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Fox Chase Cancer Center
Fox Chase Cancer Center is a National Cancer Institute-designated Comprehensive Cancer Center research facility and hospital located in the Fox Chase section of Philadelphia, Pennsylvania, United States. The main facilities of the center are located on property adjoining Burholme Park. The center is part of the Temple University Health System (TUHS) and specializes in the treatment and prevention of cancer. The center was formed in 1974 by the merger of the American Oncologic Hospital, which was founded in 1904 as the first cancer hospital in the United States, and the Institute for Cancer Research, founded in 1927. The center was an independent, non-profit institution until it became part of TUHS July 1, 2012. Today it has almost 2,400 employees and an operating budget of $300 million. Research is conducted in more than 80 laboratories by a staff of more than 325 physicians and scientists who hold medical degrees, Ph.D.s or both. Fox Chase's 100-bed hospital is one of the few ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Temple University Health System
Temple Health also known as Temple University Health System is a non-profit academic healthcare network based in the Philadelphia, Pennsylvania, United States. The healthcare network serves Pennsylvania and its flagship hospital is Temple University Hospital, a safety net hospital, located in Philadelphia. Research activities are carried out by the affiliates of Temple University Health System and the Lewis Katz School of Medicine at Temple University. Locations Temple Health operates the following hospitals: *Temple University Hospital *Temple University Hospital – Jeanes Campus *Temple University Hospital – Episcopal Campus *Temple University Hospital – Northeastern Campus *Temple Health - Fox Chase Cancer Center *Temple Health - Chestnut Hill Hospital History Temple Health began in 1891 as a way for the poor to get needed medical care. Samaritan Hospital was founded by Grace Baptist of Philadelphia and its leader Russell Conwell. In the hospital’s first year, it was o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
William Procter Prize For Scientific Achievement
The William Procter Prize for Scientific Achievement is an award given by Sigma Xi, a scientific-research honor society. The Procter Prize is presented annually to a scientist who has made an outstanding contribution to scientific research and has demonstrated an ability to communicate the significance of this research to scientists in other disciplines. The prize consists of a Steuben glass sculpture and $5,000. In addition, each recipient is asked to designate a younger scholar, usually working in the same field, to receive a $5,000 Grant-in-Aid of Research. Presentation of the Procter Prize is traditionally a principal event at the Sigma Xi Annual Meeting, where the recipient delivers the Procter Prize Address. The Prize is named for William Procter, an heir of one of the founders of the Procter and Gamble Company. He was active in Sigma Xi and its affiliated organization, the Research Society of America (RESA), and endowed the award that bears his name in 1950, the year befor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Knudson Hypothesis
The Knudson hypothesis, also known as the two-hit hypothesis, is the hypothesis that most tumor suppressor genes require both alleles to be inactivated, either through mutations or through epigenetic silencing, to cause a phenotypic change. It was first formulated by Alfred G. Knudson in 1971 and led indirectly to the identification of tumor suppressor genes. Knudson won the 1998 Albert Lasker Clinical Medical Research Award for this work. Knudson performed a statistical analysis on cases of retinoblastoma, a tumor of the retina that occurs both as an inherited disease and sporadically. He noted that inherited retinoblastoma occurs at a younger age than the sporadic disease. In addition, the children with inherited retinoblastoma often developed the tumor in both eyes, suggesting an underlying predisposition. Knudson suggested that two "hits" to DNA were necessary to cause the cancer. In the children with inherited retinoblastoma, the first mutation in what later came to be identi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mitosis
In cell biology, mitosis () is a part of the cell cycle in which replicated chromosomes are separated into two new nuclei. Cell division by mitosis gives rise to genetically identical cells in which the total number of chromosomes is maintained. Therefore, mitosis is also known as equational division. In general, mitosis is preceded by S phase of interphase (during which DNA replication occurs) and is often followed by telophase and cytokinesis; which divides the cytoplasm, organelles and cell membrane of one cell into two new cells containing roughly equal shares of these cellular components. The different stages of mitosis altogether define the mitotic (M) phase of an animal cell cycle—the division of the mother cell into two daughter cells genetically identical to each other. The process of mitosis is divided into stages corresponding to the completion of one set of activities and the start of the next. These stages are preprophase (specific to plant cells), prophase ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
AKT2
AKT2, also known as RAC-beta serine/threonine-protein kinase, is an enzyme that in humans is encoded by the ''AKT2'' gene. It influences metabolite storage as part of the insulin signal transduction pathway. Function This gene is a putative oncogene encoding a protein belonging to the AKT subfamily of serine/threonine kinases that contain SH2-like (Src homology 2-like) domains. The encoded protein is a general protein kinase capable of phosphorylating several known proteins. AKT2 has important roles in controlling glycogenesis, gluconeogenesis, and glucose transport as part of the insulin signal transduction pathway. Clinical significance The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. Mice lacking Akt2 have a normal body mass, but display a profound diabetic phenotype, indicating that A ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
AKT1
RAC(Rho family)-alpha serine/threonine-protein kinase is an enzyme that in humans is encoded by the ''AKT1'' gene. This enzyme belongs to the AKT subfamily of serine/threonine kinases that contain SH2 (Src homology 2-like) protein domains. It is commonly referred to as PKB, or by both names as "Akt/PKB". Function The serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ubiquitin
Ubiquitin is a small (8.6 kDa) regulatory protein found in most tissues of eukaryotic organisms, i.e., it is found ''ubiquitously''. It was discovered in 1975 by Gideon Goldstein and further characterized throughout the late 1970s and 1980s. Four genes in the human genome code for ubiquitin: UBB, UBC, UBA52 and RPS27A. The addition of ubiquitin to a substrate protein is called ubiquitylation (or, alternatively, ubiquitination or ubiquitinylation). Ubiquitylation affects proteins in many ways: it can mark them for degradation via the proteasome, alter their cellular location, affect their activity, and promote or prevent protein interactions. Ubiquitylation involves three main steps: activation, conjugation, and ligation, performed by ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s), respectively. The result of this sequential cascade is to bind ubiquitin to lysine residues on the protein substrate via an isopeptide bond, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Avram Hershko
Avram Hershko ( he, אברהם הרשקו, Avraham Hershko, hu, Herskó Ferenc Ábrahám; born December 31, 1937) is a Hungarian-Israeli biochemist who received the Nobel Prize in Chemistry in 2004. Biography He was born Herskó Ferenc in Karcag, Hungary, the son of Shoshana/Margit 'Manci' (née Wulc) and Moshe Hershko, both teachers. including the Nobel Lecture ''The Ubiquitin System for Protein Degradation and some of its Roles in the Control of the Cell Division Cycle'' During the Second World War, his father was forced into labor service in the Hungarian army and then taken as a prisoner by the Soviet Army. For years, Avram's family didn't known anything about what had happened to his father. Avram, his mother and older brother were put in a ghetto in Szolnok. During the final days of the ghetto, most Jews were sent to be murdered in Auschwitz, but Avram and his family managed to board trains that took them to a concentration camp in Austria, where they were forced into lab ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aaron Ciechanover
Aaron Ciechanover ( ; he, אהרן צ'חנובר; born October 1, 1947) is an Israeli biologist who won the Nobel Prize in Chemistry for characterizing the method that cells use to degrade and recycle proteins using ubiquitin. Biography Early life Ciechanover was born in Haifa, British Mandate of Palestine on 1 October 1947. He is the son of Bluma (Lubashevsky), a teacher of English, and Yitzhak Ciechanover, an office worker. His mother and father supported the Zionist movement and immigrated to Israel from Poland in the 1920s. Education He earned a master's degree in science in 1971 and graduated from Hadassah Medical School in Jerusalem in 1974. He received his doctorate in biochemistry in 1981 from the Technion – Israel Institute of Technology in Haifa before conducting postdoctoral research in the laboratory of Harvey Lodish at the Whitehead Institute at MIT from 1981 to 1984. Recent Ciechanover is currently a Technion Distinguished Research Professor in the Rut ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Irwin Rose
Irwin Allan Rose (July 16, 1926 – June 2, 2015) was an American biologist. Along with Aaron Ciechanover and Avram Hershko, he was awarded the 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation. Education and early life Rose was born in Brooklyn, New York, into a secular Jewish family, the son of Ella (Greenwald) and Harry Royze, who owned a flooring store. including the Nobel Lecture on December 8, 2004 ''Ubiquitin at Fox Chase'' Rose attended Washington State University for one year prior to serving in the Navy during World War II. Upon returning from the war he received his Bachelor of Science degree in 1948 and his PhD in biochemistry in 1952, both from the University of Chicago. He did his post-doctoral studies at NYU. Career and research Rose served on the faculty of Yale School of Medicine's department of biochemistry from 1954 to 1963. He then joined the Fox Chase Cancer Center in 1963 and stayed there until he retired in 1995. H ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nobel Prize In Chemistry
) , image = Nobel Prize.png , alt = A golden medallion with an embossed image of a bearded man facing left in profile. To the left of the man is the text "ALFR•" then "NOBEL", and on the right, the text (smaller) "NAT•" then "MDCCCXXXIII" above, followed by (smaller) "OB•" then "MDCCCXCVI" below. , awarded_for = Outstanding contributions in chemistry , presenter = Royal Swedish Academy of Sciences , location = Stockholm, Sweden , reward = 9 million SEK (2017) , year = 1901 , holder = Carolyn R. Bertozzi, Morten P. Meldal and Karl Barry Sharpless (2022) , most_awards = Frederick Sanger and Karl Barry Sharpless (2) , website nobelprize.org, previous = 2021 , year2=2022, main=2022, next=2023 The Nobel Prize in Chemistry is awarded annually by the Royal Swedish Academy of Sciences to scientists in the various fields of chemistry. It is one of the five Nobel Prizes established by the will of Alfred Nobel in 1895, awarded for ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alfred G
Alfred may refer to: Arts and entertainment *''Alfred J. Kwak'', Dutch-German-Japanese anime television series * ''Alfred'' (Arne opera), a 1740 masque by Thomas Arne * ''Alfred'' (Dvořák), an 1870 opera by Antonín Dvořák *"Alfred (Interlude)" and "Alfred (Outro)", songs by Eminem from the 2020 album ''Music to Be Murdered By'' Business and organisations * Alfred, a radio station in Shaftesbury, England *Alfred Music, an American music publisher *Alfred University, New York, U.S. *The Alfred Hospital, a hospital in Melbourne, Australia People * Alfred (name) includes a list of people and fictional characters called Alfred * Alfred the Great (848/49 – 899), or Alfred I, a king of the West Saxons and of the Anglo-Saxons Places Antarctica * Mount Alfred (Antarctica) Australia * Alfredtown, New South Wales * County of Alfred, South Australia Canada * Alfred and Plantagenet, Ontario * Alfred Island, Nunavut * Mount Alfred, British Columbia United States * Alfred, Maine, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
