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European Chemical Substances Information System
The European chemical Substances Information System (ESIS) was a chemoinformatics database that stored information system on chemicals of the European Union. It was created by the former European Chemicals Bureau, which completed its mandate in 2008, in the year 2003. ESIS was set up by the Joint Research Centre of the European Commission in order to make data on the safety of chemicals more readily accessible to the public, offering a single search tool on chemicals and the legislation under which they are presently covered. By October 3, 2013, ESIS contained 14,897 substance records. ESIS provided access to several registers and lists, shown below: * EINECS (European Inventory of Existing Commercial chemical Substances) * NLP (No-Longer Polymers) * BPD ( Biocidal Products Directive) * Export and Import of Dangerous Chemicals The following databases were originally part of ESIS, but have been taken over by the European Chemicals Agency (ECHA), which will also ensure further updat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemoinformatics
Cheminformatics (also known as chemoinformatics) refers to use of physical chemistry theory with computer and information science techniques—so called "''in silico''" techniques—in application to a range of descriptive and prescriptive problems in the field of chemistry, including in its applications to biology and related molecular fields. Such '' in silico'' techniques are used, for example, by pharmaceutical companies and in academic settings to aid and inform the process of drug discovery, for instance in the design of well-defined combinatorial libraries of synthetic compounds, or to assist in structure-based drug design. The methods can also be used in chemical and allied industries, and such fields as environmental science and pharmacology, where chemical processes are involved or studied. History Cheminformatics has been an active field in various guises since the 1970s and earlier, with activity in academic departments and commercial pharmaceutical research a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
European Chemicals Agency
The European Chemicals Agency (ECHA; ) is an agency of the European Union which manages the technical and administrative aspects of the implementation of the European Union regulation called Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH). ECHA is the driving force among regulatory authorities in implementing the EU's chemicals legislation. ECHA has to ascertain that companies comply with the legislation, advances the safe use of chemicals, provides information on chemicals and addresses chemicals of concern. It is located in Helsinki, Finland. ECHA is an independent and mature regulatory agency established by REACH. It is not a subsidiary entity of the European Commission. The agency, currently headed by Acting Executive Director Shay O’Malley, started working on 1 June 2007. Establishment The ECHA was created by European Union regulation dating from 18 December 2006 to manage the then-new legislation to regulate the manufacture and use of chemic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cheminformatics
Cheminformatics (also known as chemoinformatics) refers to use of physical chemistry theory with computer and information science techniques—so called "''in silico''" techniques—in application to a range of descriptive and prescriptive problems in the field of chemistry, including in its applications to biology and related molecular fields. Such ''in silico'' techniques are used, for example, by pharmaceutical companies and in academic settings to aid and inform the process of drug discovery, for instance in the design of well-defined combinatorial libraries of synthetic compounds, or to assist in structure-based drug design. The methods can also be used in chemical and allied industries, and such fields as environmental science and pharmacology, where chemical processes are involved or studied. History Cheminformatics has been an active field in various guises since the 1970s and earlier, with activity in academic departments and commercial pharmaceutical research and dev ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Risk Assessment
Broadly speaking, a risk assessment is the combined effort of: # identifying and analyzing potential (future) events that may negatively impact individuals, assets, and/or the environment (i.e. hazard analysis); and # making judgments "on the tolerability of the risk on the basis of a risk analysis" while considering influencing factors (i.e. risk evaluation). Put in simpler terms, a risk assessment determines possible mishaps, their likelihood and consequences, and the tolerances for such events. The results of this process may be expressed in a quantitative or qualitative fashion. Risk assessment is an inherent part of a broader risk management strategy to help reduce any potential risk-related consequences. Need Individual risk assessment Risk assessment are done in individual cases, including patient and physician interactions. Individual judgements or assessments of risk may be affected by psychological, ideological, religious or otherwise subjective factors, which impa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
IUCLID
IUCLID (; International Uniform Chemical Information Database) is a software application to capture, store, maintain and exchange data on intrinsic and hazard properties of chemical substances. Distributed free of charge, the software is especially useful to chemical industry companies and to government authorities. It is the key tool for chemical industry to fulfill data submission obligations under REACH, the most important European Union legal document covering the production and use of chemical substances. The software is maintained by the European Chemicals Agency, ECHA. The latest version, version 6, was made available on 29 April 2016. History IUCLID versions 1 to 4 1993: First version of IUCLID for the European Existing Substances Regulation 793/93/EEC. 1999: IUCLID becomes the recommended tool for the OECD HPV Programme. 2000: IUCLID is the software prescribed in the EU Biocides legislation to notify existing active substances (Art. 4 of Commission Regulation (EC) N ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Persistent, Bioaccumulative And Toxic Substances
Persistent, bioaccumulative and toxic substances (PBTs) are a class of compounds that have high resistance to degradation from abiotic and biotic factors, high mobility in the environment and high toxicity. Because of these factors PBTs have been observed to have a high order of bioaccumulation and biomagnification, very long retention times in various media, and widespread distribution across the globe. Most PBTs in the environment are either created through industry or are unintentional byproducts.Blais J. 2005. Biogeochemistry of persistent bioaccumulative toxicants: processes affecting the transport of contaminants to remote areas. Canadian Journal of Fisheries and Aquatic Sciences 62: 236-243. History Persistent organic pollutants (POPs) were the focal point of the Stockholm Convention 2001 due to their persistence, ability to biomagnify and the threat posed to both human health and the environment. The goal of the Stockholm Convention was to determine the classification of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Persistent Bioaccumulative Toxic Pollutants
Persistent organic pollutants (POPs), sometimes known as "forever chemicals", are organic compounds that are resistant to environmental degradation through chemical, biological, and photolytic processes. They are toxic chemicals that adversely affect human health and the environment around the world. Because they can be transported by wind and water, most POPs generated in one country can and do affect people and wildlife far from where they are used and released. The effect of POPs on human and environmental health was discussed, with intention to eliminate or severely restrict their production, by the international community at the Stockholm Convention on Persistent Organic Pollutants in 2001. Most POPs are pesticides or insecticides, and some are also solvents, pharmaceuticals, and industrial chemicals. Although some POPs arise naturally (e.g. from volcanoes), most are man-made. The "dirty dozen" POPs identified by the Stockholm Convention include aldrin, chlordane, dieldri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
European List Of Notified Chemical Substances
The European List of Notified Chemical Substances (ELINCS) provides an EINECS number. The system was used by the European Union to identify commercially available chemical substances. Since 1 June 2007 EU Members, Liechtenstein, Iceland and Norway Norway, officially the Kingdom of Norway, is a Nordic country in Northern Europe, the mainland territory of which comprises the western and northernmost portion of the Scandinavian Peninsula. The remote Arctic island of Jan Mayen and t ... apply the REACH protocol (Registration, Evaluation, Authorisation of Chemicals). References {{reflist External links EC Inventory Chemical numbering schemes European Union law Regulation of chemicals in the European Union ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biocide
A biocide is defined in the European legislation as a chemical substance or microorganism intended to destroy, deter, render harmless, or exert a controlling effect on any harmful organism. The US Environmental Protection Agency (EPA) uses a slightly different definition for biocides as "a diverse group of poisonous substances including preservatives, insecticides, disinfectants, and pesticides used for the control of organisms that are harmful to human or animal health or that cause damage to natural or manufactured products". When compared, the two definitions roughly imply the same, although the US EPA definition includes plant protection products and some veterinary medicines. The terms "biocides" and "pesticides" are regularly interchanged, and often confused with "plant protection products". To clarify this, pesticides include both biocides and plant protection products, where the former refers to substances for non-food and feed purposes and the latter refers to substances ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Database
In computing, a database is an organized collection of data stored and accessed electronically. Small databases can be stored on a file system, while large databases are hosted on computer clusters or cloud storage. The design of databases spans formal techniques and practical considerations, including data modeling, efficient data representation and storage, query languages, security and privacy of sensitive data, and distributed computing issues, including supporting concurrent access and fault tolerance. A database management system (DBMS) is the software that interacts with end users, applications, and the database itself to capture and analyze the data. The DBMS software additionally encompasses the core facilities provided to administer the database. The sum total of the database, the DBMS and the associated applications can be referred to as a database system. Often the term "database" is also used loosely to refer to any of the DBMS, the database system or an appli ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
EINECS
The European Community number (EC number) is a unique seven-digit identifier that was assigned to substances for regulatory purposes within the European Union by the European Commission. The ''EC Inventory'' comprises three individual inventories, EINECS, ELINCS and the NLP list. Structure The EC number may be written in a general form as: NNN-NNN-R, where R is a check digit and N represents integers. The check digit is calculated using the ISBN method. According to this method, the check digit R is the following sum modulo 11: :R = (N_1 + 2 N_2 + 3N_3 + 4N_4 + 5N_5 + 6N_6) \bmod 11 If the remainder R is equal to 10, that combination of digits is not used for an EC number. To illustrate, the EC number of dexamethasone is 200-003-9. N1 is 2, N2 through N5 are 0, and N6 is 3. :\frac = \frac = 1 + \frac The remainder is 9, which is the check digit. There is a set of 181 ELINCS numbers (EC numbers starting with 4) for which the checksum by the above algorithm is 10 and the n ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
European Commission
The European Commission (EC) is the executive of the European Union (EU). It operates as a cabinet government, with 27 members of the Commission (informally known as "Commissioners") headed by a President. It includes an administrative body of about 32,000 European civil servants. The Commission is divided into departments known as Directorates-General (DGs) that can be likened to departments or ministries each headed by a Director-General who is responsible to a Commissioner. There is one member per member state, but members are bound by their oath of office to represent the general interest of the EU as a whole rather than their home state. The Commission President (currently Ursula von der Leyen) is proposed by the European Council (the 27 heads of state/governments) and elected by the European Parliament. The Council of the European Union then nominates the other members of the Commission in agreement with the nominated President, and the 27 members as a team are then ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
