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Emil R. Unanue
Emil Raphael Unanue (September 13, 1934 – December 16, 2022) was a Cuban-American immunologist and Paul & Ellen Lacy Professor Emeritus at Washington University School of Medicine. He is a member of the National Academy of Sciences, the American Academy of Arts and Sciences and the Institute of Medicine. He previously served as chair of the National Academy of Sciences Section of Microbiology and Immunology. Area of expertise Unanue initiated a field of study known as antigen presentation; it is critical to the development of vaccines and underlies an understanding of microbial immunity and autoimmune diseases. In the late 1970s, it was recognized that T lymphocytes could not recognize antigen directly and instead required an interaction with another specialized cell known as the Antigen-presenting cell. Nobel Prize winners, Rolf Zinkernagel and Peter C. Doherty showed that this recognition also required the antigen-presenting cell to be from the same genetic background as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cuba
Cuba ( , ), officially the Republic of Cuba ( es, República de Cuba, links=no ), is an island country comprising the island of Cuba, as well as Isla de la Juventud and several minor archipelagos. Cuba is located where the northern Caribbean Sea, Gulf of Mexico, and Atlantic Ocean meet. Cuba is located east of the Yucatán Peninsula (Mexico), south of both the American state of Florida and the Bahamas, west of Hispaniola ( Haiti/Dominican Republic), and north of both Jamaica and the Cayman Islands. Havana is the largest city and capital; other major cities include Santiago de Cuba and Camagüey. The official area of the Republic of Cuba is (without the territorial waters) but a total of 350,730 km² (135,418 sq mi) including the exclusive economic zone. Cuba is the second-most populous country in the Caribbean after Haiti, with over 11 million inhabitants. The territory that is now Cuba was inhabited by the Ciboney people from the 4th millennium BC with the Gua ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antigen-presenting Cell
An antigen-presenting cell (APC) or accessory cell is a cell that displays antigen bound by major histocompatibility complex (MHC) proteins on its surface; this process is known as antigen presentation. T cells may recognize these complexes using their T cell receptors (TCRs). APCs process antigens and present them to T-cells. Almost all cell types can present antigens in some way. They are found in a variety of tissue types. Professional antigen-presenting cells, including macrophages, B cells and dendritic cells, present foreign antigens to helper T cells, while virus-infected cells (or cancer cells) can present antigens originating inside the cell to cytotoxic T cells. In addition to the MHC family of proteins, antigen presentation relies on other specialized signaling molecules on the surfaces of both APCs and T cells. Antigen-presenting cells are vital for effective adaptive immune response, as the functioning of both cytotoxic and helper T cells is dependent on APCs. Antigen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Institute For Medical Research
The National Institute for Medical Research (commonly abbreviated to NIMR), was a medical research institute based in Mill Hill, on the outskirts of north London, England. It was funded by the Medical Research Council (MRC); In 2016, the NIMR became part of the new Francis Crick Institute, which was constructed next to St Pancras railway station in the Camden area of central London. History Foundation The Medical Research Council, founded in 1913, was immediately charged with establishing a central research institute in London. Later that year, premises at Hampstead were acquired and the National Institute for Medical Research was founded. However, the outbreak of World War I soon afterwards delayed occupation of the building, although senior staff were appointed and began work. By 1920 the institute at Mount Vernon Hospital was fully operational and remained so for 30 years until the move to Mill Hill. The original institute, under the directorship of Sir Henry Dale, had ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brigitte Askonas
Brigitte Alice Askonas (1 April 1923 – 9 January 2013) was a British immunologist and a visiting professor at Imperial College London from 1995. Education Brigitte Askonas was born to Czechoslovak parents, Jewish converts to Catholicism, who fled Austria after the Nazi takeover. Vienna-born Askonas studied biochemistry at McGill University (BSc, MSc) and carried out her postgraduate work in the school of biochemistry at the University of Cambridge where she was a student of Girton College, Cambridge. Her role models in the department included two distinguished scientists, Marjory Stephenson and Dorothy Needham, two of the first women to be elected to the Royal Society. She said they taught her that "good science gets recognition regardless of the sex of the scientist". Her PhD research was supervised by Malcolm Dixon. Career and research Her first position was at the Allan Memorial Institute of Psychiatry (associated with McGill University). In 1952, she joined the staff ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glomerulonephritis
Glomerulonephritis (GN) is a term used to refer to several kidney diseases (usually affecting both kidneys). Many of the diseases are characterised by inflammation either of the glomeruli or of the small blood vessels in the kidneys, hence the name, but not all diseases necessarily have an inflammatory component. As it is not strictly a single disease, its presentation depends on the specific disease entity: it may present with isolated hematuria and/or proteinuria (blood or protein in the urine); or as a nephrotic syndrome, a nephritic syndrome, acute kidney injury, or chronic kidney disease. They are categorized into several different pathological patterns, which are broadly grouped into non-proliferative or proliferative types. Diagnosing the pattern of GN is important because the outcome and treatment differ in different types. Primary causes are intrinsic to the kidney. Secondary causes are associated with certain infections (bacterial, viral or parasitic pathogens), dru ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Frank J
Frank or Franks may refer to: People * Frank (given name) * Frank (surname) * Franks (surname) * Franks, a medieval Germanic people * Frank, a term in the Muslim world for all western Europeans, particularly during the Crusades - see Farang Currency * Liechtenstein franc or frank, the currency of Liechtenstein since 1920 * Swiss franc or frank, the currency of Switzerland since 1850 * Westphalian frank, currency of the Kingdom of Westphalia between 1808 and 1813 * The currencies of the German-speaking cantons of Switzerland (1803–1814): ** Appenzell frank ** Argovia frank ** Basel frank ** Berne frank ** Fribourg frank ** Glarus frank ** Graubünden frank ** Luzern frank ** Schaffhausen frank ** Schwyz frank ** Solothurn frank ** St. Gallen frank ** Thurgau frank ** Unterwalden frank ** Uri frank ** Zürich frank Places * Frank, Alberta, Canada, an urban community, formerly a village * Franks, Illinois, United States, an unincorporated community * Franks, Missouri, United ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
La Jolla
La Jolla ( , ) is a hilly, seaside neighborhood within the city of San Diego, California, United States, occupying of curving coastline along the Pacific Ocean. The population reported in the 2010 census was 46,781. La Jolla is surrounded on three sides by ocean bluffs and beaches and is located north of Downtown San Diego and south of the Orange County, California, Orange County line. The climate is mild, with an average daily temperature of . La Jolla is home to many educational institutions and a variety of businesses in the areas of lodging, dining, shopping, software, finance, real estate, bioengineering, medical practice and scientific research. The University of California, San Diego (UCSD) is located in La Jolla, as are the Salk Institute for Biological Studies, Salk Institute, Scripps Institution of Oceanography (part of UCSD), Scripps Research Institute, and the headquarters of National University (California), National University (though its academic campuses are ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Scripps Research Institute
Scripps Research, previously known as The Scripps Research Institute (TSRI), is a nonprofit American medical research facility that focuses on research and education in the biomedical sciences. Headquartered in San Diego, California, the institute has over 170 laboratories employing 2,100 scientists, technicians, graduate students, and administrative and other staff, making it the largest private, non-profit biomedical research organization in the United States and among the largest in the world. The institute holds over 1,100 patents, has produced 11 FDA-approved therapeutics, and has generated over 50 spin-off companies. According to the 2017 Nature Innovation Index, Scripps Research is the #1 most influential research institution in the world. The Scripps Research graduate program is ranked 9th nationally in the biological sciences, 6th for organic chemistry, and 6th for biochemistry. In 2022, their Jupiter, FL campus became a part of the University of Florida. Jupiter-based ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Pittsburgh
The University of Pittsburgh (Pitt) is a public state-related research university in Pittsburgh, Pennsylvania. The university is composed of 17 undergraduate and graduate schools and colleges at its urban Pittsburgh campus, home to the university's central administration and around 28,000 undergraduate and graduate students. The 132-acre Pittsburgh campus includes various historic buildings that are part of the Schenley Farms Historic District, most notably its 42-story Gothic revival centerpiece, the Cathedral of Learning. Pitt is a member of the Association of American Universities and is classified among "R1: Doctoral Universities – Very high research activity". It is the second-largest non-government employer in the Pittsburgh metropolitan area. Pitt traces its roots to the Pittsburgh Academy founded by Hugh Henry Brackenridge in 1787. While the city was still on the edge of the American frontier at the time, Pittsburgh's rapid growth meant that a proper university was so ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Major Histocompatibility Complex
The major histocompatibility complex (MHC) is a large locus on vertebrate DNA containing a set of closely linked polymorphic genes that code for cell surface proteins essential for the adaptive immune system. These cell surface proteins are called MHC molecules. This locus got its name because it was discovered via the study of transplanted tissue compatibility. Later studies revealed that tissue rejection due to incompatibility is only a facet of the full function of MHC molecules: binding an antigen derived from self-proteins, or from pathogens, and bringing the antigen presentation to the cell surface for recognition by the appropriate T-cells. MHC molecules mediate the interactions of leukocytes, also called white blood cells (WBCs), with other leukocytes or with body cells. The MHC determines donor compatibility for organ transplant, as well as one's susceptibility to autoimmune diseases. In a cell, protein molecules of the host's own phenotype or of other biologic entities ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paul M
Paul may refer to: *Paul (given name), a given name (includes a list of people with that name) *Paul (surname), a list of people People Christianity * Paul the Apostle (AD c.5–c.64/65), also known as Saul of Tarsus or Saint Paul, early Christian missionary and writer *Pope Paul (other), multiple Popes of the Roman Catholic Church *Saint Paul (other), multiple other people and locations named "Saint Paul" Roman and Byzantine empire *Lucius Aemilius Paullus Macedonicus (c. 229 BC – 160 BC), Roman general *Julius Paulus Prudentissimus (), Roman jurist *Paulus Catena (died 362), Roman notary *Paulus Alexandrinus (4th century), Hellenistic astrologer *Paul of Aegina or Paulus Aegineta (625–690), Greek surgeon Royals * Paul I of Russia (1754–1801), Tsar of Russia *Paul of Greece (1901–1964), King of Greece Other people *Paul the Deacon or Paulus Diaconus (c. 720 – c. 799), Italian Benedictine monk *Paul (father of Maurice), the father of Maurice, Byz ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MHC Restriction
MHC-restricted antigen recognition, or MHC restriction, refers to the fact that a T cell can interact with a self-major histocompatibility complex molecule and a foreign peptide bound to it, but will only respond to the antigen when it is bound to a particular MHC molecule. When foreign proteins enter a cell, they are broken into smaller pieces called peptides. These peptides, also known as antigens, can derive from pathogens such as viruses or intracellular bacteria. Foreign peptides are brought to the surface of the cell and presented to T cells by proteins called the major histocompatibility complex (MHC). During T cell development, T cells go through a selection process in the thymus to ensure that the T cell receptor ( TCR) will not recognize MHC molecule presenting self-antigens, i.e that its affinity is not too high. High affinity means it will be autoreactive, but no affinity means it will not bind strongly enough to the MHC. The selection process results in developed T cell ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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