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Ernst Freese
Dr. Ernst Freese (September 27, 1925 - March 30, 1990) was a molecular biologist who worked on the mechanism of mutations in DNA. From 1962 until his death he was Chief of the National Institute of Neurological Disorders and Stroke (NINDS) Laboratory of Molecular Biology at the National Institutes of Health (NIH). Ernst Freese's scientific career started in theoretical particle physics and later moved to molecular biology where he contributed to early genetics research. Education and academic career Ernst Freese began his career as a student of physics with Werner Heisenberg at the University of Göttingen, Göttingen, Germany, where Freese received his PhD in 1953 in work in theoretical particle physics. He came to the United States in 1954 to work as a postdoctoral fellow with Enrico Fermi at the University of Chicago. He started his career in biology at Max Delbrück's laboratory at the California Institute of Technology in 1955. He held research positions at the University o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Göttingen
The University of Göttingen, officially the Georg August University of Göttingen, (german: Georg-August-Universität Göttingen, known informally as Georgia Augusta) is a public research university in the city of Göttingen, Germany. Founded in 1734 by George II, King of Great Britain and Elector of Hanover, and starting classes in 1737, the Georgia Augusta was conceived to promote the ideals of the Enlightenment. It is the oldest university in the state of Lower Saxony and the largest in student enrollment, which stands at around 31,600. Home to many noted figures, it represents one of Germany's historic and traditional institutions. According to an official exhibition held by the University of Göttingen in 2002, 44 Nobel Prize winners had been affiliated with the University of Göttingen as alumni, faculty members or researchers by that year alone. The University of Göttingen was previously supported by the German Universities Excellence Initiative, holds memberships ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Proceedings Of The National Academy Of Sciences Of The United States Of America
''Proceedings of the National Academy of Sciences of the United States of America'' (often abbreviated ''PNAS'' or ''PNAS USA'') is a peer-reviewed multidisciplinary scientific journal. It is the official journal of the National Academy of Sciences, published since 1915, and publishes original research, scientific reviews, commentaries, and letters. According to ''Journal Citation Reports'', the journal has a 2021 impact factor of 12.779. ''PNAS'' is the second most cited scientific journal, with more than 1.9 million cumulative citations from 2008 to 2018. In the mass media, ''PNAS'' has been described variously as "prestigious", "sedate", "renowned" and "high impact". ''PNAS'' is a delayed open access journal, with an embargo period of six months that can be bypassed for an author fee ( hybrid open access). Since September 2017, open access articles are published under a Creative Commons license. Since January 2019, ''PNAS'' has been online-only, although print issues are ava ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Humboldt Prize
The Humboldt Prize, the Humboldt-Forschungspreis in German, also known as the Humboldt Research Award, is an award given by the Alexander von Humboldt Foundation of Germany to internationally renowned scientists and scholars who work outside of Germany in recognition of their lifetime's research achievements. Recipients are "academics whose fundamental discoveries, new theories or insights have had a significant impact on their own discipline and who are expected to continue producing cutting-edge academic achievements in the future". The prize is currently valued at €60,000 with the possibility of further support during the prize winner's life. Up to one hundred such awards are granted each year. Nominations must be submitted by established academics in Germany. The award is named after the Prussian naturalist and explorer Alexander von Humboldt. Past winners Biology Günter Blobel, Serge Daan, Aaron M. Ellison, Eberhard Fetz, Daniel Gianola, Hendrikus Granzier, Dan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Brain Research
''Molecular Brain Research'' was a peer-reviewed scientific journal of molecular neuroscience. It was established in 1989 and was merged with ''Brain Research ''Brain Research'' is a peer-reviewed scientific journal focusing on several aspects of neuroscience. It publishes research reports and " minireviews". The editor-in-chief is Matthew J. LaVoie (University of Florida). Until 2011, full reviews were ...'' in 2006. External links ''Molecular Brain Research''online archive List of ''Molecular Brain Research'' issuesat IngentaConnect ''Brain Research'' Neuroscience journals Academic journals established in 1989 Publications disestablished in 2005 Elsevier academic journals English-language journals {{neuroscience-journal-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glial Fibrillary Acidic Protein
Glial fibrillary acidic protein (GFAP) is a protein that is encoded by the ''GFAP'' gene in humans. It is a type III intermediate filament (IF) protein that is expressed by numerous cell types of the central nervous system (CNS), including astrocytes and ependymal cells during development. GFAP has also been found to be expressed in glomeruli and peritubular fibroblasts taken from rat kidneys, Leydig cells of the testis in both hamsters and humans, human keratinocytes, human osteocytes and chondrocytes and stellate cells of the pancreas and liver in rats. GFAP is closely related to the other three non-epithelial type III IF family members, vimentin, desmin and peripherin, which are all involved in the structure and function of the cell’s cytoskeleton. GFAP is thought to help to maintain astrocyte mechanical strength as well as the shape of cells, but its exact function remains poorly understood, despite the number of studies using it as a cell marker. The protein was named and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Penguin Press
Penguin Group is a British trade book publisher and part of Penguin Random House, which is owned by the German media conglomerate Bertelsmann. The new company was created by a merger that was finalised on 1 July 2013, with Bertelsmann initially owning 53% of the joint venture, and Pearson PLC initially owning the remaining 47%. Since 18 December 2019, Penguin Random House has been wholly owned by Bertelsmann. Penguin Books has its registered office in City of Westminster, London.Maps ." . Retrieved 28 August 2009. Its British division is Penguin Books Ltd. Other separate divisions are located in the |
Craig Venter
John Craig Venter (born October 14, 1946) is an American biotechnologist and businessman. He is known for leading one of the first draft sequences of the human genome and assembled the first team to transfect a cell with a synthetic chromosome. Venter founded Celera Genomics, the Institute for Genomic Research (TIGR) and the J. Craig Venter Institute (JCVI). He was the co-founder of Human Longevity Inc. and Synthetic Genomics. He was listed on ''Time'' magazine's 2007 and 2008 ''Time'' 100 list of the most influential people in the world. In 2010, the British magazine ''New Statesman'' listed Craig Venter at 14th in the list of "The World's 50 Most Influential Figures 2010". In 2012, Venter was honored with Dan David Prize for his contribution to genome research. He was elected to the American Philosophical Society in 2013. He is a member of the USA Science and Engineering Festival's advisory board. retrieved 2010-07-05 Early life and education Venter was born in Salt Lake ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
John E
John is a common English name and surname: * John (given name) * John (surname) John may also refer to: New Testament Works * Gospel of John, a title often shortened to John * First Epistle of John, often shortened to 1 John * Second Epistle of John, often shortened to 2 John * Third Epistle of John, often shortened to 3 John People * John the Baptist (died c. AD 30), regarded as a prophet and the forerunner of Jesus Christ * John the Apostle (lived c. AD 30), one of the twelve apostles of Jesus * John the Evangelist, assigned author of the Fourth Gospel, once identified with the Apostle * John of Patmos, also known as John the Divine or John the Revelator, the author of the Book of Revelation, once identified with the Apostle * John the Presbyter, a figure either identified with or distinguished from the Apostle, the Evangelist and John of Patmos Other people with the given name Religious figures * John, father of Andrew the Apostle and Saint Peter * Pope J ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Environmental Mutagen Society
The Environmental Mutagenesis and Genomics Society (EMGS) is a scientific society "for the promotion of critical scientific knowledge and research into the causes and consequences of damage to the genome and epigenome in order to inform and support national and international efforts to ensure a healthy, sustainable environment for future generations." The society promotes scientific research into the causes of DNA damage and repair and the relevance of these to disease. It also promotes the application and communication of this knowledge, especially through education, to help protect human health and the environment. History The society, originally founded as the Environmental Mutagen Society (EMS) was formed in the USA in 1969 by Drs. Alexander Hollaender, Joshua Lederberg, James Crow, Ernst Freese, James Neel, William Russell, Heinrich Malling, Frederick J. de Serres, Matthew Meselson, and others. The initial aim was to support the study of environmental mutagenesis, original ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pyrimidine
Pyrimidine (; ) is an aromatic, heterocyclic, organic compound similar to pyridine (). One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has nitrogen atoms at positions 1 and 3 in the ring. The other diazines are pyrazine (nitrogen atoms at the 1 and 4 positions) and pyridazine (nitrogen atoms at the 1 and 2 positions). In nucleic acids, three types of nucleobases are pyrimidine derivatives: cytosine (C), thymine (T), and uracil (U). Occurrence and history The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. It is also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Although pyrimidine derivatives such as alloxan were known in the early 19th century, a laboratory synthesis of a pyrimidine was not carried out until 1879, when Grimaux reported the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Purine
Purine is a heterocyclic compound, heterocyclic aromatic organic compound that consists of two rings (pyrimidine and imidazole) fused together. It is water-soluble. Purine also gives its name to the wider class of molecules, purines, which include substituted purines and their tautomers. They are the most widely occurring nitrogen-containing heterocycles in nature. Dietary sources Purines are found in high concentration in meat and meat products, especially internal organs such as liver and kidney. In general, plant-based diets are low in purines. High-purine plants and algae include some legumes (lentils and Black-eyed pea, black eye peas) and Spirulina (dietary supplement), spirulina. Examples of high-purine sources include: sweetbreads, Anchovies as food, anchovies, Sardines as food, sardines, liver, beef kidneys, Brain as food, brains, meat extracts (e.g., Oxo (food), Oxo, Bovril), herring, mackerel, scallops, game meats, yeast (beer, yeast extract, nutritional yeast) and g ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transition (genetics)
Transition, in genetics and molecular biology, refers to a point mutation that changes a purine nucleotide to another purine ( A ↔ G), or a pyrimidine nucleotide to another pyrimidine ( C ↔ T). Approximately two out of three single nucleotide polymorphisms (SNPs) are transitions. Transitions can be caused by oxidative deamination and tautomerization. Although there are twice as many possible transversions, transitions appear more often in genomes, possibly due to the molecular mechanisms that generate them. 5-Methylcytosine is more prone to transition than unmethylated cytosine, due to spontaneous deamination. This mechanism is important because it dictates the rarity of CpG islands. See also * Transversion Transversion, in molecular biology, refers to a point mutation in DNA in which a single (two ring) purine ( A or G) is changed for a (one ring) pyrimidine ( T or C), or vice versa. A transversion can be spontaneous, or it can be caused by i ... References ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
