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Foal Immunodeficiency Syndrome
Foal immunodeficiency syndrome (FIS), originally known as Fell pony syndrome, mainly affects two breeds of ponies: the Fell and Dales. FIS is a recessive genetic disease. Affected foals appear normal at birth, but become weak, and either die or are euthanized by three months of age due to persistent infections caused by immunodeficiency. Symptoms Affected foals are healthy when born. By one month of age, foals become depressed, lose weight, and have diarrhea, and a cough with nasal discharge. The diarrhea and cough initially improve in response to treatment, but then worsen as treatment becomes ineffective. The foal's coat becomes dry and staring and the foal weakens further by two months of age as the foal fails to suckle, and by the age of 3 months, the foal dies (or is euthanized), giving this disease a 100% mortality rate. Genetics FIS is a recessive genetic disease; affected foals are homozygous for the affected gene, that is, they have two copies of the gene, one inherited ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fell Pony
The Fell pony is a versatile working breed of mountain and moorland pony originating on Cumberland and Westmorland farms of northwest England and is used for riding and driving. The breed is closely related to its geographic neighbour, the Dales Pony, but is a little smaller and more pony-like in build. The Fell Pony is noted for hardiness, agility, strength and sure-footedness. Breed characteristics Fell Ponies vary a good deal in weight and size, so ponies may be found to carry almost any rider. The average height of the breed is , and the upper height limit for the breed is . The breed was bred for the unforgiving mountainous environment of Cumbria in north-west England, so they are adaptable to almost any temperate climate. The colours accepted in the breed are black, dark chestnut, bay, grey, and chestnuts (if both parents are registered). Piebalds, and skewbalds are not allowed. A star on the head and/or a small amount of white on or below the hind fetlock is acc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dales Pony
The Dales Pony is a British breed of pony or small horse. It originated in, and is named for, the Dales of Yorkshire in northern England. It is one the nine native mountain and moorland pony breeds of the United Kingdom, and belongs to the broader Celtic group of ponies which extends from Portugal and northern Spain to Scandinavia. It was originally a working pony, and its history is closely linked to the history of lead mining in the Dales. A stud-book was established in 1916. It was used extensively by the British Army in both world wars, and during the Second World War came close to extinction. Subsequent conservation efforts have had some success in rebuilding the population, but it is still an endangered breed, and is listed as "critical" by the Rare Breeds Survival Trust. Its qualities include strength, hardiness, stamina, courage, intelligence and good disposition. History Horses have been present and used in the Dales area from early times. Horse remains dating t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dominance (genetics)
In genetics, dominance is the phenomenon of one variant (allele) of a gene on a chromosome masking or overriding the effect of a different variant of the same gene on the other copy of the chromosome. The first variant is termed dominant and the second recessive. This state of having two different variants of the same gene on each chromosome is originally caused by a mutation in one of the genes, either new (''de novo'') or inherited. The terms autosomal dominant or autosomal recessive are used to describe gene variants on non-sex chromosomes ( autosomes) and their associated traits, while those on sex chromosomes (allosomes) are termed X-linked dominant, X-linked recessive or Y-linked; these have an inheritance and presentation pattern that depends on the sex of both the parent and the child (see Sex linkage). Since there is only one copy of the Y chromosome, Y-linked traits cannot be dominant or recessive. Additionally, there are other forms of dominance such as incomplete d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetic Disorder
A genetic disorder is a health problem caused by one or more abnormalities in the genome. It can be caused by a mutation in a single gene (monogenic) or multiple genes (polygenic) or by a chromosomal abnormality. Although polygenic disorders are the most common, the term is mostly used when discussing disorders with a single genetic cause, either in a gene or chromosome. The mutation responsible can occur spontaneously before embryonic development (a ''de novo'' mutation), or it can be Heredity, inherited from two parents who are carriers of a faulty gene (autosomal recessive inheritance) or from a parent with the disorder (autosomal dominant inheritance). When the genetic disorder is inherited from one or both parents, it is also classified as a hereditary disease. Some disorders are caused by a mutation on the X chromosome and have X-linked inheritance. Very few disorders are inherited on the Y linkage, Y chromosome or Mitochondrial disease#Causes, mitochondrial DNA (due to t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Homozygous
Zygosity (the noun, zygote, is from the Greek "yoked," from "yoke") () is the degree to which both copies of a chromosome or gene have the same genetic sequence. In other words, it is the degree of similarity of the alleles in an organism. Most eukaryotes have two matching sets of chromosomes; that is, they are diploid. Diploid organisms have the same loci on each of their two sets of homologous chromosomes except that the sequences at these loci may differ between the two chromosomes in a matching pair and that a few chromosomes may be mismatched as part of a chromosomal sex-determination system. If both alleles of a diploid organism are the same, the organism is homozygous at that locus. If they are different, the organism is heterozygous at that locus. If one allele is missing, it is hemizygous, and, if both alleles are missing, it is nullizygous. The DNA sequence of a gene often varies from one individual to another. These gene variants are called alleles. While some gen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gypsy Horse
The Gypsy Cob, also known as the Traditional Gypsy Cob, Irish Cob, Gypsy Horse, Gypsy Vanner, or Tinker Horse is a type or breed of domestic horse from the islands Great Britain and Ireland. It is a small, solidly-built horse of cob conformation and is often, but not always, piebald or skewbald; it is particularly associated with Irish Travellers and English Romanichal Travellers of Ireland and Great Britain. There was no stud-book or breed registry for horses of this type until 1996, but as breeders developed standards and recorded pedigrees, there are now organizations that register qualifying horses.. From about 1850, travelling people in the British Isles began to use a distinct type of horse to pull their vardos, the caravans in which they had just begun to live and travel. The color and look of the breed were refined in the years after the Second World War. Horses of this type were first exported to the United States in 1996. Characteristics The Gypsy horse is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Single Nucleotide Polymorphism
In genetics, a single-nucleotide polymorphism (SNP ; plural SNPs ) is a germline substitution of a single nucleotide at a specific position in the genome. Although certain definitions require the substitution to be present in a sufficiently large fraction of the population (e.g. 1% or more), many publications do not apply such a frequency threshold. For example, at a specific base position in the human genome, the G nucleotide may appear in most individuals, but in a minority of individuals, the position is occupied by an A. This means that there is a SNP at this specific position, and the two possible nucleotide variations – G or A – are said to be the alleles for this specific position. SNPs pinpoint differences in our susceptibility to a wide range of diseases, for example age-related macular degeneration (a common SNP in the CFH gene is associated with increased risk of the disease) or nonalcoholic fatty liver disease (a SNP in the PNPLA3 gene is associated with incr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sodium
Sodium is a chemical element with the symbol Na (from Latin ''natrium'') and atomic number 11. It is a soft, silvery-white, highly reactive metal. Sodium is an alkali metal, being in group 1 of the periodic table. Its only stable isotope is 23Na. The free metal does not occur in nature, and must be prepared from compounds. Sodium is the sixth most abundant element in the Earth's crust and exists in numerous minerals such as feldspars, sodalite, and halite (NaCl). Many salts of sodium are highly water-soluble: sodium ions have been leached by the action of water from the Earth's minerals over eons, and thus sodium and chlorine are the most common dissolved elements by weight in the oceans. Sodium was first isolated by Humphry Davy in 1807 by the electrolysis of sodium hydroxide. Among many other useful sodium compounds, sodium hydroxide (lye) is used in soap manufacture, and sodium chloride (edible salt) is a de-icing agent and a nutrient for animals including h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Myo-inositol
Inositol, or more precisely ''myo''-inositol, is a carbocyclic sugar that is abundant in the brain and other mammalian tissues; it mediates cell signal transduction in response to a variety of hormones, neurotransmitters, and growth factors and participates in osmoregulation. It is a sugar alcohol with half the sweetness of sucrose (table sugar). It is made naturally in the human body from glucose. A human kidney makes about two grams per day. Other tissues synthesize it too, and the highest concentration is in the brain, where it plays an important role by making other neurotransmitters and some steroid hormones bind to their receptors. Inositol is promoted as a dietary supplement in the management of polycystic ovary syndrome (PCOS). However, there is only evidence of very low quality for its efficacy in increasing fertility for IVF in women with PCOS. Overview ''myo''-Inositol plays an important role as the structural basis for a number of secondary messengers in eukaryotic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Symporter
A symporter is an integral membrane protein that is involved in the transport of two (or more) different molecules across the cell membrane in the same direction. The symporter works in the plasma membrane and molecules are transported across the cell membrane at the same time, and is, therefore, a type of cotransporter. The transporter is called a symporter, because the molecules will travel in the same direction in relation to each other. This is in contrast to the antiport transporter. Typically, the ion(s) will move down the electrochemical gradient, allowing the other molecule(s) to move against the concentration gradient. The movement of the ion(s) across the membrane is facilitated diffusion, and is coupled with the active transport of the molecule(s). In symport, two molecule move in 'similar direction' at the 'same time' Example of symport:- movement of glucose along with sodium ion Examples SGLT1 in the intestinal epithelium transports sodium ions (Na+) and glucose acro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SLC5A3
Sodium/myo-inositol cotransporter is a protein that in humans is encoded by the ''SLC5A3'' gene. Expression of the myo-inositol transport protein is regulated by osmotic stress Osmotic shock or osmotic stress is physiologic dysfunction caused by a sudden change in the solute concentration around a cell, which causes a rapid change in the movement of water across its cell membrane. Under hypertonic conditions - conditions .... See also * Solute carrier family References Further reading * * * * * * * * * * Solute carrier family {{membrane-protein-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Osmotic Stress
Osmotic shock or osmotic stress is physiologic dysfunction caused by a sudden change in the solute concentration around a cell, which causes a rapid change in the movement of water across its cell membrane. Under hypertonic conditions - conditions of high concentrations of either salts, substrates or any solute in the supernatant - water is drawn out of the cells through osmosis. This also inhibits the transport of substrates and cofactors into the cell thus “shocking” the cell. Alternatively, under hypotonic conditions - when concentrations of solutes are low - water enters the cell in large amounts, causing it to swell and either burst or undergo apoptosis. All organisms have mechanisms to respond to osmotic shock, with sensors and signal transduction networks providing information to the cell about the osmolarity of its surroundings; these signals activate responses to deal with extreme conditions. Cells that have a cell wall tend to be more resistant to osmotic shock becau ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
