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Frei Test
The Frei test was developed in 1925 by Wilhelm Siegmund Frei, a German dermatologist, to identify lymphogranuloma venereum. Antigen made from sterile pus aspirated from previously unruptured abscesses, produced a reaction in patients with lymphogranuloma venereum when injected intradermally. Other sources of antigen have been explored, most deriving from various tissues of mice infected with Chlamydia Chlamydia, or more specifically a chlamydia infection, is a sexually transmitted infection caused by the bacterium ''Chlamydia trachomatis''. Most people who are infected have no symptoms. When symptoms do appear they may occur only several wee .... The test is no longer used but stands as a milestone in our understanding of immunology. A heat inactivated LGV 0.1ml grown in yolk sac of embryonated egg is injected intra dermally on the forearm and a control material prepared from noninfected yolk sac on the other forearm i.e. control. After 48–72 hours, an inflammatory nodule mor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wilhelm Siegmund Frei
Wilhelm Siegmund Frei (5 September 1885 – 27 January 1943) was a German dermatologist best known for his contributions to Durand-Nicolas-Favre disease, a sexually transmitted disease found mainly in tropical and subtropical climates. He is also known for the Frei Test, which was developed in 1925 for the detection of lymphogranuloma venereum (LGV). Early life Wilhelm Siegmund Frei was born in Neustadt, Upper Silesia. His father, Emil Frei, was a mining firm director, from Neustadt. His mother was Frederika Ring, who came from Austria. Wilhelm had two sisters, Gerta Frei (1887 — presumably killed by Nazis) and Josephina Frei (1888). Life Wilhelm studied medicine in Freiburg, Germany, and went on to get his doctorate in Göttingen in 1913. He met Magda Frankfurter (1885–1973) when they were both studying medicine in Freiburg and was married on 12 January 1912. They had their first child Marianne, later that year on 7 November 1912, and their second child Fritz was born ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lymphogranuloma Venereum
Lymphogranuloma venereum (LGV; also known as climatic bubo, Durand–Nicolas–Favre disease, poradenitis inguinale, lymphogranuloma inguinale, and strumous bubo) is a sexually transmitted disease caused by the invasive serovars L1, L2, L2a, L2b, or L3 of ''Chlamydia trachomatis''. LGV is primarily an infection of lymphatics and lymph nodes. ''Chlamydia trachomatis'' is the bacterium responsible for LGV. It gains entrance through breaks in the skin, or it can cross the epithelial cell layer of mucous membranes. The organism travels from the site of inoculation down the lymphatic channels to multiply within mononuclear phagocytes of the lymph nodes it passes. In developed nations, it was considered rare before 2003. However, a recent outbreak in the Netherlands among gay men has led to an increase of LGV in Europe and the United States. LGV was first described by Wallace in 1833 and again by Durand, Nicolas, and Favre in 1913. Since the 2004 Dutch outbreak many additional cases ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Abscess
An abscess is a collection of pus that has built up within the tissue of the body. Signs and symptoms of abscesses include redness, pain, warmth, and swelling. The swelling may feel fluid-filled when pressed. The area of redness often extends beyond the swelling. Carbuncles and boils are types of abscess that often involve hair follicles, with carbuncles being larger. They are usually caused by a bacterial infection. Often many different types of bacteria are involved in a single infection. In many areas of the world, the most common bacteria present is ''methicillin-resistant Staphylococcus aureus''. Rarely, parasites can cause abscesses; this is more common in the developing world. Diagnosis of a skin abscess is usually made based on what it looks like and is confirmed by cutting it open. Ultrasound imaging may be useful in cases in which the diagnosis is not clear. In abscesses around the anus, computer tomography (CT) may be important to look for deeper infection. Standa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chlamydia Infection
Chlamydia, or more specifically a chlamydia infection, is a sexually transmitted infection caused by the bacterium ''Chlamydia trachomatis''. Most people who are infected have no symptoms. When symptoms do appear they may occur only several weeks after infection; the incubation period between exposure and being able to infect others is thought to be on the order of two to six weeks. Symptoms in women may include vaginal discharge or burning with urination. Symptoms in men may include discharge from the penis, burning with urination, or pain and swelling of one or both testicles. The infection can spread to the upper genital tract in women, causing pelvic inflammatory disease, which may result in future infertility or ectopic pregnancy. Chlamydia infections can occur in other areas besides the genitals, including the anus, eyes, throat, and lymph nodes. Repeated chlamydia infections of the eyes that go without treatment can result in trachoma, a common cause of blindness i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
