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Experimental System
In scientific research, an experimental system is the physical, technical and procedural basis for an experiment or series of experiments. Historian of science Hans-Jörg Rheinberger defines an experimental system as: "A basic unit of experimental activity combining local, technical, instrumental, institutional, social, and epistemic aspects." Scientists (particularly laboratory biologists) and historians and philosophers of biology have pointed to the development and spread of successful experimental systems, such as those based on popular model organism or scientific apparatus, as key elements in the history of science, particularly since the early 20th century. The choice of an appropriate experimental system is often seen as critical for a scientist's long-term success, as experimental systems can be very productive for some kinds of questions and less productive for others, acquiring a sort of momentum that takes research in unpredicted directions. A successful experimental ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scientific Research
The scientific method is an empirical method for acquiring knowledge that has characterized the development of science since at least the 17th century (with notable practitioners in previous centuries; see the article history of scientific method for additional detail.) It involves careful observation, applying rigorous skepticism about what is observed, given that cognitive assumptions can distort how one interprets the observation. It involves formulating hypotheses, via induction, based on such observations; the testability of hypotheses, experimental and the measurement-based statistical testing of deductions drawn from the hypotheses; and refinement (or elimination) of the hypotheses based on the experimental findings. These are ''principles'' of the scientific method, as distinguished from a definitive series of steps applicable to all scientific enterprises. Although procedures vary from one field of inquiry to another, the underlying process is frequently the sa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Strain (biology)
In biology, a strain is a genetic variant, a subtype or a culture within a biological species. Strains are often seen as inherently artificial concepts, characterized by a specific intent for genetic isolation. This is most easily observed in microbiology where strains are derived from a single cell colony and are typically quarantined by the physical constraints of a Petri dish. Strains are also commonly referred to within virology, botany, and with rodents used in experimental studies. Microbiology and virology It has been said that "there is no universally accepted definition for the terms 'strain', ' variant', and 'isolate' in the virology community, and most virologists simply copy the usage of terms from others". A strain is a genetic variant or subtype of a microorganism (e.g., a virus, bacterium or fungus). For example, a "flu strain" is a certain biological form of the influenza or "flu" virus. These flu strains are characterized by their differing isoforms of su ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Systems Theory
Systems theory is the interdisciplinary study of systems, i.e. cohesive groups of interrelated, interdependent components that can be natural or human-made. Every system has causal boundaries, is influenced by its context, defined by its structure, function and role, and expressed through its relations with other systems. A system is "more than the sum of its parts" by expressing synergy or emergent behavior. Changing one component of a system may affect other components or the whole system. It may be possible to predict these changes in patterns of behavior. For systems that learn and adapt, the growth and the degree of adaptation depend upon how well the system is engaged with its environment and other contexts influencing its organization. Some systems support other systems, maintaining the other system to prevent failure. The goals of systems theory are to model a system's dynamics, constraints, conditions, and relations; and to elucidate principles (such as purpose, measure ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Historiography Of Science
The historiography of science or the historiography of the history of science is the study of the history and methodology of the sub-discipline of history, known as the history of science, including its disciplinary aspects and practices (methods, theories, schools) and the study of its own historical development ("History of History of Science", i.e., the history of the discipline called History of Science). Historiographical debates regarding the proper method for the study of the history of science are sometimes difficult to demarcate from historical controversies regarding the course of science. Early controversies of the latter kind are considered by some to be the inception of the sub-discipline. Amateur historiography of science Histories of science were originally written by practicing and retired scientists, a notable early example being William Whewell's ''History of the Inductive Sciences'' (1837). Biographies of natural philosophers (early scientists) were also pop ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Philosophy Of Science
Philosophy of science is a branch of philosophy concerned with the foundations, methods, and implications of science. The central questions of this study concern what qualifies as science, the reliability of scientific theories, and the ultimate purpose of science. This discipline overlaps with metaphysics, ontology, and epistemology, for example, when it explores the relationship between science and truth. Philosophy of science focuses on metaphysical, epistemic and semantic aspects of science. Ethical issues such as bioethics and scientific misconduct are often considered ethics or science studies rather than the philosophy of science. There is no consensus among philosophers about many of the central problems concerned with the philosophy of science, including whether science can reveal the truth about unobservable things and whether scientific reasoning can be justified at all. In addition to these general questions about science as a whole, philosophers of science consi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paul Rabinow
Paul M. Rabinow (June 21, 1944 – April 6, 2021) was professor of anthropology at the University of California (Berkeley), director of the Anthropology of the Contemporary Research Collaboratory (ARC), and former director of human practices for the Synthetic Biology Engineering Research Center (SynBERC). He is perhaps most famous for his widely influential commentary and expertise on the French philosopher Michel Foucault. His major works include ''Reflections on Fieldwork in Morocco'' (1977 and 2007), ''Michel Foucault: Beyond Structuralism and Hermeneutics'' (1983) (with Hubert Dreyfus), ''The Foucault Reader'' (1984), ''French Modern: Norms and Forms of the Social Environment'' (1989), ''Making PCR: A Story of Biotechnology'' (1993), ''Essays on the Anthropology of Reason'' (1996), ''Anthropos Today: Reflections on Modern Equipment'' (2003), and ''Marking Time: On the Anthropology of the Contemporary'' (2007). Biographical details Rabinow was born in Florida, but was raise ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Har Gobind Khorana
Har Gobind Khorana (9 January 1922 – 9 November 2011) was an Indian American biochemist. While on the faculty of the University of Wisconsin–Madison, he shared the 1968 Nobel Prize for Physiology or Medicine with Marshall W. Nirenberg and Robert W. Holley for research that showed the order of nucleotides in nucleic acids, which carry the genetic code of the cell and control the cell's synthesis of proteins. Khorana and Nirenberg were also awarded the Louisa Gross Horwitz Prize from Columbia University in the same year. Born in British India, Khorana served on the faculties of three universities in North America. He became a naturalized citizen of the United States in 1966, and received the National Medal of Science in 1987. Biography Khorana was born to Krishna Devi Khorana and Ganpat Rai Khorana, in Raipur, a village in Multan, Punjab, British India in a Punjabi Hindu family. The exact date of his birth is not certain but he believed that it might have been 9 January 19 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cetus Corporation
Cetus Corporation was one of the first biotechnology companies. It was established in Berkeley, California, in 1971, but conducted most of its operations in nearby Emeryville. Before merging with Chiron Corporation in 1991 (now a part of Novartis), it developed several significant pharmaceutical drugs as well as a revolutionary DNA amplification technique. History Cetus was founded in 1971 by Ronald E. Cape, Peter Farley, and Nobelist Donald A. Glaser. Its early efforts involved automated methods to select for industrial microorganisms that could produce greater amounts of chemical feedstocks, antibiotics, or vaccine components. By the late 1970s, however, three new revolutionary techniques had been developed: recombinant DNA, monoclonal antibodies, and gene expression, the foundations of the biotechnology industry. In order to enter these new fields, Cetus raised $108 million in an initial public offering (IPO) in 1981, the largest IPO to that date. Its first large deve ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kary Mullis
Kary Banks Mullis (December 28, 1944August 7, 2019) was an American biochemist. In recognition of his role in the invention of the polymerase chain reaction (PCR) technique, he shared the 1993 Nobel Prize in Chemistry with Michael Smith and was awarded the Japan Prize in the same year. PCR became a central technique in biochemistry and molecular biology, described by ''The New York Times'' as "highly original and significant, virtually dividing biology into the two epochs of before PCR and after PCR." Mullis attracted controversy for downplaying humans' role in climate change and for expressing doubts that HIV is the sole cause of AIDS. Early life Mullis was born in Lenoir, North Carolina, near the Blue Ridge Mountains, on December 28, 1944 to Cecil Banks Mullis and Bernice Barker Mullis. His family had a background in farming in this rural area. As a child, Mullis said, he was interested in observing organisms in the countryside. He and his cousins would often taunt live ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polymerase Chain Reaction
The polymerase chain reaction (PCR) is a method widely used to rapidly make millions to billions of copies (complete or partial) of a specific DNA sample, allowing scientists to take a very small sample of DNA and amplify it (or a part of it) to a large enough amount to study in detail. PCR was invented in 1983 by the American biochemist Kary Mullis at Cetus Corporation; Mullis and biochemist Michael Smith (chemist), Michael Smith, who had developed other essential ways of manipulating DNA, were jointly awarded the Nobel Prize in Chemistry in 1993. PCR is fundamental to many of the procedures used in genetic testing and research, including analysis of Ancient DNA, ancient samples of DNA and identification of infectious agents. Using PCR, copies of very small amounts of DNA sequences are exponentially amplified in a series of cycles of temperature changes. PCR is now a common and often indispensable technique used in medical laboratory research for a broad variety of applications ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Domestication
Domestication is a sustained multi-generational relationship in which humans assume a significant degree of control over the reproduction and care of another group of organisms to secure a more predictable supply of resources from that group. A broader biological definition is that it is a coevolutionary process that arises from a mutualism, in which one species (the domesticator) constructs an environment where it actively manages both the survival and reproduction of another species (the domesticate) in order to provide the former with resources and/or services. The domestication of plants and animals by humans was a major cultural innovation ranked in importance with the conquest of fire, the manufacturing of tools, and the development of verbal language. Charles Darwin recognized the small number of traits that made domestic species different from their wild ancestors. He was also the first to recognize the difference between conscious selective breeding (i.e. artificial se ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Experiment
An experiment is a procedure carried out to support or refute a hypothesis, or determine the efficacy or likelihood of something previously untried. Experiments provide insight into Causality, cause-and-effect by demonstrating what outcome occurs when a particular factor is manipulated. Experiments vary greatly in goal and scale but always rely on repeatable procedure and logical analysis of the results. There also exist natural experiment, natural experimental studies. A child may carry out basic experiments to understand how things fall to the ground, while teams of scientists may take years of systematic investigation to advance their understanding of a phenomenon. Experiments and other types of hands-on activities are very important to student learning in the science classroom. Experiments can raise test scores and help a student become more engaged and interested in the material they are learning, especially when used over time. Experiments can vary from personal and in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
