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Gramine
Gramine (also called donaxine) is a naturally occurring indole alkaloid present in several plant species. Gramine may play a defensive role in these plants, since it is toxic to many organisms. Occurrence Gramine has been found in the giant reed, ''Arundo donax'', ''Acer saccharinum'' (Silver Maple), ''Hordeum'', (a grass genus that includes barley) and ''Phalaris'' (another grass genus). Effects and toxicity Gramine has been found to act as an agonist of the adiponectin receptor 1 Adiponectin receptor 1 (AdipoR1) is a protein which in humans is encoded by the ''ADIPOR1'' gene. It is a member of the progestin and adipoQ receptor (PAQR) family, and is also known as PAQR1. Structure Similar to G protein-coupled receptors (GP ... (AdipoR1). The LD50 of gramine is 44.6 mg/ kg iv in mice and 62.9 mg/ kg iv in rats. Numerous studies have been done on the toxicity in insects harmful to crops for use as a possible insecticide. References {{Reflist Adiponectin receptor a ...
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Indole Alkaloids
Indole alkaloids are a class of alkaloids containing a structural moiety of indole; many indole alkaloids also include isoprene groups and are thus called terpene indole or secologanin tryptamine alkaloids. Containing more than 4100 known different compounds, it is one of the largest classes of alkaloids. Many of them possess significant physiological activity and some of them are used in medicine. The amino acid tryptophan is the biochemical precursor of indole alkaloids. History The action of some indole alkaloids has been known for ages. Aztecs used the psilocybin mushrooms which contain alkaloids psilocybin and psilocin. The flowering plant ''Rauvolfia serpentina'' which contains reserpine was a common medicine in India around 1000 BC. Africans used the roots of the perennial rainforest shrub Tabernanthe iboga, Iboga, which contain ibogaine, as a stimulant. An infusion of Calabar bean seeds was given to people accused of crime in Nigeria: its rejection by stomach was regarded ...
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Indole
Indole is an aromatic heterocyclic organic compound with the formula C8 H7 N. It has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered pyrrole ring. Indole is widely distributed in the natural environment and can be produced by a variety of bacteria. As an intercellular signal molecule, indole regulates various aspects of bacterial physiology, including spore formation, plasmid stability, resistance to drugs, biofilm formation, and virulence. The amino acid tryptophan is an indole derivative and the precursor of the neurotransmitter serotonin. General properties and occurrence Indole is a solid at room temperature. It occurs naturally in human feces and has an intense fecal odor. At very low concentrations, however, it has a flowery smell, and is a constituent of many perfumes. It also occurs in coal tar. The corresponding substituent is called indolyl. Indole undergoes electrophilic substitution, mainly at position 3 (see diagra ...
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Arundo Donax
''Arundo donax'' is a tall perennial cane. It is one of several so-called reed species. It has several common names including giant cane, elephant grass, carrizo, arundo, Spanish cane, Colorado river reed, wild cane, and giant reed. ''Arundo'' and ''donax'' are respectively the old Latin and Greek names for reed. ''Arundo donax'' grows in damp soils, either fresh or moderately saline, and is native to the Greater Middle East.CABI, 2020. Arundo donax (giant reed). In: Invasive Species Compendium. Wallingford, UK: CAB International. https://www.cabi.org/isc/datasheet/1940Global Invasive Species Database (2020) Species profile: Arundo donax. Downloaded from http://www.iucngisd.org/gisd/species.php?sc=112 on 12-01-2020. It has been widely planted and naturalised in the mild temperate, subtropical and tropical regions of both hemispheres, especially in the Mediterranean, California, the western Pacific and the Caribbean and is considered invasive in North America and Oceania.Perdue, R ...
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Phalaris (plant)
''Phalaris'' is a genus of grasses. Various species of ''Phalaris'' grow on every continent except Antarctica. They can be found in a broad range of habitats from below sea level to thousands of feet above sea level and from wet marshy areas to dry places. ''P. arundinacea'' and ''P. aquatica'' are sometimes invasive species in wetlands. Alkaloids Some ''Phalaris'' species contain gramine, which, in sheep and to a lesser extent in cattle, is toxic and can cause brain damage, other organ damage, central nervous system damage, and death. ''Phalaris arundinacea'', ''Phalaris aquatica'', and '' Phalaris brachystachys'' are known to contain the alkaloids DMT, 5-MeO-DMT, and 5-OH-DMT (bufotenin). Some research has been done into the variability of alkaloids in the ''Phalaris'' grasses. Strains with high levels of alkaloids are best avoided in locations with grazing cattle and sheep, due to potential toxicity. Such high-alkaloid strains include ''Phalaris aquatica AQ-1'' and the spe ...
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Alkaloid
Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar structure may also be termed alkaloids. In addition to carbon, hydrogen and nitrogen, alkaloids may also contain oxygen, sulfur and, more rarely, other elements such as chlorine, bromine, and phosphorus.Chemical Encyclopedia: alkaloids
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Alkaloids are produced by a large variety of organisms including , , Medicinal plant, plants, an ...
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Phytochemistry (journal)
''Phytochemistry'' is a peer-reviewed scientific journal covering pure and applied plant chemistry, plant biochemistry and molecular biology. It is published by Elsevier and is an official publication for the Phytochemical Society of Europe, the Phytochemical Society of North America, and the Phytochemical Society of Asia. A sister journal ''Phytochemistry Letters'' is published since 2008. Abstracting and indexing ''Phytochemistry'' is abstracted and indexed in: According to the ''Journal Citation Reports'', the journal has a 2020 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as i ... of 4.072. References External links {{Official website, http://www.journals.elsevier.com/phytochemistry/ Biochemistry journals Botany journals Elsevier academic journals Eng ...
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Berichte Der Deutschen Chemischen Gesellschaft
''Chemische Berichte'' (usually abbreviated as ''Ber.'' or ''Chem. Ber.'') was a German-language scientific journal of all disciplines of chemistry founded in 1868. It was one of the oldest scientific journals in chemistry, until it merged with ''Recueil des Travaux Chimiques des Pays-Bas'' to form ''Chemische Berichte/Recueil'' in 1997. ''Chemische Berichte/Recueil'' was then merged with other European journals in 1998 to form ''European Journal of Inorganic Chemistry''. History Founded in 1868 as ''Berichte der Deutschen Chemischen Gesellschaft'' (, CODEN BDCGAS), it operated under this title until 1928 (Vol. 61). The journal was then split into: * ''Berichte der Deutschen Chemischen Gesellschaft, A: Vereins-Nachrichten'' (, CODEN BDCAAS), and * ''Berichte der Deutschen Chemischen Gesellschaft, B: Abhandlungen'' (, CODEN BDCBAD). Vol. 78 and 79 (1945–1946) were omitted and not published due to World War II. The journal was renamed ''Chemische Berichte'' (, CODEN CHBEAM) in 19 ...
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Acer Saccharinum
''Acer saccharinum'', commonly known as silver maple, creek maple, silverleaf maple, soft maple, large maple, water maple, swamp maple, or white maple, is a species of maple native to the eastern and central United States and southeastern Canada. It is one of the most common trees in the United States. Although the silver maple's Latin name is similar, it should not be confused with '' Acer saccharum'', the sugar maple. Some of the common names are also applied to other maples, especially ''Acer rubrum''. Description The silver maple tree is a relatively fast-growing deciduous tree, commonly reaching a height of , exceptionally . Its spread will generally be wide. A 10-year-old sapling will stand about tall. It is often found along waterways and in wetlands, leading to the colloquial name "water maple". It is a highly adaptable tree, although it has higher sunlight requirements than other maple trees. The leaves are simple and palmately veined, long and broad, with deep ...
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Silver Maple
''Acer saccharinum'', commonly known as silver maple, creek maple, silverleaf maple, soft maple, large maple, water maple, swamp maple, or white maple, is a species of maple native to the eastern and central United States and southeastern Canada. It is one of the most common trees in the United States. Although the silver maple's Latin name is similar, it should not be confused with ''Acer saccharum'', the sugar maple. Some of the common names are also applied to other maples, especially ''Acer rubrum''. Description The silver maple tree is a relatively fast-growing deciduous tree, commonly reaching a height of , exceptionally . Its spread will generally be wide. A 10-year-old sapling will stand about tall. It is often found along waterways and in wetlands, leading to the colloquial name "water maple". It is a highly adaptable tree, although it has higher sunlight requirements than other maple trees. The leaves are simple and palmately veined, long and broad, with deep an ...
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Journal Of Organic Chemistry
''The Journal of Organic Chemistry'', colloquially known as ''JOC'', is a peer-reviewed scientific journal for original contributions of fundamental research in all branches of theory and practice in organic and bioorganic chemistry. It is published by the publishing arm of the American Chemical Society, with 24 issues per year. According to the ''Journal Citation Reports'', the journal had a 2017 impact factor of 4.805 and it is the journal that received the most cites (100,091 in 2017) in the field of organic chemistry. According to Web of Knowledge (and as December 2012), eleven papers from the journal have received more than 1,000 citations, with the most cited paper having received 7,967 citations. The current editor-in-chief is Scott J. Miller from Yale University. Indexing ''J. Org. Chem.'' is currently indexed in: See also *Organic Letters *Organometallics ''Organometallics'' is a biweekly journal published by the American Chemical Society. Its area of focus is ...
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Hordeum
''Hordeum'' is a genus of annual and perennial plants in the grass family. They are native throughout the temperate regions of Africa, Eurasia, and the Americas. One species, ''Hordeum vulgare'' (barley), has become of major commercial importance as a cereal grain, used as fodder crop and for malting in the production of beer and whiskey. Some species are nuisance weeds introduced worldwide by human activities, others have become endangered due to habitat loss. ''Hordeum'' species are used as food plants by the larvae of some Lepidoptera species, including the flame, rustic shoulder-knot and setaceous Hebrew character. The name '' Hordeum'' comes from the Latin word for "to bristle" (''horreō'', ''horrēre''), and is akin to the word " horror". Species Species include: * '' Hordeum aegiceras'' – Mongolia, China including Tibet * ''Hordeum arizonicum'' US (CA AZ NV NM), Mexico (Baja California, Sonora, Durango) * '' Hordeum bogdanii'' – from Turkey and European Ru ...
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Agonist
An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the agonist, while an inverse agonist causes an action opposite to that of the agonist. Etymology From the Greek αγωνιστής (agōnistēs), contestant; champion; rival < αγων (agōn), contest, combat; exertion, struggle < αγω (agō), I lead, lead towards, conduct; drive


Types of agonists

can be activated by either endogenous agonists (such as