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Erik De Clercq
Erik De Clercq M.D. Ph.D., (1941) is a Belgian physician and biologist. He studied medicine at the Catholic University of Leuven (Leuven, Belgium). He did research and later became a professor at the Department of Medicine, where he specialised in microbiology and immunology. He worked at the Rega Institute for Medical Research. He is one of the founders and the second president of the International Society for Antiviral Research. Since 1976 Erik De Clercq has collaborated on the development of new antiretroviral drugs with Antonín Holý, of the Institute of Organic Chemistry and Biochemistry (IOCB Prague) of the Czechoslovak Academy of Sciences in Prague, Czech Republic. Together they discovered amongst others Tenofovir. In 2008 he received the European Inventor Award Lifetime Achievement for landmark contributions to antiviral treatment, including the development of the drug cocktail for AIDS. In 2010 De Clercq was awarded the 2010 Dr. Paul Janssen Award for Biomedica ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Virology
Virology is the Scientific method, scientific study of biological viruses. It is a subfield of microbiology that focuses on their detection, structure, classification and evolution, their methods of infection and exploitation of host (biology), host cell (biology), cells for reproduction, their interaction with host organism physiology and immunity, the diseases they cause, the techniques to isolate and culture them, and their use in research and therapy. The identification of the causative agent of tobacco mosaic disease (TMV) as a novel pathogen by Martinus Beijerinck (1898) is now acknowledged as being the history of virology, official beginning of the field of virology as a discipline distinct from bacteriology. He realized the source was neither a bacterial nor a fungal infection, but something completely different. Beijerinck used the word "virus" to describe the mysterious agent in his 'contagium vivum fluidum' ('contagious living fluid'). Rosalind Franklin proposed the f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Czechoslovak Academy Of Sciences
The Czechoslovak Academy of Sciences (Czech: ''Československá akademie věd'', Slovak: ''Česko-slovenská akadémia vied'') was established in 1953 to be the scientific center for Czechoslovakia. It was succeeded by the Czech Academy of Sciences (''Akademie věd České republiky'') and Slovak Academy of Sciences (''Slovenská akadémia vied'') in 1992. History The Royal Czech Society of Sciences, which encompassed both the humanities and the natural sciences, was established in the Czech Crown lands in 1784. After the Communist regime came to power in Czechoslovakia in 1948, all scientific, non-university institutions and learned societies were dissolved and, in their place, the Czechoslovak Academy of Sciences was founded by Act No. 52/1952. It comprised both a complex of research institutes and a learned society. The Slovak Academy of Sciences, established in 1942 and re-established in 1953, was a formal part of the Czechoslovak Academy of Sciences from 1960 to 1992. During ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Catholic University Of Leuven (1834–1968) Alumni
{{School disambiguation ...
University of Leuven or University of Louvain (french: Université de Louvain, link=no; nl, Universiteit Leuven, link=no) may refer to: * Old University of Leuven (1425–1797) * State University of Leuven (1817–1835) * Catholic University of Leuven (1834–1968) * Katholieke Universiteit Leuven or KU Leuven (1968–), a Dutch-speaking university in Leuven * Université catholique de Louvain or UCLouvain (1968–), a French-speaking university in Louvain-la-Neuve, Brussels, Mons, Namur, Charleroi and Tournai See also * Split of the Catholic University of Leuven * Universities in Leuven * Leuven University Press Leuven University Press ( nl, Universitaire Pers Leuven) is a university press located in Leuven, Belgium. It was established in 1971 in association with KU Leuven KU Leuven (or Katholieke Universiteit Leuven) is a Catholic research univ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Belgian Immunologists
Belgian may refer to: * Something of, or related to, Belgium * Belgians, people from Belgium or of Belgian descent * Languages of Belgium, languages spoken in Belgium, such as Dutch, French, and German *Ancient Belgian language, an extinct language formerly spoken in Gallia Belgica *Belgian Dutch or Flemish, a variant of Dutch *Belgian French, a variant of French *Belgian horse (other), various breeds of horse *Belgian waffle, in culinary contexts * SS ''Belgian'', a cargo ship in service with F Leyland & Co Ltd from 1919 to 1934 *''The Belgian'', a 1917 American silent film See also * *Belgica (other) Gallia Belgica was a province of the Roman Empire in present-day Belgium, Luxembourg, and the Netherlands. Belgica may also refer to: Places * Belgica Glacier, Antarctica * Belgica Guyot, an undersea tablemount off Antarctica * Belgica Mountain ... * Belgic (other) {{Disambiguation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Flemish Scientists
Flemish (''Vlaams'') is a Low Franconian dialect cluster of the Dutch language. It is sometimes referred to as Flemish Dutch (), Belgian Dutch ( ), or Southern Dutch (). Flemish is native to Flanders, a historical region in northern Belgium; it is spoken by Flemings, the dominant ethnic group of the region. Outside of Flanders, it is also spoken to some extent in French Flanders and the Dutch Zeelandic Flanders. Terminology The term ''Flemish'' itself has become ambiguous. Nowadays, it is used in at least five ways, depending on the context. These include: # An indication of Dutch written and spoken in Flanders including the Dutch standard language as well as the non-standardized dialects, including intermediate forms between vernacular dialects and the standard. Some linguists avoid the term ''Flemish'' in this context and prefer the designation ''Belgian-Dutch'' or ''South-Dutch'' # A synonym for the so-called intermediate language in Flanders region, the # An indicatio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1941 Births
Events Below, the events of World War II have the "WWII" prefix. January * January–August – 10,072 men, women and children with mental and physical disabilities are asphyxiated with carbon monoxide in a gas chamber, at Hadamar Euthanasia Centre in Germany, in the first phase of mass killings under the Action T4 program here. * January 1 – Thailand's Prime Minister Plaek Phibunsongkhram decrees January 1 as the official start of the Thai solar calendar new year (thus the previous year that began April 1 had only 9 months). * January 3 – A decree (''Normalschrifterlass'') promulgated in Germany by Martin Bormann, on behalf of Adolf Hitler, requires replacement of blackletter typefaces by Antiqua. * January 4 – The short subject ''Elmer's Pet Rabbit'' is released, marking the second appearance of Bugs Bunny, and also the first to have his name on a title card. * January 5 – WWII: Battle of Bardia in Libya: Australian and British troops def ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anti-viral Therapy
Antiviral drugs are a class of medication used for treating viral infections. Most antivirals target specific viruses, while a broad-spectrum antiviral is effective against a wide range of viruses. Unlike most antibiotics, antiviral drugs do not destroy their target pathogen; instead they inhibit its development. Antiviral drugs are one class of antimicrobials, a larger group which also includes antibiotic (also termed antibacterial), antifungal and antiparasitic drugs, or antiviral drugs based on monoclonal antibodies. Most antivirals are considered relatively harmless to the host, and therefore can be used to treat infections. They should be distinguished from viricides, which are not medication but deactivate or destroy virus particles, either inside or outside the body. Natural viricides are produced by some plants such as eucalyptus and Australian tea trees. Medical uses Most of the antiviral drugs now available are designed to help deal with HIV, herpes viruses, the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nucleotide Analogues
Reverse-transcriptase inhibitors (RTIs) are a class of antiretroviral drugs used to treat HIV infection or AIDS, and in some cases hepatitis B. RTIs inhibit activity of reverse transcriptase, a viral DNA polymerase that is required for replication of HIV and other retroviruses. Mechanism of action When HIV infects a cell, reverse transcriptase copies the viral single stranded RNA genome into a double-stranded viral DNA. The viral DNA is then integrated into the host chromosomal DNA, which then allows host cellular processes, such as transcription and translation, to reproduce the virus. RTIs block reverse transcriptase's enzymatic function and prevent completion of synthesis of the double-stranded viral DNA, thus preventing HIV from multiplying. A similar process occurs with other types of viruses. The hepatitis B virus, for example, carries its genetic material in the form of DNA, and employs an RNA-dependent DNA polymerase to replicate. Some of the same compounds used as RTIs c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anti-HIV Medications
The human immunodeficiency viruses (HIV) are two species of '' Lentivirus'' (a subgroup of retrovirus) that infect humans. Over time, they cause acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. Without treatment, average survival time after infection with HIV is estimated to be 9 to 11 years, depending on the HIV subtype. In most cases, HIV is a sexually transmitted infection and occurs by contact with or transfer of blood, pre-ejaculate, semen, and vaginal fluids. Non-sexual transmission can occur from an infected mother to her infant during pregnancy, during childbirth by exposure to her blood or vaginal fluid, and through breast milk. Within these bodily fluids, HIV is present as both free virus particles and virus within infected immune cells. Research has shown (for both same-sex and opposite-sex couples) that HIV is untransmittable throug ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tenofovir
Tenofovir disoproxil, sold under the trade name Viread among others, is a medication used to treat chronic hepatitis B and to prevent and treat HIV/AIDS. It is generally recommended for use with other antiretrovirals. It may be used for prevention of HIV/AIDS among those at high risk before exposure, and after a needlestick injury or other potential exposure. It is sold both by itself and together in combinations such as emtricitabine/tenofovir, efavirenz/emtricitabine/tenofovir, and elvitegravir/cobicistat/emtricitabine/tenofovir. It does not cure HIV/AIDS or hepatitis B. It is available by mouth as a tablet or powder. Common side effects include nausea, rash, diarrhea, headache, pain, depression, and weakness. Severe side effects include lactic acidosis, high blood lactate and an hepatomegaly, enlarged liver. There are no absolute contraindications. It is often recommended during pregnancy and appears to be safe. It is a Reverse-transcriptase inhibitor, nucleotide reverse tr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Czech Republic
The Czech Republic, or simply Czechia, is a landlocked country in Central Europe. Historically known as Bohemia, it is bordered by Austria to the south, Germany to the west, Poland to the northeast, and Slovakia to the southeast. The Czech Republic has a hilly landscape that covers an area of with a mostly temperate continental and oceanic climate. The capital and largest city is Prague; other major cities and urban areas include Brno, Ostrava, Plzeň and Liberec. The Duchy of Bohemia was founded in the late 9th century under Great Moravia. It was formally recognized as an Imperial State of the Holy Roman Empire in 1002 and became a kingdom in 1198. Following the Battle of Mohács in 1526, the whole Crown of Bohemia was gradually integrated into the Habsburg monarchy. The Protestant Bohemian Revolt led to the Thirty Years' War. After the Battle of White Mountain, the Habsburgs consolidated their rule. With the dissolution of the Holy Empire in 1806, the Cro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Prague
Prague ( ; cs, Praha ; german: Prag, ; la, Praga) is the capital and largest city in the Czech Republic, and the historical capital of Bohemia. On the Vltava river, Prague is home to about 1.3 million people. The city has a temperate oceanic climate, with relatively warm summers and chilly winters. Prague is a political, cultural, and economic hub of central Europe, with a rich history and Romanesque, Gothic, Renaissance and Baroque architectures. It was the capital of the Kingdom of Bohemia and residence of several Holy Roman Emperors, most notably Charles IV (r. 1346–1378). It was an important city to the Habsburg monarchy and Austro-Hungarian Empire. The city played major roles in the Bohemian and the Protestant Reformations, the Thirty Years' War and in 20th-century history as the capital of Czechoslovakia between the World Wars and the post-war Communist era. Prague is home to a number of well-known cultural attractions, many of which survived the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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