Granatin B

	Granatin B Granatin B is an ellagitannin found in the fruit of ''Punica granatum'' (pomegranate). It is a molecule having an enantiomeric dehydrohexahydroxydiphenoyl group. It is a highly active carbonic anhydrase inhibitor Carbonic anhydrase inhibitors are a class of pharmaceuticals that suppress the activity of carbonic anhydrase. Their clinical use has been established as anti-glaucoma agents, diuretics, antiepileptics, in the management of mountain sickness, g .... References Pomegranate ellagitannins Carbonic anhydrase inhibitors {{aromatic-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Ellagitannin The ellagitannins are a diverse class of hydrolyzable tannins, a type of polyphenol formed primarily from the oxidative linkage of galloyl groups in 1,2,3,4,6-pentagalloyl glucose. Ellagitannins differ from gallotannins, in that their galloyl groups are linked through C-C bonds, whereas the galloyl groups in gallotannins are linked by depside bonds. Ellagitannins contain various numbers of hexahydroxydiphenoyl units, as well as galloyl units and/or sanguisorboyl units bounded to sugar moiety. In order to determine the quantity of every individual unit, the hydrolysis of the extracts with trifluoroacetic acid in methanol/water system is performed. Hexahydroxydiphenic acid, created after hydrolysis, spontaneously lactonized to ellagic acid, and sanguisorbic acid to sanguisorbic acid dilactone, while gallic acid remains intact. Ellagitannins generally form macrocycles, whereas gallotannins do not. Examples * Castalagin * Castalin * Casuarictin * Grandinin * Oenothein B from ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Punica Granatum The pomegranate (''Punica granatum'') is a fruit-bearing deciduous shrub in the family Lythraceae, subfamily Punicoideae, that grows between tall. The pomegranate was originally described throughout the Mediterranean region. It was introduced into Spanish America in the late 16th century and into California by Spanish settlers in 1769. The fruit is typically in season in the Southern Hemisphere from March to May, and in the Northern Hemisphere from September to February. As intact sarcotestas or juice, pomegranates are used in baking, cooking, juice blends, meal garnishes, smoothies, and alcoholic beverages, such as cocktails and wine. Pomegranates are widely cultivated throughout the Middle East and Caucasus region, north and tropical Africa, Iran, Armenia, the Indian subcontinent, Central Asia, the drier parts of Southeast Asia, and the Mediterranean Basin. Etymology The name pomegranate derives from medieval Latin "apple" and "seeded". Possibly stemming from the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Dehydrohexahydroxydiphenoyl Dehydrohexahydroxydiphenic acid is a group found in dehydroellagitannins. It is formed from hexahydroxydiphenic acid (HHDP) through oxidation of the plant hydrolysable tannins.Correlation of oxidative transformations of hydrolyzable tannins and plant evolution. Takashi Yoshida and Tsutomu Hatano, Phytochemistry, November 2000, Volume 55, Issue 6, Pages 513–529, It is found in ellagitannins such as euphorbin A, geraniin or mallotusinic acid. In geraniin Geraniin is a dehydroellagitannin found in geraniums. It is found for instance in ''Geranium thunbergii'', which is one of the most popular folk medicines and also an official antidiarrheic drug in Japan. It can also be found in the rind of ''Neph ..., it is forming an equilibrium mixture of six-membered hemi-ketal and five-membered hemi-ketal forms. References Ellagitannins Carboxylic acids Heterocyclic compounds with 3 rings Oxygen heterocycles {{aromatic-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Carbonic Anhydrase Inhibitor Carbonic anhydrase inhibitors are a class of pharmaceuticals that suppress the activity of carbonic anhydrase. Their clinical use has been established as anti-glaucoma agents, diuretics, antiepileptics, in the management of mountain sickness, gastric and duodenal ulcers, idiopathic intracranial hypertension, neurological disorders, or osteoporosis. Medical uses Carbonic anhydrase inhibitors are primarily used for the treatment of glaucoma. They may also be used to treat seizure disorder and acute mountain sickness. Because they encourage solubilization and excretion of uric acid, they can be used in the treatment of gout. Glaucoma Acetazolamide is an inhibitor of carbonic anhydrase. It is used for glaucoma, epilepsy (rarely), idiopathic intracranial hypertension, and altitude sickness. For the reduction of intraocular pressure (IOP), acetazolamide inactivates carbonic anhydrase and interferes with the sodium pump, which decreases aqueous humor formation and thus lowe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Pomegranate Ellagitannins The pomegranate ellagitannins, which include punicalagin isomers, are ellagitannins found in the sarcotestas, rind (peel), bark or heartwood of pomegranates (''Punica granatum''). Chemistry As the chemistry of punicalagins became known it was found to be not unique to pomegranate. Punicalagins are present in numerous species of the genus ''Terminalia (plant), Terminalia'', species ''Terminalia chebula, chebula'' Retz. (“Fructus Chebulae”), ''Terminalia myriocarpa, myriocarpa'', ''Terminalia catappa, catappa'' and Terminalia citrina, citrina (tropical flowering trees historically used in African traditional medicine for antibiotic and antifungal purposes). They have also been isolated from ''Cistus salvifolius'' (a Mediterranean shrub) and ''Combretum molle'' (an African shrub). Pomegranate fruits natural phenols can be extracted with ethyl acetate and fractionation can afford the ellagitannin punicalagins. Dietary supplementation A few dietary supplements and nutritional ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]