Extensions Of Fisher's Method
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Extensions Of Fisher's Method
In statistics, extensions of Fisher's method are a group of approaches that allow approximately valid statistical inferences to be made when the assumptions required for the direct application of Fisher's method are not valid. Fisher's method is a way of combining the information in the p-values from different statistical tests so as to form a single overall test: this method requires that the individual test statistics (or, more immediately, their resulting p-values) should be statistically independent. Dependent statistics A principal limitation of Fisher's method is its exclusive design to combine independent p-values, which renders it an unreliable technique to combine dependent p-values. To overcome this limitation, a number of methods were developed to extend its utility. Known covariance Brown's method Fisher's method showed that the log-sum of ''k'' independent p-values follow a ''χ''2-distribution with 2''k'' degrees of freedom: : X = -2\sum_^k \log_e(p_i) \sim \chi^ ...
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Statistics
Statistics (from German language, German: ''wikt:Statistik#German, Statistik'', "description of a State (polity), state, a country") is the discipline that concerns the collection, organization, analysis, interpretation, and presentation of data. In applying statistics to a scientific, industrial, or social problem, it is conventional to begin with a statistical population or a statistical model to be studied. Populations can be diverse groups of people or objects such as "all people living in a country" or "every atom composing a crystal". Statistics deals with every aspect of data, including the planning of data collection in terms of the design of statistical survey, surveys and experimental design, experiments.Dodge, Y. (2006) ''The Oxford Dictionary of Statistical Terms'', Oxford University Press. When census data cannot be collected, statisticians collect data by developing specific experiment designs and survey sample (statistics), samples. Representative sampling as ...
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Fisher's Method
In statistics, Fisher's method, also known as Fisher's combined probability test, is a technique for data fusion or "meta-analysis" (analysis of analyses). It was developed by and named for Ronald Fisher. In its basic form, it is used to combine the results from several independence tests bearing upon the same overall hypothesis (''H''0). Application to independent test statistics Fisher's method combines extreme value probabilities from each test, commonly known as "p-values", into one test statistic (''X''2) using the formula :X^2_ \sim -2\sum_^k \log(p_i), where ''p''''i'' is the p-value for the ''i''th hypothesis test. When the p-values tend to be small, the test statistic ''X''2 will be large, which suggests that the null hypotheses are not true for every test. When all the null hypotheses are true, and the ''p''''i'' (or their corresponding test statistics) are independent, ''X''2 has a chi-squared distribution with 2''k'' degrees of freedom, where ''k'' is the num ...
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P-value
In null-hypothesis significance testing, the ''p''-value is the probability of obtaining test results at least as extreme as the result actually observed, under the assumption that the null hypothesis is correct. A very small ''p''-value means that such an extreme observed outcome would be very unlikely under the null hypothesis. Reporting ''p''-values of statistical tests is common practice in academic publications of many quantitative fields. Since the precise meaning of ''p''-value is hard to grasp, misuse is widespread and has been a major topic in metascience. Basic concepts In statistics, every conjecture concerning the unknown probability distribution of a collection of random variables representing the observed data X in some study is called a ''statistical hypothesis''. If we state one hypothesis only and the aim of the statistical test is to see whether this hypothesis is tenable, but not to investigate other specific hypotheses, then such a test is called a null ...
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Chi-squared Distribution
In probability theory and statistics, the chi-squared distribution (also chi-square or \chi^2-distribution) with k degrees of freedom is the distribution of a sum of the squares of k independent standard normal random variables. The chi-squared distribution is a special case of the gamma distribution and is one of the most widely used probability distributions in inferential statistics, notably in hypothesis testing and in construction of confidence intervals. This distribution is sometimes called the central chi-squared distribution, a special case of the more general noncentral chi-squared distribution. The chi-squared distribution is used in the common chi-squared tests for goodness of fit of an observed distribution to a theoretical one, the independence of two criteria of classification of qualitative data, and in confidence interval estimation for a population standard deviation of a normal distribution from a sample standard deviation. Many other statistical tests a ...
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Harmonic Mean P-value
The harmonic mean ''p''-value (HMP) is a statistical technique for addressing the multiple comparisons problem that controls the strong-sense family-wise error rate (this claim has been disputed). It improves on the power of Bonferroni correction by performing combined tests, i.e. by testing whether ''groups'' of ''p''-values are statistically significant, like Fisher's method. However, it avoids the restrictive assumption that the ''p''-values are independent, unlike Fisher's method. Consequently, it controls the false positive rate when tests are dependent, at the expense of less power (i.e. a higher false negative rate) when tests are independent. Besides providing an alternative to approaches such as Bonferroni correction that controls the stringent family-wise error rate, it also provides an alternative to the widely-used Benjamini-Hochberg procedure (BH) for controlling the less-stringent false discovery rate. This is because the power of the HMP to detect significant ''gr ...
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Student's T-distribution
In probability and statistics, Student's ''t''-distribution (or simply the ''t''-distribution) is any member of a family of continuous probability distributions that arise when estimating the mean of a normally distributed population in situations where the sample size is small and the population's standard deviation is unknown. It was developed by English statistician William Sealy Gosset under the pseudonym "Student". The ''t''-distribution plays a role in a number of widely used statistical analyses, including Student's ''t''-test for assessing the statistical significance of the difference between two sample means, the construction of confidence intervals for the difference between two population means, and in linear regression analysis. Student's ''t''-distribution also arises in the Bayesian analysis of data from a normal family. If we take a sample of n observations from a normal distribution, then the ''t''-distribution with \nu=n-1 degrees of freedom can be de ...
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Cauchy Distribution
The Cauchy distribution, named after Augustin Cauchy, is a continuous probability distribution. It is also known, especially among physicists, as the Lorentz distribution (after Hendrik Lorentz), Cauchy–Lorentz distribution, Lorentz(ian) function, or Breit–Wigner distribution. The Cauchy distribution f(x; x_0,\gamma) is the distribution of the -intercept of a ray issuing from (x_0,\gamma) with a uniformly distributed angle. It is also the distribution of the ratio of two independent normally distributed random variables with mean zero. The Cauchy distribution is often used in statistics as the canonical example of a "pathological" distribution since both its expected value and its variance are undefined (but see below). The Cauchy distribution does not have finite moments of order greater than or equal to one; only fractional absolute moments exist., Chapter 16. The Cauchy distribution has no moment generating function. In mathematics, it is closely related to the P ...
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