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ETS Transcription Factor Family
In the field of molecular biology, the ETS (E26 transformation-specific or E-twenty-six. (Erythroblast Transformation Specific)) family is one of the largest families of transcription factors and is unique to animals. There are 29 genes in humans, 28 in the mouse, 10 in ''Caenorhabditis elegans'' and 9 in '' Drosophila.'' The founding member of this family was identified as a gene transduced by the leukemia virus, E26. The members of the family have been implicated in the development of different tissues as well as cancer progression. Subfamilies The ETS (Erythroblast Transformation Specific)family is divided into 12 subfamilies, which are listed below: Structure All ETS (Erythroblast Transformation Specific) family members are identified through a highly conserved DNA binding domain, the ETS domain, which is a winged helix-turn-helix structure that binds to DNA sites with a central GGA(A/T) DNA sequence. As well as DNA-binding functions, evidence suggests that the ETS ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Biology
Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physical structure of biological macromolecules is known as molecular biology. Molecular biology was first described as an approach focused on the underpinnings of biological phenomena - uncovering the structures of biological molecules as well as their interactions, and how these interactions explain observations of classical biology. In 1945 the term molecular biology was used by physicist William Astbury. In 1953 Francis Crick, James Watson, Rosalind Franklin, and colleagues, working at Medical Research Council unit, Cavendish laboratory, Cambridge (now the MRC Laboratory of Molecular Biology), made a double helix model of DNA which changed the entire research scenario. They proposed the DNA structure based on previous research done by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
EHF (gene)
ETS homologous factor is a protein that in humans is encoded by the ''EHF'' gene. This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be associated with asthma susceptibility. This protein may be involved in epithelial differentiation and carcinogenesis Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed into cancer cells. The process is characterized by changes at the cellular, genetic, and epigenetic levels and abnorm .... Further reading Cangemi, R., Mensah, A., Albertini, V., Jain, A., Mello-Grand, M., Chiorino, G., Catapano, C.V. & Carbone, G.M. Reduced expression and tumor suppressor function of the ETS transcription factor ESE-3 in prostate cancer. Oncogene 27, 2877-2885 (2008). Albino D, Longoni N, Curti L, Mello-Grand M, Pinton S, Civenni G, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ETV6
ETV6 (i.e. translocation-Ets-leukemia virus) protein is a transcription factor that in humans is encoded by the ''ETV6'' (previously known as ''TEL'') gene. The ETV6 protein regulates the development and growth of diverse cell types, particularly those of hematological tissues. However, its gene, ''ETV6'' frequently suffers various mutations that lead to an array of potentially lethal cancers, i.e., ''ETV6'' is a clinically significant proto-oncogene in that it can fuse with other genes to drive the development and/or progression of certain cancers. However, ''ETV6'' is also an anti-oncogene or tumor suppressor gene in that mutations in it that encode for a truncated and therefore inactive protein are also associated with certain types of cancers. Gene The human ''ETV6'' gene is located at position "13.2" on the short (i.e. "p") arm of chromosome 12, i.e. its notated position is 12p13.2. The gene has 8 exons and two start codons, one located at exon 1 at the start of the gene and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ELK3
ETS domain-containing protein Elk-3 is a protein that in humans is encoded by the ''ELK3'' gene. The protein encoded by this gene is a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. Interactions ELK3 has been shown to interact Advocates for Informed Choice, doing business as, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex trai ... with TCF3. References Further reading * * * * * * * * * * * * * * External links * Transcription factors {{gene-12 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ELK4
ETS domain-containing protein Elk-4 is a protein that in humans is encoded by the ''ELK4'' gene. Function This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene. Interactions ELK4 has been shown to interact with: * BRCA1 Breast cancer type 1 susceptibility protein is a protein that in humans is encoded by the ''BRCA1'' () gene. Orthologs are common in other vertebrate species, whereas invertebrate genomes may encode a more distantly related gene. ''BRCA1'' is a ..., and * Serum response factor References Further reading * * * * * * * * * * * * * * * External links * * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SPIB
Transcription factor Spi-B is a protein that in humans is encoded by the ''SPIB'' gene. Function SPI1 (MIM 165170) and SPIB are members of a subfamily of ETS (see ETS1; MIM 164720) transcription factors. ETS proteins share a conserved ETS domain that mediates specific DNA binding. SPIB and SPI1 bind to a purine-rich sequence, the PU box (5-prime-GAGGAA-3-prime). upplied by OMIMref name="entrez" /> Interactions SPIB has been shown to interact with MAPK3 and MAPK8 Mitogen-activated protein kinase 8 (also known as JNK1) is a ubiquitous enzyme that in humans is encoded by the ''MAPK8'' gene. Function The protein encoded by this gene is a member of the MAP kinase and JNK family. MAP kinases act as an inte .... References Further reading * * * * * * * * * * * * External links * Transcription factors {{gene-19-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SPI1
Transcription factor PU.1 is a protein that in humans is encoded by the ''SPI1'' gene. Function This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found on enhancers of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. Structure The ETS domain is the DNA-binding module of PU.1 and other ETS-family transcription factors. Interactions SPI1 has been shown to interact with: * FUS, * GATA2, * IRF4, and * NONO Nono may refer to: Places * Nono, Argentina, a municipality in the Province of Córdoba * Nono, Ecuador, a parish in the municipality of Quito in the province of Pichincha * Nono, Illubabor, Oromia (wor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ETV1
ETS translocation variant 1 is a protein that in humans is encoded by the ''ETV1'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba .... References Further reading * * * * * * * * * * * * * * External links * {{Transcription factors, g3 Transcription factors ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ETV4
ETS translocation variant 4 (ETV4), also known as polyoma enhancer activator 3 (PEA3), is a member of the PEA3 subfamily of Ets transcription factors. Disease marker Two variants of a disease associated with ETV4 is Ewing Sarcoma and Extraosseous Ewing's Sarcoma. While both are cancerous tumors, the former grows in the bones most commonly affecting the arms, legs, hips, and spine, while the later affects the soft tissue in the chest, foot, pelvis and spine. References Further reading * * * * * * * * * * * * * * * * * External links * * Transcription factors {{gene-17-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
