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Germacrone
Germacrone is a sesquiterpene which has been isolated from ''Geranium macrorrhizum''. It has shown antiviral properties in an animal model An animal model (short for animal disease model) is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease process without the risk of ha ... of influenza infection. References {{organic-compound-stub Sesquiterpenes ...
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Geranium Macrorrhizum
''Geranium macrorrhizum'' is a species of hardiness (plants), hardy flowering herbaceous plant, herbaceous perennial plant in the genus ''Geranium'', family (biology), family Geraniaceae. It is native plant, native to the South east Alps and the Balkans. Its common names include bigroot geranium, Bulgarian geranium, and rock crane's-bill. It has five-lobed (palmate) leaves that are aromatic when crushed, with pale pink flowers in summer. It is cultivated as an ornamental plant in temperateness, temperate regions, where it is used as a flowering groundcover, with named cultivars selected for flower colors from white through pink to magenta. The cultivars 'Will Ingwersen, Ingwersen's Variety' (pale pink) and 'White-ness' have gained the Royal Horticultural Society's Award of Garden Merit. The plant has been used in traditional herbal medicine. The name for all types of geraniums in general in the Bulgarian language is derived from the word :wikt:здрав#Bulgarian, ''здрав ...
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Sesquiterpene
Sesquiterpenes are a class of terpenes that consist of three isoprene units and often have the molecular formula C15H24. Like monoterpenes, sesquiterpenes may be cyclic or contain rings, including many unique combinations. Biochemical modifications such as oxidation or rearrangement produce the related sesquiterpenoids. Sesquiterpenes are found naturally in plants and insects, as semiochemicals, e.g. defensive agents or pheromones. Biosynthesis and examples The reaction of geranyl pyrophosphate with isopentenyl pyrophosphate results in the 15-carbon farnesyl pyrophosphate (FPP), which is an intermediate in the biosynthesis of sesquiterpenes such as farnesene. Cyclic sesquiterpenes are more common than cyclic monoterpenes because of the increased chain length and additional double bond in the sesquiterpene precursors. In addition to common six-membered ring systems such as the ones found in zingiberene and bisacurone, cyclization of one end of the chain to the other end can l ...
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Animal Model
An animal model (short for animal disease model) is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease process without the risk of harming a human. Although biological activity in an animal model does not ensure an effect in humans, many drugs, treatments and cures for human diseases are developed in part with the guidance of animal models. Animal models representing specific taxonomic groups in the research and study of developmental processes are also referred to as model organisms. There are three main types of animal models: Homologous, Isomorphic and Predictive. Homologous animals have the same causes, symptoms and treatment options as would humans who have the same disease. Isomorphic animals share the same symptoms and treatments, only. Predictive models are similar to a particular human disease in only a couple of aspects. However, these are useful in isolating ...
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