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Geoffrey W. Hoffmann
Geoffrey W. Hoffmann, (born October 20, 1944) is an Australian-Canadian theoretical biologist. Hoffmann was a faculty member in the Department of Physics at the University of British Columbia and the founder of Network Immunology Inc. in Vancouver, Canada. He is best known for symmetric immune network theory. Education and early research Hoffmann studied physics at the University of Melbourne then obtained a PhD at the Technische Universität Braunschweig as a student of Manfred Eigen for research done at the Max Planck Institute for Biophysical Chemistry in Göttingen. His initial work in theoretical biology addressed Leslie Orgel's paradox in origin of life theories. Hoffmann showed that an early sloppy translation machinery can be stable against the error catastrophe envisaged by Orgel and provided analyses of the expected occurrence of required catalytic activities and exclusion of disruptive catalytic activities. These calculations support the view that the origin of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immune Network Theory
The immune network theory is a theory of how the adaptive immune system works, that has been developed since 1974 mainly by Niels Jerne and Geoffrey W. Hoffmann. The theory states that the immune system is an interacting network of lymphocytes and molecules that have variable (V) regions. These V regions bind not only to things that are foreign to the vertebrate, but also to other V regions within the system. The immune system is therefore seen as a network, with the components connected to each other by V-V interactions. It has been suggested that the phenomena that the theory describes in terms of networks are also explained by clonal selection theory. The scope of the symmetrical network theory developed by Hoffmann includes the phenomena of low dose and high dose tolerance, first reported for a single antigen by Avrion Mitchison,N. A. Mitchison (1964) Induction of immunological paralysis in two zones of dosage. Proc. Royal Soc. Lond. B161, 275-292 and confirmed by Geoffrey She ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Manfred Eigen
Manfred Eigen (; 9 May 1927 – 6 February 2019) was a German Biophysical chemistry, biophysical chemist who won the 1967 Nobel Prize in Chemistry for work on measuring fast chemical reactions. Eigen's research helped solve major problems in physical chemistry and aided in the understanding of chemical processes that occur in living organisms. In later years, he explored the biochemical roots of life and evolution. He worked to install a multidisciplinary program at the Max Planck Institute to study the underpinnings of life at the molecular level. His work was hailed for creating a new scientific and technological discipline: evolutionary biotechnology. Education and early life Eigen was born on 9 May 1927 in Bochum, the son of Hedwig (Feld) and Ernst Eigen, a chamber musician. As a child he developed a deep passion for music, and studied piano. World War II interrupted his formal education. At age fifteen he was drafted into service in a German antiaircraft unit. He was ca ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Niels Jerne
Niels is a male given name, equivalent to Nicholas, which is common in Denmark, Belgium, Norway (formerly) and the Netherlands. The Norwegian and Swedish variant is Nils. The name is a developed short form of Nicholas or Greek Nicolaos after Saint Nicholas. Its pet form is Nisse, and female variants are Nielsine, Nielsina, and Nielsa. Niels may refer to: People *Niels, King of Denmark (1065–1134) *Niels, Count of Halland (died 1218) * Niels Aagaard (1612–1657), Danish poet *Niels Aall (1769–1854), Norwegian businessman and politician *Niels Henrik Abel (1802–1829), Norwegian mathematician *Niels Arestrup (born 1949), French actor *Niels Viggo Bentzon (1919–2000), Danish composer and pianist *Niels Bohr (1885–1962), Danish physicist and Nobel Prize recipient *Niels Busk (born 1942), Danish politician *Niels Ebbesen (died 1340), Danish squire and national hero *Niels Feijen (born 1977), Dutch pool player * Niels Ferguson (born 1965), Dutch cryptographer *Niels Friis (d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mathematical And Theoretical Biology
Mathematical and theoretical biology, or biomathematics, is a branch of biology which employs theoretical analysis, mathematical models and abstractions of the living organisms to investigate the principles that govern the structure, development and behavior of the systems, as opposed to experimental biology which deals with the conduction of experiments to prove and validate the scientific theories. The field is sometimes called mathematical biology or biomathematics to stress the mathematical side, or theoretical biology to stress the biological side. Theoretical biology focuses more on the development of theoretical principles for biology while mathematical biology focuses on the use of mathematical tools to study biological systems, even though the two terms are sometimes interchanged. Mathematical biology aims at the mathematical representation and modeling of biological processes, using techniques and tools of applied mathematics. It can be useful in both theoretical and prac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of British Columbia
The University of British Columbia (UBC) is a public university, public research university with campuses near Vancouver and in Kelowna, British Columbia. Established in 1908, it is British Columbia's oldest university. The university ranks among the top three universities in Canada. With an annual research budget of $759million, UBC funds over 8,000 projects a year. The Vancouver campus is situated adjacent to the University Endowment Lands located about west of downtown Vancouver. UBC is home to TRIUMF, Canada's national laboratory for Particle physics, particle and nuclear physics, which houses the world's largest cyclotron. In addition to the Peter Wall Institute for Advanced Studies and Stuart Blusson Quantum Matter Institute, UBC and the Max Planck Society collectively established the first Max Planck Institute in North America, specializing in quantum materials. One of the largest research libraries in Canada, the UBC Library system has over 9.9million volumes among it ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immune Network Theory
The immune network theory is a theory of how the adaptive immune system works, that has been developed since 1974 mainly by Niels Jerne and Geoffrey W. Hoffmann. The theory states that the immune system is an interacting network of lymphocytes and molecules that have variable (V) regions. These V regions bind not only to things that are foreign to the vertebrate, but also to other V regions within the system. The immune system is therefore seen as a network, with the components connected to each other by V-V interactions. It has been suggested that the phenomena that the theory describes in terms of networks are also explained by clonal selection theory. The scope of the symmetrical network theory developed by Hoffmann includes the phenomena of low dose and high dose tolerance, first reported for a single antigen by Avrion Mitchison,N. A. Mitchison (1964) Induction of immunological paralysis in two zones of dosage. Proc. Royal Soc. Lond. B161, 275-292 and confirmed by Geoffrey She ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Melbourne
The University of Melbourne is a public research university located in Melbourne, Australia. Founded in 1853, it is Australia's second oldest university and the oldest in Victoria. Its main campus is located in Parkville, an inner suburb north of Melbourne's central business district, with several other campuses located across Victoria. Incorporated in the 19th century by the colony of Victoria, the University of Melbourne is one of Australia's six sandstone universities and a member of the Group of Eight, Universitas 21, Washington University's McDonnell International Scholars Academy, and the Association of Pacific Rim Universities. Since 1872, many residential colleges have become affiliated with the university, providing accommodation for students and faculty, and academic, sporting and cultural programs. There are ten colleges located on the main campus and in nearby suburbs. The university comprises ten separate academic units and is associated with numerous institut ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Technische Universität Braunschweig
The Technische Universität Braunschweig (unofficially University of Braunschweig – Institute of Technology), commonly referred to as TU Braunschweig, is the oldest ' (comparable to an institute of technology in the American system) in Germany. It was founded in 1745 as Collegium Carolinum and is a member of TU9, an incorporated society of the most renowned and largest German institutes of technology. It is commonly ranked among the top universities for engineering in Germany. TU Braunschweig's research profile is very interdisciplinary, but with a focus on aeronautics, vehicle engineering including autonomous driving and electric mobility, manufacturing, life sciences, and metrology. Research is conducted in close collaboration with external organizations such as the German Aerospace Center, Helmholtz Centre for Infection Research, several Fraunhofer Institutes, and Germany's national metrology institute ( PTB), among many others. As one of very few research institutions of its ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Max Planck Institute For Biophysical Chemistry
The Max Planck Institute for Biophysical Chemistry (german: Max-Planck-Institut für biophysikalische Chemie), also known as the Karl-Friedrich Bonhoeffer Institute (german: Karl-Friedrich-Bonhoeffer-Institut), was a research institute of the Max Planck Society, located in Göttingen, Germany. On January 1, 2022, the institute merged with the Max Planck Institute for Experimental Medicine in Göttingen to form the Max Planck Institute for Multidisciplinary Sciences. This was the only Max Planck Institute (MPI) which combined the three classical scientific disciplines – biology, physics and chemistry. Founded in 1971, its initial focus was on problems in physics in chemistry. It had undergone a continuous evolution manifested by an expanding range of core subjects and work areas such as neurobiology, biochemistry, and molecular biology. At the time of merger, 850 people worked at the institute, about half of them scientists. Four researchers working at the institute (Stefan Hel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leslie Orgel
Leslie Eleazer Orgel FRS (12 January 1927 – 27 October 2007) was a British chemist. He is known for his theories on the origin of life. Biography Leslie Orgel was born in London, England, on . He received his Bachelor of Arts degree in chemistry with first-class honours from the University of Oxford in 1948. In 1951 he was elected a Fellow of Magdalen College, Oxford and in 1953 was awarded his PhD in chemistry. Orgel started his career as a theoretical inorganic chemist and continued his studies in this field at Oxford, the California Institute of Technology and the University of Chicago. Together with Sydney Brenner, Jack Dunitz, Dorothy Hodgkin, and Beryl M. Oughton he was one of the first people in April 1953 to see the model of the structure of DNA, constructed by Francis Crick and James Watson, at the time he and the other scientists were working at Oxford University's Chemistry Department. According to the late Dr. Beryl Oughton, later Rimmer, they all travelled toge ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Origin Of Life
In biology, abiogenesis (from a- 'not' + Greek bios 'life' + genesis 'origin') or the origin of life is the natural process by which life has arisen from non-living matter, such as simple organic compounds. The prevailing scientific hypothesis is that the transition from non-living to living entities on Earth was not a single event, but an evolutionary process of increasing complexity that involved the formation of a habitable planet, the prebiotic synthesis of organic molecules, molecular self-replication, self-assembly, autocatalysis, and the emergence of cell membranes. Many proposals have been made for different stages of the process. The study of abiogenesis aims to determine how pre-life chemical reactions gave rise to life under conditions strikingly different from those on Earth today. It primarily uses tools from biology and chemistry, with more recent approaches attempting a synthesis of many sciences. Life functions through the specialized chemistry of carbon and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Basel Institute For Immunology
The Basel Institute for Immunology (BII) was founded in 1969 as a basic research institute in immunology located at 487 Grenzacherstrasse, Basel, Switzerland on the Rhine River down the street from the main Hoffmann-La Roche campus near the Swiss-German border. The institute opened its doors in 1971. Description It was a unique concept in the history of mechanisms for funding basic science and the relationship between basic science and industry. Through the influence of Paul Sacher, Swiss conductor and patron of the arts and sciences, drug company Hoffmann-LaRoche committed unrestricted support of $24 million per year and freedom of design of the institute to its founding director Niels K. Jerne. Jerne retired in 1980 and was succeeded by Fritz Melchers, who generally maintained Jerne's themes and vision. Research groups The institute was constructed to consist of about 50 scientists in interactive research groups of 3 to 5 researchers supported by technical staff with no titl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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