|
Ferruginol
Ferruginol is a natural phenol with a terpenoid substructure. Specifically, it is a diterpene of the abietane chemical class, meaning it is characterized by three fused six-membered rings and alkyl functional groups. Ferruginol was first identified in 1939 by Brandt and Neubauer as the main component in the resin of the Prumnopitys ferruginea, Miro tree (''Podocarpus ferrugneus)'' and has since been isolated from other conifer species in the families ''Cupressaceae'' and ''Podocarpaceae''. As a biomarker, the presence of ferruginol in fossils, mainly resin, is used to describe the density of these conifers in that particular biosphere throughout time. Background Ferruginol is a phenolic abietene, a type of tricyclic diterpenoid derived from terrestrial plants. It has a molecular composition of C20H30O with a molecular weight of 286 g/mole. Along with its presence in the ''Verbenaceae'' family, it has been found in a variety of conifer families including ''Podocarpaceae,'' the anc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ferruginol Case Study- Edited (1)
Ferruginol is a natural phenol with a terpenoid substructure. Specifically, it is a diterpene of the abietane chemical class, meaning it is characterized by three fused six-membered rings and alkyl functional groups. Ferruginol was first identified in 1939 by Brandt and Neubauer as the main component in the resin of the Prumnopitys ferruginea, Miro tree (''Podocarpus ferrugneus)'' and has since been isolated from other conifer species in the families ''Cupressaceae'' and ''Podocarpaceae''. As a biomarker, the presence of ferruginol in fossils, mainly resin, is used to describe the density of these conifers in that particular biosphere throughout time. Background Ferruginol is a phenolic abietene, a type of tricyclic diterpenoid derived from terrestrial plants. It has a molecular composition of C20H30O with a molecular weight of 286 g/mole. Along with its presence in the ''Verbenaceae'' family, it has been found in a variety of conifer families including ''Podocarpaceae,'' the anc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ferruginol Ms -edit
Ferruginol is a natural phenol with a terpenoid substructure. Specifically, it is a diterpene of the abietane chemical class, meaning it is characterized by three fused six-membered rings and alkyl functional groups. Ferruginol was first identified in 1939 by Brandt and Neubauer as the main component in the resin of the Miro tree (''Podocarpus ferrugneus)'' and has since been isolated from other conifer species in the families ''Cupressaceae'' and ''Podocarpaceae''. As a biomarker, the presence of ferruginol in fossils, mainly resin, is used to describe the density of these conifers in that particular biosphere throughout time. Background Ferruginol is a phenolic abietene, a type of tricyclic diterpenoid derived from terrestrial plants. It has a molecular composition of C20H30O with a molecular weight of 286 g/mole. Along with its presence in the ''Verbenaceae'' family, it has been found in a variety of conifer families including ''Podocarpaceae,'' the ancient ''Araucariaceae,'' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Abietane
Abietane is a diterpene that forms the structural basis for a variety of natural chemical compounds such as abietic acid, carnosic acid, and ferruginol which are collectively known as abietanes or abietane diterpenes. Abietanes are found in the tissues and resins of certain higher plants, particularly gymnosperms. Although the functions of terpenes are not fully understood, conifers appear to produce abietane diterpenoids as a form of defense against insect and microbial attack. Some abietane diterpenoids, especially aromatic abietenes, are of interest to the pharmacology and natural products communities for their potential biological activities. In the rock record, abietanes are commonly found in amber as well as in fossil wood, sometimes in the form of the mineral fichtelite. Additionally, abietanes are observed in sediments—both riverine and marine—and in coals, where they are often interpreted as geochemical biomarkers for terrestrial input from conifers. Chemical str ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phenol
Phenol (also called carbolic acid) is an aromatic organic compound with the molecular formula . It is a white crystalline solid that is volatile. The molecule consists of a phenyl group () bonded to a hydroxy group (). Mildly acidic, it requires careful handling because it can cause chemical burns. Phenol was first extracted from coal tar, but today is produced on a large scale (about 7 billion kg/year) from petroleum-derived feedstocks. It is an important industrial commodity as a precursor to many materials and useful compounds. It is primarily used to synthesize plastics and related materials. Phenol and its chemical derivatives are essential for production of polycarbonates, epoxies, Bakelite, nylon, detergents, herbicides such as phenoxy herbicides, and numerous pharmaceutical drugs. Properties Phenol is an organic compound appreciably soluble in water, with about 84.2 g dissolving in 1000 mL (0.895 M). Homogeneous mixtures of phenol and water at phenol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Magic Angle Spinning
In solid-state NMR spectroscopy, magic-angle spinning (MAS) is a technique routinely used to produce better resolution NMR spectra. MAS NMR consists in spinning the sample (usually at a frequency of 1 to 130 kHz) at the magic angle θm (ca. 54.74°, where cos2θm=1/3) with respect to the direction of the magnetic field. Three main interactions responsible in solid state NMR (dipolar, chemical shift anisotropy, quadrupolar) often lead to very broad and featureless NMR lines. However, these three interactions in solids are orientation-dependent and can be averaged to some extent by MAS: * The nuclear dipolar interaction has a 3\cos^2\theta - 1 dependence, where \theta is the angle between the internuclear axis and the main magnetic field. As a result, the dipolar interaction vanish at the magic angle θm and the interaction contributing to the line broadening is removed. Even though all internuclear vectors cannot be all set to the magic angle, rotating the sample around this ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ipubi Formation
The Ipubi Formation is the middle geological formation of the Santana Group, the middle part of the Araripe Group, in the Araripe Basin of northeastern Brazil. The formation is dated to the Aptian to Albian stages of the Early Cretaceous, unconformably overlying the Crato Formation and unconformably overlain by the Romualdo Formation, formerly known as the Romualdo Member of the Santana Formation. The averaging thick Ipubi Formation comprises shales and sandstones in the lower section and evaporites in the upper part of the formation, deposited in a transgressive to highstand lacustrine environment in the Araripe rift basin. The Ipubi Formation contains little fossils, apart from an indeterminate Pelomedusoides turtle, but contains high levels of TOC and the formation is identified as a potential target for shale gas development. Description The Ipubi Formation was described as a member of the Santana Formation by Beurlen in 1971.Assine, 1992, p.291 Later revision of the strat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Araripe Basin
The Araripe Basin () is a rift basin covering about ,Neto et al., 2013, p.1 in Ceará, Piauí and Pernambuco states of northeastern Brazil. It is bounded by the Patos and Pernambuco lineaments, and is situated east of the Parnaíba Basin, southwest of the Rio do Peixe Basin and northwest of the Tucano and Jatobá Basins. The basin has provided a variety of unique fossils in the Crato and Santana Formations and includes the Araripe Geopark, a member of the UNESCO Global Geoparks since 2006. The pterosaurs ''Araripesaurus'' and ''Araripedactylus'' (now considered a ''nomen dubium''), crocodylian ''Araripesuchus'', the turtle ''Araripemys'', amphibian '' Arariphrynus'', the fish ''Araripelepidotes'' and the insect '' Araripenymphes'' were named after the basin. The bituminous shales of the Ipubi Formation in the Araripe Basin have potential for shale gas development.Neto et al., 2013, p.3 Basin history The tectono-sedimentary evolution of the Araripe Basin, located in the Bor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ulcerative Colitis
Ulcerative colitis (UC) is a long-term condition that results in inflammation and ulcers of the colon and rectum. The primary symptoms of active disease are abdominal pain and diarrhea mixed with blood (hematochezia). Weight loss, fever, and anemia may also occur. Often, symptoms come on slowly and can range from mild to severe. Symptoms typically occur intermittently with periods of no symptoms between flares. Complications may include abnormal dilation of the colon (megacolon), inflammation of the eye, joints, or liver, and colon cancer. The cause of UC is unknown. Theories involve immune system dysfunction, genetics, changes in the normal gut bacteria, and environmental factors. Rates tend to be higher in the developed world with some proposing this to be the result of less exposure to intestinal infections, or to a Western diet and lifestyle. The removal of the appendix at an early age may be protective. Diagnosis is typically by colonoscopy with tissue biopsies. It is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Growth Inhibition
''Growth inhibition'' (GI) is a medical term pertaining to cancer therapy and the specific reduction in growth of tumors and oncogene cells by a chemical compound, mechanical therapy (e.g. electroporation), radiation, gene therapy, protein therapy, ultrasound waves, light, or any other treatment. Measured in micromoles/liter or micrograms/liter. See also *Chemotherapy *Radiotherapy *Cancer *Oncology *Electroporation *Protein therapy Protein replacement therapy is a medical treatment that supplements or replaces a protein in patients in whom that particular protein is deficient or absent. There have been significant advances in this treatment. PRT is being tested in clinical tr ... Sources {{reflist Cancer treatments ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Apoptosis
Apoptosis (from grc, ἀπόπτωσις, apóptōsis, 'falling off') is a form of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, DNA fragmentation, and mRNA decay. The average adult human loses between 50 and 70 billion cells each day due to apoptosis. For an average human child between eight and fourteen years old, approximately twenty to thirty billion cells die per day. In contrast to necrosis, which is a form of traumatic cell death that results from acute cellular injury, apoptosis is a highly regulated and controlled process that confers advantages during an organism's life cycle. For example, the separation of fingers and toes in a developing human embryo occurs because cells between the digits undergo apoptosis. Unlike necrosis, apoptosis produces cell fragments called apoptotic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oncogene
An oncogene is a gene that has the potential to cause cancer. In tumor cells, these genes are often mutated, or expressed at high levels.Kimball's Biology Pages. "Oncogenes" Free full text Most normal cells will undergo a programmed form of rapid cell death () when critical functions are altered and malfunctioning. Activated oncogenes can cause those cells designated for apoptosis to survive and proliferate instead. Most oncogenes began as proto-oncogenes: normal genes involved in cell growth and proliferation or inhibition of apoptosis. If, through mutation, normal genes promoting cellular growth are up-regulated (gain-of-function mutation), they will predisp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell Line
An immortalised cell line is a population of cells from a multicellular organism which would normally not proliferate indefinitely but, due to mutation, have evaded normal cellular senescence and instead can keep undergoing division. The cells can therefore be grown for prolonged periods ''in vitro''. The mutations required for immortality can occur naturally or be intentionally induced for experimental purposes. Immortal cell lines are a very important tool for research into the biochemistry and cell biology of multicellular organisms. Immortalised cell lines have also found uses in biotechnology. An immortalised cell line should not be confused with stem cells, which can also divide indefinitely, but form a normal part of the development of a multicellular organism. Relation to natural biology and pathology There are various immortal cell lines. Some of them are normal cell lines (e.g. derived from stem cells). Other immortalised cell lines are the ''in vitro'' equivalent ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
.jpg "Click for more on -> Ferruginol Case Study- Edited (1)")
