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Frances Ashcroft
Dame Frances Mary Ashcroft (born 1952) is a British ion channel physiologist. She is Royal Society GlaxoSmithKline Research Professor at the University Laboratory of Physiology at the University of Oxford. She is a fellow of Trinity College, Oxford, and is a director of the Oxford Centre for Gene Function. Her research group has an international reputation for work on insulin secretion, type II diabetes and neonatal diabetes. Her work with Andrew Hattersley has helped enable children born with diabetes to switch from insulin injections to tablet therapy. Education Ashcroft was educated at Talbot Heath School and the University of Cambridge where she was awarded a degree in Natural Sciences (Cambridge), Natural Sciences followed by a PhD in zoology in 1978. Career and research Ashcroft then did postdoctoral research at the University of Leicester and the University of California at Los Angeles. Ashcroft is a director of Oxion: Ion Channels and Disease Initiative, a research and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dame
''Dame'' is an honorific title and the feminine form of address for the honour of damehood in many Christian chivalric orders, as well as the Orders, decorations, and medals of the United Kingdom, British honours system and those of several other Commonwealth realms, such as Australia and New Zealand, with the masculine form of address being ''Sir''. It is the female equivalent for knighthood, which is traditionally granted to males. Dame is also style used by baronetesses Suo jure, in their own right. A woman appointed to the grades of the Dame Commander or Dame Grand Cross of the Order of Saint John (Bailiwick of Brandenburg), Order of Saint John, Equestrian Order of the Holy Sepulchre, Most Honourable Order of the Bath, the Most Distinguished Order of Saint Michael and Saint George, the Royal Victorian Order, or the Most Excellent Order of the British Empire becomes a dame. A Central European order in which female members receive the rank of Dame is the Order of St. George (H ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oxford Centre For Gene Function
The Oxford Centre for Gene Function is a multidisciplinary research institute in the University of Oxford, England. It is directed by Frances Ashcroft, Kay Davies and Peter Donnelly. It involves the departments of Human anatomy and genetics, Physiology, and Statistics Statistics (from German language, German: ''wikt:Statistik#German, Statistik'', "description of a State (polity), state, a country") is the discipline that concerns the collection, organization, analysis, interpretation, and presentation of .... External links Oxford Centre for Gene Function websiteWellcome Trust Centre for Human Genetics Departments of the University of Oxford Genetics in the United Kingdom Human genetics Research institutes in Oxford {{UOxford-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Physiology
Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemical and physical functions in a living system. According to the classes of organisms, the field can be divided into medical physiology, animal physiology, plant physiology, cell physiology, and comparative physiology. Central to physiological functioning are biophysical and biochemical processes, homeostatic control mechanisms, and communication between cells. ''Physiological state'' is the condition of normal function. In contrast, ''pathological state'' refers to abnormal conditions, including human diseases. The Nobel Prize in Physiology or Medicine is awarded by the Royal Swedish Academy of Sciences for exceptional scientific achievements in physiology related to the field of medicine. Foundations Cells Although there are differ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Popular Science
''Popular Science'' (also known as ''PopSci'') is an American digital magazine carrying popular science content, which refers to articles for the general reader on science and technology subjects. ''Popular Science'' has won over 58 awards, including the American Society of Magazine Editors awards for its journalistic excellence in 2003 (for General Excellence), 2004 (for Best Magazine Section), and 2019 (for Single-Topic Issue). With roots beginning in 1872, ''Popular Science'' has been translated into over 30 languages and is distributed to at least 45 countries. Early history ''The Popular Science Monthly'', as the publication was originally called, was founded in May 1872 by Edward L. Youmans to disseminate scientific knowledge to the educated layman. Youmans had previously worked as an editor for the weekly ''Appleton's Journal'' and persuaded them to publish his new journal. Early issues were mostly reprints of English periodicals. The journal became an outlet for writings ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Science
Science is a systematic endeavor that builds and organizes knowledge in the form of testable explanations and predictions about the universe. Science may be as old as the human species, and some of the earliest archeological evidence for scientific reasoning is tens of thousands of years old. The earliest written records in the history of science come from Ancient Egypt and Mesopotamia in around 3000 to 1200 BCE. Their contributions to mathematics, astronomy, and medicine entered and shaped Greek natural philosophy of classical antiquity, whereby formal attempts were made to provide explanations of events in the physical world based on natural causes. After the fall of the Western Roman Empire, knowledge of Greek conceptions of the world deteriorated in Western Europe during the early centuries (400 to 1000 CE) of the Middle Ages, but was preserved in the Muslim world during the Islamic Golden Age and later by the efforts of Byzantine Greek scholars who brought Greek ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ATP-sensitive Potassium Channel
An ATP-sensitive potassium channel (or KATP channel) is a type of potassium channel that is gated by intracellular nucleotides, ATP and ADP. ATP-sensitive potassium channels are composed of Kir6.x-type subunits and sulfonylurea receptor (SUR) subunits, along with additional components. KATP channels are found in the plasma membrane; however some may also be found on subcellular membranes. These latter classes of KATP channels can be classified as being either sarcolemmal ("sarcKATP"), mitochondrial ("mitoKATP"), or nuclear ("nucKATP"). Discovery and structure KATP channels were first identified in cardiac myocytes by the Akinori Noma group in Japan. They have also been found in pancreas where they control insulin secretion, but are in fact widely distributed in plasma membranes. SarcKATP are composed of eight protein subunits (octamer). Four of these are members of the inward-rectifier potassium ion channel family Kir6.x (either Kir6.1 or Kir6.2), while the other four ar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wellcome Trust
The Wellcome Trust is a charitable foundation focused on health research based in London, in the United Kingdom. It was established in 1936 with legacies from the pharmaceutical magnate Henry Wellcome (founder of one of the predecessors of GlaxoSmithKline) to fund research to improve human and animal health. The aim of the Trust is to "support science to solve the urgent health challenges facing everyone." It had a financial endowment of Pound sterling, £29.1 billion in 2020, making it the fourth List of wealthiest charitable foundations, wealthiest charitable foundation in the world. In 2012, the Wellcome Trust was described by the ''Financial Times'' as the United Kingdom's largest provider of non-governmental funding for scientific research, and one of the largest providers in the world. According to their annual report, the Wellcome Trust spent GBP Pound sterling, £1.1Bn on charitable activities across their 2019/2020 financial year. According to the OECD, the Wellcome ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of California At Los Angeles
The University of California, Los Angeles (UCLA) is a public university, public Land-grant university, land-grant research university in Los Angeles, California. UCLA's academic roots were established in 1881 as a Normal school, teachers college then known as the southern branch of the California State Normal School (now San Jose State University, San José State University). This school was absorbed with the official founding of UCLA as the Southern Branch of the University of California in 1919, making it the second-oldest of the 10-campus University of California system (after UC Berkeley). UCLA offers 337 undergraduate and graduate degree programs in a wide range of disciplines, enrolling about 31,600 undergraduate and 14,300 graduate and professional students. UCLA received 174,914 undergraduate applications for Fall 2022, including transfers, making the school the most applied-to Higher education in the United States, university in the United States. The university is or ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Postdoctoral Research
A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). The ultimate goal of a postdoctoral research position is to pursue additional research, training, or teaching in order to have better skills to pursue a career in academia, research, or any other field. Postdocs often, but not always, have a temporary academic appointment, sometimes in preparation for an academic faculty position. They continue their studies or carry out research and further increase expertise in a specialist subject, including integrating a team and acquiring novel skills and research methods. Postdoctoral research is often considered essential while advancing the scholarly mission of the host institution; it is expected to produce relevant publications in peer-reviewed academic journals or conferences. In some countries, postdoctoral research may lead to further formal qualificati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Zoology
Zoology ()The pronunciation of zoology as is usually regarded as nonstandard, though it is not uncommon. is the branch of biology that studies the Animal, animal kingdom, including the anatomy, structure, embryology, evolution, Biological classification, classification, Ethology, habits, and distribution of all animals, both living and extinction, extinct, and how they interact with their ecosystems. The term is derived from Ancient Greek , ('animal'), and , ('knowledge', 'study'). Although humans have always been interested in the natural history of the animals they saw around them, and made use of this knowledge to domesticate certain species, the formal study of zoology can be said to have originated with Aristotle. He viewed animals as living organisms, studied their structure and development, and considered their adaptations to their surroundings and the function of their parts. The Greek physician Galen studied human anatomy and was one of the greatest surgeons of the a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Natural Sciences (Cambridge)
The Natural Sciences Tripos (NST) is the framework within which most of the science at the University of Cambridge is taught. The tripos includes a wide range of Natural Sciences from physics, astronomy, and geoscience, to chemistry and biology, which are taught alongside the history and philosophy of science. The tripos covers several courses which form the University of Cambridge system of Tripos. It is known for its broad range of study in the first year, in which students cannot study just one discipline, but instead must choose three courses in different areas of the natural sciences and one in mathematics. As is traditional at Cambridge, the degree awarded after Part II (three years of study) is a Bachelor of Arts (BA). A Master of Natural Sciences degree (MSci) is available to those who take the optional Part III (one further year). It was started in the 19th Century. Teaching Teaching is carried out by 16 different departments. Subjects offered in Part IA in 2019 are Biol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Andrew Hattersley
Andrew Tym Hattersley CBE FRS (born 1958, London) is a Professor of Molecular Medicine at the University of Exeter and is known for his research in monogenic diabetes. He was elected a Fellow of the Royal Society in 2010. He is also an Emeritus Senior Investigator at the National Institute for Health and Care Research (NIHR). Education and career In 1981, he received his BA from Emmanuel College, Cambridge. He received his BM BCh in 1984 and his DM in 1997, both from Oxford University. He did further training in diabetes at Hammersmith Hospital. He was a lecturer at the University of Birmingham from 1993-1994, and he has worked at Exeter since 1995. He identified glucokinase as the first gene causing diabetes and has published over 500 papers on the topic of diabetes. His subsequent work has developed the understanding of MODY and the treatments and supportive therapies available. Awards * 1998 Fellow of the Royal College of Physicians, London, UK * 2004 Fellow of the Academy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
