Genital Tubercle
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Genital Tubercle
A genital tubercle or phallic tubercle is a body of tissue present in the development of the reproductive system. It forms in the ventral, caudal region of mammalian embryos of both sexes, and eventually develops into a primordial phallus. In the human fetus, the genital tubercle develops around week 4 of gestation, and by week 9 becomes recognizably either a clitoris or penis. This should not be confused with the sinus tubercle which is a proliferation of endoderm induced by paramesonephric ducts. Even after the phallus is developed, the term genital tubercle remains, but only as the terminal end of it, which develops into either the glans penis or the glans clitoridis. The genital tubercle is sensitive to dihydrotestosterone and rich in 5-alpha-reductase, so that the amount of fetal testosterone present after the second month is a major determinant of phallus size at birth. See also *Sexual differentiation Sexual differentiation is the process of development of the sex differ ...
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Reproductive System
The reproductive system of an organism, also known as the genital system, is the biological system made up of all the anatomical organs involved in sexual reproduction. Many non-living substances such as fluids, hormones, and pheromones are also important accessories to the reproductive system. Unlike most organ systems, the sexes of differentiated species often have significant differences. These differences allow for a combination of genetic material between two individuals, which allows for the possibility of greater genetic fitness of the offspring. Reproductive System 2001
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Animals

In mammals, the major organs of the reproductive system include the external

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Gestation
Gestation is the period of development during the carrying of an embryo, and later fetus, inside viviparous animals (the embryo develops within the parent). It is typical for mammals, but also occurs for some non-mammals. Mammals during pregnancy can have one or more gestations at the same time, for example in a multiple birth. The time interval of a gestation is called the '' gestation period''. In obstetrics, ''gestational age'' refers to the time since the onset of the last menses, which on average is fertilization age plus two weeks. Mammals In mammals, pregnancy begins when a zygote (fertilized ovum) implants in the female's uterus and ends once the fetus leaves the uterus during labor or an abortion (whether induced or spontaneous). Humans In humans, pregnancy can be defined clinically or biochemically. Clinically, pregnancy starts from first day of the mother's last period. Biochemically, pregnancy starts when a woman's human chorionic gonadotropin (hCG) levels ...
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Testosterone
Testosterone is the primary sex hormone and anabolic steroid in males. In humans, testosterone plays a key role in the development of Male reproductive system, male reproductive tissues such as testes and prostate, as well as promoting secondary sexual characteristics such as increased muscle and bone mass, and the growth of androgenic hair, body hair. In addition, testosterone in both sexes is involved in health and well-being, including moods, behaviour, and in the prevention of osteoporosis. Insufficient levels of testosterone in men may lead to abnormalities including frailty and bone loss. Testosterone is a steroid from the androstane class containing a ketone and a hydroxyl group at positions three and seventeen respectively. It is Biosynthesis, biosynthesized in several steps from cholesterol and is converted in the liver to inactive metabolites. It exerts its action through binding to and activation of the androgen receptor. In humans and most other vertebrates, testost ...
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Dihydrotestosterone
Dihydrotestosterone (DHT, 5α-dihydrotestosterone, 5α-DHT, androstanolone or stanolone) is an endogenous androgen sex steroid and hormone. The enzyme 5α-reductase catalyzes the formation of DHT from testosterone in certain tissues including the prostate gland, seminal vesicles, epididymides, skin, hair follicles, liver, and brain. This enzyme mediates reduction of the C4-5 double bond of testosterone. Relative to testosterone, DHT is considerably more potent as an agonist of the androgen receptor (AR). In addition to its role as a natural hormone, DHT has been used as a medication, for instance in the treatment of low testosterone levels in men; for information on DHT as a medication, see the androstanolone article. Biological function DHT is biologically important for sexual differentiation of the male genitalia during embryogenesis, maturation of the penis and scrotum at puberty, growth of facial, body, and pubic hair, and development and maintenance of the pro ...
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Glans Clitoridis
The glans (, plural "glandes" ; from the Latin word for "acorn") is a vascular structure located at the tip of the penis in male mammals or a homologous genital structure of the clitoris in female mammals. Structure The exterior structure of the glans consists of mucous membrane, which is usually covered by foreskin or clitoral hood in naturally developed genitalia. This covering, called the prepuce, is normally retractable in adulthood. The glans naturally joins with the frenulum of the penis or clitoris, as well as the inner labia in women, and the foreskin in uncircumcised men. In non-technical or sexual discussions, often the word "clitoris" refers to the external glans alone, excluding the clitoral hood, frenulum, and internal body of the clitoris. Similarly, phrases "tip" or "head" of the penis refers to the glans alone. Sex differences in humans In males, the glans is known as the glans penis, while in females the glans is known as the clitoral glans. In females, the c ...
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Glans Penis
In male human anatomy, the glans penis, commonly referred to as the glans, is the bulbous structure at the distal end of the human penis that is the human male's most sensitive erogenous zone and their primary anatomical source of sexual pleasure. It is anatomically homologous to the clitoral glans. The glans penis is part of the male reproductive organs in humans and other mammals where it may appear smooth, spiny, elongated or divided. It is externally lined with mucosal tissue, which creates a smooth texture and glossy appearance. In humans, the glans is a continuation of the corpus spongiosum of the penis. At the summit appears the urinary meatus and at the base forms the corona glandis. An elastic band of tissue, known as the frenulum, runs on its ventral surface. In men who are not circumcised, it is completely or partially covered by the foreskin. In adults, the foreskin can generally be retracted over and past the glans manually or sometimes automatically during an ...
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Endoderm
Endoderm is the innermost of the three primary germ layers in the very early embryo. The other two layers are the ectoderm (outside layer) and mesoderm (middle layer). Cells migrating inward along the archenteron form the inner layer of the gastrula, which develops into the endoderm. The endoderm consists at first of flattened cells, which subsequently become columnar. It forms the epithelial lining of multiple systems. In plant biology, endoderm corresponds to the innermost part of the cortex ( bark) in young shoots and young roots often consisting of a single cell layer. As the plant becomes older, more endoderm will lignify. Production The following chart shows the tissues produced by the endoderm. The embryonic endoderm develops into the interior linings of two tubes in the body, the digestive and respiratory tube. Liver and pancreas cells are believed to derive from a common precursor. In humans, the endoderm can differentiate into distinguishable organs after 5 week ...
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Sinus Tubercle
Sinus tubercle (also known as sinual tubercle or Müllerian eminence) is the proliferation of endoderm induced by the paramesonephric ducts. It is located in the developing fetus between the orifices of the mesonephric ducts on the urogenital sinus. The uterovaginal primoridium, which is a fusion of the caudal ends of paramesonephric ducts, contacts the dorsal wall of the urogenital sinus and, induces the formation of the sinus tubercle. This occurs in both sexes: *In the female the mesonephric duct loses all association with the gonad and, disappears. The sinus tubercle then gives rise to the sino-vaginal bulbs and, when it later becomes solid it is referred to as the vaginal plate. It likewise gives rise to the hymen, which eventually breaks down in most cases. * In the males, the sinus tubercle gives rise to the seminal colliculus The seminal colliculus (Latin ''colliculus seminalis''), or verumontanum, of the prostatic urethra is a landmark distal to the entrance of the ejac ...
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Fetus
A fetus or foetus (; plural fetuses, feti, foetuses, or foeti) is the unborn offspring that develops from an animal embryo. Following embryonic development the fetal stage of development takes place. In human prenatal development, fetal development begins from the ninth week after fertilization (or eleventh week gestational age) and continues until birth. Prenatal development is a continuum, with no clear defining feature distinguishing an embryo from a fetus. However, a fetus is characterized by the presence of all the major body organs, though they will not yet be fully developed and functional and some not yet situated in their final anatomical location. Etymology The word ''fetus'' (plural ''fetuses'' or '' feti'') is related to the Latin '' fētus'' ("offspring", "bringing forth", "hatching of young") and the Greek "φυτώ" to plant. The word "fetus" was used by Ovid in Metamorphoses, book 1, line 104. The predominant British, Irish, and Commonwealth spelling is '' ...
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Somatopleure
In the anatomy of an embryo, the somatopleure is a structure created during embryogenesis when the lateral plate mesoderm splits into two layers. The outer (or somatic) layer becomes applied to the inner surface of the ectoderm, and with it (partially) forms the somatopleure. The combination of ectoderm and mesoderm, or somatopleure, forms the amnion, the chorion and the lateral body wall of the embryo. The limbs are formed from the somatic mesoderm cells are induced by hox genes and the expression of other molecules to suffer and epithelial-mesenchyme transition. The embryonic somatopleure is then divided into 3 sections, the anterior limb bud formation, the posterior limb bud formation and the non limb forming wall. The bud forming sections grow in size at the somatic mesoderm under the ectoderm proliferate in mesenchyme form. In chicken, the extraembryonic tissues are separated into two layers: the splanchnopleure composed of the endoderm and splanchnic mesoderm, and the s ...
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Primordial Phallus
In embryology, the primordial phallus refers to the clitoris of a female or the penis in the male, particularly during fetal development of the urinary and reproductive organs, before sexual differentiation is evident. This is also the case for the immature male analog, the immature glans penis. Image:Primordial_phallus,_low_mag.jpg, Micrograph of the primordial phallus, H&E stain. Image:Primordial_phallus,_intermed._mag.1.jpg, Micrograph of the primordial phallus, H&E stain. See also * Aphallia * Genital tubercle A genital tubercle or phallic tubercle is a body of tissue present in the development of the reproductive system. It forms in the ventral, caudal region of mammalian embryos of both sexes, and eventually develops into a primordial phallus. In the ... Embryology of urogenital system {{developmental-biology-stub ...
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