Georges Bardet
Georges, Louis, Bardet (1885–1966) was a French physician who is known for first describing a rare genetic disease. In his graduation thesis at the University of Paris in 1920, Bardet wrote about a medical condition characterized by obesity, retinitis pigmentosa, polydactyly and hypogonadism. Two years later, Hungarian physician Arthur Biedl described the same symptoms in two sisters, separate from Bardet's findings. This condition has since become known as the Bardet–Biedl syndrome. Georges Bardet was the uncle of Jean Bardet, the founder of Éditions du Seuil Éditions du Seuil (), also known as ''Le Seuil'', is a French publishing house established in 1935 by Catholic intellectual Jean Plaquevent (1901–1965), and currently owned by La Martinière Groupe. It owes its name to this goal "The ''seuil' .... References 20th-century French physicians 1885 births 1970 deaths {{France-med-bio-stub ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
|
University Of Paris
, image_name = Coat of arms of the University of Paris.svg , image_size = 150px , caption = Coat of Arms , latin_name = Universitas magistrorum et scholarium Parisiensis , motto = ''Hic et ubique terrarum'' (Latin) , mottoeng = Here and anywhere on Earth , established = Founded: c. 1150Suppressed: 1793Faculties reestablished: 1806University reestablished: 1896Divided: 1970 , type = Corporative then public university , city = Paris , country = France , campus = Urban The University of Paris (french: link=no, Université de Paris), metonymically known as the Sorbonne (), was the leading university in Paris, France, active from 1150 to 1970, with the exception between 1793 and 1806 under the French Revolution. Emerging around 1150 as a corporation associated with the cathedral school of Notre Dame de Paris, it was considered the second-oldest university in Europe. Haskins, C. H.: ''The Rise of Universities'', Henry Holt and Company, 1923, p. 292. Officially chartered i ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
|
Obesity
Obesity is a medical condition, sometimes considered a disease, in which excess body fat has accumulated to such an extent that it may negatively affect health. People are classified as obese when their body mass index (BMI)—a person's weight divided by the square of the person's height—is over ; the range is defined as overweight. Some East Asian countries use lower values to calculate obesity. Obesity is a major cause of disability and is correlated with various diseases and conditions, particularly cardiovascular diseases, type 2 diabetes, obstructive sleep apnea, certain types of cancer, and osteoarthritis. Obesity has individual, socioeconomic, and environmental causes. Some known causes are diet, physical activity, automation, urbanization, genetic susceptibility, medications, mental disorders, economic policies, endocrine disorders, and exposure to endocrine-disrupting chemicals. While a majority of obese individuals at any given time are attempting to ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
|
Retinitis Pigmentosa
Retinitis pigmentosa (RP) is a genetic disorder of the eyes that causes loss of vision. Symptoms include trouble seeing at night and decreasing peripheral vision (side and upper or lower visual field). As peripheral vision worsens, people may experience "tunnel vision". Complete blindness is uncommon. Onset of symptoms is generally gradual and often begins in childhood. Retinitis pigmentosa is generally inherited from one or both parents or rarely it can be caused by a miscoding during DNA division. It is caused by genetic miscoding of proteins in one of more than 300 genes involved. The underlying mechanism involves the progressive loss of rod photoreceptor cells that line the retina of the eyeball. The rod cells secrete a neuroprotective substance (Rod-derived cone viability factor, RdCVF) that protects the cone cells from apoptosis (cell death). However, when the rod cells die, this substance is no longer provided. This is generally followed by the loss of cone photorecept ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
|
Polydactyly
Polydactyly or polydactylism (), also known as hyperdactyly, is an anomaly in humans and animals resulting in supernumerary fingers and/or toes. Polydactyly is the opposite of oligodactyly (fewer fingers or toes). Signs and symptoms In humans/animals this condition can present itself on one or both hands or feet. The extra digit is usually a small piece of soft tissue that can be removed. Occasionally it contains bone without joints; rarely it may be a complete functioning digit. The extra digit is most common on the ulnar (little finger) side of the hand, less common on the radial (thumb) side, and very rarely within the middle three digits. These are respectively known as postaxial (little finger), preaxial (thumb), and central (ring, middle, index fingers) polydactyly. The extra digit is most commonly an abnormal fork in an existing digit, or it may rarely originate at the wrist as a normal digit does. The incidence of congenital deformities in newborns is approximately 2%, ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
|
Hypogonadism
Hypogonadism means diminished functional activity of the gonads—the testes or the ovaries—that may result in diminished production of sex hormones. Low androgen (e.g., testosterone) levels are referred to as hypoandrogenism and low estrogen (e.g., estradiol) as hypoestrogenism. These are responsible for the observed signs and symptoms in both males and females. Hypogonadism, commonly referred to by the symptom "low testosterone" or "Low T", can also decrease other hormones secreted by the gonads including progesterone, DHEA, anti-Müllerian hormone, activin, and inhibin. Sperm development (spermatogenesis) and release of the egg from the ovaries (ovulation) may be impaired by hypogonadism, which, depending on the degree of severity, may result in partial or complete infertility. In January 2020, the American College of Physicians issued clinical guidelines for testosterone treatment in adult men with age-related low levels of testosterone. The guidelines are supported b ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
|
Arthur Biedl
Arthur Biedl (4 October 1869 – 26 August 1933) was a Hungarian pathologist born in what today is ComloÈ™u Mic, Romania. He studied medicine at the University of Vienna, and from 1893 served as an assistant to Salomon Stricker (1834-1898), Philipp Knoll (1841-1900), and Richard Paltauf (1858-1924) at the institute of experimental pathology in Vienna. In 1899 he became an associate professor, followed by a full professorship in 1902. In 1898, Biedl and colleague R. Kraus demonstrated that "bile salts," when injected into the bloodstream of animals, failed to elicit a behavioral change. They hypothesized that this was due to a semipermeable membrane that protected the central nervous system from the passive diffusion of solutes in the bloodstream. Two years later, Max Lewandowsky coined the term "Blood–brain barrier" when these findings were confirmed with other biological compounds. Edwin Goldmann and his mentor Paul Ehrlich further confirmed these findings with aniline ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
|
Bardet–Biedl Syndrome
Bardet–Biedl syndrome (BBS) is a ciliopathic human genetic disorder that produces many effects and affects many body systems. It is characterized by rod/cone dystrophy, polydactyly, central obesity, hypogonadism, and kidney dysfunction in some cases. Historically, slower mental processing has also been considered a principal symptom but is now not regarded as such. Signs and symptoms Bardet–Biedl syndrome is a pleiotropic disorder with variable expressivity and a wide range of clinical variability observed both within and between families. The most common clinical features are rod–cone dystrophy, with childhood-onset night-blindness followed by increasing visual loss; postaxial polydactyly; truncal obesity that manifests during infancy and remains problematic throughout adulthood; varying degrees of learning disabilities; male hypogenitalism and complex female genitourinary malformations; and renal dysfunction, a major cause of morbidity and mortality. There is a wide ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
|
Éditions Du Seuil
Éditions du Seuil (), also known as ''Le Seuil'', is a French publishing house established in 1935 by Catholic intellectual Jean Plaquevent (1901–1965), and currently owned by La Martinière Groupe. It owes its name to this goal "The ''seuil'' (threshold) is the whole excitement of parting and arriving. It is also the brand new threshold that we refashion at the door of the Church to allow entry to many whose foot gropes around it" (Jean Plaquevent, letter dated 28 December 1934). Description Éditions du Seuil was the publisher of the ''Don Camillo'' series, and of Chairman Mao Zedong's ''Little Red Book''. The large sales that these generated have allowed the house to publish more specialized titles, particularly in the social sciences. Seuil is widely respected in the publishing world, maintaining good relations with its authors. Seuil has published works by Jacques Lacan, Roland Barthes and Philippe Sollers (in his first period), and later by Edgar Morin, Maurice Genevoix ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
|
1885 Births
Events January–March * January 3– 4 – Sino-French War – Battle of Núi Bop: French troops under General Oscar de Négrier defeat a numerically superior Qing Chinese force, in northern Vietnam. * January 4 – The first successful appendectomy is performed by Dr. William W. Grant, on Mary Gartside. * January 17 – Mahdist War in Sudan – Battle of Abu Klea: British troops defeat Mahdist forces. * January 20 – American inventor LaMarcus Adna Thompson patents a roller coaster. * January 24 – Irish rebels damage Westminster Hall and the Tower of London with dynamite. * January 26 – Mahdist War in Sudan: Troops loyal to Mahdi Muhammad Ahmad conquer Khartoum; British commander Charles George Gordon is killed. * February 5 – King Leopold II of Belgium establishes the Congo Free State, as a personal possession. * February 9 – The first Japanese arrive in Hawaii. * February 16 – Charles Dow publishes ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |