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Flavopiridol
Alvocidib (INN; also known as flavopiridol) is a flavonoid alkaloid CDK9 kinase inhibitor under clinical development by Tolero Pharmaceuticals for the treatment of acute myeloid leukemia. It has been studied also for the treatment of arthritis and atherosclerotic plaque formation. The target of alvocidib is the positive transcription elongation factor P-TEFb. Treatment of cells with alvocidib leads to inhibition of P-TEFb and the loss of mRNA production. The compound is a synthetic analog of natural product rohitukine which was initially extracted from '' Aphanamixis polystachya'' (formerly ''Amoora rohituka'', hence the name) and later from ''Dysoxylum binectariferum''. Orphan drug The FDA has granted orphan drug designation to alvocidib for the treatment of patients with acute myeloid leukemia Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
P-TEFb
The positive transcription elongation factor, P-TEFb, is a multiprotein complex that plays an essential role in the regulation of transcription by RNA polymerase II (Pol II) in eukaryotes. Immediately following initiation Pol II becomes trapped in promoter proximal paused positions on the majority of human genes (Figure 1). P-TEFb is a cyclin dependent kinase that can phosphorylate the DRB sensitivity inducing factor (DSIF) and negative elongation factor (NELF), as well as the carboxyl terminal domain of the large subunit of Pol IIMarshall NF, Peng J, Xie Z, Price DH. Control of RNA polymerase II elongation potential by a novel carboxyl-terminal domain kinase. J Biol Chem 1996; 271:27176-83. and this causes the transition into productive elongation leading to the synthesis of mRNAs. P-TEFb is regulated in part by a reversible association with the 7SK snRNP.Peterlin BM, Brogie JE, Price DH. 7SK snRNA: a noncoding RNA that plays a major role in regulating eukaryotic transcription. Wi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chromones
Chromone (or 1,4-benzopyrone) is a derivative of benzopyran with a substituted keto group on the pyran ring. It is an isomer of coumarin. Derivatives of chromone are collectively known as ''chromones''. Most, though not all, chromones are also phenylpropanoids. Examples * 6,7-dimethoxy-2,3-dihydrochromone has been isolated from ''Sarcolobus globosus''. * Eucryphin, a chromone rhamnoside, can be isolated from the bark of ''Eucryphia cordifolia''. * Cromolyn (disodium cromoglicate) was found to inhibit antigen challenge as well as stress induced symptoms.HOWELL, J.B. & ALTOUNYAN, R.E. (1967). A double-blind trial of disodium cromoglycate in the treatment of allergic bronchial asthma. Lancet, 2, 539–542Abstract/ref> Cromoglicate is used as a mast cell stabilizer in allergic rhinitis, asthma and allergic conjunctivitis. * Nedocromil sodium was found to have a somewhat longer half-life than cromolyn; however, production was discontinued in the US in 2008. * Xanthone with a sec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Experimental Cancer Drugs
An experiment is a procedure carried out to support or refute a hypothesis, or determine the efficacy or likelihood of something previously untried. Experiments provide insight into cause-and-effect by demonstrating what outcome occurs when a particular factor is manipulated. Experiments vary greatly in goal and scale but always rely on repeatable procedure and logical analysis of the results. There also exist natural experimental studies. A child may carry out basic experiments to understand how things fall to the ground, while teams of scientists may take years of systematic investigation to advance their understanding of a phenomenon. Experiments and other types of hands-on activities are very important to student learning in the science classroom. Experiments can raise test scores and help a student become more engaged and interested in the material they are learning, especially when used over time. Experiments can vary from personal and informal natural comparisons (e. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Orphan Drug
An orphan drug is a pharmaceutical agent developed to treat medical conditions which, because they are so rare, would not be profitable to produce without government assistance. The conditions are referred to as orphan diseases. The assignment of orphan status to a disease and to drugs developed to treat it is a matter of public policy in many countries and has yielded medical breakthroughs that might not otherwise have been achieved, due to the economics of drug research and development. In the U.S. and the EU, it is easier to gain marketing approval for an orphan drug. There may be other financial incentives, such as an extended period of exclusivity, during which the producer has sole rights to market the drug. All are intended to encourage development of drugs which would otherwise lack sufficient profit motive to attract corporate research budgets and personnel. Definition According to the US Food and Drug Administration (FDA), an orphan drug is defined as one "intended for ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dysoxylum Binectariferum
''Dysoxylum gotadhora'' is a tree in the family Meliaceae. It is native to Bhutan, India, Laos, Nepal, Thailand, and Vietnam. The name ''Dysoxylum ficiforme'' (Wight) Gamble in India and Sri Lanka Sri Lanka (, ; si, ශ්රී ලංකා, Śrī Laṅkā, translit-std=ISO (); ta, இலங்கை, Ilaṅkai, translit-std=ISO ()), formerly known as Ceylon and officially the Democratic Socialist Republic of Sri Lanka, is an ... is categorized as the same plant as is ''D. binectariferum.'' Description The tree grows up to tall. Hartwood is reddish color. Leaves are compound, imparipinnate; apex acuminate; base asymmetric-attenuate with entire margin. Flowers are white colored and show axillary panicles inflorescence. Fruit is a four-seeded obovoid capsule, becomes red when ripened. Seeds are dark purple with white aril. References Other sources * gotadhora Trees of the Indian subcontinent Trees of Indo-China Plants described in 1875 {{Meliaceae ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aphanamixis Polystachya
''Aphanamixis polystachya'', the pithraj tree, is a species of tree in the family Meliaceae. It is native to India, Pakistan, Nepal, Bhutan, Bangladesh, Myanmar and Sri Lanka. It is a widely used as a medicinal plant in Ayurveda. Description The Bengali name of the tree is (). Another name of this tree is (). Oil is not edible and can be used as biodiesel and lighting. The very fine wood is used for construction and ship-making. The tree is 20m tall. Leaves are compound, imparipinnate, alternate; oblong-lanceolate, apex acuminate; base asymmetric; with entire margin. Flowers are polygamous and show panicles inflorescence. Fruit is a single seeded pale-reddish subglobose capsule. Common names *Assamese— *Bengali— *English—rohituka tree *Hindi— (), *Kannada—, , , *Khasi— *Kuki— *Malayalam—, *Manipuri— *Marathi— () *Rongmei— *Sanskrit—, , , , *Sinhala— *Tamil—, , *Telugu—, Chemistry The fruit shell contains triterpenes, aphanamixin. The bar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MRNA
In molecular biology, messenger ribonucleic acid (mRNA) is a single-stranded molecule of RNA that corresponds to the genetic sequence of a gene, and is read by a ribosome in the process of Protein biosynthesis, synthesizing a protein. mRNA is created during the process of Transcription (biology), transcription, where an enzyme (RNA polymerase) converts the gene into primary transcript mRNA (also known as pre-mRNA). This pre-mRNA usually still contains introns, regions that will not go on to code for the final amino acid sequence. These are removed in the process of RNA splicing, leaving only exons, regions that will encode the protein. This exon sequence constitutes mature mRNA. Mature mRNA is then read by the ribosome, and, utilising amino acids carried by transfer RNA (tRNA), the ribosome creates the protein. This process is known as Translation (biology), translation. All of these processes form part of the central dogma of molecular biology, which describes the flow of genet ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Structural Analog
A structural analog (analogue in modern traditional English; Commonwealth English), also known as a chemical analog or simply an analog, is a compound having a structure similar to that of another compound, but differing from it in respect to a certain component. It can differ in one or more atoms, functional groups, or substructures, which are replaced with other atoms, groups, or substructures. A structural analog can be imagined to be formed, at least theoretically, from the other compound. Structural analogs are often isoelectronic. Despite a high chemical similarity, structural analogs are not necessarily functional analogs and can have very different physical, chemical, biochemical, or pharmacological properties. In drug discovery, either a large series of structural analogs of an initial lead compound are created and tested as part of a structure–activity relationship study or a database is screened for structural analogs of a lead compound. Chemical analogues of il ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Flavonoid Alkaloid
A flavonoid alkaloid also known as a flavoalkaloid is a type of natural product produced by plants that contains both a flavonoid core structure and a nitrogen containing substituent so that the substance is also classified as an alkaloid. The most common flavonoid alkaloids contain a nitrogen heterocycle such as a pyridine or piperidine which is covalently bonded to the A-ring of a chromone. One flavonoid alkaloid, lilaline, was isolated from Lilium candidum in 1987. The synthesis of flavonoid alkaloids has been achieved Zhen, J., Dai, Y., Villani, T., Giurleo, D., Simon, J. and Wu, Q., 2017. Synthesis of novel flavonoid alkaloids as α-glucosidase inhibitors. Bioorganic & Medicinal Chemistry. Pharmacology A number of flavonoid alkaloids have been discovered that possess diverse pharmacological activity that may have application in the treatment of a range of diseases. One example is alvocidib, a potent CDK9 kinase inhibitor that is being developed for the treatment of chroni ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Atherosclerotic Plaque
An atheroma, or atheromatous plaque, is an abnormal and reversible accumulation of material in the inner layer of an arterial wall. The material consists of mostly macrophage cells, or debris, containing lipids, calcium and a variable amount of fibrous connective tissue. The accumulated material forms a swelling in the artery wall, which may intrude into the lumen of the artery, narrowing it and restricting blood flow. Atheroma is the pathological basis for the disease entity atherosclerosis, a subtype of arteriosclerosis. Signs and symptoms For most people, the first symptoms result from atheroma progression within the heart arteries, most commonly resulting in a heart attack and ensuing debility. The heart arteries are difficult to track because they are small (from about 5 mm down to microscopic), they are hidden deep within the chest and they never stop moving. Additionally, all mass-applied clinical strategies focus on both minimal cost and the overall safety of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
