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FOXI3
Forkead box I3 (FOXI3) is a protein that in humans is encoded by the ''FOXI3'' gene. FOXI3 is a forkhead box transcription factor that is expressed in the development of hair and teeth. One of its mutations is a dominant allele responsible for the heterozygous Hh hairless trait in dogs. It was identified in 2008. See also * Chinese Crested Dog * Mexican Hairless Dog * Peruvian Inca Orchid The Peruvian Hairless Dog, Peruvian viringo, naked dog, or Chimú dog is one of several breeds of hairless dog. It is native to Peru and it is usually raised as a pet. It has been officially recognized as part of Peru's cultural heritage. ... (Peruvian Hairless Dog) * Dog coat genetics References {{Transcription factors, g3 Animal hair Genes Forkhead transcription factors ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dog Coat Genetics
Dogs have a wide range of coat colors, patterns, textures and lengths. Dog coat color is governed by how genes are passed from dogs to their puppies and how those genes are expressed in each dog. Dogs have about 19,000 genes in their genome but only a handful affect the physical variations in their coats. Most genes come in pairs, one being from the dog’s mother and one being from its father. Genes of interest have more than one expression (or version) of an allele. Usually only one, or a small number of alleles exist for each gene. In any one gene locus a dog will either be homozygous where the gene is made of two identical alleles (one from its mother and one its father) or heterozygous where the gene is made of two different alleles (one inherited from each parent). To understand why a dog’s coat looks the way it does based on its genes requires an understanding of a handful of genes and their alleles which affect the dog's coat. For example, to find how a black and white g ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Forkhead Box
FOX (forkhead box) proteins are a family of transcription factors that play important roles in regulating the expression of genes involved in cell growth, proliferation, differentiation, and longevity. Many FOX proteins are important to embryonic development. FOX proteins also have pioneering transcription activity by being able to bind condensed chromatin during cell differentiation processes. The defining feature of FOX proteins is the forkhead box, a sequence of 80 to 100 amino acids forming a motif that binds to DNA. This forkhead motif is also known as the winged helix, due to the butterfly-like appearance of the loops in the protein structure of the domain. Forkhead proteins are a subgroup of the helix-turn-helix class of proteins. Biological roles Many genes encoding FOX proteins have been identified. For example, the FOXF2 gene encodes forkhead box F2, one of many human homologues of the ''Drosophila melanogaster'' transcription factor forkhead. FOXF2 is expresse ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chinese Crested Dog
The Chinese Crested Dog is a hairless breed of dog. Like most hairless dog breeds, the Chinese Crested Dog comes in three varieties, with hair, without hair and a combination of the two, which can be born in the same litter: the Powderpuff, the Hairless and the Hairy-Hairless. Description The Chinese Crested is considered a small breed, weighing on average . At first look, the Hairless and Powderpuff varieties of Chinese Crested Dogs appear to be two different breeds, but hairlessness is an incomplete dominant trait within a single breed. The Hairless has soft, humanlike skin, as well as tufts of hair on its paws ("socks") and tail ("plume") and long, flowing hair on its head ("crest"). In addition to being an incomplete dominant gene, the "hairless" gene has a prenatal lethal effect when homozygous. Zygotes affected with double hairless genes never develop into puppies, and are reabsorbed in the womb. All Hairless Chinese Crested Dogs are therefore heterozygous. The Hairles ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mexican Hairless Dog
The Xoloitzcuintle (or Xoloitzquintle, Xoloitzcuintli, or Xolo) is one of several breeds of hairless dog. It is found in standard, intermediate, and miniature sizes. The Xolo also comes in a coated variety, totally covered in fur. Coated and hairless can be born in the same litter as a result of the same combination of genes. The hairless variant is known as the Perro pelón mexicano or Mexican hairless dog. It is characterized by its duality, wrinkles, and dental abnormalities, along with a primitive temper. In Nahuatl, from which its name originates, it is ''xōlōitzcuintli'' (singular) and ''xōlōitzcuintin'' (plural).''Nahuatl Dictionary.'' (1997). Wired Humanities Project. University of Oregon. Retrieved September 1, 2012, frolink/ref> The name comes from the god ''Xolotl'' that according to ancient narratives is its creator and ''itzcuīntli'' , meaning 'dog' in Nahuatl language. History Ceramic sculptures of a hairless breed of dog have been found in burial sites in an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid residue ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transcription Factor
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The function of TFs is to regulate—turn on and off—genes in order to make sure that they are expressed in the desired cells at the right time and in the right amount throughout the life of the cell and the organism. Groups of TFs function in a coordinated fashion to direct cell division, cell growth, and cell death throughout life; cell migration and organization (body plan) during embryonic development; and intermittently in response to signals from outside the cell, such as a hormone. There are up to 1600 TFs in the human genome. Transcription factors are members of the proteome as well as regulome. TFs work alone or with other proteins in a complex, by promoting (as an activator), or blocking (as a repressor) the recruitment of RNA ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dominant Allele
In genetics, dominance is the phenomenon of one variant (allele) of a gene on a chromosome masking or overriding the effect of a different variant of the same gene on the other copy of the chromosome. The first variant is termed dominant and the second recessive. This state of having two different variants of the same gene on each chromosome is originally caused by a mutation in one of the genes, either new (''de novo'') or inherited. The terms autosomal dominant or autosomal recessive are used to describe gene variants on non-sex chromosomes ( autosomes) and their associated traits, while those on sex chromosomes (allosomes) are termed X-linked dominant, X-linked recessive or Y-linked; these have an inheritance and presentation pattern that depends on the sex of both the parent and the child (see Sex linkage). Since there is only one copy of the Y chromosome, Y-linked traits cannot be dominant or recessive. Additionally, there are other forms of dominance such as incomplete d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Heterozygous
Zygosity (the noun, zygote, is from the Greek "yoked," from "yoke") () is the degree to which both copies of a chromosome or gene have the same genetic sequence. In other words, it is the degree of similarity of the alleles in an organism. Most eukaryotes have two matching sets of chromosomes; that is, they are diploid. Diploid organisms have the same loci on each of their two sets of homologous chromosomes except that the sequences at these loci may differ between the two chromosomes in a matching pair and that a few chromosomes may be mismatched as part of a chromosomal sex-determination system. If both alleles of a diploid organism are the same, the organism is homozygous at that locus. If they are different, the organism is heterozygous at that locus. If one allele is missing, it is hemizygous, and, if both alleles are missing, it is nullizygous. The DNA sequence of a gene often varies from one individual to another. These gene variants are called alleles. While some gen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Peruvian Inca Orchid
The Peruvian Hairless Dog, Peruvian viringo, naked dog, or Chimú dog is one of several breeds of hairless dog. It is native to Peru and it is usually raised as a pet. It has been officially recognized as part of Peru's cultural heritage. Appearance According to the FCI breed standard, the most important aspect of its appearance is its hairlessness. The dog may have short hair on top of its head, on its feet, and on the tip of its tail. In Peru, breeders tend to prefer completely hairless dogs. The color of skin can be chocolate-brown, elephant-grey, copper, or mottled. They can be totally one color or one color with tongue pink spots. Albinism is not accepted. The eye color is linked to the skin color. It is always brown, but dogs with light colors can have clearer eyes than darker-skinned dogs. Peruvian Hairless Dogs come in three sizes: *Small 25 – 40 cm (10 – 16 inches) *Medium 40 – 50 cm (16 – 20 inches) *Large 50&nbs ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Animal Hair
Fur is a thick growth of hair that covers the skin of mammals. It consists of a combination of oily guard hair on top and thick underfur beneath. The guard hair keeps moisture from reaching the skin; the underfur acts as an insulating blanket that keeps the animal warm. The fur of mammals has many uses: protection, sensory purposes, waterproofing, and camouflaging, with the primary usage being thermoregulation. The types of hair include * ''definitive'', which may be shed after reaching a certain length; * ''vibrissae'', which are sensory hairs and are most commonly whiskers; * ''pelage'', which consists of guard hairs, under-fur, and awn hair; * '' spines'', which are a type of stiff guard hair used for defense in, for example, porcupines; * ''bristles'', which are long hairs usually used in visual signals, such as the mane of a lion; * ''velli'', often called "down fur", which insulates newborn mammals; and * ''wool'', which is long, soft, and often curly. Hair length ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genes
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a basic unit of heredity and the molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and noncoding genes. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes (many different genes) as well as gen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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