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GARP Study
P. Eline Slagboom (born January 18, 1960, Dordrecht, the Netherlands) is a Dutch biologist specializing in the human familial longevity and ageing. Education Slagboom attended Christelijk Lyceum in Delft, graduating in 1978, before continuing to Leiden University for her Bachelors (1979) and Masters (1985) degrees in biology, followed by a Ph.D. focusing on Genomic Instability and Aging (1993) from the same institution. Career After receiving her Ph.D., Slagboom joined the Department of Vascular and Connective Tissues Research at the Gaubius Laboratory (TNO-PG, the Netherlands). As a post doc she initiated a unit for genetic epidemiological studies aimed at the identification of genetic determinants of multifactorial diseases. Slagboom started between 1995 and 1997 a genetic research line on osteoarthritis (OA) including linkage studies in families with early onset OA, genetic association studies in population cohorts and linkage studies in populations of affected sibling-p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dordrecht
Dordrecht (), historically known in English as Dordt (still colloquially used in Dutch, ) or Dort, is a city and municipality in the Western Netherlands, located in the province of South Holland. It is the province's fifth-largest city after Rotterdam, The Hague, Zoetermeer and Leiden, with a population of . The municipality covers the entire Dordrecht Island, also often called ''Het Eiland van Dordt'' ("the Island of Dordt"), bordered by the rivers Oude Maas, Beneden Merwede, Nieuwe Merwede, Hollands Diep, and Dordtsche Kil. Located about 17 km south east of Rotterdam, Dordrecht is the largest and most important city in the Drechtsteden and is also part of the Randstad, the main conurbation in the Netherlands. Dordrecht is the oldest city in Holland and has a rich history and culture. Etymology The name Dordrecht comes from ''Thuredriht'' (circa 1120), ''Thuredrecht'' (circa 1200). The name seems to mean 'thoroughfare'; a ship-canal or -river through which ships were pulle ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Proteomics
Proteomics is the large-scale study of proteins. Proteins are vital parts of living organisms, with many functions such as the formation of structural fibers of muscle tissue, enzymatic digestion of food, or synthesis and replication of DNA. In addition, other kinds of proteins include antibodies that protect an organism from infection, and hormones that send important signals throughout the body. The proteome is the entire set of proteins produced or modified by an organism or system. Proteomics enables the identification of ever-increasing numbers of proteins. This varies with time and distinct requirements, or stresses, that a cell or organism undergoes. Proteomics is an interdisciplinary domain that has benefited greatly from the genetic information of various genome projects, including the Human Genome Project. It covers the exploration of proteomes from the overall level of protein composition, structure, and activity, and is an important component of functional genomics. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1960 Births
Year 196 ( CXCVI) was a leap year starting on Thursday (link will display the full calendar) of the Julian calendar. At the time, it was known as the Year of the Consulship of Dexter and Messalla (or, less frequently, year 949 ''Ab urbe condita''). The denomination 196 for this year has been used since the early medieval period, when the Anno Domini calendar era became the prevalent method in Europe for naming years. Events By place Roman Empire * Emperor Septimius Severus attempts to assassinate Clodius Albinus but fails, causing Albinus to retaliate militarily. * Emperor Septimius Severus captures and sacks Byzantium; the city is rebuilt and regains its previous prosperity. * In order to assure the support of the Roman legion in Germany on his march to Rome, Clodius Albinus is declared Augustus by his army while crossing Gaul. * Hadrian's wall in Britain is partially destroyed. China * First year of the '' Jian'an era of the Chinese Han Dynasty. * Emperor Xian o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Toon Roos
Toon may refer to: Places * Tōon, Ehime, a Japanese city in Ehime Prefecture * Toon, the former name of Ferdows, a city in South Khorasan Province, Iran * Toon, Somaliland, a town in the Garoodi region People * Toon (name), a list of people with the given name, nickname or surname Arts and entertainment * Toon (TV series), ''Toon'' (TV series), a 2016 Dutch television series * Toon (role-playing game), ''Toon'' (role-playing game), published by Steve Jackson Games * Toon, a term in the film ''Who Framed Roger Rabbit'' (1988) for cartoon characters * Toon, a shortened name for Cartoon#Animation, cartoon animation Businesses * Cartoon Network, an animation-oriented cable television network, sometimes abbreviated to Toon * Toon Books an American comic book publisher * Toon Studio, Disneyland Paris Other uses * Toon, trees of the genus ''Toona'' * A nickname for Newcastle upon Tyne based on the local dialect pronunciation of the word "town" * A nickname for Newcastle United ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Woubrugge
Woubrugge is a village in the Dutch province of South Holland. It is located about 10 km east of the city of Leiden, in the municipality of Kaag en Braassem. History The village was first mentioned in 1493 as Woubregge, and means "bridge over the Woudwetering". The Woutbroeke mentioned in 1252 is a different settlement. Woubrugge started as a peat excavation settlement, but turned into a linear agricultural settlement along the Woudwetering. The Dutch Reformed church is a pseudo cruciform church between 1652 and 1653 and designed by Pieter Post. It has a twelve sided ridge turret with needle spire. Woubrugge was home to 932 people in 1840. It was a separate municipality until 1991, when it became part of Jacobswoude. In 2009, it became part of the municipality of Kaag en Braassem. Notable residents * Hans Vijlbrief, born 17 August 1963, lives in Woubrugge, civil servant, economist, and State Secretary for Finance * Henk Angenent, born 1 November 1967, lives in Woubrugg ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cardiovascular Diseases
Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels. CVD includes coronary artery diseases (CAD) such as angina and myocardial infarction (commonly known as a heart attack). Other CVDs include stroke, heart failure, hypertensive heart disease, rheumatic heart disease, cardiomyopathy, abnormal heart rhythms, congenital heart disease, valvular heart disease, carditis, aortic aneurysms, peripheral artery disease, thromboembolic disease, and venous thrombosis. The underlying mechanisms vary depending on the disease. It is estimated that dietary risk factors are associated with 53% of CVD deaths. Coronary artery disease, stroke, and peripheral artery disease involve atherosclerosis. This may be caused by high blood pressure, smoking, diabetes mellitus, lack of exercise, obesity, high blood cholesterol, poor diet, excessive alcohol consumption, and poor sleep, among other things. High blood pressure is estimated to account for appr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Proteins
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid residues ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Urine
Urine is a liquid by-product of metabolism in humans and in many other animals. Urine flows from the kidneys through the ureters to the urinary bladder. Urination results in urine being excretion, excreted from the body through the urethra. Cell (biology), Cellular metabolism generates many by-products that are rich in nitrogen and must be clearance (medicine), cleared from the Circulatory system, bloodstream, such as urea, uric acid, and creatinine. These by-products are expelled from the body during urination, which is the primary method for excreting water-soluble chemicals from the body. A urinalysis can detect nitrogenous wastes of the mammalian body. Urine plays an important role in the earth's nitrogen cycle. In balanced ecosystems, urine fertilizes the soil and thus helps plants to grow. Therefore, Reuse of excreta, urine can be used as a fertilizer. Some animals use it to territory (animal)#Scent marking, mark their territories. Historically, aged or fermented urine (kn ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PBMC
A peripheral blood mononuclear cell (PBMC) is any peripheral blood cell having a round nucleus. These cells consist of lymphocytes (T cells, B cells, NK cells) and monocytes, whereas erythrocytes and platelets have no nuclei, and granulocytes (neutrophils, basophils, and eosinophils) have multi-lobed nuclei. In humans, lymphocytes make up the majority of the PBMC population, followed by monocytes, and only a small percentage of dendritic cells. These cells can be extracted from whole blood or buffy coat samples using a hydrophilic colloid and density gradient centrifugation, which separates the blood into a top layer of plasma, followed by a layer of PBMCs and a bottom fraction of polymorphonuclear cells (such as neutrophils and eosinophils) and erythrocytes. The polymorphonuclear cells can be further isolated by lysing the erythrocytes. Basophils are sometimes found in both the denser and the PBMC fractions. A high-quality PBMC isolate has a viability over 90% and a low concen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Blood
Blood is a body fluid in the circulatory system of humans and other vertebrates that delivers necessary substances such as nutrients and oxygen to the cells, and transports metabolic waste products away from those same cells. Blood in the circulatory system is also known as ''peripheral blood'', and the blood cells it carries, ''peripheral blood cells''. Blood is composed of blood cells suspended in blood plasma. Plasma, which constitutes 55% of blood fluid, is mostly water (92% by volume), and contains proteins, glucose, mineral ions, hormones, carbon dioxide (plasma being the main medium for excretory product transportation), and blood cells themselves. Albumin is the main protein in plasma, and it functions to regulate the colloidal osmotic pressure of blood. The blood cells are mainly red blood cells (also called RBCs or erythrocytes), white blood cells (also called WBCs or leukocytes) and platelets (also called thrombocytes). The most abundant cells in vertebrate blo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wageningen University And Research Centre
Wageningen University & Research (also known as Wageningen UR; abbreviation: WUR) is a public university in Wageningen, Netherlands, specializing in life sciences with a focus on agriculture, technical and engineering subjects. It is a globally important center for life sciences and agricultural research. It is located in a region of the Netherlands known as the Food Valley. WUR consists of Wageningen University and the former agricultural research institutes of the Dutch Ministry of Agriculture. Wageningen University, as a research university, grants degrees at the BSc, MSc and PhD level in life and social sciences. It focuses its research on scientific, social and commercial problems in the field of life sciences and natural resources. It is widely known for its agriculture, forestry, and environmental studies programs. The university has about 12,000 students from over 100 countries. It is a member of the Euroleague for Life Sciences (ELLS) university network. WUR has been p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Seventh Framework Programme
The Framework Programmes for Research and Technological Development, also called Framework Programmes or abbreviated FP1 to FP9, are funding programmes created by the European Union/European Commission to support and foster research in the European Research Area (ERA). Starting in 2014, the funding programmes were named Horizon. The funding programmes began in 1984 and continue to the present day. The most recent programme, Horizon Europe, has a budget of 95.5 billion Euros to be distributed over 7 years. The specific objectives and actions vary between funding periods. In FP6 and FP7, focus was on technological research. In Horizon 2020, the focus was on innovation, delivering economic growth faster, and delivering solutions to end users that are often governmental agencies. Background Conducting European research policies and implementing European research programmes is an obligation under the Amsterdam Treaty, which includes a chapter on research and technological development. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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