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FAM178B
FAM178B is a Coding region, protein coding that is located on the Chromosome 2, plus strand of chromosome 2.FAM178B - Protein FAM178B - Homo sapiens (Human) - FAM178B gene & protein. (n.d.). Retrieved February 25, 2019, from https://www.uniprot.org/uniprot/Q8IXR5 The Locus (genetics), locus for the gene is 2q11.2. It is also known by the aliases Family with Sequence Similarity 178, Member B, and HSPC234. In total there are 24 Exon, exons in the gene. FAM178B spans 110,720 base pairs, and contains 827 amino acids. Forms There are two Protein isoform, isoforms of the gene transcript that exist by alternative splicing, and one gene precursor. SLF2 (FAM178A) is an important paralog of FAM178B. SLF2 is predicted to play a role in the DNA repair, DNA damage response (DDR) pathway by regulating Postreplication repair, post-replication repair of UV-damaged DNA, and genomic stability maintenance. Protein structure The Molecular mass, molecular weight of the protein is 76.5 kil ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Coding Region
The coding region of a gene, also known as the coding sequence (CDS), is the portion of a gene's DNA or RNA that codes for protein. Studying the length, composition, regulation, splicing, structures, and functions of coding regions compared to non-coding regions over different species and time periods can provide a significant amount of important information regarding gene organization and evolution of prokaryotes and eukaryotes. This can further assist in mapping the human genome and developing gene therapy. Definition Although this term is also sometimes used interchangeably with exon, it is not the exact same thing: the exon is composed of the coding region as well as the 3' and 5' untranslated regions of the RNA, and so therefore, an exon would be partially made up of coding regions. The 3' and 5' untranslated regions of the RNA, which do not code for protein, are termed non-coding regions and are not discussed on this page. There is often confusion between coding region ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tertiary Structure Of FAM178B
Tertiary ( ) is a widely used but obsolete term for the geologic period from 66 million to 2.6 million years ago. The period began with the demise of the non-avian dinosaurs in the Cretaceous–Paleogene extinction event, at the start of the Cenozoic Era, and extended to the beginning of the Quaternary glaciation at the end of the Pliocene Epoch. The time span covered by the Tertiary has no exact equivalent in the current geologic time system, but it is essentially the merged Paleogene and Neogene periods, which are informally called the Early Tertiary and the Late Tertiary, respectively. The Tertiary established the Antarctic as an icy island continent. Historical use of the term The term Tertiary was first used by Giovanni Arduino during the mid-18th century. He classified geologic time into primitive (or primary), secondary, and tertiary periods based on observations of geology in Northern Italy. Later a fourth period, the Quaternary, was applied. In the early dev ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Homo Sapiens
Humans (''Homo sapiens'') are the most abundant and widespread species of primate, characterized by bipedalism and exceptional cognitive skills due to a large and complex brain. This has enabled the development of advanced tools, culture, and language. Humans are highly social and tend to live in complex social structures composed of many cooperating and competing groups, from families and kinship networks to political states. Social interactions between humans have established a wide variety of values, social norms, and rituals, which bolster human society. Its intelligence and its desire to understand and influence the environment and to explain and manipulate phenomena have motivated humanity's development of science, philosophy, mythology, religion, and other fields of study. Although some scientists equate the term ''humans'' with all members of the genus ''Homo'', in common usage, it generally refers to ''Homo sapiens'', the only extant member. Anatomically mod ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BLAT (bioinformatics)
BLAT (BLAST-like alignment tool) is a pairwise sequence alignment algorithm that was developed by Jim Kent at the University of California Santa Cruz (UCSC) in the early 2000s to assist in the assembly and annotation of the human genome. It was designed primarily to decrease the time needed to align millions of mouse genomic reads and expressed sequence tags against the human genome sequence. The alignment tools of the time were not capable of performing these operations in a manner that would allow a regular update of the human genome assembly. Compared to pre-existing tools, BLAT was ~500 times faster with performing mRNA/ DNA alignments and ~50 times faster with protein/protein alignments. Overview BLAT is one of multiple algorithms developed for the analysis and comparison of biological sequences such as DNA, RNA and proteins, with a primary goal of inferring homology in order to discover biological function of genomic sequences. It is not guaranteed to find the mathematicall ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BLAST (biotechnology)
In bioinformatics, BLAST (basic local alignment search tool) is an algorithm and program for comparing primary biological sequence information, such as the amino-acid sequences of proteins or the nucleotides of DNA and/or RNA sequences. A BLAST search enables a researcher to compare a subject protein or nucleotide sequence (called a query) with a library or database of sequences, and identify database sequences that resemble alphabet above a certain threshold. For example, following the discovery of a previously unknown gene in the mouse, a scientist will typically perform a BLAST search of the human genome to see if humans carry a similar gene; BLAST will identify sequences in the pig genome that resemble the mouse gene based on similarity of sequence. Background BLAST, which ''The New York Times'' called ''the Google of biological research'', is one of the most widely used bioinformatics programs for sequence searching. It addresses a fundamental problem in bioinformatics r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Homology (biology)
In biology, homology is similarity due to shared ancestry between a pair of structures or genes in different taxa. A common example of homologous structures is the forelimbs of vertebrates, where the wings of bats and birds, the arms of primates, the front flippers of whales and the forelegs of four-legged vertebrates like dogs and crocodiles are all derived from the same ancestral tetrapod structure. Evolutionary biology explains homologous structures adapted to different purposes as the result of descent with modification from a common ancestor. The term was first applied to biology in a non-evolutionary context by the anatomist Richard Owen in 1843. Homology was later explained by Charles Darwin's theory of evolution in 1859, but had been observed before this, from Aristotle onwards, and it was explicitly analysed by Pierre Belon in 1555. In developmental biology, organs that developed in the embryo in the same manner and from similar origins, such as from matching p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Promoter (genetics)
In genetics, a promoter is a sequence of DNA to which proteins bind to initiate transcription of a single RNA transcript from the DNA downstream of the promoter. The RNA transcript may encode a protein (mRNA), or can have a function in and of itself, such as tRNA or rRNA. Promoters are located near the transcription start sites of genes, upstream on the DNA (towards the 5' region of the sense strand). Promoters can be about 100–1000 base pairs long, the sequence of which is highly dependent on the gene and product of transcription, type or class of RNA polymerase recruited to the site, and species of organism. Promoters control gene expression in bacteria and eukaryotes. RNA polymerase must attach to DNA near a gene for transcription to occur. Promoter DNA sequences provide an enzyme binding site. The -10 sequence is TATAAT. -35 sequences are conserved on average, but not in most promoters. Artificial promoters with conserved -10 and -35 elements transcribe more slowly. All D ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Part 2 Promoter Region FAM178B
Part, parts or PART may refer to: People * Armi Pärt (born 1991), Estonian handballer *Arvo Pärt (born 1935), Estonian classical composer * Brian Part (born 1962), American child actor *Dealtry Charles Part (1882–1961), sheriff (1926–1927) and Lord Lieutenant (1943–1957) of Bedfordshire, racehorse owner *Dionysius Part (also known as ''Denys Part''; died 1475), Roman Catholic prelate, Auxiliary Bishop of Mainz (1474–1475) * John Part (born 1966), Canadian darts player *Michael Pärt (born 1977), Estonian music producer and film composer *Veronika Part (born 1978), Russian ballet dancer *Pärt Uusberg (born 1986), Estonian composer and conductor *Parts (surname) Arts, entertainment, and media * Part (music), a single strand or melody or harmony of music within a larger ensemble or a polyphonic musical composition * ''Parts'' (book), a 1997 children's book by Tedd Arnold Transportation *Pottstown Area Rapid Transit (PART), Pennsylvania, U.S. *Putnam Area Rapid Transit (PA ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Part 1 Of Promoter Region FAM178B
Part, parts or PART may refer to: People * Armi Pärt (born 1991), Estonian handballer *Arvo Pärt (born 1935), Estonian classical composer * Brian Part (born 1962), American child actor *Dealtry Charles Part (1882–1961), sheriff (1926–1927) and Lord Lieutenant (1943–1957) of Bedfordshire, racehorse owner *Dionysius Part (also known as ''Denys Part''; died 1475), Roman Catholic prelate, Auxiliary Bishop of Mainz (1474–1475) * John Part (born 1966), Canadian darts player *Michael Pärt (born 1977), Estonian music producer and film composer *Veronika Part (born 1978), Russian ballet dancer *Pärt Uusberg (born 1986), Estonian composer and conductor *Parts (surname) Arts, entertainment, and media * Part (music), a single strand or melody or harmony of music within a larger ensemble or a polyphonic musical composition * ''Parts'' (book), a 1997 children's book by Tedd Arnold Transportation *Pottstown Area Rapid Transit (PART), Pennsylvania, U.S. *Putnam Area Rapid Transit (PA ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene Expression FAM178B
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a basic unit of heredity and the molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and noncoding genes. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes (many different genes) as well as geneâ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hippocampus
The hippocampus (via Latin from Greek , 'seahorse') is a major component of the brain of humans and other vertebrates. Humans and other mammals have two hippocampi, one in each side of the brain. The hippocampus is part of the limbic system, and plays important roles in the consolidation of information from short-term memory to long-term memory, and in spatial memory that enables navigation. The hippocampus is located in the allocortex, with neural projections into the neocortex in humans, as well as primates. The hippocampus, as the medial pallium, is a structure found in all vertebrates. In humans, it contains two main interlocking parts: the hippocampus proper (also called ''Ammon's horn''), and the dentate gyrus. In Alzheimer's disease (and other forms of dementia), the hippocampus is one of the first regions of the brain to suffer damage; short-term memory loss and disorientation are included among the early symptoms. Damage to the hippocampus can also result from ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Allen Brain Atlas
The Allen Mouse and Human Brain Atlases are projects within the Allen Institute for Brain Science which seek to combine genomics with neuroanatomy by creating gene expression maps for the mouse and human brain. They were initiated in September 2003 with a $100 million donation from Paul G. Allen and the first atlas went public in September 2006. , seven brain atlases have been published: Mouse Brain Atlas, Human Brain Atlas, Developing Mouse Brain Atlas, Developing Human Brain Atlas, Mouse Connectivity Atlas, Non-Human Primate Atlas, and Mouse Spinal Cord Atlas. There are also three related projects with data banks: Glioblastoma, Mouse Diversity, and Sleep. It is the hope of the Allen Institute that their findings will help advance various fields of science, especially those surrounding the understanding of neurobiological diseases. The atlases are free and available for public use online. History In 2001, Paul Allen gathered a group of scientists, including James Watson and St ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
