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General Somatic Efferent
The general (spinal) somatic efferent neurons (GSE, somatomotor, or somatic motor fibers), arise from motor neuron cell bodies in the ventral horns of the gray matter within the spinal cord. They exit the spinal cord through the ventral roots, carrying motor impulses to skeletal muscle through a neuromuscular junction. Of the somatic efferent neurons, there exist subtypes. * Alpha motor neurons (α) target extrafusal muscle fibers. * Gamma motor neurons (γ) target intrafusal muscle fibres Cranial nerves also supply their own somatic efferent neurons to the extraocular muscles and some of the muscles of the tongue. See also * Nerve fiber * Efferent nerve Efferent nerve fibers refer to axonal projections that ''exit'' a particular region; as opposed to afferent projections that ''arrive'' at the region. These terms have a slightly different meaning in the context of the peripheral nervous syste ... References Peripheral nervous system {{Portal bar, Anatomy ...
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General Somatic Afferent Fibers
The general somatic afferent fibers (GSA, or somatic sensory fibers) afferent fibers arise from neurons in sensory ganglia and are found in all the spinal nerves, except occasionally the first cervical, and conduct impulses of pain Pain is a distressing feeling often caused by intense or damaging stimuli. The International Association for the Study of Pain defines pain as "an unpleasant sensory and emotional experience associated with, or resembling that associated with, ..., touch and temperature from the surface of the body through the dorsal roots to the spinal cord and impulses of muscle sense, tendon sense and joint sense from the deeper structures. See also * Afferent nerve References

Spinal cord {{Portal bar, Anatomy ...
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General Visceral Efferent Fibers
General visceral efferent fibers (GVE) or visceral efferents or autonomic efferents, are the efferent nerve fibers of the autonomic nervous system (also known as the ''visceral efferent nervous system'' that provide motor innervation to smooth muscle, cardiac muscle, and glands (contrast with special visceral efferent (SVE) fibers) through postganglionic varicosities. GVE fibers may be either sympathetic or parasympathetic. The cranial nerves containing GVE fibers include the oculomotor nerve (CN III), the facial nerve (CN VII), the glossopharyngeal nerve (CN IX) and the vagus nerve (CN X).Mehta, Samir et al. Step-Up: A High-Yield, Systems-Based Review for the USMLE Step 1. Baltimore, MD: LWW, 2003. Additional images File:Gray840.png, Sympathetic connections of the ciliary and superior cervical ganglia. See also * Nerve fiber * Preganglionic fibers * Efferent nerve Efferent nerve fibers refer to axonal projections that ''exit'' a particular region; as opposed to Af ...
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General Visceral Afferent Fibers
A general officer is an officer of high rank in the armies, and in some nations' air forces, space forces, and marines or naval infantry. In some usages the term "general officer" refers to a rank above colonel."general, adj. and n.". OED Online. March 2021. Oxford University Press. https://www.oed.com/view/Entry/77489?rskey=dCKrg4&result=1 (accessed May 11, 2021) The term ''general'' is used in two ways: as the generic title for all grades of general officer and as a specific rank. It originates in the 16th century, as a shortening of ''captain general'', which rank was taken from Middle French ''capitaine général''. The adjective ''general'' had been affixed to officer designations since the late medieval period to indicate relative superiority or an extended jurisdiction. Today, the title of ''general'' is known in some countries as a four-star rank. However, different countries use different systems of stars or other insignia for senior ranks. It has a NATO rank sca ...
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Gray Matter
Grey matter is a major component of the central nervous system, consisting of neuronal cell bodies, neuropil (dendrites and unmyelinated axons), glial cells (astrocytes and oligodendrocytes), synapses, and capillaries. Grey matter is distinguished from white matter in that it contains numerous cell bodies and relatively few myelinated axons, while white matter contains relatively few cell bodies and is composed chiefly of long-range myelinated axons. The colour difference arises mainly from the whiteness of myelin. In living tissue, grey matter actually has a very light grey colour with yellowish or pinkish hues, which come from capillary blood vessels and neuronal cell bodies. Structure Grey matter refers to unmyelinated neurons and other cells of the central nervous system. It is present in the brain, brainstem and cerebellum, and present throughout the spinal cord. Grey matter is distributed at the surface of the cerebral hemispheres (cerebral cortex) and of the cerebellum ...
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Spinal Cord
The spinal cord is a long, thin, tubular structure made up of nervous tissue, which extends from the medulla oblongata in the brainstem to the lumbar region of the vertebral column (backbone). The backbone encloses the central canal of the spinal cord, which contains cerebrospinal fluid. The brain and spinal cord together make up the central nervous system (CNS). In humans, the spinal cord begins at the occipital bone, passing through the foramen magnum and then enters the spinal canal at the beginning of the cervical vertebrae. The spinal cord extends down to between the first and second lumbar vertebrae, where it ends. The enclosing bony vertebral column protects the relatively shorter spinal cord. It is around long in adult men and around long in adult women. The diameter of the spinal cord ranges from in the cervical and lumbar regions to in the thoracic area. The spinal cord functions primarily in the transmission of nerve signals from the motor cortex to the body, ...
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Ventral Roots
In anatomy and neurology, the ventral root of spinal nerve, anterior root, or motor root is the efferent motor root of a spinal nerve. At its distal end, the ventral root joins with the dorsal root The dorsal root of spinal nerve (or posterior root of spinal nerve or sensory root) is one of two "roots" which emerge from the spinal cord. It emerges directly from the spinal cord, and travels to the dorsal root ganglion. Nerve fibres with the v ... to form a mixed spinal nerve. Additional images Image:Cervical vertebra english.png, Cervical vertebra Image:Medulla spinalis - Section - English.svg, Medulla spinalis Image:Gray675.png, A spinal nerve with its anterior and posterior. Image:Gray764.png, The motor tract. Image:Gray770-en.svg, Diagrammatic transverse section of the medulla spinalis and its membranes. Image:Gray796.png, A portion of the spinal cord, showing its right lateral surface. The dura is opened and arranged to show the nerve roots. Image:Gray799.svg, Sch ...
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Skeletal Muscle
Skeletal muscles (commonly referred to as muscles) are organs of the vertebrate muscular system and typically are attached by tendons to bones of a skeleton. The muscle cells of skeletal muscles are much longer than in the other types of muscle tissue, and are often known as muscle fibers. The muscle tissue of a skeletal muscle is striated – having a striped appearance due to the arrangement of the sarcomeres. Skeletal muscles are voluntary muscles under the control of the somatic nervous system. The other types of muscle are cardiac muscle which is also striated and smooth muscle which is non-striated; both of these types of muscle tissue are classified as involuntary, or, under the control of the autonomic nervous system. A skeletal muscle contains multiple muscle fascicle, fascicles – bundles of muscle fibers. Each individual fiber, and each muscle is surrounded by a type of connective tissue layer of fascia. Muscle fibers are formed from the cell fusion, fusion of ...
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Neuromuscular Junction
A neuromuscular junction (or myoneural junction) is a chemical synapse between a motor neuron and a muscle fiber. It allows the motor neuron to transmit a signal to the muscle fiber, causing muscle contraction. Muscles require innervation to function—and even just to maintain muscle tone, avoiding atrophy. In the neuromuscular system nerves from the central nervous system and the peripheral nervous system are linked and work together with muscles. Synaptic transmission at the neuromuscular junction begins when an action potential reaches the presynaptic terminal of a motor neuron, which activates voltage-gated calcium channels to allow calcium ions to enter the neuron. Calcium ions bind to sensor proteins (synaptotagmins) on synaptic vesicles, triggering vesicle fusion with the cell membrane and subsequent neurotransmitter release from the motor neuron into the synaptic cleft. In vertebrates, motor neurons release acetylcholine (ACh), a small molecule neurotransmitter, whic ...
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Alpha Motor Neurons
Alpha (α) motor neurons (also called alpha motoneurons), are large, multipolar lower motor neurons of the brainstem and spinal cord. They innervate extrafusal muscle fibers of skeletal muscle and are directly responsible for initiating their contraction. Alpha motor neurons are distinct from gamma motor neurons, which innervate intrafusal muscle fibers of muscle spindles. While their cell bodies are found in the central nervous system (CNS), α motor neurons are also considered part of the somatic nervous system—a branch of the peripheral nervous system (PNS)—because their axons extend into the periphery to innervate skeletal muscles. An alpha motor neuron and the muscle fibers it innervates is a motor unit. A motor neuron pool contains the cell bodies of all the alpha motor neurons involved in contracting a single muscle. Location Alpha motor neurons (α-MNs) innervating the head and neck are found in the brainstem; the remaining α-MNs innervate the rest of the body and a ...
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Extrafusal Muscle Fiber
Extrafusal muscle fibers are the standard skeletal muscle fibers that are innervated by alpha motor neurons and generate tension by contracting, thereby allowing for skeletal movement. They make up the large mass of skeletal striated muscle tissue and are attached to bone by fibrous tissue extensions (tendons). Each alpha motor neuron and the extrafusal muscle fibers innervated by it make up a motor unit. The connection between the alpha motor neuron and the extrafusal muscle fiber is a neuromuscular junction, where the neuron's signal, the action potential, is transduced to the muscle fiber by the neurotransmitter acetylcholine. Extrafusal muscle fibers are not to be confused with intrafusal muscle fibers, which are innervated by sensory nerve endings in central noncontractile parts and by gamma motor neurons in contractile ends and thus serve as a sensory proprioceptor. Extrafusal muscle fibers can be generated in vitro (in a dish) from pluripotent stem cells through dire ...
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Gamma Motor Neurons
A gamma motor neuron (γ motor neuron), also called gamma motoneuron, or fusimotor neuron, is a type of lower motor neuron that takes part in the process of muscle contraction, and represents about 30% of ( Aγ) fibers going to the muscle. Like alpha motor neurons, their cell bodies are located in the anterior grey column of the spinal cord. They receive input from the reticular formation of the pons in the brainstem. Their axons are smaller than those of the alpha motor neurons, with a diameter of only 5  μm. Unlike the alpha motor neurons, gamma motor neurons do not directly adjust the lengthening or shortening of muscles. However, their role is important in keeping muscle spindles taut, thereby allowing the continued firing of alpha neurons, leading to muscle contraction. These neurons also play a role in adjusting the sensitivity of muscle spindles. The presence of myelination in gamma motor neurons allows a conduction velocity of 4 to 24 meters per second, significantl ...
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Intrafusal Muscle Fibre
Intrafusal muscle fibers are skeletal muscle fibers that serve as specialized sensory organs (proprioceptors). They detect the amount and rate of change in length of a muscle.Casagrand, Janet (2008) ''Action and Movement: Spinal Control of Motor Units and Spinal Reflexes.'' University of Colorado, Boulder. They constitute the muscle spindle, and are innervated by both sensory (afferent) and motor (efferent) fibers. Intrafusal muscle fibers are not to be confused with extrafusal muscle fibers, which contract, generating skeletal movement and are innervated by alpha motor neurons. Structure Types There are two types of intrafusal muscle fibers: nuclear bag fibers and nuclear chain fibers. They bear two types of sensory ending, known as annulospiral and flower-spray endings. Both ends of these fibers contract, but the central region only stretches and does not contract. Intrafusal muscle fibers are walled off from the rest of the muscle by an outer connective tissue sheath ...
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