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NM_001973
NM_021795

NM_007923

RefSeq (protein)

NP_001964
NP_068567
NP_068567.1
NP_001964.2

NP_031949

Location (UCSC) Chr 1: 205.6 – 205.63 Mb Chr 1: 132.01 – 132.03 Mb PubMed search [3] [4] Wikidata
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ETS domain-containing protein Elk-4 is a protein that in humans is encoded by the ELK4 gene.[5][6][7]

Function

This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene.[7]

Interactions

ELK4 has been shown to interact with:

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000158711 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026436 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Shipley J, Sheer D, Dalton S, Treisman R, Patel K (Mar 1995). "Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectively". Genomics. 23 (3): 710–1. doi:10.1006/geno.1994.1564. PMID 7851904. 
  6. ^ Giovane A, Sobieszczuk P, Mignon C, Mattei MG, Wasylyk B (Mar 1996). "Locations of the ets subfamily members net, elk1, and sap1 (ELK3, ELK1, and ELK4) on three homologous regions of the mouse and human genomes". Genomics. 29 (3): 769–72. doi:10.1006/geno.1995.9938. PMID 8575773. 
  7. ^ a b "Entrez Gene: ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)". 
  8. ^ Chai Y, Chipitsyna G, Cui J, Liao B, Liu S, Aysola K, Yezdani M, Reddy ES, Rao VN (Mar 2001). "c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells". Oncogene. 20 (11): 1357–67. doi:10.1038/sj.onc.1204256. PMID 11313879. 
  9. ^ Hassler M, Richmond TJ (Jun 2001). "The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex". EMBO J. 20 (12): 3018–28. doi:10.1093/emboj/20.12.3018. PMC 150215Freely accessible. PMID 11406578. 
  10. ^ Zhu C, Johansen FE, Prywes R (Sep 1997). "Interaction of ATF6 and serum response factor". Mol. Cell. Biol. 17 (9): 4957–66. PMC 232347Freely accessible. PMID 9271374. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.