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Fridolin Sulser
Fridolin Sulser (2 December 1926 – 3 January 2016) was a Swiss-American pharmacologist who specialized in the treatment of mental disorders. Life and work He was born in Grabs, Switzerland and grew up in the town of Maienfeld. He graduated from the Humanistische Gymnasium in Chur in 1947 and left to attend respectively school at the University of Basel (pre-clinical) and the University of Zurich (clinical), graduating from the latter with an M.D. in 1955. During his college years he was highly influenced by the works of Karl Jaspers. This influence has pushed him towards experimental biology, culminating in a decision to move from psychoanalysis to pharmacology. Before having been appointed assistant professor at the University of Bern, he served a mandatory 2-year term officer in the Swiss Army. He moved with his family to the United States in the fall of 1958, having obtained a post-doctoral fellowship in neuropsychopharmacology at the National Institutes of Health in B ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Grabs, Switzerland
Grabs is a municipality in the ''Wahlkreis'' (constituency) of Werdenberg in the canton of St. Gallen in Switzerland. History Grabs is first mentioned in 841 as ''Quaravedes''. In 979 it was mentioned as ''Quadravedes'', then in 1235 as ''Grabdis'' and in 1253 as ''Graps''. Geography Grabs has an area, , of . Of this area, 50% is used for agricultural purposes, while 32.2% is forested. Of the rest of the land, 4.8% is settled (buildings or roads) and the remainder (12.9%) is non-productive (rivers or lakes). The municipality is located in the Werdenberg ''Wahlkreis.'' The eastern portion of the municipality is on edge of the Rhine valley, but doesn't reach the Rhine. The larger part of the municipality is on the eastern slope of the Churfirsten-Alvier group. It consists of the village of Grabs, scattered settlements on the Grabserberg with the hamlets of Forst, Lehn and Schluss, the village section of Studen, the scattered settlement of Studnerberg and the little city of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bethesda, Maryland
Bethesda () is an unincorporated, census-designated place in southern Montgomery County, Maryland. It is located just northwest of Washington, D.C. It takes its name from a local church, the Bethesda Meeting House (1820, rebuilt 1849), which in turn took its name from Jerusalem's Pool of Bethesda. The National Institutes of Health's main campus and the Walter Reed National Military Medical Center are in Bethesda, in addition to a number of corporate and government headquarters. As an unincorporated community, Bethesda has no official boundaries. According to the 2020 U.S. census, the community had a total population of 68,056. History Bethesda is located in a region that was populated by the Piscataway and Nacotchtank tribes at the time of European colonization. Fur trader Henry Fleet became the first European to visit the area, reaching it by sailing up the Potomac River. He stayed with the Piscataway tribe from 1623 to 1627, either as a guest or prisoner (historical accounts ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Pharmacologists
American(s) may refer to: * American, something of, from, or related to the United States of America, commonly known as the "United States" or "America" ** Americans, citizens and nationals of the United States of America ** American ancestry, people who self-identify their ancestry as "American" ** American English, the set of varieties of the English language native to the United States ** Native Americans in the United States, indigenous peoples of the United States * American, something of, from, or related to the Americas, also known as "America" ** Indigenous peoples of the Americas * American (word), for analysis and history of the meanings in various contexts Organizations * American Airlines, U.S.-based airline headquartered in Fort Worth, Texas * American Athletic Conference, an American college athletic conference * American Recordings (record label), a record label previously known as Def American * American University, in Washington, D.C. Sports teams Soccer * B ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Swiss Pharmacologists
Swiss may refer to: * the adjectival form of Switzerland *Swiss people Places *Swiss, Missouri * Swiss, North Carolina *Swiss, West Virginia *Swiss, Wisconsin Other uses *Swiss-system tournament, in various games and sports *Swiss International Air Lines **Swiss Global Air Lines, a subsidiary *Swissair, former national air line of Switzerland *.swiss alternative TLD for Switzerland See also *Swiss made, label for Swiss products *Swiss cheese (other) *Switzerland (other) *Languages of Switzerland, none of which are called "Swiss" *International Typographic Style, also known as Swiss Style, in graphic design *Schweizer (other), meaning Swiss in German *Schweitzer, a family name meaning Swiss in German *Swisse Swisse is a vitamin, supplement, and skincare brand. Founded in Australia in 1969 and globally headquartered in Melbourne, and was sold to Health & Happiness, a Chinese company based in Hong Kong previously known as Biostime International, in a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2016 Deaths
This is a list of deaths of notable people, organised by year. New deaths articles are added to their respective month (e.g., Deaths in ) and then linked here. 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 See also * Lists of deaths by day The following pages, corresponding to the Gregorian calendar, list the historical events, births, deaths, and holidays and observances of the specified day of the year: Footnotes See also * Leap year * List of calendars * List of non-standard ... * Deaths by year {{DEFAULTSORT:deaths by year ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1926 Births
Events January * January 3 – Theodoros Pangalos (general), Theodoros Pangalos declares himself dictator in Greece. * January 8 **Abdul-Aziz ibn Saud is crowned King of Kingdom of Hejaz, Hejaz. ** Bảo Đại, Crown Prince Nguyễn Phúc Vĩnh Thuy ascends the throne, the last monarch of Vietnam. * January 12 – Freeman Gosden and Charles Correll premiere their radio program ''Sam 'n' Henry'', in which the two white performers portray two black characters from Harlem looking to strike it rich in the big city (it is a precursor to Gosden and Correll's more popular later program, ''Amos 'n' Andy''). * January 16 – A BBC comic radio play broadcast by Ronald Knox, about a workers' revolution, causes a panic in London. * January 21 – The Belgian Parliament accepts the Locarno Treaties. * January 26 – Scottish inventor John Logie Baird demonstrates a mechanical television system at his London laboratory for members of the Royal Institution and a report ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nature (journal)
''Nature'' is a British weekly scientific journal founded and based in London, England. As a multidisciplinary publication, ''Nature'' features peer-reviewed research from a variety of academic disciplines, mainly in science and technology. It has core editorial offices across the United States, continental Europe, and Asia under the international scientific publishing company Springer Nature. ''Nature'' was one of the world's most cited scientific journals by the Science Edition of the 2019 ''Journal Citation Reports'' (with an ascribed impact factor of 42.778), making it one of the world's most-read and most prestigious academic journals. , it claimed an online readership of about three million unique readers per month. Founded in autumn 1869, ''Nature'' was first circulated by Norman Lockyer and Alexander Macmillan as a public forum for scientific innovations. The mid-20th century facilitated an editorial expansion for the journal; ''Nature'' redoubled its efforts in exp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adrenergic Receptor
The adrenergic receptors or adrenoceptors are a class of G protein-coupled receptors that are targets of many catecholamines like norepinephrine (noradrenaline) and epinephrine (adrenaline) produced by the body, but also many medications like beta blockers, beta-2 (β2) agonists and alpha-2 (α2) agonists, which are used to treat high blood pressure and asthma, for example. Many cells have these receptors, and the binding of a catecholamine to the receptor will generally stimulate the sympathetic nervous system (SNS). The SNS is responsible for the fight-or-flight response, which is triggered by experiences such as exercise or fear-causing situations. This response dilates pupils, increases heart rate, mobilizes energy, and diverts blood flow from non-essential organs to skeletal muscle. These effects together tend to increase physical performance momentarily. History By the turn of the 19th century, it was agreed that the stimulation of sympathetic nerves could cause different ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Downregulation And Upregulation
In the biological context of organisms' production of gene products, downregulation is the process by which a cell decreases the quantity of a cellular component, such as RNA or protein, in response to an external stimulus. The complementary process that involves increases of such components is called upregulation. An example of downregulation is the cellular decrease in the expression of a specific receptor in response to its increased activation by a molecule, such as a hormone or neurotransmitter, which reduces the cell's sensitivity to the molecule. This is an example of a locally acting (negative feedback) mechanism. An example of upregulation is the response of liver cells exposed to such xenobiotic molecules as dioxin. In this situation, the cells increase their production of cytochrome P450 enzymes, which in turn increases degradation of these dioxin molecules. Downregulation or upregulation of an RNA or protein may also arise by an epigenetic alteration. Such an epigene ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jerzy Vetulani
Jerzy Adam Gracjan Vetulani (; 21 January 1936 – 6 April 2017) was a Polish neuroscientist, pharmacologist and biochemist, professor of natural sciences, member of the Polish Academy of Sciences and the Polish Academy of Learning, one of the most frequently cited Polish scientists in the field of biomedicine after 1965. Associated with the Institute of Pharmacology of the Polish Academy of Sciences in Kraków, at which he was a professor, head of the Department of Biochemistry (1976–2006), deputy director for Science Affairs (1994–2002) and vice chairman of the Scientific Council (2003–2017), he published more than 240 original research papers. He first gained recognition for an early hypothesis of the mechanism of action of antidepressant drugs, suggesting in 1975 together with Fridolin Sulser that downregulation of beta- adrenergic receptors is responsible for their effects. At the time, Vetulani was a Research Associate Professor at the Vanderbilt University (1973–1 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antidepressant
Antidepressants are a class of medication used to treat major depressive disorder, anxiety disorders, chronic pain conditions, and to help manage addictions. Common side-effects of antidepressants include dry mouth, weight gain, dizziness, headaches, sexual dysfunction, and emotional blunting. There is a slight increased risk of suicidal thinking and behavior when taken by children, adolescents, and young adults. Discontinuation syndrome may occur after stopping any antidepressant which resembles recurrent depression. Some research regarding the effectiveness of antidepressants for depression in adults has found benefits, whilst other research has not. Evidence of benefit in children and adolescents is unclear. The twenty-one most commonly prescribed antidepressant medications are more effective than placebo for the short-term (acute) treatments of adults with major depressive disorder. There is debate in the medical community about how much of the observed effects of antidep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vanderbilt University School Of Medicine
Vanderbilt University School of Medicine is a graduate medical school of Vanderbilt University located in Nashville, Tennessee. Located in the Vanderbilt University Medical Center on the southeastern side of the Vanderbilt University campus, the School of Medicine claims several Nobel laureates in the field of medicine. Through the Vanderbilt Health Affiliated Network, VUSM is affiliated with over 60 hospitals and 5,000 clinicians across Tennessee and five neighboring states, managing more than 2 million patient visits each year. It is considered one of the largest academic medical centers in the United States and is the primary resource for specialty and primary care in hundreds of adult and pediatric specialties for patients throughout the Mid-South. History The Vanderbilt University School of Medicine (abbreviated VUSM) was founded in 1851 as the school of medicine at the University of Nashville and only became affiliated with Vanderbilt University in 1874. The first degrees iss ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
