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Eupenicillium Shearii
''Eupenicillium shearii'' is a fungus in the genus ''Penicillium''. The Type (biology), type strain was first isolated in 1931 by Dr. Otto R. Reinking from a soil sample taken in Honduras. It has also been isolated from soil collected in the Democratic Republic of the Congo and near Abidjan. It was named and described in 1967. ''E. shearii'' is of interest to medicinal chemists due to its production of kaitocephalin, a substance that may protect the brain and nervous system. Therefore, kaitocephalin is an attractive scaffold for drug development. Drugs based on this compound may be used to treat neurological conditions including Alzheimer%27s_disease, Alzheimer’s, amyotrophic lateral sclerosis (ALS), and stroke.Philip Garner et al., "A concise [C+NC+CC] coupling-enabled synthesis of kaitocephalin", ''Chem. Commun.'' 50 (2014): 4908-4910 See also *List of Penicillium species References {{reflist Penicillium Fungi described in 1931 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fungus
A fungus ( : fungi or funguses) is any member of the group of eukaryotic organisms that includes microorganisms such as yeasts and molds, as well as the more familiar mushrooms. These organisms are classified as a kingdom, separately from the other eukaryotic kingdoms, which by one traditional classification include Plantae, Animalia, Protozoa, and Chromista. A characteristic that places fungi in a different kingdom from plants, bacteria, and some protists is chitin in their cell walls. Fungi, like animals, are heterotrophs; they acquire their food by absorbing dissolved molecules, typically by secreting digestive enzymes into their environment. Fungi do not photosynthesize. Growth is their means of mobility, except for spores (a few of which are flagellated), which may travel through the air or water. Fungi are the principal decomposers in ecological systems. These and other differences place fungi in a single group of related organisms, named the ''Eumycota'' (''true f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Penicillium
''Penicillium'' () is a genus of ascomycetous fungi that is part of the mycobiome of many species and is of major importance in the natural environment, in food spoilage, and in food and drug production. Some members of the genus produce penicillin, a molecule that is used as an antibiotic, which kills or stops the growth of certain kinds of bacteria. Other species are used in cheesemaking. According to the ''Dictionary of the Fungi'' (10th edition, 2008), the widespread genus contains over 300 species. Taxonomy The genus was first described in the scientific literature by Johann Heinrich Friedrich Link in his 1809 work ''Observationes in ordines plantarum naturales''; he wrote, "''Penicillium. Thallus e floccis caespitosis septatis simplicibus aut ramosis fertilibus erectis apice penicillatis''", where ''penicillatis'' means "having tufts of fine hair". Link included three species—'' P. candidum'', '' P. expansum'', and '' P. glaucum''—all of which produ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Type (biology)
In biology, a type is a particular specimen (or in some cases a group of specimens) of an organism to which the scientific name of that organism is formally attached. In other words, a type is an example that serves to anchor or centralizes the defining features of that particular taxon. In older usage (pre-1900 in botany), a type was a taxon rather than a specimen. A taxon is a scientifically named grouping of organisms with other like organisms, a set that includes some organisms and excludes others, based on a detailed published description (for example a species description) and on the provision of type material, which is usually available to scientists for examination in a major museum research collection, or similar institution. Type specimen According to a precise set of rules laid down in the International Code of Zoological Nomenclature (ICZN) and the International Code of Nomenclature for algae, fungi, and plants (ICN), the scientific name of every taxon is almost al ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Honduras
Honduras, officially the Republic of Honduras, is a country in Central America. The republic of Honduras is bordered to the west by Guatemala, to the southwest by El Salvador, to the southeast by Nicaragua, to the south by the Pacific Ocean at the Gulf of Fonseca, and to the north by the Gulf of Honduras, a large inlet of the Caribbean Sea. Its capital and largest city is Tegucigalpa. Honduras was home to several important Mesoamerican cultures, most notably the Maya, before the Spanish Colonization in the sixteenth century. The Spanish introduced Catholicism and the now predominant Spanish language, along with numerous customs that have blended with the indigenous culture. Honduras became independent in 1821 and has since been a republic, although it has consistently endured much social strife and political instability, and remains one of the poorest countries in the Western Hemisphere. In 1960, the northern part of what was the Mosquito Coast was transferred from Nicara ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Democratic Republic Of The Congo
The Democratic Republic of the Congo (french: République démocratique du Congo (RDC), colloquially "La RDC" ), informally Congo-Kinshasa, DR Congo, the DRC, the DROC, or the Congo, and formerly and also colloquially Zaire, is a country in Central Africa. It is bordered to the northwest by the Republic of the Congo, to the north by the Central African Republic, to the northeast by South Sudan, to the east by Uganda, Rwanda, and Burundi, and by Tanzania (across Lake Tanganyika), to the south and southeast by Zambia, to the southwest by Angola, and to the west by the South Atlantic Ocean and the Cabinda exclave of Angola. By area, it is the second-largest country in Africa and the 11th-largest in the world. With a population of around 108 million, the Democratic Republic of the Congo is the most populous officially Francophone country in the world. The national capital and largest city is Kinshasa, which is also the nation's economic center. Centered on the Cong ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Abidjan
Abidjan ( , ; N'Ko script, N’ko: ߊߓߌߖߊ߲߬) is the economic capital of the Ivory Coast. As of the Demographics of Ivory Coast, 2021 census, Abidjan's population was 6.3 million, which is 21.5 percent of overall population of the country, making it the sixth most populous city proper in Africa, after Lagos, Cairo, Kinshasa, Dar es Salaam, and Johannesburg. A cultural crossroads of West Africa, Abidjan is characterised by a high level of industrialisation and urbanisation. It also is one of the most populous French-speaking cities in Africa. The city expanded quickly after the construction of a new wharf in 1931, followed by its designation as the capital city of the then-French colony in 1933. The completion of the Vridi Canal in 1951 enabled Abidjan to become an important sea port. Abidjan remained the capital of the Ivory Coast after its independence from France in 1960. In 1983, the city of Yamoussoukro was designated as the official political capital of Ivory Coast. Ho ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kaitocephalin
Kaitocephalin is a non-selective ionotropic glutamate receptor antagonist, meaning it blocks the action of the neurotransmitter glutamate. It is produced by the fungus '' Eupenicillium shearii''. Although similar molecules have been produced synthetically, kaitocephalin is the only known naturally occurring glutamate receptor antagonist. There is some evidence that kaitocephalin can protect the brain and central nervous system, so it is said to have neuroprotective properties. Kaitocephalin protects neurons by inhibiting excitotoxicity, a mechanism which causes cell death by overloading neurons with glutamate. Because of this, it is of interest as a potential scaffold for drug development. Drugs based on kaitocephalin may be useful in treating neurological conditions, including Alzheimer's, amyotrophic lateral sclerosis (ALS), and stroke. Synthesis Kaitocephalin was originally isolated in 1997 from ''Eupenicillium shearii'', a fungus in the same genus as those that produce ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alzheimer%27s Disease
Alzheimer's disease (AD) is a neurodegeneration, neurodegenerative disease that usually starts slowly and progressively worsens. It is the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in short-term memory, remembering recent events. As the disease advances, symptoms can include primary progressive aphasia, problems with language, Orientation (mental), disorientation (including easily getting lost), mood swings, loss of motivation, self-neglect, and challenging behaviour, behavioral issues. As a person's condition declines, they often withdraw from family and society. Gradually, bodily functions are lost, ultimately leading to death. Although the speed of progression can vary, the typical life expectancy following diagnosis is three to nine years. The cause of Alzheimer's disease is poorly understood. There are many environmental and genetic risk factors associated with its development. The strongest genetic risk factor is from an alle ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND) or Lou Gehrig's disease, is a neurodegenerative disease that results in the progressive loss of motor neurons that control voluntary muscles. ALS is the most common type of motor neuron diseases. Early symptoms of ALS include stiff muscles, muscle twitches, and gradual increasing weakness and muscle wasting. ''Limb-onset ALS'' begins with weakness in the arms or legs, while ''bulbar-onset ALS'' begins with difficulty speaking or swallowing. Half of the people with ALS develop at least mild difficulties with thinking and behavior, and about 15% develop frontotemporal dementia. Most people experience pain. The affected muscles are responsible for chewing food, speaking, and walking. Motor neuron loss continues until the ability to eat, speak, move, and finally the ability to breathe is lost. ALS eventually causes paralysis and early death, usually from respiratory failure. Most cases of ALS (a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stroke
A stroke is a medical condition in which poor blood flow to the brain causes cell death. There are two main types of stroke: ischemic, due to lack of blood flow, and hemorrhagic, due to bleeding. Both cause parts of the brain to stop functioning properly. Signs and symptoms of a stroke may include an inability to move or feel on one side of the body, problems understanding or speaking, dizziness, or loss of vision to one side. Signs and symptoms often appear soon after the stroke has occurred. If symptoms last less than one or two hours, the stroke is a transient ischemic attack (TIA), also called a mini-stroke. A hemorrhagic stroke may also be associated with a severe headache. The symptoms of a stroke can be permanent. Long-term complications may include pneumonia and loss of bladder control. The main risk factor for stroke is high blood pressure. Other risk factors include high blood cholesterol, tobacco smoking, obesity, diabetes mellitus, a previous TIA, end-st ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
List Of Penicillium Species
This is a list of ''Penicillium'' species. The genus has over 300 species. Species A * '' Penicillium abidjanum'' * '' Penicillium adametzii'' * '' Penicillium adametzioides'' * '' Penicillium aeris'' * '' Penicillium aethiopicum'' * '' Penicillium albicans'' * '' Penicillium albidum '' * ''Penicillium albocoremium'' * '' Penicillium alexiae'' * '' Penicillium alfredii'' * '' Penicillium alicantinum'' * '' Penicillium allahabadense'' * '' Penicillium allii'' * '' Penicillium allii-sativi'' * '' Penicillium alogum'' * '' Penicillium alutaceum'' * ''Penicillium anatolicum'' * '' Penicillium amagasakiense'' * '' Penicillium amaliae'' * '' Penicillium amphipolaria'' * ''Penicillium anatolicum'' * ''Penicillium angulare'' * ''Penicillium angustiporcatum'' * ''Penicillium antarcticum'' * ''Penicillium annulatum'' * ''Penicillium aotearoae'' * ''Penicillium araracuarense'' * ''Penicillium ardesiacum'' * ''Penicillium arenicola'' * ''Penicillium aragonense'' * ''Penicillium arian ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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