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Filanesib
Filanesib (code name ARRY-520) is a kinesin spindle protein (KIF11) inhibitor which has recently been proposed as a cancer treatment, specifically for multiple myeloma. History of research In 2009, two in vitro studies on the effects of filanesib on either ovarian cancer cells or acute myeloid leukemia cells were published. The former reported that filanesib "...has similar anti-tumor activity in EOC pithelial ovarian cancercells as that of paclitaxel. However, unlike paclitaxel, it does not induce these pro-tumor effects in Type I cells." The detrimental effects attributed to paclitaxel were alleged to be "...due to paclitaxel-induced enhancement of NF-κB and ERK activities, and cytokine production (e.g. IL-6), which promote chemoresistance and tumor progression." The latter study also reported promising results, concluding that filanesib "...potently induces cell cycle block and subsequent death in leukemic cells via the mitochondrial pathway and has the potential to eradica ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kinesin Family Member 11
Kinesin-like protein KIF11 is a molecular motor protein that is essential in mitosis. In humans it is coded for by the gene ''KIF11''. Kinesin-like protein KIF11 is a member of the kinesin superfamily, which are nanomotors that move along microtubule tracks in the cell. Named from studies in the early days of discovery, it is also known as Kinesin-5, or as BimC, Eg5 or N-2, based on the founding members of this kinesin family. Currently, there are over 70 different eukaryotic kinesin-5 proteins identified by sequence similarity. Members of this protein family are known to be involved in various kinds of spindle dynamics and essential for mitosis. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. The human kinesin-5 protein has been actively studied for its role in mitosis and its potential as a therapeutic target for cancer. Function KIF11 (also known as kinesin-5 and Eg5) is a h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Texas MD Anderson Cancer Center
The University of Texas MD Anderson Cancer Center (colloquially MD Anderson Cancer Center) is a comprehensive cancer center in Houston, Texas. It is the largest cancer center in the U.S. and one of the original three comprehensive cancer centers in the country. It is both a degree-granting academic institution and a cancer treatment and research center located at the Texas Medical Center in Houston. It is affiliated with The University of Texas Health Science Center at Houston. According to Newsweek, MD Anderson Cancer Center is considered the best hospital in the world for oncology and related cancer treatment. History The cancer center is named after Monroe Dunaway Anderson, a banker and cotton trader from Jackson, Tennessee. He was a member of a business partnership with his brother-in-law Will Clayton. Their company became the largest cotton company in the world. Anderson feared that in the event of one of the partners' deaths, the company would lose a large amount of money t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Experimental Cancer Drugs
An experiment is a procedure carried out to support or refute a hypothesis, or determine the efficacy or likelihood of something previously untried. Experiments provide insight into cause-and-effect by demonstrating what outcome occurs when a particular factor is manipulated. Experiments vary greatly in goal and scale but always rely on repeatable procedure and logical analysis of the results. There also exist natural experimental studies. A child may carry out basic experiments to understand how things fall to the ground, while teams of scientists may take years of systematic investigation to advance their understanding of a phenomenon. Experiments and other types of hands-on activities are very important to student learning in the science classroom. Experiments can raise test scores and help a student become more engaged and interested in the material they are learning, especially when used over time. Experiments can vary from personal and informal natural comparisons (e. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dexamethasone
Dexamethasone is a glucocorticoid medication used to treat rheumatic problems, a number of skin diseases, severe allergies, asthma, chronic obstructive lung disease, croup, brain swelling, eye pain following eye surgery, superior vena cava syndrome (a complication of some forms of cancer), and along with antibiotics in tuberculosis. In adrenocortical insufficiency, it may be used in combination with a mineralocorticoid medication such as fludrocortisone. In preterm labor, it may be used to improve outcomes in the baby. It may be given by mouth, as an injection into a muscle, as an injection into a vein, as a topical cream or ointment for the skin or as a topical ophthalmic solution to the eye. The effects of dexamethasone are frequently seen within a day and last for about three days. The long-term use of dexamethasone may result in thrush, bone loss, cataracts, easy bruising, or muscle weakness. It is in pregnancy category C in the United States, meaning that it should ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bortezomib
Bortezomib, sold under the brand name Velcade among others, is an anti-cancer medication used to treat multiple myeloma and mantle cell lymphoma. This includes multiple myeloma in those who have and have not previously received treatment. It is generally used together with other medications. It is given by injection. Common side effects include nausea, diarrhea, tiredness, low platelets, fever, numbness, low white blood cells, shortness of breath, rash and abdominal pain. Other severe side effects include low blood pressure, tumour lysis syndrome, heart failure, and reversible posterior leukoencephalopathy syndrome. It is in the class of medications known as proteasome inhibitor. It works by inhibiting proteasomes, cellular complexes that break down proteins. Bortezomib was approved for medical use in the United States in 2003 and in the European Union in 2004. It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication. Medic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Expert Review Of Hematology
''Expert Review of Hematology'' is a MEDLINE-indexed, peer-reviewed, international medical journal publishing review articles and original papers on all aspects of hematology. It is part of the ''Expert Review'' series, published by Informa. The journal provides commentary and analysis to elucidate best clinical practice in hematology and to translate advances in research – in areas such as immunology, stem cell research, and cell and gene therapy – into the clinical context. Each review includes an ‘expert commentary’ and a 'five-year view' section, in which authors are asked to provide their personal view on the current status and future direction of the research discussed. The journal is aided by an international editorial advisory board of experts practicing within the field. ''Expert Review of Hematology'' is currently in its 7th year of publication, has an Impact Factor''Thomson ISI Journal Citation Reports 2013'' of 2.07, and is available online or is published in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Elotuzumab
Elotuzumab, sold under the brand name Empliciti, is a humanized IgG1 monoclonal antibody medication used in combination with lenalidomide and dexamethasone, for adults that have received 1 to 3 prior therapies for the treatment of multiple myeloma. It is also indicated for adult patients in combination with pomalidomide and dexamethasone, who have received 2 prior therapies including lenalidomide and a protease inhibitor. Administration of elotuzumab is done intravenously. Each intravenous injection of elotuzumab should be premedicated with dexamethasone, diphenhydramine, ranitidine and acetaminophen. It is being developed by Bristol Myers Squibb and AbbVie. Common side effects of elotuzumab with lenalidomide and dexamethasone includes fatigue, diarrhea, pyrexia, constipation, cough, peripheral neuropathy, nasopharyngitis, upper respiratory tract infection, decreased appetite, and pneumonia. The most common side effects of elotuzumab with pomalidomide and dexamethasone includes c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Daratumumab
Daratumumab, sold under the brand name Darzalex, is an anti-cancer monoclonal antibody medication. It binds to CD38, which is overexpressed in multiple myeloma cells. Daratumumab was originally developed by Genmab, but it is now being jointly developed by Genmab along with the Johnson & Johnson subsidiary Janssen Biotech, which acquired worldwide commercialization rights to the drug from Genmab. Daratumumab was granted breakthrough therapy drug status in 2013, for multiple myeloma. It was granted orphan drug status for multiple myeloma, diffuse large B cell lymphoma, follicular lymphoma, and mantle cell lymphoma. Medical uses In May 2018, the U.S. Food and Drug Administration (FDA) approved daratumumab for use in combination with bortezomib, melphalan and prednisone to include the treatment of people with newly diagnosed multiple myeloma who are ineligible for autologous stem cell transplant. In the European Union it is indicated as monotherapy for the treatment of adults ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Salamanca
The University of Salamanca ( es, Universidad de Salamanca) is a Spanish higher education institution, located in the city of Salamanca, in the autonomous community of Castile and León. It was founded in 1218 by King Alfonso IX. It is the oldest university in the Hispanic world and one of the oldest in the world in continuous operation. It has over 30,000 students from 50 different nationalities. History Prior to the foundation of the university, Salamanca was home to a cathedral school, known to have been in existence by 1130. The university was founded as a ''studium generale'' by the Leonese King Alfonso IX in 1218 as the ''scholas Salamanticae'', with the actual creation of the university (or the transformation of the existing school into the university) occurring between August 1218 and the following winter. A further royal charter from King Alfonso X, dated 8 May 1254, established rules for the organisation and financial endowment of the university, and referre ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fool
Fool, The Fool, or Fools may refer to: *A jester, also called a ''fool'', a type of historical entertainer known for their witty jokes *An insult referring to someone of low intelligence or easy gullibility Arts, entertainment and media Fictional characters * Fool (stock character) in literature and folklore * Shakespearean fool, an archetypal character in numerous works by Shakespeare Film * ''A Fool'', a 2015 Chinese film directed by Chen Jianbin * ''Fools'' (1970 film), an American film * Fools (2003 film), an Indian film directed by Dasari Narayana Rao * The Fool (1913 film), a 1913 British silent film * The Fool (1925 film), a lost silent film * ''The Fool'' (1990 film), a British film * ''The Fool'' (2014 film), a Russian film Gaming and Tarot * Fool (card game) * The Fool (Tarot card games) * The Fool (cartomantic Tarot cards) Literature * ''Fool'' (novel), a 2009 novel by Christopher Moore * ''Fools'' (play), a 1981 play by Neil Simon * ''The Fool'' (novel), ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Society Of Hematology
The American Society of Hematology (ASH) is a professional organization representing hematologists. It was founded in 1958. Its annual meeting is held in December of every year and has attracted more than 30,000 attendees. The society publishes the medical journal ''Blood'', the most cited peer-reviewed publication in the field, and ''Blood Advances'', an online, peer-reviewed open-access journal. The first official ASH meeting was held in Atlantic City, New Jersey, in April 1958. More than 300 hematologists met together to discuss the key research and clinical issues related to blood and blood diseases. Since the first gathering, ASH has been an important member in the development of hematology as a discipline. For more than six decades, ASH has sponsored its annual meeting. Today, ASH has more than 17,000 members, many of whom have made major advancements in understanding and treating blood diseases. Annual meeting Held each year in December, the annual meeting brings together ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
