|
Gary Siuzdak
Gary Siuzdak is an American chemist best known for his work in the field of metabolomics, activity metabolomics (a termed coined in 2019), and mass spectrometry. His lab discovered indole-3-propionic acid as a gut bacteria derived metabolite in 2009. He is currently the Professor and Director of The Center for Metabolomics and Mass Spectrometry at Scripps Research in La Jolla, California. Siuzdak has also made contributions to virus analysis, viral structural dynamics, as well as developing mass spectrometry imaging technology using nanostructured surfaces. The Siuzdak lab is also responsible for creating the research tools XCMS, METLIN, METLIN Neutral Loss and Q-MRM. As of January 2021, the XCMS/METLIN platform has over 50,000 registered users. Siuzdak studied chemistry (B.S.) and applied mathematics (B.A.) at Rhode Island College. He then went to Dartmouth College for his graduate work where he built his first mass spectrometer to perform multi-photon ionization mass spectrometr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Metabolomics
Metabolomics is the scientific study of chemical processes involving metabolites, the small molecule substrates, intermediates, and products of cell metabolism. Specifically, metabolomics is the "systematic study of the unique chemical fingerprints that specific cellular processes leave behind", the study of their small-molecule metabolite profiles. The metabolome represents the complete set of metabolites in a biological cell, tissue, organ, or organism, which are the end products of cellular processes. Messenger RNA (mRNA), gene expression data, and proteomics, proteomic analyses reveal the set of gene products being produced in the cell, data that represents one aspect of cellular function. Conversely, metabolic profiling can give an instantaneous snapshot of the physiology of that cell, and thus, metabolomics provides a direct "functional readout of the physiological state" of an organism. There are indeed quantifiable correlations between the metabolome and the other cellular ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oleamide
Oleamide is an organic compound with the formula CH3(CH2)7CH=CH(CH2)7CONH2(. It is the amide derived from the fatty acid oleic acid. It is a colorless waxy solid and occurs in nature. Sometimes labeled as a fatty acid primary amide (FAPA), it is biosynthesized from N-oleoylglycine. Biochemical and medical aspects In terms of natural occurrence, oleamide was first detected in human plasma. It was later shown to accumulate in the cerebrospinal fluid during sleep deprivation and induces sleep in animals. It has been considered as a potential treatment for mood and sleep disorders, as well as cannabinoid-regulated depression. In terms of its sleep inducing effects, it is speculated that oleamide interacts with multiple neurotransmitter systems. Some in-vitro studies show that the cis enantomer of oleamide is an agnoist for the cannabinoid receptor CB-1 with an affinity around 8 micromolar. However, given oleamide's relatively low affinity for CB-1 and uncertainty about the concentr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Living People
Related categories * :Year of birth missing (living people) / :Year of birth unknown * :Date of birth missing (living people) / :Date of birth unknown * :Place of birth missing (living people) / :Place of birth unknown * :Year of death missing / :Year of death unknown * :Date of death missing / :Date of death unknown * :Place of death missing / :Place of death unknown * :Missing middle or first names See also * :Dead people * :Template:L, which generates this category or death years, and birth year and sort keys. : {{DEFAULTSORT:Living people 21st-century people People by status ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scripps Research Faculty
Scripps may refer to: People * Edward W. Scripps (1854–1926), American publisher and media financier * Ellen Browning Scripps (1836–1932), American philanthropist, half-sister of Edward W. Scripps * James E. Scripps (1835–1906), American newspaper publisher, brother of Ellen Browning Scripps * Samuel H. Scripps (1927–2007), American philanthropist in theater and dance, grandson of Edward W. Scripps * Anne Scripps (1946–1993), heiress to the Scripps newspaper publishing and great-great granddaughter of James E. Scripps * Charles Scripps (1920–2007), chairman of the board of the E. W. Scripps Company and grandson of Edward W. Scripps * Dan Scripps, American politician * John Locke Scripps (1818–1866), attorney, journalist, and author. First cousin once removed of E.W. Scripps * John Martin Scripps (1959–1996), British serial killer * Natalee Scripps (born 1978), New Zealand cricketer * William Edmund Scripps (1882–1952), American founder of WWJ radio, son of James ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dartmouth College Alumni
This list of alumni of Dartmouth College includes alumni and current students of Dartmouth College and its graduate schools. In addition to its undergraduate program, Dartmouth offers graduate degrees in nineteen departments and includes three graduate schools: the Tuck School of Business, the Thayer School of Engineering, and Dartmouth Medical School. Since its founding in 1769, Dartmouth has graduated classes of students and today has approximately 66,500 living alumni. This list uses the following notation: * D or unmarked years – recipient of Dartmouth College Bachelor of Arts * DMS – recipient of Dartmouth Medical School degree (Bachelor of Medicine 1797–1812, Doctor of Medicine 1812–present) * Th – recipient of any of several Thayer School of Engineering degrees (see Thayer School of Engineering#Academics) * T – recipient of Tuck School of Business Master of Business Administration, or graduate of other programs as indicated *M.A., M.A.L.S., M.S., Ph.D, etc. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rhode Island College Alumni , the smallest U.S. state by area
*Rode (other)
*Rhodes (other)
*Rohde
{{disambiguation, geo ...
Rhode may refer to: *In Greek mythology: :*Rhodos, goddess and personification of the island of Rhodes :*Rhode, one of the fifty daughters of Danaus * ''Rhode'' (spider), a genus of spiders *Rhode (surname) *Rhode, County Offaly, an Irish town *Rhode, now Roses, Girona, Spain *Rhode, a suburb of Olpe, Germany * Rhode River, Maryland *Rhode-Saint-Genèse, a Belgian municipality See also * *Rhode Island Rhode Island (, like ''road'') is a state in the New England region of the Northeastern United States. It is the smallest U.S. state by area and the seventh-least populous, with slightly fewer than 1.1 million residents as of 2020, but it ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Desorption/ionization On Silicon
Desorption/ionization on silicon (DIOS) is a soft laser desorption method used to generate gas-phase ions for mass spectrometry analysis. DIOS is considered the first surface-based surface-assisted laser desorption/ionization (SALDI-MS) approach. Prior approaches were accomplished using nanoparticles in a matrix of glycerol, while DIOS is a matrix-free technique in which a sample is deposited on a nanostructured (porous silicon) surface and the sample desorbed directly from the nanostructured surface through the adsorption of laser light energy. DIOS has been used to analyze organic molecules, metabolites, biomolecules and peptides, and, ultimately, to image tissues and cells. Background Soft laser desorption is a soft ionization technique which desorbs and ionizes molecules from surfaces with minimal fragmentation. This is useful for a broad range of small and large molecules and molecules that fragment easily. The first soft laser desorption techniques included Matrix-assisted l ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hormone
A hormone (from the Greek participle , "setting in motion") is a class of signaling molecules in multicellular organisms that are sent to distant organs by complex biological processes to regulate physiology and behavior. Hormones are required for the correct development of animals, plants and fungi. Due to the broad definition of a hormone (as a signaling molecule that exerts its effects far from its site of production), numerous kinds of molecules can be classified as hormones. Among the substances that can be considered hormones, are eicosanoids (e.g. prostaglandins and thromboxanes), steroids (e.g. oestrogen and brassinosteroid), amino acid derivatives (e.g. epinephrine and auxin), protein or peptides (e.g. insulin and CLE peptides), and gases (e.g. ethylene and nitric oxide). Hormones are used to communicate between organs and tissues. In vertebrates, hormones are responsible for regulating a variety of physiological processes and behavioral activities such as diges ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scripps Research
Scripps Research, previously known as The Scripps Research Institute (TSRI), is a nonprofit American medical research facility that focuses on research and education in the biomedical sciences. Headquartered in San Diego, California, the institute has over 170 laboratories employing 2,100 scientists, technicians, graduate students, and administrative and other staff, making it the largest private, non-profit biomedical research organization in the United States and among the largest in the world. The institute holds over 1,100 patents, has produced 11 FDA-approved therapeutics, and has generated over 50 spin-off companies. According to the 2017 Nature Innovation Index, Scripps Research is the #1 most influential research institution in the world. The Scripps Research graduate program is ranked 9th nationally in the biological sciences, 6th for organic chemistry, and 6th for biochemistry. In 2022, their Jupiter, FL campus became a part of the University of Florida. Jupiter-based ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lipid
Lipids are a broad group of naturally-occurring molecules which includes fats, waxes, sterols, fat-soluble vitamins (such as vitamins A, D, E and K), monoglycerides, diglycerides, phospholipids, and others. The functions of lipids include storing energy, signaling, and acting as structural components of cell membranes. Lipids have applications in the cosmetic and food industries, and in nanotechnology. Lipids may be broadly defined as hydrophobic or amphiphilic small molecules; the amphiphilic nature of some lipids allows them to form structures such as vesicles, multilamellar/unilamellar liposomes, or membranes in an aqueous environment. Biological lipids originate entirely or in part from two distinct types of biochemical subunits or "building-blocks": ketoacyl and isoprene groups. Using this approach, lipids may be divided into eight categories: fatty acyls, glycerolipids, glycerophospholipids, sphingolipids, saccharolipids, and polyketides (derived from condensati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oleamide
Oleamide is an organic compound with the formula CH3(CH2)7CH=CH(CH2)7CONH2(. It is the amide derived from the fatty acid oleic acid. It is a colorless waxy solid and occurs in nature. Sometimes labeled as a fatty acid primary amide (FAPA), it is biosynthesized from N-oleoylglycine. Biochemical and medical aspects In terms of natural occurrence, oleamide was first detected in human plasma. It was later shown to accumulate in the cerebrospinal fluid during sleep deprivation and induces sleep in animals. It has been considered as a potential treatment for mood and sleep disorders, as well as cannabinoid-regulated depression. In terms of its sleep inducing effects, it is speculated that oleamide interacts with multiple neurotransmitter systems. Some in-vitro studies show that the cis enantomer of oleamide is an agnoist for the cannabinoid receptor CB-1 with an affinity around 8 micromolar. However, given oleamide's relatively low affinity for CB-1 and uncertainty about the concentr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
