencing of fixed tissue, and native RNA molecule sequencing with single-molecule real-time s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bioinformatics
Bioinformatics () is an interdisciplinary field that develops methods and software tools for understanding biological data, in particular when the data sets are large and complex. As an interdisciplinary field of science, bioinformatics combines biology, chemistry, physics, computer science, information engineering, mathematics and statistics to analyze and interpret the biological data. Bioinformatics has been used for '' in silico'' analyses of biological queries using computational and statistical techniques. Bioinformatics includes biological studies that use computer programming as part of their methodology, as well as specific analysis "pipelines" that are repeatedly used, particularly in the field of genomics. Common uses of bioinformatics include the identification of candidates genes and single nucleotide polymorphisms (SNPs). Often, such identification is made with the aim to better understand the genetic basis of disease, unique adaptations, desirable properties (e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Next-generation Sequencing
Massive parallel sequencing or massively parallel sequencing is any of several high-throughput approaches to DNA sequencing using the concept of massively parallel processing; it is also called next-generation sequencing (NGS) or second-generation sequencing. Some of these technologies emerged between 1994 and 1998 and have been commercially available since 2005. These technologies use miniaturized and parallelized platforms for sequencing of 1 million to 43 billion short reads (50 to 400 bases each) per instrument run. Many NGS platforms differ in engineering configurations and sequencing chemistry. They share the technical paradigm of massive parallel sequencing via spatially separated, clonally amplified DNA templates or single DNA molecules in a flow cytometry, flow cell. This design is very different from that of Sanger sequencing—also known as capillary sequencing or first-generation sequencing—which is based on electrophoretic separation of chain-termination products produ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Third-generation Sequencing
Third-generation sequencing (also known as long-read sequencing) is a class of DNA sequencing methods currently under active development. Third generation sequencing technologies have the capability to produce substantially longer reads than second generation sequencing, also known as next-generation sequencing. Such an advantage has critical implications for both genome science and the study of biology in general. However, third generation sequencing data have much higher error rates than previous technologies, which can complicate downstream genome assembly and analysis of the resulting data. These technologies are undergoing active development and it is expected that there will be improvements to the high error rates. For applications that are more tolerant to error rates, such as structural variant calling, third generation sequencing has been found to outperform existing methods, even at a low depth of sequencing coverage. Current technologies Sequencing technologies with a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Konstanz
Konstanz (, , locally: ; also written as Constance in English) is a university city with approximately 83,000 inhabitants located at the western end of Lake Constance in the south of Germany. The city houses the University of Konstanz and was the residence of the Roman Catholic Diocese of Konstanz for more than 1,200 years. Location The city is located in the state of Baden-Württemberg and situated at the banks of Lake Constance (''Bodensee'' in German). The river Rhine, which starts in the Swiss Alps, passes through Lake Constance and leaves it, considerably larger, by flowing under a bridge connecting the two parts of the city. North of the river lies the larger part of the city with residential areas, industrial estates, and the University of Konstanz; while south of the river is the old town, which houses the administrative centre and shopping facilities in addition to the ''Hochschule'' or the ''University of Applied Sciences''. Car ferries provide access across Lake Con ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cologne
Cologne ( ; german: Köln ; ksh, Kölle ) is the largest city of the German western States of Germany, state of North Rhine-Westphalia (NRW) and the List of cities in Germany by population, fourth-most populous city of Germany with 1.1 million inhabitants in the city proper and 3.6 million people in the Cologne Bonn Region, urban region. Centered on the left bank of the Rhine, left (west) bank of the Rhine, Cologne is about southeast of NRW's state capital Düsseldorf and northwest of Bonn, the former capital of West Germany. The city's medieval Catholic Cologne Cathedral (), the third-tallest church and tallest cathedral in the world, constructed to house the Shrine of the Three Kings, is a globally recognized landmark and one of the most visited sights and pilgrimage destinations in Europe. The cityscape is further shaped by the Twelve Romanesque churches of Cologne, and Cologne is famous for Eau de Cologne, that has been produced in the city since 1709, and "col ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cologne Bonn Airport
Cologne Bonn Airport (german: Flughafen Köln/Bonn 'Konrad Adenauer') is the international airport of Germany's fourth-largest city Cologne, and also serves Bonn, former capital of West Germany. With around 12.4 million passengers passing through it in 2017, it is the seventh-largest passenger airport in Germany and the third-largest in terms of cargo operations. By traffic units, which combines cargo and passengers, the airport is in fifth position in Germany. As of March 2015, Cologne Bonn Airport had services to 115 passenger destinations in 35 countries. The airport is named after Cologne native Konrad Adenauer, the first post-war Chancellor of West Germany. The airport is located in the district of Porz and is surrounded by the ''Wahner Heide'' nature reserve. The airport is centrally located in the Cologne Bonn Region southeast of Cologne city centre and northeast of Bonn. Cologne Bonn Airport is one of the country's few 24-hour airports and serves as a hub for Eurowin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eurofins Scientific
Eurofins Scientific SE is a French group of laboratories headquartered in Luxembourg, providing testing and support services to the pharmaceutical, food, environmental, agriscience and consumer products industriesLe réseau, botte secrète d'Eurofins n° 2965, 26 May 2005 and to governments. Eurofins Group has an international network of more than 900 laboratories across 50 countries and a portfolio of over 200,000 validated analytical methods for characterising the safety, identity, purity, composition, authenticity and origin of products and [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Saccharomyces Cerevisiae
''Saccharomyces cerevisiae'' () (brewer's yeast or baker's yeast) is a species of yeast (single-celled fungus microorganisms). The species has been instrumental in winemaking, baking, and brewing since ancient times. It is believed to have been originally isolated from the skin of grapes. It is one of the most intensively studied eukaryotic model organisms in molecular biology, molecular and cell biology, much like ''Escherichia coli'' as the model bacteria, bacterium. It is the microorganism behind the most common type of fermentation (biochemistry), fermentation. ''S. cerevisiae'' cells are round to ovoid, 5–10 micrometre, μm in diameter. It reproduces by budding. Many proteins important in human biology were first discovered by studying their Homology (biology), homologs in yeast; these proteins include cell cycle proteins, signaling proteins, and protein-processing enzymes. ''S. cerevisiae'' is currently the only yeast cell known to have Berkeley body, Berkeley bo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genomics Companies
Genomics is an interdisciplinary field of biology focusing on the structure, function, evolution, mapping, and editing of genomes. A genome is an organism's complete set of DNA, including all of its genes as well as its hierarchical, three-dimensional structural configuration. In contrast to genetics, which refers to the study of ''individual'' genes and their roles in inheritance, genomics aims at the collective characterization and quantification of ''all'' of an organism's genes, their interrelations and influence on the organism. Genes may direct the production of proteins with the assistance of enzymes and messenger molecules. In turn, proteins make up body structures such as organs and tissues as well as control chemical reactions and carry signals between cells. Genomics also involves the sequencing and analysis of genomes through uses of high throughput DNA sequencing and bioinformatics to assemble and analyze the function and structure of entire genomes. Advances in gen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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