Gel Dosimetry
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Gel Dosimetry
Gel dosimeters, also called Fricke gel dosimeters, are manufactured from radiation sensitive chemicals that, upon irradiation with ionising radiation, undergo a fundamental change in their properties as a function of the absorbed radiation dose. Over many years individuals have endeavoured to measure absorbed radiation dose distributions using gels. As long ago as 1950, the radiation-induced colour change in dyes was used to investigate radiation doses in gels. Further, in 1957 depth doses of photons and electrons in agar gels were investigated using spectrophotometry. Gel dosimetry today however, is founded mainly on the work of Gore ''et al'' who in 1984 demonstrated that changes due to ionising radiation in Fricke dosimetry solutions, developed in the 1920s, could be measured using nuclear magnetic resonance (NMR). Gel dosimeters generally consist of two types; Fricke and polymer gel dosimeters and are usually evaluated or 'read-out' using magnetic resonance imaging (MRI), optica ...
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Nuclear Magnetic Resonance
Nuclear magnetic resonance (NMR) is a physical phenomenon in which nuclei in a strong constant magnetic field are perturbed by a weak oscillating magnetic field (in the near field) and respond by producing an electromagnetic signal with a frequency characteristic of the magnetic field at the nucleus. This process occurs near resonance, when the oscillation frequency matches the intrinsic frequency of the nuclei, which depends on the strength of the static magnetic field, the chemical environment, and the magnetic properties of the isotope involved; in practical applications with static magnetic fields up to ca. 20  tesla, the frequency is similar to VHF and UHF television broadcasts (60–1000 MHz). NMR results from specific magnetic properties of certain atomic nuclei. Nuclear magnetic resonance spectroscopy is widely used to determine the structure of organic molecules in solution and study molecular physics and crystals as well as non-crystalline materials. ...
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Magnetic Resonance Imaging
Magnetic resonance imaging (MRI) is a medical imaging technique used in radiology to form pictures of the anatomy and the physiological processes of the body. MRI scanners use strong magnetic fields, magnetic field gradients, and radio waves to generate images of the organs in the body. MRI does not involve X-rays or the use of ionizing radiation, which distinguishes it from CT and PET scans. MRI is a medical application of nuclear magnetic resonance (NMR) which can also be used for imaging in other NMR applications, such as NMR spectroscopy. MRI is widely used in hospitals and clinics for medical diagnosis, staging and follow-up of disease. Compared to CT, MRI provides better contrast in images of soft-tissues, e.g. in the brain or abdomen. However, it may be perceived as less comfortable by patients, due to the usually longer and louder measurements with the subject in a long, confining tube, though "Open" MRI designs mostly relieve this. Additionally, implants and oth ...
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Computer Tomography
A computed tomography scan (CT scan; formerly called computed axial tomography scan or CAT scan) is a medical imaging technique used to obtain detailed internal images of the body. The personnel that perform CT scans are called radiographers or radiology technologists. CT scanners use a rotating X-ray tube and a row of detectors placed in a gantry to measure X-ray attenuations by different tissues inside the body. The multiple X-ray measurements taken from different angles are then processed on a computer using tomographic reconstruction algorithms to produce tomographic (cross-sectional) images (virtual "slices") of a body. CT scans can be used in patients with metallic implants or pacemakers, for whom magnetic resonance imaging (MRI) is contraindicated. Since its development in the 1970s, CT scanning has proven to be a versatile imaging technique. While CT is most prominently used in medical diagnosis, it can also be used to form images of non-living objects. The 1979 Nob ...
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Computer Tomography
A computed tomography scan (CT scan; formerly called computed axial tomography scan or CAT scan) is a medical imaging technique used to obtain detailed internal images of the body. The personnel that perform CT scans are called radiographers or radiology technologists. CT scanners use a rotating X-ray tube and a row of detectors placed in a gantry to measure X-ray attenuations by different tissues inside the body. The multiple X-ray measurements taken from different angles are then processed on a computer using tomographic reconstruction algorithms to produce tomographic (cross-sectional) images (virtual "slices") of a body. CT scans can be used in patients with metallic implants or pacemakers, for whom magnetic resonance imaging (MRI) is contraindicated. Since its development in the 1970s, CT scanning has proven to be a versatile imaging technique. While CT is most prominently used in medical diagnosis, it can also be used to form images of non-living objects. The 1979 Nob ...
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Ultrasound
Ultrasound is sound waves with frequency, frequencies higher than the upper audible limit of human hearing range, hearing. Ultrasound is not different from "normal" (audible) sound in its physical properties, except that humans cannot hear it. This limit varies from person to person and is approximately 20 Hertz, kilohertz (20,000 hertz) in healthy young adults. Ultrasound devices operate with frequencies from 20 kHz up to several gigahertz. Ultrasound is used in many different fields. Ultrasonic devices are used to detect objects and measure distances. Ultrasound imaging or sonography is often used in medicine. In the nondestructive testing of products and structures, ultrasound is used to detect invisible flaws. Industrially, ultrasound is used for cleaning, mixing, and accelerating chemical processes. Animals such as bats and porpoises use ultrasound for locating Predation, prey and obstacles. History Acoustics, the science of sound, starts as far back as Pyth ...
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Xylenol Orange
Xylenol orange is an organic reagent, most commonly used as a tetrasodium salt as an indicator for metal titrations. When used for metal titrations, it will appear red in the titrand and become yellow once it reaches its endpoint. Historically, commercial preparations of it have been notoriously impure, sometimes consisting of as little as 20% xylenol orange, and containing large amounts of semi-xylenol orange and iminodiacetic acid Iminodiacetic acid is the organic compound with the formula HN(CH2CO2H)2, often abbreviated to IDA. A white solid, the compound is a dicarboxylic acid amine (the nitrogen atom forms a secondary amino group, not an imino group as the name suggests .... Purities as high as 90% are now available. It is fluorescent, and has excitation maximums of 440 & 570 nm and an emission maximum of 610 nm. References Analytical reagents Triarylmethane dyes Benzoxathioles Acetic acids {{Organic-compound-stub ...
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Clive Baldock
Clive Baldock is a British-born Australian professor. He graduated with a BSc (hons) in Physics from the University of Sussex, an MSc in Radiation Physics from St Bartholomew's Hospital Medical College, University of London, a PhD in Medical Physics from King's College London and a Masters of Tertiary Education Management from the University of Melbourne. He also graduated from the University of Oxford Saïd Business School Executive Leadership Programme. His previous roles included Head of the School of Physics at the University of Sydney, Executive Dean of Science at Macquarie University, Executive Director for Physical Sciences, Engineering, Mathematics and Information Sciences at the Australian Research Council (ARC), Dean of Graduate Research and Pro Vice-Chancellor for Researcher Development at the University of Tasmania, and Dean of Graduate Research at the University of Wollongong. He is currently Dean of Graduate Studies and Researcher Development aWestern Sydney Univer ...
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American Association Of Physicists In Medicine
The American Association of Physicists in Medicine (AAPM) is a scientific, educational, and professional organization of Medical Physicists. In 2011, it absorbed the American College of Medical Physics Their headquarters are located at 1631 Prince Street, Alexandria, Virginia. Publications include two scientific journals ''Medical Physics'' and the ''Journal of Applied Clinical Medical Physics'' (JACMP), as well as technical reports, and symposium proceedings. The purposes of the American Association of Physicists in Medicine are to promote the application of physics to medicine and biology and to encourage interest and training in medical physics and related fields. AAPM has established ''Medical Physics'' as its primary scientific and informational journal. AAPM is a Member of the American Institute of Physics and has over 8000 members. Regional chapters of the AAPM hold regular scientific meetings for their members. For example the New England Chapter typically meets three ...
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Cancer
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss, and a change in bowel movements. While these symptoms may indicate cancer, they can also have other causes. Over 100 types of cancers affect humans. Tobacco use is the cause of about 22% of cancer deaths. Another 10% are due to obesity, poor diet, lack of physical activity or excessive drinking of alcohol. Other factors include certain infections, exposure to ionizing radiation, and environmental pollutants. In the developing world, 15% of cancers are due to infections such as ''Helicobacter pylori'', hepatitis B, hepatitis C, human papillomavirus infection, Epstein–Barr virus and human immunodeficiency virus (HIV). These factors act, at least partly, by changing the genes of ...
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Hugo Fricke
Hugo Fricke (August 15, 1892, in Aarhus, Denmark – April 5, 1972, in Huntington, New York, US) was a Danish-American physicist who studied the chemical (radiolysis) and biological (radiation biology) effects of X-ray and electron beams and who also invented the Fricke dosimeter named after him. He also made important contributions to the theory of impedance measurements. Early life, education and career Hugo Fricke was born on August 15, 1892, in Aarhus, Denmark, to Hedevig (''née'' Kämpfner) and Gunnar Fricke, the oldest of four siblings. Fricke relocated to Copenhagen in 1910, where he studied at the University of Copenhagen from 1910 to 1916, where he also worked as an assistant to Niels Bohr. In 1918, he moved to Lund University where he worked with Manne Siegbahn on X-ray spectroscopy. In 1919 he emigrated to the US, working at Columbia University and at Harvard University with Theodore Lyman until 1921. He moved to Cleveland Clinic by invitation of George Crile to he ...
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Radiation Therapy
Radiation therapy or radiotherapy, often abbreviated RT, RTx, or XRT, is a therapy using ionizing radiation, generally provided as part of cancer treatment to control or kill malignant cells and normally delivered by a linear accelerator. Radiation therapy may be curative in a number of types of cancer if they are localized to one area of the body. It may also be used as part of adjuvant therapy, to prevent tumor recurrence after surgery to remove a primary malignant tumor (for example, early stages of breast cancer). Radiation therapy is synergistic with chemotherapy, and has been used before, during, and after chemotherapy in susceptible cancers. The subspecialty of oncology concerned with radiotherapy is called radiation oncology. A physician who practices in this subspecialty is a radiation oncologist. Radiation therapy is commonly applied to the cancerous tumor because of its ability to control cell growth. Ionizing radiation works by damaging the DNA of cancerous tissue ...
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Magnetic Resonance Imaging
Magnetic resonance imaging (MRI) is a medical imaging technique used in radiology to form pictures of the anatomy and the physiological processes of the body. MRI scanners use strong magnetic fields, magnetic field gradients, and radio waves to generate images of the organs in the body. MRI does not involve X-rays or the use of ionizing radiation, which distinguishes it from CT and PET scans. MRI is a medical application of nuclear magnetic resonance (NMR) which can also be used for imaging in other NMR applications, such as NMR spectroscopy. MRI is widely used in hospitals and clinics for medical diagnosis, staging and follow-up of disease. Compared to CT, MRI provides better contrast in images of soft-tissues, e.g. in the brain or abdomen. However, it may be perceived as less comfortable by patients, due to the usually longer and louder measurements with the subject in a long, confining tube, though "Open" MRI designs mostly relieve this. Additionally, implants and oth ...
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