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Georges Mathé
Georges Mathé (9 July 1922 – 15 October 2010) was a French oncologist and immunologist. In November 1958, he performed the first successful allogeneic bone marrow transplant ever performed on unrelated human beings. In 1963, he applied the bone marrow graft technique to cure a leukemic patient. Biography Georges Mathé was born in 1922 in the village of Sermages, France, from a rural family. Selected by his village school master, he was sent to study in a boarding school in Moulins, Allier. Education and early career During World War II, he participated in the French Resistance, and studied to become a medical doctor in Paris. He graduated in 1950–51 with honors. Oncology and bone marrow transplants He engaged in medical research in the early fifties, and took an internship in immunology and oncology in the Memorial Sloan–Kettering Cancer Center, New York. He specialised in hematology when working with Pr. Paul Chevallier and Pr. Jean Bernard, and devoting himself t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical Grafting
Grafting refers to a surgical procedure to move tissue from one site to another on the body, or from another creature, without bringing its own blood supply with it. Instead, a new blood supply grows in after it is placed. A similar technique where tissue is transferred with the blood supply intact is called a flap. In some instances, a graft can be an artificially manufactured device. Examples of this are a tube to carry blood flow across a defect or from an artery to a vein for use in hemodialysis. Classification Autografts and isografts are usually not considered as foreign and, therefore, do not elicit rejection. Allografts and xenografts may be recognized as foreign by the recipient and rejected. * Autograft: graft taken from one part of the body of an individual and transplanted onto another site in the same individual, e.g., skin graft. * Isograft: graft taken from one individual and placed on another individual of the same genetic constitution, e.g., grafts between ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
World Cultural Council
The World Cultural Council is an international organization whose goals are to promote cultural values, goodwill and philanthropy among individuals. The organization founded in 1981 and based in Mexico, has held a yearly award ceremony since 1984 by granting the Albert Einstein World Award of Science, the José Vasconcelos World Award of Education, and the Leonardo da Vinci World Award of Arts to outstanding scientists, educators, and artists, who have contributed positively to the cultural enrichment of mankind. The members of the Council include several Nobel laureates. Founding members The founding members of the World Cultural Council are 124 distinguished personalities in such fields as the arts, biology, chemistry, physics, medicine, psychology, neuroscience, astronomy, oceanography, astrophysics, anthropology, and zoology. Some of these members are recipients of awards because of their outstanding achievements including the Nobel Prize, the National Medal of Science, t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
EORTC
The European Organisation for Research and Treatment of Cancer (EORTC) is a unique pan-European non-profit clinical cancer research organisation established in 1962 operating as an international association under Belgium law. It develops, conducts, coordinates and stimulates high-quality translational and clinical trial research to improve the survival and quality of life of cancer patients. This is achieved through the development of new drugs and other innovative approaches, and the testing of more effective therapeutic strategies, using currently approved drugs, surgery and/or radiotherapy in clinical trials conducted under the auspices of a vast network of clinical cancer researchers supported by 220 staff members based in Brussels. The EORTC has the expertise to conduct large and complex trials especially specific populations such as the older patient and rare tumours. Mission, achievements, and network The EORTC's mission is to increase people's survival and quality of li ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Silvio Garattini
Silvio Garattini (born in Bergamo November 12, 1928) is an Italian scientist, pharmacology research scientist, physician and professor in chemotherapy and pharmacology and director of the Mario Negri Institute for Pharmacological Research. Biography Chemical technical specialist and medical doctor, he began his career as an assistant at the Pharmacology Institute of the University of Milan where he remained until 1962 as a senior lecturer in pharmacology and chemotherapy. In 1963 he founded the Mario Negri Institute for Pharmacological Research of which he became the first director. Over the years, the institute developed to reach staffing of approximately 850 researchers over four different locations in Milan, Bergamo, Ranica and Santa Maria Imbaro. From 1965 to 1968 he chaired the European Organisation for Research and Treatment of Cancer (EORTC); he is a component of the " Group 2003", a group of Italian researchers held in high esteem in the global pharmaceutical e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ellipticine
Ellipticine is an alkaloid first extracted from trees of the species '' Ochrosia elliptica'' and ''Rauvolfia sandwicensis'', which inhibits the enzyme topoisomerase II via intercalative binding to DNA. Natural occurrence and synthesis Ellipticine is an organic compound present in several trees within the genera ''Ochrosia'', ''Rauvolfia'', ''Aspidosperma'', and ''Apocynaceae''. It was first isolated from '' Ochrosia elliptica'' Labill., a flowering tree native to Australia and New Caledonia which gives the alkaloid its name, in 1959, and synthesised by Robert Burns Woodward later the same year. Biological activity Ellipticine is a known intercalator, capable of entering a DNA strand between base pairs. In its intercalated state, ellipticine binds strongly and lies parallel to the base pairs, increasing the superhelical density of the DNA. Intercalated ellipticine binds directly to topoisomerase II, an enzyme involved in DNA replication, inhi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hôpital Paul-Brousse
Hôpital Paul-Brousse is a hospital in Villejuif, Val-de-Marne, France. It is named after Paul Brousse Paul Brousse (; 23 January 18441 April 1912) was a French socialist, leader of the '' possibilistes'' group. He was active in the Jura Federation, a section of the International Working Men's Association (IWMA), from the northwestern part of Swit ..., a French socialist. Marc Zelter MD and Daniel Vittecoq MD were professors in this hospital. Camille Loiseau, the from March 26, 2005 to August 12, 2006, died at the Hôpital Paul-Brousse. References {{DEFAULTSORT:Hopital Paul-Brousse Hospitals in Val-de-Marne Hospitals with year of establishment missing Villejuif ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Paris
, image_name = Coat of arms of the University of Paris.svg , image_size = 150px , caption = Coat of Arms , latin_name = Universitas magistrorum et scholarium Parisiensis , motto = ''Hic et ubique terrarum'' (Latin) , mottoeng = Here and anywhere on Earth , established = Founded: c. 1150Suppressed: 1793Faculties reestablished: 1806University reestablished: 1896Divided: 1970 , type = Corporative then public university , city = Paris , country = France , campus = Urban The University of Paris (french: link=no, Université de Paris), metonymically known as the Sorbonne (), was the leading university in Paris, France, active from 1150 to 1970, with the exception between 1793 and 1806 under the French Revolution. Emerging around 1150 as a corporation associated with the cathedral school of Notre Dame de Paris, it was considered the second-oldest university in Europe. Haskins, C. H.: ''The Rise of Universities'', Henry Holt and Company, 1923, p. 292. Officially chartered i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Villejuif
Villejuif () is a commune in the southern suburbs of Paris, France. It is located from the centre of Paris. Name The earliest reference to Villejuif appears in a bill signed by the Pope Callixtus II on 27 November 1119. It refers to Villa Judea, the Latinized version of the Old French expression meaning 'Jewish settlement'. During the following centuries, the toponym appears as Villejuifve, that is, following the archaic French spelling of the expression with the same meaning, cognate to modern French Villejuive. The French author from the 17th century Louis Moréri indicates that the settlement was founded by Jews expelled from Paris. This idea, however, remains speculative as available medieval Christian and Jewish sources do not mention the existence of the Jewish community in this place. Geography Climate Villejuif has a oceanic climate (Köppen climate classification ''Cfb''). The average annual temperature in Villejuif is . The average annual rainfall is with October ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Institut Gustave Roussy
Gustave Roussy is the first leader cancer-research hospital in Europe and ranked among the top 3 best specialized hospitals in the world . It is a centre for high quality patient care, research and teaching. It is highly-known for the treatment of (among others): skin cancers like melanoma, breast cancer, and lung cancer. It provides access to care with many expert doctors who have historically revolutionized the treatment of cancer and contributed to the surge of new molecules in the treatment of cancers and tumors. It is located in the Parisian area. It is named after Gustave Roussy, a Swiss-French neuropathologist. In April 2019, three new interventional radiology rooms were inaugurated, making it the largest platform of this type in Europe, entirely dedicated to oncology. Interventional radiology is a so-called "minimally invasive" diagnostic and treatment technique, which uses images to guide access to deep-lying organs, without having to "open up" patients. Gustave Roussy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cancer
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss, and a change in bowel movements. While these symptoms may indicate cancer, they can also have other causes. Over 100 types of cancers affect humans. Tobacco use is the cause of about 22% of cancer deaths. Another 10% are due to obesity, poor diet, lack of physical activity or excessive drinking of alcohol. Other factors include certain infections, exposure to ionizing radiation, and environmental pollutants. In the developing world, 15% of cancers are due to infections such as ''Helicobacter pylori'', hepatitis B, hepatitis C, human papillomavirus infection, Epstein–Barr virus and human immunodeficiency virus (HIV). These factors act, at least partly, by changing the genes of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Radiation Damage
Radiation damage is the effect of ionizing radiation on physical objects including non-living structural materials. It can be either detrimental or beneficial for materials. Radiobiology is the study of the action of ionizing radiation on living things, including the health effects of radiation in humans. High doses of ionizing radiation can cause damage to living tissue such as radiation burning and harmful mutations such as causing cells to become cancerous, and can lead to health problems such as radiation poisoning. Causes This radiation may take several forms: *Cosmic rays and subsequent energetic particles caused by their collision with the atmosphere and other materials. *Radioactive daughter products (radioisotopes) caused by the collision of cosmic rays with the atmosphere and other materials, including living tissues. *Energetic particle beams from a particle accelerator. *Energetic particles or electro-magnetic radiation (X-rays) released from collisions of such part ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
