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Elena Conti
Elena Conti (born 14 February 1967 in Varese, Italy) is an Italian biochemist and molecular biologist. She serves as Director and Scientific Member of the Max Planck Institute of Biochemistry in Martinsried, Germany, where she uses structural biology and biophysical techniques to study RNA transport and RNA metabolism. Together with Elisa Izaurralde, she helped characterize proteins important for exporting mRNA out of the nucleus. Early life and education After graduating in chemistry at the University of Pavia in 1991, Conti achieved a PhD on protein cristallography at the Imperial College in London in 1996, with a thesis on the crystal structure of firefly luciferase". From 1997 to 1999 she worked as a postdoctoral fellow at the Rockefeller University in New York City; her postdoc advisor was John Kuriyan. Career She worked as a group leader at the European Molecular Biology Laboratory in Heidelberg, Germany from 1999 until January 2006, when she became director and scientifi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Varese, Italy
Varese ( , , or ; lmo, label= Varesino, Varés ; la, Baretium; archaic german: Väris) is a city and ''comune'' in north-western Lombardy, northern Italy, north-west of Milan. The population of Varese in 2018 has reached 80,559. It is the capital of the Province of Varese. The hinterland or exurban part of the city is called ''Varesotto''. Geography The city of Varese lies at the foot of Sacro Monte di Varese, part of the Campo dei Fiori mountain range, that hosts an astronomical observatory, as well as the Prealpino Geophysical Centre. The village which is in the middle of the mountain is called Santa Maria del Monte because of the medieval sanctuary, which is reached through the avenue of the chapels of the Sacred Mountain. Varese is situated on seven hills: the San Pedrino Hill, the Giubiano Hill, the Campigli Hill, the Sant'Albino Hill, the Biumo Superiore Hill, Colle di Montalbano (Villa Mirabello) and the Hill of Miogni. The city also looks over Lake Varese. Clim ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biophysics
Biophysics is an interdisciplinary science that applies approaches and methods traditionally used in physics to study biological phenomena. Biophysics covers all scales of biological organization, from molecular to organismic and populations. Biophysical research shares significant overlap with biochemistry, molecular biology, physical chemistry, physiology, nanotechnology, bioengineering, computational biology, biomechanics, developmental biology and systems biology. The term ''biophysics'' was originally introduced by Karl Pearson in 1892.Roland Glaser. Biophysics: An Introduction'. Springer; 23 April 2012. . The term ''biophysics'' is also regularly used in academia to indicate the study of the physical quantities (e.g. electric current, temperature, stress, entropy) in biological systems. Other biological sciences also perform research on the biophysical properties of living organisms including molecular biology, cell biology, chemical biology, and biochemistry. Overview ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
European Molecular Biology Organization
The European Molecular Biology Organization (EMBO) is a professional, non-profit organization of more than 1,800 life scientists. Its goal is to promote research in life science and enable international exchange between scientists. It co-funds courses, workshops and conferences, publishes five scientific journals and supports individual scientists. The organization was founded in 1964 and is a founding member of the Initiative for Science in Europe. the Director of EMBO is Fiona Watt, a stem cell researcher, professor at King's College London and a group leader at the European Molecular Biology Laboratory. Conferences and journals EMBO funds or co-funds over 90 meetings involving more than 11,000 participants every year. EMBO publishes five peer-reviewed scientific journals: ''The EMBO Journal'', ''EMBO Reports'', ''Molecular Systems Biology'', ''EMBO Molecular Medicine'', and ''Life Science Alliance'', History The European Molecular Biology Organization (EMBO) was launched ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Utrecht University
Utrecht University (UU; nl, Universiteit Utrecht, formerly ''Rijksuniversiteit Utrecht'') is a public research university in Utrecht, Netherlands. Established , it is one of the oldest universities in the Netherlands. In 2018, it had an enrollment of 31,801 students, and employed 7,191 faculty and staff. In 2018, 525 PhD degrees were awarded and 6,948 scientific articles were published. The 2018 budget of the university was €857 million. Utrecht University counts a number of distinguished scholars among its alumni and faculty, including 12 Nobel Prize laureates and 13 Spinoza Prize laureates. Utrecht University has been placed consistently in the top 100 universities in the world by prominent international ranking tables. The university is ranked as the best university in the Netherlands by the Shanghai Ranking of World Universities 2022, ranked 14th in Europe and 54th in the world. The university's motto is "Sol Iustitiae Illustra Nos", which means ''May the Sun of Righteous ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bijvoet Center For Biomolecular Research
The Bijvoet Centre for Biomolecular Research is a research institute at Utrecht University. The Bijvoet Centre performs research on the relation between the structure and function of biomolecules, including proteins and lipids, which play a role in biological processes such as regulation, interaction and recognition. The Bijvoet Centre houses advanced infrastructures for the analysis of proteins and other biomolecules using NMR, X-ray crystallography, electron microscopy and mass spectrometry. The institute is named after famous Dutch chemist Johannes Martin Bijvoet, who worked at Utrecht University. History Utrecht University and the Netherlands Foundation for Chemical Research (SON, which later became the Chemical Sciences division of NWO, the Netherlands Organisation for Scientific Research) founded the Bijvoet Centre for Biomolecular Research as a joint research institute on March 25, 1988. The goal was to create a centre for research and expertise in structural biology with ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Heidelberg
Heidelberg (; Palatine German language, Palatine German: ''Heidlberg'') is a city in the States of Germany, German state of Baden-Württemberg, situated on the river Neckar in south-west Germany. As of the 2016 census, its population was 159,914, of which roughly a quarter consisted of students. Located about south of Frankfurt, Heidelberg is the List of cities in Baden-Württemberg by population, fifth-largest city in Baden-Württemberg. Heidelberg is part of the densely populated Rhine-Neckar, Rhine-Neckar Metropolitan Region. Heidelberg University, founded in 1386, is Germany's oldest and one of Europe's most reputable universities. Heidelberg is a Science, scientific hub in Germany and home to several internationally renowned #Research, research facilities adjacent to its university, including the European Molecular Biology Laboratory and four Max Planck Society, Max Planck Institutes. The city has also been a hub for the arts, especially literature, throughout the centurie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
European Molecular Biology Laboratory
The European Molecular Biology Laboratory (EMBL) is an intergovernmental organization dedicated to molecular biology research and is supported by 27 member states, two prospect states, and one associate member state. EMBL was created in 1974 and is funded by public research money from its member states. Research at EMBL is conducted by approximately 110 independent research and service groups and teams covering the spectrum of molecular biology and bioinformatics. The list of Groups and Teams at EMBL can be found at . The Laboratory operates from six sites: the main laboratory in Heidelberg, and sites in Hinxton (the European Bioinformatics Institute (EBI), in England), Grenoble (France), Hamburg (Germany), Rome (Italy) and Barcelona (Spain). EMBL groups and laboratories perform basic research in molecular biology and molecular medicine as well as train scientists, students, and visitors. The organization aids in the development of services, new instruments and methods, and techn ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
John Kuriyan
John Kuriyan is the Dean of Basic Sciences and a Professor of Biochemistry at Vanderbilt University School of Medicine. He was formerly the Chancellor's Professor at the University of California, Berkeley in the departments of Molecular and Cell Biology (MCB) and Chemistry, a Faculty Scientist in Berkeley Lab's Physical Biosciences Division, and a Howard Hughes Medical Institute investigator. He is a member of the National Academy of Sciences and he has also been on the Life Sciences jury for the Infosys Prize in 2009, 2019 and 2020. Education Kuriyan received his B.S. in chemistry from Juniata College in Pennsylvania, followed by his PhD in physical chemistry at the Massachusetts Institute of Technology supervised by Gregory Petsko and Martin Karplus. Research and career Kuriyan did postdoctoral research work for one year supervised by Karplus at Harvard before becoming an assistant professor at the Rockefeller University. Kuriyan's laboratory studies the structure and mechanism ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Firefly Luciferase
Firefly luciferase is the light-emitting enzyme responsible for the bioluminescence of fireflies and click beetles. The enzyme catalyses the oxidation of firefly luciferin, requiring oxygen and ATP. Because of the requirement of ATP, firefly luciferases have been used extensively in biotechnology. Mechanism of reaction The chemical reaction catalyzed by firefly luciferase takes place in two steps: * luciferin + ATP → luciferyl adenylate + PPi * luciferyl adenylate + O2 → oxyluciferin + AMP + light Light is produced because the reaction forms oxyluciferin in an electronically excited state. The reaction releases a photon of light as oxyluciferin goes back to the ground state. Luciferyl adenylate can additionally participate in a side reaction with O2 to form hydrogen peroxide and dehydroluciferyl-AMP. About 20% of the luciferyl adenylate intermediate is oxidized in this pathway. Firefly luciferase generates light from luciferin in a multistep process. First, D-luci ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Imperial College London
Imperial College London (legally Imperial College of Science, Technology and Medicine) is a public research university in London, United Kingdom. Its history began with Prince Albert, consort of Queen Victoria, who developed his vision for a cultural area that included the Royal Albert Hall, Victoria & Albert Museum, Natural History Museum and royal colleges. In 1907, Imperial College was established by a royal charter, which unified the Royal College of Science, Royal School of Mines, and City and Guilds of London Institute. In 1988, the Imperial College School of Medicine was formed by merging with St Mary's Hospital Medical School. In 2004, Queen Elizabeth II opened the Imperial College Business School. Imperial focuses exclusively on science, technology, medicine, and business. The main campus is located in South Kensington, and there is an innovation campus in White City. Facilities also include teaching hospitals throughout London, and with Imperial College Healthcare ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein Crystallography
X-ray crystallography is the experimental science determining the atomic and molecular structure of a crystal, in which the crystalline structure causes a beam of incident X-rays to diffract into many specific directions. By measuring the angles and intensities of these diffracted beams, a crystallographer can produce a three-dimensional picture of the density of electrons within the crystal. From this electron density, the mean positions of the atoms in the crystal can be determined, as well as their chemical bonds, their crystallographic disorder, and various other information. Since many materials can form crystals—such as salts, metals, minerals, semiconductors, as well as various inorganic, organic, and biological molecules—X-ray crystallography has been fundamental in the development of many scientific fields. In its first decades of use, this method determined the size of atoms, the lengths and types of chemical bonds, and the atomic-scale differences among various mat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell Nucleus
The cell nucleus (pl. nuclei; from Latin or , meaning ''kernel'' or ''seed'') is a membrane-bound organelle found in eukaryotic cells. Eukaryotic cells usually have a single nucleus, but a few cell types, such as mammalian red blood cells, have no nuclei, and a few others including osteoclasts have many. The main structures making up the nucleus are the nuclear envelope, a double membrane that encloses the entire organelle and isolates its contents from the cellular cytoplasm; and the nuclear matrix, a network within the nucleus that adds mechanical support. The cell nucleus contains nearly all of the cell's genome. Nuclear DNA is often organized into multiple chromosomes – long stands of DNA dotted with various proteins, such as histones, that protect and organize the DNA. The genes within these chromosomes are structured in such a way to promote cell function. The nucleus maintains the integrity of genes and controls the activities of the cell by regulating gene expres ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
