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Edward Penley Abraham
Sir Edward Penley Abraham, (10 June 1913 – 8 May 1999) was an English biochemist instrumental in the development of the first antibiotics penicillin and cephalosporin. Early life and education Abraham was born on 10 June 1913 at 47 South View Road, Shirley, Southampton. From 1924 Abraham attended King Edward VI School, Southampton, before achieving a First in Chemistry at The Queen's College, Oxford. Abraham completed his DPhil at the University of Oxford under the supervision of Sir Robert Robinson, during which he was the first to crystallise lysozyme, an enzyme discovered by Sir Alexander Fleming and shown to have antibacterial properties, and was later the first enzyme to have its structure solved using X-ray crystallography, by Lord David Philips. Research He then won a Rockefeller Foundation scholarship and spent a year in Stockholm at the Biokemiska Institut. He then moved back to Oxford and became part of a research team led by Sir Howard Florey at th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Shirley, Southampton
Shirley is a broad district and a former village on the western side of Southampton, England. Shirley's main roles are retailing and residential. It is the most important suburban shopping area in the west of the city. Housing is a mixture of council houses in the centre of the district surrounded by private housing, with larger suburban houses concentrated in Upper Shirley. Shirley is separated from Highfield by Southampton Common, a large green public space. History The place-name Shirley commonly means "bright clearing", from the Old English very similarly pronounced ''scir'' (bright) and ''leah'' (cleared land in a wood). Shirley is recorded as a manor with a mill in the Domesday Book; the mill standing to the west of the present Romsey Road/Winchester Road junction, at the confluence of the Hollybrook and Tanner's Brook streams. Shirley Mill had three large ponds, to the north of Winchester Road. One of the three mill ponds remains today, accessed by following the Lordswo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
British Degree Classification
The British undergraduate degree classification system is a grading structure for undergraduate degrees or bachelor's degrees and integrated master's degrees in the United Kingdom. The system has been applied (sometimes with significant variations) in other countries and regions. History The classification system as currently used in the United Kingdom was developed in 1918. Honours were then a means to recognise individuals who demonstrated depth of knowledge or originality, as opposed to relative achievement in examination conditions. Concern exists about possible grade inflation. It is claimed that academics are under increasing pressure from administrators to award students good marks and grades with little regard for those students' actual abilities, in order to maintain their league table rankings. The percentage of graduates who receive a First (First Class Honours) has grown from 7% in 1997 to 26% in 2017, with the rate of growth sharply accelerating toward the end of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Beta-lactam
A beta-lactam (β-lactam) ring is a four-membered lactam. A ''lactam'' is a cyclic amide, and ''beta''-lactams are named so because the nitrogen atom is attached to the β-carbon atom relative to the carbonyl. The simplest β-lactam possible is 2-azetidinone. β-lactams are significant structural units of medicines as manifested in many β-lactam antibiotics Up to 1970, most β-lactam research was concerned with the penicillin and cephalosporin groups, but since then, a wide variety of structures have been described. Clinical significance The β-lactam ring is part of the core structure of several antibiotic families, the principal ones being the penicillins, cephalosporins, carbapenems, and monobactams, which are, therefore, also called β-lactam antibiotics. Nearly all of these antibiotics work by inhibiting bacterial cell wall biosynthesis. This has a lethal effect on bacteria, although any given bacteria population will typically contain a subgroup that is resistant ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ernst Boris Chain
Sir Ernst Boris Chain (19 June 1906 – 12 August 1979) was a German-born British biochemist best known for being a co-recipient of the Nobel Prize in Physiology or Medicine for his work on penicillin. Life and career Chain was born in Berlin, the son of Margarete () and Michael Chain, a chemist and industrialist dealing in chemical products. His family was of both Sephardic and Ashkenazi Jewish descent. His father emigrated from Russia to study chemistry abroad and his mother was from Berlin. In 1930, he received his degree in chemistry from Friedrich Wilhelm University. His father descends from Zerahiah ben Shealtiel Ḥen who was a prominent figure among the Catalonian Jewry and whose ancestors were leading Jewish figures in Babylonia. He was a lifelong friend of Professor Albert Neuberger, whom he met in Berlin in the 1930s. After the Nazis came to power, Chain understood that, being Jewish, he would no longer be safe in Germany. He left Germany and moved to Englan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Penicillinase
Beta-lactamases, (β-lactamases) are enzymes () produced by bacteria that provide multi-resistance to beta-lactam antibiotics such as penicillins, cephalosporins, cephamycins, monobactams and carbapenems ( ertapenem), although carbapenems are relatively resistant to beta-lactamase. Beta-lactamase provides antibiotic resistance by breaking the antibiotics' structure. These antibiotics all have a common element in their molecular structure: a four-atom ring known as a beta-lactam (β-lactam) ring. Through hydrolysis, the enzyme lactamase breaks the β-lactam ring open, deactivating the molecule's antibacterial properties. Beta-lactam antibiotics are typically used to target a broad spectrum of gram-positive and gram-negative bacteria. Beta-lactamases produced by gram-negative bacteria are usually secreted, especially when antibiotics are present in the environment. Structure The structure of a ''Streptomyces'' serine β-lactamase (SBLs) is given by . The alpha-beta fold ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemical Structure
A chemical structure determination includes a chemist's specifying the molecular geometry and, when feasible and necessary, the electronic structure of the target molecule or other solid. Molecular geometry refers to the spatial arrangement of atoms in a molecule and the chemical bonds that hold the atoms together, and can be represented using structural formulae and by molecular models; complete electronic structure descriptions include specifying the occupation of a molecule's molecular orbitals. Structure determination can be applied to a range of targets from very simple molecules (e.g., diatomic oxygen or nitrogen), to very complex ones (e.g., such as protein or DNA). Background Theories of chemical structure were first developed by August Kekulé, Archibald Scott Couper, and Aleksandr Butlerov, among others, from about 1858. These theories were first to state that chemical compounds are not a random cluster of atoms and functional groups, but rather had a definite order ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sir William Dunn School Of Pathology
The Sir William Dunn School of Pathology is a department within the University of Oxford. Its research programme includes the cellular and molecular biology of pathogens, the immune response, cancer and cardiovascular disease. It teaches undergraduate and graduate courses in the medical sciences. The school is named for Sir William Dunn, 1st Baronet, of Lakenheath, whose will provided the initial funding. It is located towards the east end of South Parks Road, to the north of the city centre. __TOC__ History The first course of Pathology teaching in the University of Oxford was given in 1894 by Professor John Burdon Sanderson, Professor of Physiology, (Regius Professor of Medicine from 1895 to 1905), and Dr James Ritchie, who, in 1897, was appointed as the first University Lecturer in Pathology. The first Department of Pathology was opened in 1901 and functioned until 1927 when it was handed over to Pharmacology on completion of the new purpose-built Sir William Dunn School of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Howard Florey
Howard Walter Florey, Baron Florey (24 September 189821 February 1968) was an Australian pharmacologist and pathologist who shared the Nobel Prize in Physiology or Medicine in 1945 with Sir Ernst Chain and Sir Alexander Fleming for his role in the development of penicillin. Although Fleming received most of the credit for the discovery of penicillin, it was Florey who carried out the first clinical trials of penicillin in 1941 at the Radcliffe Infirmary in Oxford on the first patient, a police constable from Oxford. The patient started to recover, but subsequently died because Florey was unable, at that time, to make enough penicillin. It was Florey and Chain who actually made a useful and effective drug out of penicillin, after the task had been abandoned as too difficult. Florey's discoveries, along with the discoveries of Fleming and Ernst Chain, are estimated to have saved over 200 million lives, and he is consequently regarded by the Australian scientific and medical comm ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stockholm
Stockholm () is the Capital city, capital and List of urban areas in Sweden by population, largest city of Sweden as well as the List of urban areas in the Nordic countries, largest urban area in Scandinavia. Approximately 980,000 people live in the Stockholm Municipality, municipality, with 1.6 million in the Stockholm urban area, urban area, and 2.4 million in the Metropolitan Stockholm, metropolitan area. The city stretches across fourteen islands where Mälaren, Lake Mälaren flows into the Baltic Sea. Outside the city to the east, and along the coast, is the island chain of the Stockholm archipelago. The area has been settled since the Stone Age, in the 6th millennium BC, and was founded as a city in 1252 by Swedish statesman Birger Jarl. It is also the county seat of Stockholm County. For several hundred years, Stockholm was the capital of Finland as well (), which then was a part of Sweden. The population of the municipality of Stockholm is expected to reach o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rockefeller Foundation
The Rockefeller Foundation is an American private foundation and philanthropic medical research and arts funding organization based at 420 Fifth Avenue, New York City. The second-oldest major philanthropic institution in America, after the Carnegie Corporation, the foundation was ranked as the 39th largest U.S. foundation by total giving as of 2015. By the end of 2016, assets were tallied at $4.1 billion (unchanged from 2015), with annual grants of $173 million. According to the OECD, the foundation provided US$103.8 million for development in 2019. The foundation has given more than $14 billion in current dollars. The foundation was started by Standard Oil magnate John D. Rockefeller ("Senior") and son "Junior", and their primary business advisor, Frederick Taylor Gates, on May 14, 1913, when its charter was granted by New York. The foundation has had an international reach since the 1930s and major influence on global non-governmental organizations. The World Health Organiza ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
David Chilton Phillips
David Chilton Phillips, Baron Phillips of Ellesmere, KBE, FRS (7 March 1924 – 23 February 1999) was a pioneering, British structural biologist and an influential figure in science and government. Research Phillips lead the team which determined in atomic detail the structure of the enzyme lysozyme, which he did in the Davy Faraday Research Laboratories of the Royal Institution in London in 1965. Lysozyme, which was discovered in 1922 by Alexander Fleming, is found in tear drops, nasal mucus, gastric secretions and egg white. Lysozyme exhibits some antibacterial activity so that the discovery of its structure and mode of action were key scientific objectives. David Phillips solved the structure of lysozyme and also explained the mechanism of its action in destroying certain bacteria by a brilliant application of the technique of X-ray crystallography, a technique to which he had been introduced as a PhD student at the University in Cardiff, and to which he later made major in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
X-ray Crystallography
X-ray crystallography is the experimental science determining the atomic and molecular structure of a crystal, in which the crystalline structure causes a beam of incident X-rays to diffract into many specific directions. By measuring the angles and intensities of these diffracted beams, a crystallographer can produce a three-dimensional picture of the density of electrons within the crystal. From this electron density, the mean positions of the atoms in the crystal can be determined, as well as their chemical bonds, their crystallographic disorder, and various other information. Since many materials can form crystals—such as salts, metals, minerals, semiconductors, as well as various inorganic, organic, and biological molecules—X-ray crystallography has been fundamental in the development of many scientific fields. In its first decades of use, this method determined the size of atoms, the lengths and types of chemical bonds, and the atomic-scale differences among various mat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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